membrane attack complex Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description A protein complex produced by sequentially activated components of the complement cascade inserted into a target cell membrane and forming a pore leading to cell lysis via ion and water flow. (Gene Ontology, GO_0005579)
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Genes

143 proteins co-occuring with the membrane attack complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
CD59 CD59 molecule, complement regulatory protein 3.11009
C5AR1 complement component 5a receptor 1 2.53893
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 2.34081
PIGA phosphatidylinositol glycan anchor biosynthesis, class A 1.9784
CFP complement factor properdin 1.92647
CD46 CD46 molecule, complement regulatory protein 1.83474
CR1 complement component (3b/4b) receptor 1 (Knops blood group) 1.82524
CDSN corneodesmosin 1.80841
PRF1 perforin 1 (pore forming protein) 1.73624
C9 complement component 9 1.64015
SEBOX SEBOX homeobox 1.55821
C3 complement component 3 1.52371
C6 complement component 6 1.51243
CFH complement factor H 1.48758
C5 complement component 5 1.42993
C8B complement component 8, beta polypeptide 1.36472
C7 complement component 7 1.36252
C4A complement component 4A (Rodgers blood group) 1.34392
C2 complement component 2 1.28516
C1R complement component 1, r subcomponent 1.14443
CFHR2 complement factor H-related 2 1.12807
CFB complement factor B 1.11735
C1S complement component 1, s subcomponent 1.11174
CFHR1 complement factor H-related 1 1.09645
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 1.04833
CLU clusterin 1.03129
CFI complement factor I 0.998086
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 0.994652
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1 0.993672
C8A complement component 8, alpha polypeptide 0.980501
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) 0.943533
CRP C-reactive protein, pentraxin-related 0.918579
CXCL8 chemokine (C-X-C motif) ligand 8 0.903673
MPO myeloperoxidase 0.888859
IL6 interleukin 6 0.881016
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 0.86077
C3AR1 complement component 3a receptor 1 0.852961
FCN2 ficolin (collagen/fibrinogen domain containing lectin) 2 0.850665
MBL2 mannose-binding lectin (protein C) 2, soluble 0.827712
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1 0.821288
ALB albumin 0.765893
ICAM1 intercellular adhesion molecule 1 0.762252
CD79A CD79a molecule, immunoglobulin-associated alpha 0.758161
TNF tumor necrosis factor 0.752716
SELE selectin E 0.74322
RGCC regulator of cell cycle 0.742769
CDC42SE1 CDC42 small effector 1 0.736014
FLVCR2 feline leukemia virus subgroup C cellular receptor family, member 2 0.725258
SELP selectin P (granule membrane protein 140kDa, antigen CD62) 0.719906
FCN3 ficolin (collagen/fibrinogen domain containing) 3 0.69427
CREG1 cellular repressor of E1A-stimulated genes 1 0.69427
LTF lactotransferrin 0.691202
MASP2 mannan-binding lectin serine peptidase 2 0.665962
C1QB complement component 1, q subcomponent, B chain 0.665529
CFHR5 complement factor H-related 5 0.657757
ELANE elastase, neutrophil expressed 0.645716
CFHR3 complement factor H-related 3 0.633305
C5AR2 complement component 5a receptor 2 0.632878
TPT1 tumor protein, translationally-controlled 1 0.580922
LRP2 low density lipoprotein receptor-related protein 2 0.573828
F2 coagulation factor II (thrombin) 0.5597
VWF von Willebrand factor 0.54194
CR2 complement component (3d/Epstein Barr virus) receptor 2 0.541529
LDLR low density lipoprotein receptor 0.527569
IL1B interleukin 1, beta 0.50635
FCN1 ficolin (collagen/fibrinogen domain containing) 1 0.504318
PROCR protein C receptor, endothelial 0.503506
SHE Src homology 2 domain containing E 0.496205
MASP1 mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor) 0.493371
IL1A interleukin 1, alpha 0.488923
SELL selectin L 0.482467
PRELP proline/arginine-rich end leucine-rich repeat protein 0.4608
THBD thrombomodulin 0.455613
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 0.449643
CD4 CD4 molecule 0.447656
COLEC11 collectin sub-family member 11 0.444482
CD2 CD2 molecule 0.441312
CCL2 chemokine (C-C motif) ligand 2 0.432224
LAMA2 laminin, alpha 2 0.425531
F3 coagulation factor III (thromboplastin, tissue factor) 0.421212
C8G complement component 8, gamma polypeptide 0.404026
HLA-B major histocompatibility complex, class I, B 0.398199
CXCL12 chemokine (C-X-C motif) ligand 12 0.397423
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.395098
PDE7B phosphodiesterase 7B 0.389682
RNF34 ring finger protein 34, E3 ubiquitin protein ligase 0.367771
GATC glutamyl-tRNA(Gln) amidotransferase, subunit C 0.364331
MPEG1 macrophage expressed 1 0.361277
VCAM1 vascular cell adhesion molecule 1 0.358609
TCTA T-cell leukemia translocation altered 0.351762
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin) 0.348346
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1 0.341151
DIABLO diablo, IAP-binding mitochondrial protein 0.336619
SDC1 syndecan 1 0.335864
ENDOU endonuclease, polyU-specific 0.334356
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.328332
APOE apolipoprotein E 0.324201
ICAM2 intercellular adhesion molecule 2 0.324201
GPR182 G protein-coupled receptor 182 0.30924
PLAT plasminogen activator, tissue 0.30924
MBTPS1 membrane-bound transcription factor peptidase, site 1 0.30254
EDA ectodysplasin A 0.301054
DCLK3 doublecortin-like kinase 3 0.292897
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 0.285876
FBXO3 F-box protein 3 0.275569
SEC23B Sec23 homolog B (S. cerevisiae) 0.266042
PLG plasminogen 0.26385
IL10 interleukin 10 0.262025
SERPINF2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 0.26166
HRG histidine-rich glycoprotein 0.260566
NUDT10 nudix (nucleoside diphosphate linked moiety X)-type motif 10 0.256925
SERPINB7 serpin peptidase inhibitor, clade B (ovalbumin), member 7 0.25438
C1QC complement component 1, q subcomponent, C chain 0.253291
CSMD1 CUB and Sushi multiple domains 1 0.251476
FMOD fibromodulin 0.250751
STX2 syntaxin 2 0.226686
LBP lipopolysaccharide binding protein 0.226331
IGHV3-30 immunoglobulin heavy variable 3-30 0.22385
NTSR1 neurotensin receptor 1 (high affinity) 0.216111
DNASE1L1 deoxyribonuclease I-like 1 0.209513
QRSL1 glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1 0.204378
CD5 CD5 molecule 0.204378
DEFB103A defensin, beta 103A 0.204039
NPY1R neuropeptide Y receptor Y1 0.203361
GAA glucosidase, alpha; acid 0.200328
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.196999
PGAP3 post-GPI attachment to proteins 3 0.194045
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 0.186708
HPX hemopexin 0.186397
S100B S100 calcium binding protein B 0.181227
KCP kielin/chordin-like protein 0.179752
MPG N-methylpurine-DNA glycosylase 0.176587
COMP cartilage oligomeric matrix protein 0.176305
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13 0.175466
ST8SIA2 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 0.173273
BCKDHA branched chain keto acid dehydrogenase E1, alpha polypeptide 0.165463
FSTL1 follistatin-like 1 0.16477
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.16342
LYZ lysozyme 0.16342
DEFB103B defensin, beta 103B 0.159462
SPON1 spondin 1, extracellular matrix protein 0.159268
MGAM maltase-glucoamylase 0.158882
CFD complement factor D (adipsin) 0.157397