melatonin-2431 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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195 genes differentially expressed following the melatonin-2431 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADCK4 aarF domain containing kinase 4
ADCY6 adenylate cyclase 6
ADCY9 adenylate cyclase 9
ADH7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
AFF1 AF4/FMR2 family, member 1
ALOX12P2 arachidonate 12-lipoxygenase pseudogene 2
AP4E1 adaptor-related protein complex 4, epsilon 1 subunit
APBB1IP amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
APOD apolipoprotein D
ATP2A3 ATPase, Ca++ transporting, ubiquitous
ATXN3 ataxin 3
AURKA aurora kinase A
BCL6 B-cell CLL/lymphoma 6
C20ORF27 chromosome 20 open reading frame 27
CCDC57 coiled-coil domain containing 57
CD9 CD9 molecule
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CEP164 centrosomal protein 164kDa
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
CNN3 calponin 3, acidic
COL18A1 collagen, type XVIII, alpha 1
CPNE1 copine I
CPTP ceramide-1-phosphate transfer protein
CRAT carnitine O-acetyltransferase
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
CYP2W1 cytochrome P450, family 2, subfamily W, polypeptide 1
DHRS12 dehydrogenase/reductase (SDR family) member 12
DLG3 discs, large homolog 3 (Drosophila)
ECE1 endothelin converting enzyme 1
EIF5A2 eukaryotic translation initiation factor 5A2
ESRRA estrogen-related receptor alpha
FABP3 fatty acid binding protein 3, muscle and heart
FBLN1 fibulin 1
FBXO31 F-box protein 31
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FGFBP1 fibroblast growth factor binding protein 1
FKBP1A FK506 binding protein 1A, 12kDa
FOXP3 forkhead box P3
GNMT glycine N-methyltransferase
GPRIN2 G protein regulated inducer of neurite outgrowth 2
HDAC11 histone deacetylase 11
HN1L hematological and neurological expressed 1-like
IDS iduronate 2-sulfatase
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
L3MBTL1 l(3)mbt-like 1 (Drosophila)
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LPPR1 lipid phosphate phosphatase-related protein type 1
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
METTL16 methyltransferase like 16
MRC2 mannose receptor, C type 2
MTSS1 metastasis suppressor 1
NEBL nebulette
NOX1 NADPH oxidase 1
NR6A1 nuclear receptor subfamily 6, group A, member 1
NUP188 nucleoporin 188kDa
NXPE3 neurexophilin and PC-esterase domain family, member 3
PDE4DIP phosphodiesterase 4D interacting protein
PKD1 polycystic kidney disease 1 (autosomal dominant)
PLCE1 phospholipase C, epsilon 1
PLK3 polo-like kinase 3
PREX2 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
PRR7 proline rich 7 (synaptic)
PTBP3 polypyrimidine tract binding protein 3
PYCRL pyrroline-5-carboxylate reductase-like
RAB13 RAB13, member RAS oncogene family
RAB35 RAB35, member RAS oncogene family
REEP1 receptor accessory protein 1
REPS1 RALBP1 associated Eps domain containing 1
RFPL3 ret finger protein-like 3
RNASE3 ribonuclease, RNase A family, 3
RPL10L ribosomal protein L10-like
RPS2P45 ribosomal protein S2 pseudogene 45
RSPH14 radial spoke head 14 homolog (Chlamydomonas)
RXRB retinoid X receptor, beta
SARM1 sterile alpha and TIR motif containing 1
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SEZ6L2 seizure related 6 homolog (mouse)-like 2
SH2D3A SH2 domain containing 3A
SHOX2 short stature homeobox 2
SIGLEC8 sialic acid binding Ig-like lectin 8
SLC12A4 solute carrier family 12 (potassium/chloride transporter), member 4
SLC16A5 solute carrier family 16 (monocarboxylate transporter), member 5
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5
SMAD5 SMAD family member 5
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
STAG3L4 stromal antigen 3-like 4 (pseudogene)
SYCP2 synaptonemal complex protein 2
TEX40 testis expressed 40
THSD7A thrombospondin, type I, domain containing 7A
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
TNPO2 transportin 2
UBR4 ubiquitin protein ligase E3 component n-recognin 4
UNC45A unc-45 homolog A (C. elegans)
ZFHX4 zinc finger homeobox 4
ZFYVE9 zinc finger, FYVE domain containing 9
ZIM2 zinc finger, imprinted 2

decreased expression

Symbol Name
AEN apoptosis enhancing nuclease
AGPAT4 1-acylglycerol-3-phosphate O-acyltransferase 4
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1
ASGR2 asialoglycoprotein receptor 2
ATHL1 ATH1, acid trehalase-like 1 (yeast)
BCAR3 breast cancer anti-estrogen resistance 3
BPI bactericidal/permeability-increasing protein
C22ORF46 chromosome 22 open reading frame 46
C3ORF18 chromosome 3 open reading frame 18
C7ORF43 chromosome 7 open reading frame 43
C9ORF9 chromosome 9 open reading frame 9
CCNT1 cyclin T1
CDK3 cyclin-dependent kinase 3
CENPB centromere protein B, 80kDa
CEP97 centrosomal protein 97kDa
CHST7 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
CLCN2 chloride channel, voltage-sensitive 2
CLCN6 chloride channel, voltage-sensitive 6
CNTLN centlein, centrosomal protein
COL15A1 collagen, type XV, alpha 1
COLQ collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase
CRELD1 cysteine-rich with EGF-like domains 1
CRY2 cryptochrome circadian clock 2
CRYZ crystallin, zeta (quinone reductase)
CTSV cathepsin V
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3
DNAL4 dynein, axonemal, light chain 4
DPEP2 dipeptidase 2
FGF23 fibroblast growth factor 23
FGL1 fibrinogen-like 1
FSTL3 follistatin-like 3 (secreted glycoprotein)
FURIN furin (paired basic amino acid cleaving enzyme)
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3
GJA8 gap junction protein, alpha 8, 50kDa
HAMP hepcidin antimicrobial peptide
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3
HIST1H2AI histone cluster 1, H2ai
HIST1H2AM histone cluster 1, H2am
HIST1H2BN histone cluster 1, H2bn
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HS1BP3 HCLS1 binding protein 3
HSPBP1 HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1
ICAM5 intercellular adhesion molecule 5, telencephalin
IFNA14 interferon, alpha 14
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
INPP5A inositol polyphosphate-5-phosphatase, 40kDa
INPPL1 inositol polyphosphate phosphatase-like 1
IPO8 importin 8
KANSL1L KAT8 regulatory NSL complex subunit 1-like
LOC257152 uncharacterized LOC257152
LOC390998 ribosomal protein L10 pseudogene
LY6D lymphocyte antigen 6 complex, locus D
LZTS3 leucine zipper, putative tumor suppressor family member 3
MIR22HG MIR22 host gene
MRAS muscle RAS oncogene homolog
MTL5 metallothionein-like 5, testis-specific (tesmin)
NCKAP1L NCK-associated protein 1-like
NIPAL2 NIPA-like domain containing 2
NOTCH4 notch 4
P2RY11 purinergic receptor P2Y, G-protein coupled, 11
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PCSK7 proprotein convertase subtilisin/kexin type 7
PDGFRL platelet-derived growth factor receptor-like
PHACTR1 phosphatase and actin regulator 1
PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5
PNOC prepronociceptin
PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4
PSKH1 protein serine kinase H1
PTPRS protein tyrosine phosphatase, receptor type, S
QPCTL glutaminyl-peptide cyclotransferase-like
QSER1 glutamine and serine rich 1
RAB33A RAB33A, member RAS oncogene family
RHBDF2 rhomboid 5 homolog 2 (Drosophila)
RPL13P5 ribosomal protein L13 pseudogene 5
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
SLITRK5 SLIT and NTRK-like family, member 5
SPATA20 spermatogenesis associated 20
SPRR2B small proline-rich protein 2B
STEAP3 STEAP family member 3, metalloreductase
STX11 syntaxin 11
THEM6 thioesterase superfamily member 6
TNS2 tensin 2
TRDMT1 tRNA aspartic acid methyltransferase 1
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TSC22D4 TSC22 domain family, member 4
TSPAN2 tetraspanin 2
TSSC4 tumor suppressing subtransferable candidate 4
TTC30A tetratricopeptide repeat domain 30A
TUFT1 tuftelin 1
VEGFC vascular endothelial growth factor C
VEZT vezatin, adherens junctions transmembrane protein
WDR13 WD repeat domain 13
WDR82 WD repeat domain 82
ZCWPW1 zinc finger, CW type with PWWP domain 1
ZKSCAN3 zinc finger with KRAB and SCAN domains 3
ZNF701 zinc finger protein 701