megestrol-6468 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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197 genes differentially expressed following the megestrol-6468 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACE angiotensin I converting enzyme
ACVRL1 activin A receptor type II-like 1
AGER advanced glycosylation end product-specific receptor
AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2
ALDOB aldolase B, fructose-bisphosphate
APOBEC3A apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A
ARL4D ADP-ribosylation factor-like 4D
ATP6V0A2 ATPase, H+ transporting, lysosomal V0 subunit a2
C5AR1 complement component 5a receptor 1
CADM4 cell adhesion molecule 4
CAMKV CaM kinase-like vesicle-associated
CIB2 calcium and integrin binding family member 2
CLEC10A C-type lectin domain family 10, member A
CLIP2 CAP-GLY domain containing linker protein 2
CNKSR2 connector enhancer of kinase suppressor of Ras 2
CREB5 cAMP responsive element binding protein 5
CRYAB crystallin, alpha B
DAPK1 death-associated protein kinase 1
DLX2 distal-less homeobox 2
DNAJB12 DnaJ (Hsp40) homolog, subfamily B, member 12
EGR3 early growth response 3
EMID1 EMI domain containing 1
ENG endoglin
EPHB2 EPH receptor B2
EPYC epiphycan
ERAP1 endoplasmic reticulum aminopeptidase 1
FABP3 fatty acid binding protein 3, muscle and heart
FAIM2 Fas apoptotic inhibitory molecule 2
FGF8 fibroblast growth factor 8 (androgen-induced)
FHL1 four and a half LIM domains 1
FIGF c-fos induced growth factor (vascular endothelial growth factor D)
FOLR1 folate receptor 1 (adult)
FOSL2 FOS-like antigen 2
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GFAP glial fibrillary acidic protein
GGTLC1 gamma-glutamyltransferase light chain 1
GJD2 gap junction protein, delta 2, 36kDa
GNG13 guanine nucleotide binding protein (G protein), gamma 13
GNRHR gonadotropin-releasing hormone receptor
GOLGA8A golgin A8 family, member A
GPLD1 glycosylphosphatidylinositol specific phospholipase D1
GRM1 glutamate receptor, metabotropic 1
HCN2 hyperpolarization activated cyclic nucleotide gated potassium channel 2
HLA-DOA major histocompatibility complex, class II, DO alpha
IL2RG interleukin 2 receptor, gamma
INADL InaD-like (Drosophila)
IRF4 interferon regulatory factor 4
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2
KIF5A kinesin family member 5A
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KLF1 Kruppel-like factor 1 (erythroid)
LAMA4 laminin, alpha 4
LECT1 leukocyte cell derived chemotaxin 1
LILRP2 leukocyte immunoglobulin-like receptor pseudogene 2
LTBP2 latent transforming growth factor beta binding protein 2
LY6G6C lymphocyte antigen 6 complex, locus G6C
MAX MYC associated factor X
MIER2 mesoderm induction early response 1, family member 2
OPCML opioid binding protein/cell adhesion molecule-like
OPLAH 5-oxoprolinase (ATP-hydrolysing)
PDLIM3 PDZ and LIM domain 3
PER1 period circadian clock 1
PIDD1 p53-induced death domain protein 1
PNPLA3 patatin-like phospholipase domain containing 3
RAB11B RAB11B, member RAS oncogene family
RIMS2 regulating synaptic membrane exocytosis 2
RNF122 ring finger protein 122
RUNX1 runt-related transcription factor 1
SAG S-antigen; retina and pineal gland (arrestin)
SCAPER S-phase cyclin A-associated protein in the ER
SCN8A sodium channel, voltage gated, type VIII alpha subunit
SDHD succinate dehydrogenase complex, subunit D, integral membrane protein
SH2D3A SH2 domain containing 3A
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2
SLC6A16 solute carrier family 6, member 16
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMAD3 SMAD family member 3
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SPRR1A small proline-rich protein 1A
SPTBN2 spectrin, beta, non-erythrocytic 2
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
SUGCT succinyl-CoA:glutarate-CoA transferase
THRB thyroid hormone receptor, beta
TP53I11 tumor protein p53 inducible protein 11
TPMT thiopurine S-methyltransferase
TRD T cell receptor delta locus
TRIM2 tripartite motif containing 2
TRMT44 tRNA methyltransferase 44 homolog (S. cerevisiae)
TUBA3C tubulin, alpha 3c
VPS13D vacuolar protein sorting 13 homolog D (S. cerevisiae)
WSCD1 WSC domain containing 1
YIF1B Yip1 interacting factor homolog B (S. cerevisiae)
YY2 YY2 transcription factor
ZBTB44 zinc finger and BTB domain containing 44
ZNF551 zinc finger protein 551
ZSCAN2 zinc finger and SCAN domain containing 2

decreased expression

Symbol Name
A4GALT alpha 1,4-galactosyltransferase
ALG12 ALG12, alpha-1,6-mannosyltransferase
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26
BCL9 B-cell CLL/lymphoma 9
BPHL biphenyl hydrolase-like (serine hydrolase)
C11ORF80 chromosome 11 open reading frame 80
C19ORF40 chromosome 19 open reading frame 40
C1ORF115 chromosome 1 open reading frame 115
C7ORF43 chromosome 7 open reading frame 43
C7ORF69 chromosome 7 open reading frame 69
C8ORF60 chromosome 8 open reading frame 60
CABYR calcium binding tyrosine-(Y)-phosphorylation regulated
CAPRIN2 caprin family member 2
CBR4 carbonyl reductase 4
CD3D CD3d molecule, delta (CD3-TCR complex)
CDKL3 cyclin-dependent kinase-like 3
CEL carboxyl ester lipase
CEP131 centrosomal protein 131kDa
CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3
CLIC2 chloride intracellular channel 2
CNR2 cannabinoid receptor 2 (macrophage)
CRABP1 cellular retinoic acid binding protein 1
CRIP1 cysteine-rich protein 1 (intestinal)
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
DCLRE1A DNA cross-link repair 1A
DDIT3 DNA-damage-inducible transcript 3
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DNAJC17 DnaJ (Hsp40) homolog, subfamily C, member 17
DNAJC28 DnaJ (Hsp40) homolog, subfamily C, member 28
DTX4 deltex 4, E3 ubiquitin ligase
EGFL7 EGF-like-domain, multiple 7
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
ERCC6 excision repair cross-complementation group 6
EXOC5 exocyst complex component 5
F3 coagulation factor III (thromboplastin, tissue factor)
GADD45G growth arrest and DNA-damage-inducible, gamma
GSTA4 glutathione S-transferase alpha 4
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3
HIST1H1B histone cluster 1, H1b
HIST1H2AK histone cluster 1, H2ak
HP1BP3 heterochromatin protein 1, binding protein 3
HSPB6 heat shock protein, alpha-crystallin-related, B6
HYAL2 hyaluronoglucosaminidase 2
HYI hydroxypyruvate isomerase (putative)
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IDI2-AS1 IDI2 antisense RNA 1
IFT81 intraflagellar transport 81
IKZF5 IKAROS family zinc finger 5 (Pegasus)
INO80D INO80 complex subunit D
IPO8 importin 8
KRT13 keratin 13, type I
MAP3K2 mitogen-activated protein kinase kinase kinase 2
METTL16 methyltransferase like 16
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1
MXD3 MAX dimerization protein 3
NAALAD2 N-acetylated alpha-linked acidic dipeptidase 2
NPIPB15 nuclear pore complex interacting protein family, member B15
OR7E156P olfactory receptor, family 7, subfamily E, member 156 pseudogene
OTUD3 OTU deubiquitinase 3
PAIP2B poly(A) binding protein interacting protein 2B
PBOV1 prostate and breast cancer overexpressed 1
PCDHA9 protocadherin alpha 9
PLEKHO2 pleckstrin homology domain containing, family O member 2
PMCHL1 pro-melanin-concentrating hormone-like 1, pseudogene
PRDM14 PR domain containing 14
PROL1 proline rich, lacrimal 1
PRSS50 protease, serine, 50
PVRL3 poliovirus receptor-related 3
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RARS arginyl-tRNA synthetase
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
RNF25 ring finger protein 25
SESN1 sestrin 1
SLC12A7 solute carrier family 12 (potassium/chloride transporter), member 7
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5
STRA6 stimulated by retinoic acid 6
TESC tescalcin
THNSL1 threonine synthase-like 1 (S. cerevisiae)
TMEM57 transmembrane protein 57
TMPRSS4 transmembrane protease, serine 4
TOM1 target of myb1 (chicken)
TRIM5 tripartite motif containing 5
TTBK2 tau tubulin kinase 2
TTLL1 tubulin tyrosine ligase-like family member 1
UBTD1 ubiquitin domain containing 1
VAV1 vav 1 guanine nucleotide exchange factor
WDR91 WD repeat domain 91
ZNF35 zinc finger protein 35
ZNF37BP zinc finger protein 37B, pseudogene
ZNF428 zinc finger protein 428
ZNF446 zinc finger protein 446
ZNF516 zinc finger protein 516
ZNF747 zinc finger protein 747
ZNF862 zinc finger protein 862