megaloblastic anemia Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description A macrocytic anemia that is characterized by inhibition of DNA synthesis during red blood cell production. (Human Disease Ontology, DOID_13382)
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Genes

83 genes co-occuring with the disease megaloblastic anemia in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
SLC19A2 solute carrier family 19 (thiamine transporter), member 2 2.64205
GIF gastric intrinsic factor (vitamin B synthesis) 2.60407
TCN2 transcobalamin II 2.21271
CUBN cubilin (intrinsic factor-cobalamin receptor) 2.10856
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase 1.92342
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase 1.81194
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family) 1.31275
MUT methylmalonyl CoA mutase 1.28654
SLC19A3 solute carrier family 19 (thiamine transporter), member 3 1.24993
MMACHC methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria 1.24211
SLC46A1 solute carrier family 46 (folate transporter), member 1 1.22995
MMAA methylmalonic aciduria (cobalamin deficiency) cblA type 1.1755
MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase 1.1605
DHFR dihydrofolate reductase 1.14772
CD320 CD320 molecule 1.10552
FTCD formimidoyltransferase cyclodeaminase 1.09461
PGA4 pepsinogen 4, group I (pepsinogen A) 1.07992
PGA3 pepsinogen 3, group I (pepsinogen A) 1.07992
HACL1 2-hydroxyacyl-CoA lyase 1 1.0109
PIGA phosphatidylinositol glycan anchor biosynthesis, class A 0.988114
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase 0.983479
TPK1 thiamin pyrophosphokinase 1 0.942858
MTHFR methylenetetrahydrofolate reductase (NAD(P)H) 0.918848
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 0.879014
ATP4B ATPase, H+/K+ exchanging, beta polypeptide 0.870006
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 0.853631
FOLR1 folate receptor 1 (adult) 0.798692
LMBRD1 LMBR1 domain containing 1 0.788442
SLC19A1 solute carrier family 19 (folate transporter), member 1 0.752085
GSPT1 G1 to S phase transition 1 0.717232
FTL ferritin, light polypeptide 0.709169
FTH1 ferritin, heavy polypeptide 1 0.709169
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.683493
TF transferrin 0.65763
EML1 echinoderm microtubule associated protein like 1 0.624927
MMD monocyte to macrophage differentiation-associated 0.619442
ALDH1L1 aldehyde dehydrogenase 1 family, member L1 0.60069
FDXR ferredoxin reductase 0.560616
GAST gastrin 0.552463
HBA1 hemoglobin, alpha 1 0.531541
CHRD chordin 0.521888
HPRT1 hypoxanthine phosphoribosyltransferase 1 0.516494
HBA2 hemoglobin, alpha 2 0.509192
MBD1 methyl-CpG binding domain protein 1 0.475634
GLIS3 GLIS family zinc finger 3 0.471846
CLCN6 chloride channel, voltage-sensitive 6 0.411283
LRP2 low density lipoprotein receptor-related protein 2 0.408292
TYMS thymidylate synthetase 0.404931
HP haptoglobin 0.399334
TFRC transferrin receptor 0.398216
HPR haptoglobin-related protein 0.393374
DUT deoxyuridine triphosphatase 0.371107
LDHA lactate dehydrogenase A 0.354868
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase) 0.346042
KRT83 keratin 83, type II 0.325916
ETV1 ets variant 1 0.315003
INS insulin 0.311739
FOLR2 folate receptor 2 (fetal) 0.302698
SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 16kDa 0.292257
CYGB cytoglobin 0.290462
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.286519
EPO erythropoietin 0.28151
FPGS folylpolyglutamate synthase 0.272597
QDPR quinoid dihydropteridine reductase 0.272241
HTN3 histatin 3 0.269753
UNG uracil-DNA glycosylase 0.268687
ALAS2 5'-aminolevulinate synthase 2 0.248203
HBE1 hemoglobin, epsilon 1 0.237009
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8 0.23666
CLCN5 chloride channel, voltage-sensitive 5 0.236312
ATP4A ATPase, H+/K+ exchanging, alpha polypeptide 0.233878
UMPS uridine monophosphate synthetase 0.231448
KCNJ11 potassium channel, inwardly rectifying subfamily J, member 11 0.226607
TES testin LIM domain protein 0.217693
SIRPA signal-regulatory protein alpha 0.212945
RER1 retention in endoplasmic reticulum sorting receptor 1 0.194865
ALPPL2 alkaline phosphatase, placental-like 2 0.193285
ALPP alkaline phosphatase, placental 0.192971
ALPL alkaline phosphatase, liver/bone/kidney 0.192344
MPO myeloperoxidase 0.189244
MPV17 MpV17 mitochondrial inner membrane protein 0.184128
APRT adenine phosphoribosyltransferase 0.167682
TKT transketolase 0.159302