megakaryocytic leukemia Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description A leukemia that derives_from blood-forming tissue in which megakaryocytes proliferate in the bone marrow and circulate in the blood in large numbers. (Human Disease Ontology, DOID_8761)
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Genes

138 genes co-occuring with the disease megakaryocytic leukemia in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
MKL1 megakaryoblastic leukemia (translocation) 1 2.29774
RBM15 RNA binding motif protein 15 2.17179
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 1.64397
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) 1.55912
GP1BA glycoprotein Ib (platelet), alpha polypeptide 1.38341
JAK3 Janus kinase 3 1.3027
SRF serum response factor (c-fos serum response element-binding transcription factor) 1.18453
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3 1.14009
GLIS2 GLIS family zinc finger 2 1.13163
ACIN1 apoptotic chromatin condensation inducer 1 1.07908
GATA1 GATA binding protein 1 (globin transcription factor 1) 1.07362
THPO thrombopoietin 1.06438
IL3 interleukin 3 1.05597
PF4 platelet factor 4 1.05177
RUNX1 runt-related transcription factor 1 1.01047
RBM6 RNA binding motif protein 6 0.97002
JAK2 Janus kinase 2 0.957033
ZFPM1 zinc finger protein, FOG family member 1 0.949519
CD33 CD33 molecule 0.935799
MPO myeloperoxidase 0.919673
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.908142
CD36 CD36 molecule (thrombospondin receptor) 0.89623
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 0.889258
OPRK1 opioid receptor, kappa 1 0.889258
DUSP14 dual specificity phosphatase 14 0.869187
ST7L suppression of tumorigenicity 7 like 0.848716
SETD1B SET domain containing 1B 0.848716
CD34 CD34 molecule 0.833558
CD7 CD7 molecule 0.827819
TUBB1 tubulin, beta 1 class VI 0.808949
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) 0.796642
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.787213
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 0.775341
SMC3 structural maintenance of chromosomes 3 0.765943
QRSL1 glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1 0.763086
NUP98 nucleoporin 98kDa 0.729357
MAP3K9 mitogen-activated protein kinase kinase kinase 9 0.722482
ETV6 ets variant 6 0.70233
MKL2 MKL/myocardin-like 2 0.701124
F8 coagulation factor VIII, procoagulant component 0.662387
NIPBL Nipped-B homolog (Drosophila) 0.641827
JAK1 Janus kinase 1 0.636708
ST18 suppression of tumorigenicity 18, zinc finger 0.626888
TYK2 tyrosine kinase 2 0.626888
HEXIM1 hexamethylene bis-acetamide inducible 1 0.613965
CDA cytidine deaminase 0.608885
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae) 0.59952
MYL9 myosin, light chain 9, regulatory 0.585497
GP9 glycoprotein IX (platelet) 0.582384
SCARB2 scavenger receptor class B, member 2 0.581217
WRB tryptophan rich basic protein 0.569941
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2 0.540055
VWF von Willebrand factor 0.534635
ACPP acid phosphatase, prostate 0.524588
PACRG PARK2 co-regulated 0.524202
EPOR erythropoietin receptor 0.523045
SCARB1 scavenger receptor class B, member 1 0.523045
AGO2 argonaute RISC catalytic component 2 0.521502
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.516494
CBS cystathionine-beta-synthase 0.513033
MEIS1 Meis homeobox 1 0.513033
NFYA nuclear transcription factor Y, alpha 0.504207
TRAF5 TNF receptor-associated factor 5 0.494266
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.493122
DLEC1 deleted in lung and esophageal cancer 1 0.485505
CCNT1 cyclin T1 0.479807
FLT3 fms-related tyrosine kinase 3 0.479047
ECT2 epithelial cell transforming 2 0.477151
KDM5A lysine (K)-specific demethylase 5A 0.47374
STAG2 stromal antigen 2 0.460883
GYPE glycophorin E (MNS blood group) 0.454847
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.452962
TRIB1 tribbles pseudokinase 1 0.450324
GATA2 GATA binding protein 2 0.450324
TRAF2 TNF receptor-associated factor 2 0.442418
AURKA aurora kinase A 0.440162
LAT linker for activation of T cells 0.43941
PDS5B PDS5 cohesin associated factor B 0.433772
MPL MPL proto-oncogene, thrombopoietin receptor 0.424765
SMC1A structural maintenance of chromosomes 1A 0.420266
TUBB tubulin, beta class I 0.410909
ZYX zyxin 0.40008
WNT2B wingless-type MMTV integration site family, member 2B 0.395235
SPN sialophorin 0.394863
CD14 CD14 molecule 0.394491
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.386308
IL11 interleukin 11 0.381481
CSF2RA colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) 0.376661
PNMA1 paraneoplastic Ma antigen 1 0.370737
RAD21 RAD21 homolog (S. pombe) 0.363716
EVPL envoplakin 0.359289
SEMA6C sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C 0.356341
RAP1A RAP1A, member of RAS oncogene family 0.350452
FANCL Fanconi anemia, complementation group L 0.347511
NOTCH1 notch 1 0.344574
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 0.341639
CLNK cytokine-dependent hematopoietic cell linker 0.340906
CD9 CD9 molecule 0.331756
VCL vinculin 0.324823
BST2 bone marrow stromal cell antigen 2 0.315729
MX2 MX dynamin-like GTPase 2 0.305948
LONP1 lon peptidase 1, mitochondrial 0.300894
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta 0.296931
KITLG KIT ligand 0.294053
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase 0.287952
FUT4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific) 0.280796
HBG2 hemoglobin, gamma G 0.270464
IL9 interleukin 9 0.266558
MYOCD myocardin 0.266558
APOC1 apolipoprotein C-I 0.26514
NUMB numb homolog (Drosophila) 0.25983
ADGRV1 adhesion G protein-coupled receptor V1 0.255594
SH2B3 SH2B adaptor protein 3 0.248203
RHOB ras homolog family member B 0.243645
SETD2 SET domain containing 2 0.242245
MNX1 motor neuron and pancreas homeobox 1 0.238403
TGFB1 transforming growth factor, beta 1 0.232836
WNT2 wingless-type MMTV integration site family member 2 0.231102
BCR breakpoint cluster region 0.229024
TFRC transferrin receptor 0.226262
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide 0.22454
HOXA10 homeobox A10 0.223509
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 0.222822
CD19 CD19 molecule 0.222479
CDK9 cyclin-dependent kinase 9 0.21974
PRAME preferentially expressed antigen in melanoma 0.216332
ALAS2 5'-aminolevulinate synthase 2 0.215992
P2RY2 purinergic receptor P2Y, G-protein coupled, 2 0.211261
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 0.209248
CD38 CD38 molecule 0.197742
CEBPB CCAAT/enhancer binding protein (C/EBP), beta 0.1936
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 0.190476
PI3 peptidase inhibitor 3, skin-derived 0.180367
CTCF CCCTC-binding factor (zinc finger protein) 0.178403
CD22 CD22 molecule 0.177301
DLK1 delta-like 1 homolog (Drosophila) 0.174354
SELP selectin P (granule membrane protein 140kDa, antigen CD62) 0.170789
CHL1 cell adhesion molecule L1-like 0.163111