mefloquine-2210 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the mefloquine-2210 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADPRM ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ATF3 activating transcription factor 3
BHLHE40 basic helix-loop-helix family, member e40
BIRC3 baculoviral IAP repeat containing 3
CGA glycoprotein hormones, alpha polypeptide
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CXCL10 chemokine (C-X-C motif) ligand 10
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
DLX2 distal-less homeobox 2
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP1 dual specificity phosphatase 1
DUSP10 dual specificity phosphatase 10
EFNA1 ephrin-A1
EGR1 early growth response 1
ELL2 elongation factor, RNA polymerase II, 2
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FAM46C family with sequence similarity 46, member C
FOS FBJ murine osteosarcoma viral oncogene homolog
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GEM GTP binding protein overexpressed in skeletal muscle
HBEGF heparin-binding EGF-like growth factor
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HES1 hes family bHLH transcription factor 1
HIST1H1C histone cluster 1, H1c
HIST1H1T histone cluster 1, H1t
HIST1H2AE histone cluster 1, H2ae
HIST1H2AG histone cluster 1, H2ag
HIST1H2BC histone cluster 1, H2bc
HIST1H2BF histone cluster 1, H2bf
HIST1H2BG histone cluster 1, H2bg
HIST1H2BH histone cluster 1, H2bh
HIST1H2BI histone cluster 1, H2bi
HIST1H2BJ histone cluster 1, H2bj
HIST1H2BN histone cluster 1, H2bn
HIST1H2BO histone cluster 1, H2bo
HIST1H3B histone cluster 1, H3b
HIST1H4E histone cluster 1, H4e
HIST1H4H histone cluster 1, H4h
HIST2H2BE histone cluster 2, H2be
HMOX1 heme oxygenase 1
HOXB2 homeobox B2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ICAM1 intercellular adhesion molecule 1
IER2 immediate early response 2
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IFNB1 interferon, beta 1, fibroblast
IL32 interleukin 32
INHBE inhibin, beta E
IRF1 interferon regulatory factor 1
IRS2 insulin receptor substrate 2
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KLF10 Kruppel-like factor 10
KLF2 Kruppel-like factor 2
KLF6 Kruppel-like factor 6
KLHL24 kelch-like family member 24
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MT2A metallothionein 2A
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A3 nuclear receptor subfamily 4, group A, member 3
OASL 2'-5'-oligoadenylate synthetase-like
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RCAN1 regulator of calcineurin 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RND1 Rho family GTPase 1
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLCO4C1 solute carrier organic anion transporter family, member 4C1
SMEK1 SMEK homolog 1, suppressor of mek1 (Dictyostelium)
SOX9 SRY (sex determining region Y)-box 9
SPRY4 sprouty homolog 4 (Drosophila)
SQSTM1 sequestosome 1
TEX14 testis expressed 14
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
VEGFA vascular endothelial growth factor A
ZFP36 ZFP36 ring finger protein
ZNF10 zinc finger protein 10
ZNF165 zinc finger protein 165

decreased expression

Symbol Name
AHNAK2 AHNAK nucleoprotein 2
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
ASAP1-IT1 ASAP1 intronic transcript 1
ATG16L1 autophagy related 16-like 1 (S. cerevisiae)
BATF basic leucine zipper transcription factor, ATF-like
BCL9 B-cell CLL/lymphoma 9
BMP4 bone morphogenetic protein 4
C1QTNF9B-AS1 C1QTNF9B antisense RNA 1
CD34 CD34 molecule
CD3D CD3d molecule, delta (CD3-TCR complex)
CGREF1 cell growth regulator with EF-hand domain 1
CHMP6 charged multivesicular body protein 6
CORO7 coronin 7
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
CYP2R1 cytochrome P450, family 2, subfamily R, polypeptide 1
DHRS11 dehydrogenase/reductase (SDR family) member 11
DIXDC1 DIX domain containing 1
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DPY19L1P1 DPY19L1 pseudogene 1
DTX2 deltex 2, E3 ubiquitin ligase
ECHDC3 enoyl CoA hydratase domain containing 3
ERMAP erythroblast membrane-associated protein (Scianna blood group)
ERN2 endoplasmic reticulum to nucleus signaling 2
FBXL7 F-box and leucine-rich repeat protein 7
FBXO22 F-box protein 22
FKBP10 FK506 binding protein 10, 65 kDa
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GAMT guanidinoacetate N-methyltransferase
GID4 GID complex subunit 4
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide
GRPR gastrin-releasing peptide receptor
GRWD1 glutamate-rich WD repeat containing 1
GSTCD glutathione S-transferase, C-terminal domain containing
GSTM5 glutathione S-transferase mu 5
HIRA histone cell cycle regulator
IFT140 intraflagellar transport 140
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KIAA0894 KIAA0894 protein
KIF13A kinesin family member 13A
KRT15 keratin 15, type I
LOC730101 uncharacterized LOC730101
LRFN3 leucine rich repeat and fibronectin type III domain containing 3
LRRC20 leucine rich repeat containing 20
LY6G6C lymphocyte antigen 6 complex, locus G6C
MAP3K6 mitogen-activated protein kinase kinase kinase 6
MAP6D1 MAP6 domain containing 1
MAPKAP1 mitogen-activated protein kinase associated protein 1
MCC mutated in colorectal cancers
MGC12488
MRPL41 mitochondrial ribosomal protein L41
MYOZ1 myozenin 1
NDST2 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2
NFE2L3 nuclear factor, erythroid 2-like 3
NLRX1 NLR family member X1
NOL10 nucleolar protein 10
NOL12 nucleolar protein 12
NPFFR1 neuropeptide FF receptor 1
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PCDHB8 protocadherin beta 8
PICK1 protein interacting with PRKCA 1
PLA2G10 phospholipase A2, group X
PLD2 phospholipase D2
PLD3 phospholipase D family, member 3
PODXL2 podocalyxin-like 2
POLH polymerase (DNA directed), eta
POP1 processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae)
PPAN peter pan homolog (Drosophila)
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
RNF121 ring finger protein 121
RNF208 ring finger protein 208
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1
ROBO3 roundabout, axon guidance receptor, homolog 3 (Drosophila)
ROM1 retinal outer segment membrane protein 1
RPL23AP32 ribosomal protein L23a pseudogene 32
SCAI suppressor of cancer cell invasion
SCN1B sodium channel, voltage gated, type I beta subunit
SKI SKI proto-oncogene
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SLIT2 slit homolog 2 (Drosophila)
SP1 Sp1 transcription factor
STAB2 stabilin 2
STMN3 stathmin-like 3
SYNC syncoilin, intermediate filament protein
TESC tescalcin
TGFB1I1 transforming growth factor beta 1 induced transcript 1
THEM6 thioesterase superfamily member 6
TLN1 talin 1
TRAF3IP1 TNF receptor-associated factor 3 interacting protein 1
TRIM21 tripartite motif containing 21
TRPC5 transient receptor potential cation channel, subfamily C, member 5
UBTD1 ubiquitin domain containing 1
UPK3B uroplakin 3B
WNT10B wingless-type MMTV integration site family, member 10B
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
XYLT2 xylosyltransferase II