mefloquine-2048 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the mefloquine-2048 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ARL2BP ADP-ribosylation factor-like 2 binding protein
ARSD arylsulfatase D
ASNS asparagine synthetase (glutamine-hydrolyzing)
B3GALT4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
BCL2 B-cell CLL/lymphoma 2
BCL6 B-cell CLL/lymphoma 6
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCNG2 cyclin G2
CCNJ cyclin J
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEP68 centrosomal protein 68kDa
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
CLUHP3 clustered mitochondria (cluA/CLU1) homolog pseudogene 3
CPZ carboxypeptidase Z
CSF1 colony stimulating factor 1 (macrophage)
CTNS cystinosin, lysosomal cystine transporter
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DSC2 desmocollin 2
DUSP10 dual specificity phosphatase 10
DVL2 dishevelled segment polarity protein 2
FCMR Fc fragment of IgM receptor
FLJ22184
FTH1 ferritin, heavy polypeptide 1
GK glycerol kinase
GPATCH3 G patch domain containing 3
GRB10 growth factor receptor-bound protein 10
GULP1 GULP, engulfment adaptor PTB domain containing 1
HDAC9 histone deacetylase 9
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HHAT hedgehog acyltransferase
HMOX1 heme oxygenase 1
IDS iduronate 2-sulfatase
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
INSIG1 insulin induced gene 1
IRS2 insulin receptor substrate 2
KLF3 Kruppel-like factor 3 (basic)
KLHL24 kelch-like family member 24
LDLR low density lipoprotein receptor
LIME1 Lck interacting transmembrane adaptor 1
LINC00341 long intergenic non-protein coding RNA 341
LMOD1 leiomodin 1 (smooth muscle)
MMP1 matrix metallopeptidase 1
MMP10 matrix metallopeptidase 10
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1M metallothionein 1M
MT1X metallothionein 1X
MT2A metallothionein 2A
MYL4 myosin, light chain 4, alkali; atrial, embryonic
N4BP1 NEDD4 binding protein 1
N4BP2L2 NEDD4 binding protein 2-like 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEK3 NIMA-related kinase 3
NUPR1 nuclear protein, transcriptional regulator, 1
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa
OASL 2'-5'-oligoadenylate synthetase-like
OVGP1 oviductal glycoprotein 1, 120kDa
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTPRE protein tyrosine phosphatase, receptor type, E
QSER1 glutamine and serine rich 1
RGS4 regulator of G-protein signaling 4
RND3 Rho family GTPase 3
RNF126P1 ring finger protein 126 pseudogene 1
RRAGC Ras-related GTP binding C
SAT1 spermidine/spermine N1-acetyltransferase 1
SAYSD1 SAYSVFN motif domain containing 1
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC6A20 solute carrier family 6 (proline IMINO transporter), member 20
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SQSTM1 sequestosome 1
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STX3 syntaxin 3
SUGP1 SURP and G patch domain containing 1
SYT1 synaptotagmin I
TMEM135 transmembrane protein 135
TPP1 tripeptidyl peptidase I
TRIB3 tribbles pseudokinase 3
ZBTB20 zinc finger and BTB domain containing 20
ZFHX2 zinc finger homeobox 2
ZFP36L1 ZFP36 ring finger protein-like 1
ZMYM5 zinc finger, MYM-type 5
ZNF165 zinc finger protein 165
ZNF358 zinc finger protein 358

decreased expression

Symbol Name
ADAT1 adenosine deaminase, tRNA-specific 1
ALAS1 5'-aminolevulinate synthase 1
ANAPC2 anaphase promoting complex subunit 2
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
BCL2A1 BCL2-related protein A1
BDNF brain-derived neurotrophic factor
C1GALT1C1 C1GALT1-specific chaperone 1
C4ORF19 chromosome 4 open reading frame 19
CCS copper chaperone for superoxide dismutase
CDKN2AIP CDKN2A interacting protein
CHMP1A charged multivesicular body protein 1A
CHST12 carbohydrate (chondroitin 4) sulfotransferase 12
COA4 cytochrome c oxidase assembly factor 4 homolog (S. cerevisiae)
CRADD CASP2 and RIPK1 domain containing adaptor with death domain
CTNNBL1 catenin, beta like 1
DCLRE1A DNA cross-link repair 1A
DDX31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
DMBT1 deleted in malignant brain tumors 1
E2F8 E2F transcription factor 8
EDC4 enhancer of mRNA decapping 4
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
ERCC5 excision repair cross-complementation group 5
EVL Enah/Vasp-like
FAM127B family with sequence similarity 127, member B
GBX2 gastrulation brain homeobox 2
GEMIN4 gem (nuclear organelle) associated protein 4
GID4 GID complex subunit 4
GLT8D2 glycosyltransferase 8 domain containing 2
GPR176 G protein-coupled receptor 176
GPRC5A G protein-coupled receptor, class C, group 5, member A
GRWD1 glutamate-rich WD repeat containing 1
GTF2F2 general transcription factor IIF, polypeptide 2, 30kDa
HAS2 hyaluronan synthase 2
HOXB13 homeobox B13
HPS6 Hermansky-Pudlak syndrome 6
IFIT5 interferon-induced protein with tetratricopeptide repeats 5
IRS1 insulin receptor substrate 1
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
JMJD4 jumonji domain containing 4
JUNB jun B proto-oncogene
KDM5C lysine (K)-specific demethylase 5C
KIAA0020 KIAA0020
KIAA0556 KIAA0556
KIAA1549L KIAA1549-like
LRRC20 leucine rich repeat containing 20
LZTR1 leucine-zipper-like transcription regulator 1
MALL mal, T-cell differentiation protein-like
MCM10 minichromosome maintenance complex component 10
MITF microphthalmia-associated transcription factor
MOB3B MOB kinase activator 3B
MPC1 mitochondrial pyruvate carrier 1
MTERF1 mitochondrial transcription termination factor 1
MYBBP1A MYB binding protein (P160) 1a
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit
NAGPA N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
NBEAL2 neurobeachin-like 2
NFS1 NFS1 cysteine desulfurase
NOP2 NOP2 nucleolar protein
NPDC1 neural proliferation, differentiation and control, 1
NUBP2 nucleotide binding protein 2
OXTR oxytocin receptor
PARD6A par-6 family cell polarity regulator alpha
PDLIM2 PDZ and LIM domain 2 (mystique)
PHF10 PHD finger protein 10
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PMEPA1 prostate transmembrane protein, androgen induced 1
POLA2 polymerase (DNA directed), alpha 2, accessory subunit
PPAT phosphoribosyl pyrophosphate amidotransferase
PPFIA3 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
PRAME preferentially expressed antigen in melanoma
PRICKLE3 prickle homolog 3 (Drosophila)
PRRG2 proline rich Gla (G-carboxyglutamic acid) 2
PRSS8 protease, serine, 8
PTK7 protein tyrosine kinase 7 (inactive)
PWP2 PWP2 periodic tryptophan protein homolog (yeast)
PYCARD PYD and CARD domain containing
RUSC2 RUN and SH3 domain containing 2
SCYL2 SCY1-like 2 (S. cerevisiae)
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC37A1 solute carrier family 37 (glucose-6-phosphate transporter), member 1
SLC39A7 solute carrier family 39 (zinc transporter), member 7
SYNPO synaptopodin
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TFRC transferrin receptor
THAP7 THAP domain containing 7
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast)
TMEM2 transmembrane protein 2
TMOD3 tropomodulin 3 (ubiquitous)
UCK2 uridine-cytidine kinase 2
USP18 ubiquitin specific peptidase 18
UTP20 UTP20, small subunit (SSU) processome component, homolog (yeast)
WDR5B WD repeat domain 5B
WNT7A wingless-type MMTV integration site family, member 7A
ZC3H12A zinc finger CCCH-type containing 12A
ZC4H2 zinc finger, C4H2 domain containing
ZDHHC11 zinc finger, DHHC-type containing 11
ZNF177 zinc finger protein 177