mefenamic acid-5109 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the mefenamic acid-5109 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAM12 ADAM metallopeptidase domain 12
ADGRE2 adhesion G protein-coupled receptor E2
ADORA1 adenosine A1 receptor
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
ALDH3B2 aldehyde dehydrogenase 3 family, member B2
ARPIN actin-related protein 2/3 complex inhibitor
BRF1 BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit
BTNL2 butyrophilin-like 2
C1ORF54 chromosome 1 open reading frame 54
CEACAM3 carcinoembryonic antigen-related cell adhesion molecule 3
CNN1 calponin 1, basic, smooth muscle
COMP cartilage oligomeric matrix protein
DAGLA diacylglycerol lipase, alpha
DGKQ diacylglycerol kinase, theta 110kDa
DOK5 docking protein 5
DUSP1 dual specificity phosphatase 1
ESR1 estrogen receptor 1
FCAR Fc fragment of IgA receptor
FCMR Fc fragment of IgM receptor
FGFR1 fibroblast growth factor receptor 1
FRS3 fibroblast growth factor receptor substrate 3
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2
GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
GPC3 glypican 3
GRB7 growth factor receptor-bound protein 7
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B
HAP1 huntingtin-associated protein 1
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
IFT140 intraflagellar transport 140
IGHD immunoglobulin heavy constant delta
IL12B interleukin 12B
IL1RN interleukin 1 receptor antagonist
KCNJ3 potassium channel, inwardly rectifying subfamily J, member 3
KIAA1456 KIAA1456
KLK13 kallikrein-related peptidase 13
LGALS8 lectin, galactoside-binding, soluble, 8
LLGL1 lethal giant larvae homolog 1 (Drosophila)
LMNA lamin A/C
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3
MFAP3L microfibrillar-associated protein 3-like
MIER2 mesoderm induction early response 1, family member 2
MLC1 megalencephalic leukoencephalopathy with subcortical cysts 1
MST1 macrophage stimulating 1
MX1 MX dynamin-like GTPase 1
MYL4 myosin, light chain 4, alkali; atrial, embryonic
NCR2 natural cytotoxicity triggering receptor 2
NDNF neuron-derived neurotrophic factor
NF1 neurofibromin 1
NRF1 nuclear respiratory factor 1
NRP2 neuropilin 2
NRTN neurturin
OR1F2P olfactory receptor, family 1, subfamily F, member 2, pseudogene
OR2H2 olfactory receptor, family 2, subfamily H, member 2
PARP11 poly (ADP-ribose) polymerase family, member 11
PAX2 paired box 2
PECAM1 platelet/endothelial cell adhesion molecule 1
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PLK4 polo-like kinase 4
PNMAL1 paraneoplastic Ma antigen family-like 1
PPP5C protein phosphatase 5, catalytic subunit
PQBP1 polyglutamine binding protein 1
PRTN3 proteinase 3
PSG1 pregnancy specific beta-1-glycoprotein 1
PTEN phosphatase and tensin homolog
RCN3 reticulocalbin 3, EF-hand calcium binding domain
RGR retinal G protein coupled receptor
RGS12 regulator of G-protein signaling 12
RPL7 ribosomal protein L7
RPS4Y1 ribosomal protein S4, Y-linked 1
RUSC2 RUN and SH3 domain containing 2
SATB2 SATB homeobox 2
SCN10A sodium channel, voltage gated, type X alpha subunit
SERHL2 serine hydrolase-like 2
SLC22A14 solute carrier family 22, member 14
SLC22A7 solute carrier family 22 (organic anion transporter), member 7
SLC48A1 solute carrier family 48 (heme transporter), member 1
SPHK2 sphingosine kinase 2
SPO11 SPO11 meiotic protein covalently bound to DSB
ST8SIA3 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3
SYDE1 synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
TAL1 T-cell acute lymphocytic leukemia 1
TBC1D30 TBC1 domain family, member 30
TDRD1 tudor domain containing 1
TDRKH tudor and KH domain containing
THY1 Thy-1 cell surface antigen
TLR4 toll-like receptor 4
TMEM63A transmembrane protein 63A
TNS1 tensin 1
TUBA4B tubulin, alpha 4b
UNC13A unc-13 homolog A (C. elegans)
WNT16 wingless-type MMTV integration site family, member 16
ZER1 zyg-11 related, cell cycle regulator
ZNF235 zinc finger protein 235
ZNF287 zinc finger protein 287
ZNF334 zinc finger protein 334
ZNF407 zinc finger protein 407
ZNF440 zinc finger protein 440

decreased expression

Symbol Name
ACAD8 acyl-CoA dehydrogenase family, member 8
ADGRG2 adhesion G protein-coupled receptor G2
ALPK1 alpha-kinase 1
ARL15 ADP-ribosylation factor-like 15
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
C1ORF159 chromosome 1 open reading frame 159
C9ORF91 chromosome 9 open reading frame 91
CCDC47 coiled-coil domain containing 47
CCZ1B CCZ1 vacuolar protein trafficking and biogenesis associated homolog B (S. cerevisiae)
CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase
CHCHD7 coiled-coil-helix-coiled-coil-helix domain containing 7
COCH cochlin
COL4A3BP collagen, type IV, alpha 3 (Goodpasture antigen) binding protein
CSRNP3 cysteine-serine-rich nuclear protein 3
DCAF13 DDB1 and CUL4 associated factor 13
DCAF16 DDB1 and CUL4 associated factor 16
DEAF1 DEAF1 transcription factor
DENND4A DENN/MADD domain containing 4A
DSC2 desmocollin 2
EHF ets homologous factor
EYA4 EYA transcriptional coactivator and phosphatase 4
FAM131A family with sequence similarity 131, member A
FBXL7 F-box and leucine-rich repeat protein 7
FBXW12 F-box and WD repeat domain containing 12
GMEB1 glucocorticoid modulatory element binding protein 1
GNA14 guanine nucleotide binding protein (G protein), alpha 14
HIST1H1E histone cluster 1, H1e
HIST1H2AJ histone cluster 1, H2aj
HOXA4 homeobox A4
HSPB8 heat shock 22kDa protein 8
HYMAI hydatidiform mole associated and imprinted (non-protein coding)
IL18 interleukin 18
INCENP inner centromere protein antigens 135/155kDa
IRF1 interferon regulatory factor 1
ISL1 ISL LIM homeobox 1
KPNA5 karyopherin alpha 5 (importin alpha 6)
LIMS2 LIM and senescent cell antigen-like domains 2
LRFN3 leucine rich repeat and fibronectin type III domain containing 3
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
MGC12488
MITF microphthalmia-associated transcription factor
MTA2 metastasis associated 1 family, member 2
MTG1 mitochondrial ribosome-associated GTPase 1
NCS1 neuronal calcium sensor 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFIX nuclear factor I/X (CCAAT-binding transcription factor)
NMRK1 nicotinamide riboside kinase 1
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
PACS1 phosphofurin acidic cluster sorting protein 1
PAIP2B poly(A) binding protein interacting protein 2B
PARD6A par-6 family cell polarity regulator alpha
PARM1 prostate androgen-regulated mucin-like protein 1
PDIA3 protein disulfide isomerase family A, member 3
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1
PLAC8 placenta-specific 8
POLH polymerase (DNA directed), eta
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RPL23AP32 ribosomal protein L23a pseudogene 32
RPP25 ribonuclease P/MRP 25kDa subunit
SAMD9 sterile alpha motif domain containing 9
SAYSD1 SAYSVFN motif domain containing 1
SCAMP5 secretory carrier membrane protein 5
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
SETD6 SET domain containing 6
SH2B3 SH2B adaptor protein 3
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group)
SLC25A28 solute carrier family 25 (mitochondrial iron transporter), member 28
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLITRK5 SLIT and NTRK-like family, member 5
SMAD5 SMAD family member 5
SMAD7 SMAD family member 7
SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium)
SNORA21 small nucleolar RNA, H/ACA box 21
SNX16 sorting nexin 16
SPIN1 spindlin 1
SPRYD7 SPRY domain containing 7
SS18L1 synovial sarcoma translocation gene on chromosome 18-like 1
STK16 serine/threonine kinase 16
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor)
TM7SF3 transmembrane 7 superfamily member 3
TMA16 translation machinery associated 16 homolog (S. cerevisiae)
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific
USP27X ubiquitin specific peptidase 27, X-linked
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
YPEL1 yippee-like 1 (Drosophila)
ZBTB38 zinc finger and BTB domain containing 38
ZBTB44 zinc finger and BTB domain containing 44
ZBTB6 zinc finger and BTB domain containing 6
ZFP30 ZFP30 zinc finger protein
ZNF230 zinc finger protein 230
ZNF358 zinc finger protein 358
ZNF408 zinc finger protein 408
ZNF816 zinc finger protein 816
ZW10 zw10 kinetochore protein