meclocycline-4982 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the meclocycline-4982 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADGRG1 adhesion G protein-coupled receptor G1
APOLD1 apolipoprotein L domain containing 1
AQP3 aquaporin 3 (Gill blood group)
ASPH aspartate beta-hydroxylase
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
BAZ1B bromodomain adjacent to zinc finger domain, 1B
BMP1 bone morphogenetic protein 1
C1QTNF9B-AS1 C1QTNF9B antisense RNA 1
C8ORF60 chromosome 8 open reading frame 60
CCDC40 coiled-coil domain containing 40
CCDC64 coiled-coil domain containing 64
CCNG2 cyclin G2
CCNO cyclin O
CD8A CD8a molecule
CDK13 cyclin-dependent kinase 13
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CEP135 centrosomal protein 135kDa
CLEC3B C-type lectin domain family 3, member B
CNN1 calponin 1, basic, smooth muscle
CNTNAP1 contactin associated protein 1
CSNK1E casein kinase 1, epsilon
CSNK1G2 casein kinase 1, gamma 2
DEDD death effector domain containing
DGAT1 diacylglycerol O-acyltransferase 1
DMTN dematin actin binding protein
DNAL4 dynein, axonemal, light chain 4
DOCK5 dedicator of cytokinesis 5
DOCK6 dedicator of cytokinesis 6
DOK4 docking protein 4
DST dystonin
DVL3 dishevelled segment polarity protein 3
EGFL7 EGF-like-domain, multiple 7
ELL2 elongation factor, RNA polymerase II, 2
ELOVL2 ELOVL fatty acid elongase 2
FAM131A family with sequence similarity 131, member A
FGFBP1 fibroblast growth factor binding protein 1
FLOT1 flotillin 1
FOXG1 forkhead box G1
GAMT guanidinoacetate N-methyltransferase
GK3P glycerol kinase 3 pseudogene
GPER1 G protein-coupled estrogen receptor 1
GRM1 glutamate receptor, metabotropic 1
GSTA4 glutathione S-transferase alpha 4
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4
HFE hemochromatosis
HOMER3 homer scaffolding protein 3
HOXB2 homeobox B2
HOXD11 homeobox D11
HPS4 Hermansky-Pudlak syndrome 4
ICAM1 intercellular adhesion molecule 1
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFNA14 interferon, alpha 14
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KLHL22 kelch-like family member 22
KMT2A lysine (K)-specific methyltransferase 2A
KPNA5 karyopherin alpha 5 (importin alpha 6)
LIG3 ligase III, DNA, ATP-dependent
LMAN1 lectin, mannose-binding, 1
LMNA lamin A/C
MAST3 microtubule associated serine/threonine kinase 3
MBD2 methyl-CpG binding domain protein 2
MMP16 matrix metallopeptidase 16 (membrane-inserted)
MT1F metallothionein 1F
MYOF myoferlin
NF2 neurofibromin 2 (merlin)
NMT1 N-myristoyltransferase 1
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein
NPY4R neuropeptide Y receptor Y4
NUCB1 nucleobindin 1
OGFR opioid growth factor receptor
PCDHA5 protocadherin alpha 5
PCNX pecanex homolog (Drosophila)
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PLAU plasminogen activator, urokinase
PLEKHS1 pleckstrin homology domain containing, family S member 1
PRB3 proline-rich protein BstNI subfamily 3
PRKCH protein kinase C, eta
PROL1 proline rich, lacrimal 1
PTHLH parathyroid hormone-like hormone
PVR poliovirus receptor
RAB6A RAB6A, member RAS oncogene family
RAD51 RAD51 recombinase
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
SCN11A sodium channel, voltage gated, type XI alpha subunit
SEMA3F sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
SFTPC surfactant protein C
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC22A18AS solute carrier family 22 (organic cation transporter), member 18 antisense
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
T T, brachyury homolog (mouse)
TEF thyrotrophic embryonic factor
TPMT thiopurine S-methyltransferase
TRAFD1 TRAF-type zinc finger domain containing 1
TRIM29 tripartite motif containing 29
TRPV4 transient receptor potential cation channel, subfamily V, member 4
UHRF1BP1L UHRF1 binding protein 1-like
VAMP5 vesicle-associated membrane protein 5

decreased expression

Symbol Name
ACADSB acyl-CoA dehydrogenase, short/branched chain
AKAP12 A kinase (PRKA) anchor protein 12
ALCAM activated leukocyte cell adhesion molecule
ALPK1 alpha-kinase 1
AMT aminomethyltransferase
ARID3B AT rich interactive domain 3B (BRIGHT-like)
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1
BMP15 bone morphogenetic protein 15
C5AR2 complement component 5a receptor 2
CA11 carbonic anhydrase XI
CA5BP1 carbonic anhydrase VB pseudogene 1
CD83 CD83 molecule
CHST7 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
DENND4B DENN/MADD domain containing 4B
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DNAJC24 DnaJ (Hsp40) homolog, subfamily C, member 24
EAF2 ELL associated factor 2
EGLN3 egl-9 family hypoxia-inducible factor 3
EHHADH enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase
ERMAP erythroblast membrane-associated protein (Scianna blood group)
FGD6 FYVE, RhoGEF and PH domain containing 6
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GEMIN8 gem (nuclear organelle) associated protein 8
GFOD1 glucose-fructose oxidoreductase domain containing 1
GFPT2 glutamine-fructose-6-phosphate transaminase 2
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide
GPATCH2 G patch domain containing 2
GPR157 G protein-coupled receptor 157
HIST2H2AA3 histone cluster 2, H2aa3
HOXC5 homeobox C5
HSPA1L heat shock 70kDa protein 1-like
IFI6 interferon, alpha-inducible protein 6
IL17RB interleukin 17 receptor B
ITGA10 integrin, alpha 10
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
KLHL26 kelch-like family member 26
KREMEN2 kringle containing transmembrane protein 2
LOC730101 uncharacterized LOC730101
LRP2 low density lipoprotein receptor-related protein 2
LYRM9 LYR motif containing 9
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAMLD1 mastermind-like domain containing 1
METTL16 methyltransferase like 16
METTL22 methyltransferase like 22
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3
MRPL52 mitochondrial ribosomal protein L52
MVD mevalonate (diphospho) decarboxylase
OTUD3 OTU deubiquitinase 3
PCSK7 proprotein convertase subtilisin/kexin type 7
PCTP phosphatidylcholine transfer protein
PLCD1 phospholipase C, delta 1
PLEKHA6 pleckstrin homology domain containing, family A member 6
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
POLL polymerase (DNA directed), lambda
POM121 POM121 transmembrane nucleoporin
PRICKLE3 prickle homolog 3 (Drosophila)
PRODH proline dehydrogenase (oxidase) 1
RBM41 RNA binding motif protein 41
REPS2 RALBP1 associated Eps domain containing 2
RFTN1 raftlin, lipid raft linker 1
RLN1 relaxin 1
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1
S100A4 S100 calcium binding protein A4
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
SIX1 SIX homeobox 1
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SLMO1 slowmo homolog 1 (Drosophila)
SMCO4 single-pass membrane protein with coiled-coil domains 4
SP1 Sp1 transcription factor
SRPX sushi-repeat containing protein, X-linked
SYCP2 synaptonemal complex protein 2
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TAOK1 TAO kinase 1
TBC1D17 TBC1 domain family, member 17
TCHH trichohyalin
THBS3 thrombospondin 3
THUMPD2 THUMP domain containing 2
TLN1 talin 1
TMEM104 transmembrane protein 104
TMEM212 transmembrane protein 212
TMEM53 transmembrane protein 53
TNS3 tensin 3
TRABD TraB domain containing
TRAIP TRAF interacting protein
UCN urocortin
URB2 URB2 ribosome biogenesis 2 homolog (S. cerevisiae)
WFDC2 WAP four-disulfide core domain 2
XK X-linked Kx blood group
ZDHHC14 zinc finger, DHHC-type containing 14
ZNF329 zinc finger protein 329
ZNF37BP zinc finger protein 37B, pseudogene
ZNF571 zinc finger protein 571
ZNF668 zinc finger protein 668
ZNF747 zinc finger protein 747
ZNF750 zinc finger protein 750
ZNF778 zinc finger protein 778
ZSCAN26 zinc finger and SCAN domain containing 26