mecamylamine-7263 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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199 genes differentially expressed following the mecamylamine-7263 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AASS aminoadipate-semialdehyde synthase
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
AEN apoptosis enhancing nuclease
ARHGAP11A Rho GTPase activating protein 11A
ARIH2 ariadne RBR E3 ubiquitin protein ligase 2
ASF1A anti-silencing function 1A histone chaperone
BRD4 bromodomain containing 4
BTN3A1 butyrophilin, subfamily 3, member A1
C1S complement component 1, s subcomponent
CAPRIN1 cell cycle associated protein 1
CD6 CD6 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CLCA1 chloride channel accessory 1
CLUHP3 clustered mitochondria (cluA/CLU1) homolog pseudogene 3
COL3A1 collagen, type III, alpha 1
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
CTNND2 catenin (cadherin-associated protein), delta 2
DFNB31 deafness, autosomal recessive 31
DNAJC4 DnaJ (Hsp40) homolog, subfamily C, member 4
DPP4 dipeptidyl-peptidase 4
EIF4EBP2 eukaryotic translation initiation factor 4E binding protein 2
EIF5A2 eukaryotic translation initiation factor 5A2
FOXJ3 forkhead box J3
FZD3 frizzled class receptor 3
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GSAP gamma-secretase activating protein
H2AFX H2A histone family, member X
HOMER3 homer scaffolding protein 3
HOXB5 homeobox B5
HPS1 Hermansky-Pudlak syndrome 1
HSPA2 heat shock 70kDa protein 2
ING2 inhibitor of growth family, member 2
IQCC IQ motif containing C
IRF6 interferon regulatory factor 6
IVNS1ABP influenza virus NS1A binding protein
KDM4B lysine (K)-specific demethylase 4B
KHSRP KH-type splicing regulatory protein
KLHL3 kelch-like family member 3
LIG4 ligase IV, DNA, ATP-dependent
LNPEP leucyl/cystinyl aminopeptidase
LRRC41 leucine rich repeat containing 41
MAP1B microtubule-associated protein 1B
MAPK7 mitogen-activated protein kinase 7
MCC mutated in colorectal cancers
MDC1 mediator of DNA-damage checkpoint 1
METTL16 methyltransferase like 16
MTAP methylthioadenosine phosphorylase
MUC1 mucin 1, cell surface associated
MYL4 myosin, light chain 4, alkali; atrial, embryonic
MYO5A myosin VA (heavy chain 12, myoxin)
NCOA3 nuclear receptor coactivator 3
NFYA nuclear transcription factor Y, alpha
NID1 nidogen 1
NRP1 neuropilin 1
NRXN3 neurexin 3
OXLD1 oxidoreductase-like domain containing 1
PAGE4 P antigen family, member 4 (prostate associated)
PAX2 paired box 2
PCDH7 protocadherin 7
PEX7 peroxisomal biogenesis factor 7
PKP3 plakophilin 3
PMS2P2 postmeiotic segregation increased 2 pseudogene 2
PODNL1 podocan-like 1
POLR2D polymerase (RNA) II (DNA directed) polypeptide D
PPCDC phosphopantothenoylcysteine decarboxylase
R3HDM4 R3H domain containing 4
RAB3B RAB3B, member RAS oncogene family
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
SAPCD1 suppressor APC domain containing 1
SCN10A sodium channel, voltage gated, type X alpha subunit
SECISBP2 SECIS binding protein 2
SERTAD3 SERTA domain containing 3
SETD6 SET domain containing 6
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC24A1 solute carrier family 24 (sodium/potassium/calcium exchanger), member 1
SLC26A6 solute carrier family 26 (anion exchanger), member 6
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SLC41A3 solute carrier family 41, member 3
SNAPC5 small nuclear RNA activating complex, polypeptide 5, 19kDa
STC1 stanniocalcin 1
STK19 serine/threonine kinase 19
STYK1 serine/threonine/tyrosine kinase 1
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae)
TBXAS1 thromboxane A synthase 1 (platelet)
TGOLN2 trans-golgi network protein 2
TIMM17A translocase of inner mitochondrial membrane 17 homolog A (yeast)
TLE3 transducin-like enhancer of split 3
TMBIM1 transmembrane BAX inhibitor motif containing 1
TMC6 transmembrane channel-like 6
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TOMM22 translocase of outer mitochondrial membrane 22 homolog (yeast)
TTC38 tetratricopeptide repeat domain 38
TXLNG taxilin gamma
UBE4B ubiquitination factor E4B
VAC14 Vac14 homolog (S. cerevisiae)
WHSC1L1 Wolf-Hirschhorn syndrome candidate 1-like 1
ZFYVE9 zinc finger, FYVE domain containing 9
ZNF473 zinc finger protein 473
ZNF75D zinc finger protein 75D

decreased expression

Symbol Name
AFAP1 actin filament associated protein 1
ANKFY1 ankyrin repeat and FYVE domain containing 1
APH1B APH1B gamma secretase subunit
ARMC6 armadillo repeat containing 6
ASB7 ankyrin repeat and SOCS box containing 7
ATG16L1 autophagy related 16-like 1 (S. cerevisiae)
BIK BCL2-interacting killer (apoptosis-inducing)
C7ORF43 chromosome 7 open reading frame 43
CBX7 chromobox homolog 7
CCBL1 cysteine conjugate-beta lyase, cytoplasmic
CCDC88C coiled-coil domain containing 88C
CCNE1 cyclin E1
CCP110 centriolar coiled coil protein 110kDa
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1
CENPQ centromere protein Q
CEP70 centrosomal protein 70kDa
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CNN2 calponin 2
COG4 component of oligomeric golgi complex 4
COLGALT2 collagen beta(1-O)galactosyltransferase 2
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CUL9 cullin 9
DCLRE1B DNA cross-link repair 1B
DHX35 DEAH (Asp-Glu-Ala-His) box polypeptide 35
DHX8 DEAH (Asp-Glu-Ala-His) box polypeptide 8
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila)
DLL3 delta-like 3 (Drosophila)
ELP6 elongator acetyltransferase complex subunit 6
EPHA4 EPH receptor A4
FAM155A family with sequence similarity 155, member A
FSTL3 follistatin-like 3 (secreted glycoprotein)
GMIP GEM interacting protein
HDAC5 histone deacetylase 5
HOXC8 homeobox C8
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IL4R interleukin 4 receptor
KBTBD4 kelch repeat and BTB (POZ) domain containing 4
KIF13B kinesin family member 13B
KLHDC4 kelch domain containing 4
KLK5 kallikrein-related peptidase 5
KRT4 keratin 4, type II
LRFN4 leucine rich repeat and fibronectin type III domain containing 4
LZTR1 leucine-zipper-like transcription regulator 1
MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2
MCM9 minichromosome maintenance complex component 9
MPP1 membrane protein, palmitoylated 1, 55kDa
MXD3 MAX dimerization protein 3
NAGPA N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
NAT9 N-acetyltransferase 9 (GCN5-related, putative)
NBEAL2 neurobeachin-like 2
NOC4L nucleolar complex associated 4 homolog (S. cerevisiae)
NPR3 natriuretic peptide receptor 3
NR3C2 nuclear receptor subfamily 3, group C, member 2
ODF2 outer dense fiber of sperm tails 2
OLFML2A olfactomedin-like 2A
ORAI3 ORAI calcium release-activated calcium modulator 3
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2
PAQR4 progestin and adipoQ receptor family member IV
PARP12 poly (ADP-ribose) polymerase family, member 12
PIGL phosphatidylinositol glycan anchor biosynthesis, class L
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
PLA2G15 phospholipase A2, group XV
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
PLEKHO2 pleckstrin homology domain containing, family O member 2
PPP1R13B protein phosphatase 1, regulatory subunit 13B
PPP1R13L protein phosphatase 1, regulatory subunit 13 like
PTPN6 protein tyrosine phosphatase, non-receptor type 6
RNF121 ring finger protein 121
RNF25 ring finger protein 25
RPL23AP32 ribosomal protein L23a pseudogene 32
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4
SAMD9 sterile alpha motif domain containing 9
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SLC25A40 solute carrier family 25, member 40
SLC29A3 solute carrier family 29 (equilibrative nucleoside transporter), member 3
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC35C2 solute carrier family 35 (GDP-fucose transporter), member C2
SMA4 glucuronidase, beta pseudogene
SMARCAL1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SNX15 sorting nexin 15
SOX12 SRY (sex determining region Y)-box 12
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TCTA T-cell leukemia translocation altered
TCTN2 tectonic family member 2
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TRIM9 tripartite motif containing 9
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2
USP27X ubiquitin specific peptidase 27, X-linked
XK X-linked Kx blood group
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
ZBED1 zinc finger, BED-type containing 1
ZBTB25 zinc finger and BTB domain containing 25
ZBTB48 zinc finger and BTB domain containing 48
ZFHX3 zinc finger homeobox 3
ZFYVE16 zinc finger, FYVE domain containing 16
ZNF134 zinc finger protein 134