mecamylamine-7023 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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198 genes differentially expressed following the mecamylamine-7023 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCB9 ATP-binding cassette, sub-family B (MDR/TAP), member 9
ABCD1 ATP-binding cassette, sub-family D (ALD), member 1
ADRBK2 adrenergic, beta, receptor kinase 2
ALS2CL ALS2 C-terminal like
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
AP1S2 adaptor-related protein complex 1, sigma 2 subunit
ARHGDIG Rho GDP dissociation inhibitor (GDI) gamma
BAIAP3 BAI1-associated protein 3
BRD4 bromodomain containing 4
C16ORF58 chromosome 16 open reading frame 58
C1RL complement component 1, r subcomponent-like
CAMTA1 calmodulin binding transcription activator 1
CCDC186 coiled-coil domain containing 186
CCDC28B coiled-coil domain containing 28B
CD300C CD300c molecule
COL6A1 collagen, type VI, alpha 1
CR1 complement component (3b/4b) receptor 1 (Knops blood group)
DIMT1 DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae)
DZANK1 double zinc ribbon and ankyrin repeat domains 1
ELL2 elongation factor, RNA polymerase II, 2
ELOVL5 ELOVL fatty acid elongase 5
EPHB2 EPH receptor B2
ERN2 endoplasmic reticulum to nucleus signaling 2
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FADS2 fatty acid desaturase 2
FAM198B family with sequence similarity 198, member B
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
FBXO38 F-box protein 38
FKBP1B FK506 binding protein 1B, 12.6 kDa
GFPT2 glutamine-fructose-6-phosphate transaminase 2
GGPS1 geranylgeranyl diphosphate synthase 1
GH1 growth hormone 1
GK glycerol kinase
GLS2 glutaminase 2 (liver, mitochondrial)
GRIK5 glutamate receptor, ionotropic, kainate 5
HAUS6 HAUS augmin-like complex, subunit 6
HSF1 heat shock transcription factor 1
IL5RA interleukin 5 receptor, alpha
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
KAT2A K(lysine) acetyltransferase 2A
MAST4 microtubule associated serine/threonine kinase family member 4
MBD2 methyl-CpG binding domain protein 2
MKLN1 muskelin 1, intracellular mediator containing kelch motifs
MTERF4 mitochondrial transcription termination factor 4
MUC3A mucin 3A, cell surface associated
N4BP2L2 NEDD4 binding protein 2-like 2
NCBP1 nuclear cap binding protein subunit 1, 80kDa
NDST2 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2
NFE2L3 nuclear factor, erythroid 2-like 3
NT5DC3 5'-nucleotidase domain containing 3
ORAI2 ORAI calcium release-activated calcium modulator 2
PACS1 phosphofurin acidic cluster sorting protein 1
PCOLCE2 procollagen C-endopeptidase enhancer 2
PDE3B phosphodiesterase 3B, cGMP-inhibited
PDE8B phosphodiesterase 8B
PDGFA platelet-derived growth factor alpha polypeptide
PHF20L1 PHD finger protein 20-like 1
PIPOX pipecolic acid oxidase
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PPP1R9A protein phosphatase 1, regulatory subunit 9A
PREX2 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
PRKAR2A protein kinase, cAMP-dependent, regulatory, type II, alpha
PVR poliovirus receptor
RAB35 RAB35, member RAS oncogene family
RANGAP1 Ran GTPase activating protein 1
RBM5 RNA binding motif protein 5
RIMS3 regulating synaptic membrane exocytosis 3
ROM1 retinal outer segment membrane protein 1
RRBP1 ribosome binding protein 1
RXRB retinoid X receptor, beta
SAV1 salvador family WW domain containing protein 1
SCAPER S-phase cyclin A-associated protein in the ER
SGSH N-sulfoglucosamine sulfohydrolase
SLC48A1 solute carrier family 48 (heme transporter), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SLCO2A1 solute carrier organic anion transporter family, member 2A1
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SOX13 SRY (sex determining region Y)-box 13
SOX4 SRY (sex determining region Y)-box 4
ST7 suppression of tumorigenicity 7
TAPBP TAP binding protein (tapasin)
TAZ tafazzin
TBC1D13 TBC1 domain family, member 13
TBX19 T-box 19
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TMEM63A transmembrane protein 63A
TP53I11 tumor protein p53 inducible protein 11
TRIM25 tripartite motif containing 25
TYRO3 TYRO3 protein tyrosine kinase
VDAC3 voltage-dependent anion channel 3
VPREB1 pre-B lymphocyte 1
XDH xanthine dehydrogenase
ZDHHC14 zinc finger, DHHC-type containing 14
ZNF45 zinc finger protein 45
ZNF492 zinc finger protein 492
ZNF576 zinc finger protein 576
ZSCAN31 zinc finger and SCAN domain containing 31

decreased expression

Symbol Name
ACTR3B ARP3 actin-related protein 3 homolog B (yeast)
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ASPHD1 aspartate beta-hydroxylase domain containing 1
BAK1 BCL2-antagonist/killer 1
BCORL1 BCL6 corepressor-like 1
BMP4 bone morphogenetic protein 4
C3ORF52 chromosome 3 open reading frame 52
C5 complement component 5
CALCOCO1 calcium binding and coiled-coil domain 1
CASZ1 castor zinc finger 1
CCDC15 coiled-coil domain containing 15
CDR2L cerebellar degeneration-related protein 2-like
CEP131 centrosomal protein 131kDa
CLCN2 chloride channel, voltage-sensitive 2
CLSPN claspin
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4
CRADD CASP2 and RIPK1 domain containing adaptor with death domain
CTSK cathepsin K
CUEDC1 CUE domain containing 1
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DEAF1 DEAF1 transcription factor
DNA2 DNA replication helicase/nuclease 2
DOCK1 dedicator of cytokinesis 1
DPH2 DPH2 homolog (S. cerevisiae)
EAF2 ELL associated factor 2
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
EFHD2 EF-hand domain family, member D2
EFNA3 ephrin-A3
ERMAP erythroblast membrane-associated protein (Scianna blood group)
FBXO22 F-box protein 22
FGGY FGGY carbohydrate kinase domain containing
FKBP5 FK506 binding protein 5
FOXC1 forkhead box C1
FRS2 fibroblast growth factor receptor substrate 2
GAMT guanidinoacetate N-methyltransferase
GCC1 GRIP and coiled-coil domain containing 1
GLB1L2 galactosidase, beta 1-like 2
HMOX1 heme oxygenase 1
INCENP inner centromere protein antigens 135/155kDa
IRF2 interferon regulatory factor 2
IRF2BP1 interferon regulatory factor 2 binding protein 1
KCTD20 potassium channel tetramerization domain containing 20
KIFAP3 kinesin-associated protein 3
KIZ kizuna centrosomal protein
KLF3 Kruppel-like factor 3 (basic)
LAMB2 laminin, beta 2 (laminin S)
LRP3 low density lipoprotein receptor-related protein 3
LYPD1 LY6/PLAUR domain containing 1
MAP7D1 MAP7 domain containing 1
MAP9 microtubule-associated protein 9
MAPK12 mitogen-activated protein kinase 12
MGAT4A mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
MIR22HG MIR22 host gene
MPP6 membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)
MT1HL1 metallothionein 1H-like 1
NECAB3 N-terminal EF-hand calcium binding protein 3
NECAP2 NECAP endocytosis associated 2
NES nestin
NKAIN1 Na+/K+ transporting ATPase interacting 1
PADI2 peptidyl arginine deiminase, type II
PARD6A par-6 family cell polarity regulator alpha
PCDHA6 protocadherin alpha 6
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor
PELI1 pellino E3 ubiquitin protein ligase 1
PEMT phosphatidylethanolamine N-methyltransferase
PLA2G10 phospholipase A2, group X
PRRG2 proline rich Gla (G-carboxyglutamic acid) 2
PTPRU protein tyrosine phosphatase, receptor type, U
RBM38 RNA binding motif protein 38
RFTN1 raftlin, lipid raft linker 1
RNF170 ring finger protein 170
SCMH1 sex comb on midleg homolog 1 (Drosophila)
SECISBP2 SECIS binding protein 2
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SLC38A10 solute carrier family 38, member 10
SMPDL3B sphingomyelin phosphodiesterase, acid-like 3B
SP140L SP140 nuclear body protein-like
STAG3L4 stromal antigen 3-like 4 (pseudogene)
SUSD6 sushi domain containing 6
TAGLN transgelin
THOP1 thimet oligopeptidase 1
THUMPD2 THUMP domain containing 2
TMEM212 transmembrane protein 212
TMEM62 transmembrane protein 62
TSPAN1 tetraspanin 1
TUBA3C tubulin, alpha 3c
UBXN6 UBX domain protein 6
VEGFC vascular endothelial growth factor C
VWA1 von Willebrand factor A domain containing 1
WRN Werner syndrome, RecQ helicase-like
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial
ZC3H3 zinc finger CCCH-type containing 3
ZCWPW1 zinc finger, CW type with PWWP domain 1
ZKSCAN3 zinc finger with KRAB and SCAN domains 3
ZNF219 zinc finger protein 219
ZNF226 zinc finger protein 226
ZNF248 zinc finger protein 248
ZSCAN5A zinc finger and SCAN domain containing 5A