maturity-onset diabetes of the young Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description A genetic disease that has_material_basis_in mutations in the MODY genes disrupting insulin production. (Human Disease Ontology, DOID_0050524)
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Genes

128 genes co-occuring with the disease maturity-onset diabetes of the young in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
HNF1A HNF1 homeobox A 3.53905
GCK glucokinase (hexokinase 4) 3.03445
HNF1B HNF1 homeobox B 2.7045
HNF4A hepatocyte nuclear factor 4, alpha 2.66686
PDX1 pancreatic and duodenal homeobox 1 2.03876
INS insulin 1.81871
NEUROD1 neuronal differentiation 1 1.72456
NFIA nuclear factor I/A 1.64532
NFIB nuclear factor I/B 1.62918
GCKR glucokinase (hexokinase 4) regulator 1.53965
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha 1.52468
NFIC nuclear factor I/C (CCAAT-binding transcription factor) 1.50447
NFIX nuclear factor I/X (CCAAT-binding transcription factor) 1.50184
ANKS4B ankyrin repeat and sterile alpha motif domain containing 4B 1.40001
KCNJ11 potassium channel, inwardly rectifying subfamily J, member 11 1.37469
TAF6 TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa 1.29527
CEL carboxyl ester lipase 1.27693
FOXM1 forkhead box M1 1.23256
TMEM27 transmembrane protein 27 1.18582
HMX1 H6 family homeobox 1 1.16179
PAX4 paired box 4 1.14687
MIR1273D microRNA 1273d 1.05934
LAD1 ladinin 1 1.05555
CAPN10 calpain 10 1.05345
NR0B2 nuclear receptor subfamily 0, group B, member 2 1.04335
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2 1.0383
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8 1.03788
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 1.03451
ONECUT1 one cut homeobox 1 1.00414
PSMD9 proteasome (prosome, macropain) 26S subunit, non-ATPase, 9 0.985585
ISL1 ISL LIM homeobox 1 0.980952
NEUROG3 neurogenin 3 0.958287
ERI1 exoribonuclease 1 0.946186
APOM apolipoprotein M 0.926279
KLF11 Kruppel-like factor 11 0.917611
INSR insulin receptor 0.910199
CDH4 cadherin 4, type 1, R-cadherin (retinal) 0.850764
HNF4G hepatocyte nuclear factor 4, gamma 0.840115
PKLR pyruvate kinase, liver and RBC 0.826999
GCG glucagon 0.803205
MPP7 membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7) 0.798282
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.74436
TCF7 transcription factor 7 (T-cell specific, HMG-box) 0.734217
SNAPIN SNAP-associated protein 0.729357
SYT9 synaptotagmin IX 0.721673
NR2F2 nuclear receptor subfamily 2, group F, member 2 0.705144
PKM pyruvate kinase, muscle 0.70233
FOXA2 forkhead box A2 0.689092
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble) 0.688692
NEUROD4 neuronal differentiation 4 0.666755
NKX2-2 NK2 homeobox 2 0.645375
REG1A regenerating islet-derived 1 alpha 0.641039
SLC30A8 solute carrier family 30 (zinc transporter), member 8 0.617094
DR1 down-regulator of transcription 1, TBP-binding (negative cofactor 2) 0.615921
FXYD2 FXYD domain containing ion transport regulator 2 0.60069
CFAP20 cilia and flagella associated protein 20 0.55712
PTPRN protein tyrosine phosphatase, receptor type, N 0.550134
PPP1R3B protein phosphatase 1, regulatory subunit 3B 0.546644
IAPP islet amyloid polypeptide 0.524974
PTF1A pancreas specific transcription factor, 1a 0.521117
PKHD1 polycystic kidney and hepatic disease 1 (autosomal recessive) 0.517649
PFKFB1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 0.510728
RPN2 ribophorin II 0.507273
HOGA1 4-hydroxy-2-oxoglutarate aldolase 1 0.501144
PLCG1 phospholipase C, gamma 1 0.490454
GCGR glucagon receptor 0.486646
DGKQ diacylglycerol kinase, theta 110kDa 0.474877
E4F1 E4F transcription factor 1 0.471468
ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 0.459373
FABP1 fatty acid binding protein 1, liver 0.457487
NPL N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase) 0.454847
RPL14 ribosomal protein L14 0.454093
CRY1 cryptochrome circadian clock 1 0.453339
SLC30A10 solute carrier family 30, member 10 0.448441
STYX serine/threonine/tyrosine interacting protein 0.446935
G6PC2 glucose-6-phosphatase, catalytic, 2 0.446182
PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 0.442418
MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1 0.422515
ZNHIT2 zinc finger, HIT-type containing 2 0.42214
ZFP36L1 ZFP36 ring finger protein-like 1 0.419892
PASK PAS domain containing serine/threonine kinase 0.418768
BLK BLK proto-oncogene, Src family tyrosine kinase 0.41465
HK2 hexokinase 2 0.408666
DGKA diacylglycerol kinase, alpha 80kDa 0.402692
PKD2 polycystic kidney disease 2 (autosomal dominant) 0.398589
SOAT2 sterol O-acyltransferase 2 0.395608
ADA adenosine deaminase 0.392629
RFX6 regulatory factor X, 6 0.391885
PPP1R3A protein phosphatase 1, regulatory subunit 3A 0.391141
GLP1R glucagon-like peptide 1 receptor 0.389281
PSMA4 proteasome (prosome, macropain) subunit, alpha type, 4 0.382223
PPARG peroxisome proliferator-activated receptor gamma 0.35892
UMOD uromodulin 0.351923
KCNJ10 potassium channel, inwardly rectifying subfamily J, member 10 0.316456
ACVR2B activin A receptor, type IIB 0.310652
HK1 hexokinase 1 0.302698
IRS1 insulin receptor substrate 1 0.299812
TGM2 transglutaminase 2 0.297651
ST5 suppression of tumorigenicity 5 0.282225
KAT2B K(lysine) acetyltransferase 2B 0.27687
KHK ketohexokinase (fructokinase) 0.273308
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1 0.270819
LDB1 LIM domain binding 1 0.26266
SOX13 SRY (sex determining region Y)-box 13 0.25877
UCP2 uncoupling protein 2 (mitochondrial, proton carrier) 0.254536
STK39 serine threonine kinase 39 0.252422
FAM167A family with sequence similarity 167, member A 0.250311
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 0.246448
BMF Bcl2 modifying factor 0.241546
PTPN3 protein tyrosine phosphatase, non-receptor type 3 0.237706
BMP3 bone morphogenetic protein 3 0.23492
APOC3 apolipoprotein C-III 0.223509
FXR1 fragile X mental retardation, autosomal homolog 1 0.223165
UCN3 urocortin 3 0.215992
GLIS3 GLIS family zinc finger 3 0.198709
GTF2H4 general transcription factor IIH, polypeptide 4, 52kDa 0.197742
SOCS3 suppressor of cytokine signaling 3 0.19582
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.192657
SLC25A18 solute carrier family 25 (glutamate carrier), member 18 0.192657
SNAP25 synaptosomal-associated protein, 25kDa 0.192031
CYP7A1 cytochrome P450, family 7, subfamily A, polypeptide 1 0.184128
KCNJ3 potassium channel, inwardly rectifying subfamily J, member 3 0.182666
RASD1 RAS, dexamethasone-induced 1 0.180937
G6PC glucose-6-phosphatase, catalytic subunit 0.179239
MYBPC1 myosin binding protein C, slow type 0.170544
LMX1A LIM homeobox transcription factor 1, alpha 0.168854
FGF19 fibroblast growth factor 19 0.167452
SEL1L sel-1 suppressor of lin-12-like (C. elegans) 0.157929