marginal zone b cell differentiation Gene Set

Dataset GO Biological Process Annotations
Category structural or functional annotations
Type biological process
Description The process in which a B cell in the spleen acquires the specialized features of a marginal zone B cell. Marginal zone B cells are localized in a distinct anatomical region of the spleen that represents the major antigen-filtering and scavenging area (by specialized macrophages resident there). It appears that they are preselected to express a BCR repertoire similar to B-1 B cells, biased toward bacterial cell wall constituents and senescent self-components (such as oxidized LDL). (Gene Ontology, GO_0002315)
External Link http://amigo.geneontology.org/amigo/term/GO:0002315
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Genes

2 genes participating in the marginal zone b cell differentiation biological process from the curated GO Biological Process Annotations dataset.

Symbol Name
BCL3 B-cell CLL/lymphoma 3
PTK2B protein tyrosine kinase 2 beta