maprotiline-6676 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

194 genes differentially expressed following the maprotiline-6676 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAMTS7 ADAM metallopeptidase with thrombospondin type 1 motif, 7
AGRN agrin
APOC1 apolipoprotein C-I
ATP6V0A1 ATPase, H+ transporting, lysosomal V0 subunit a1
BIK BCL2-interacting killer (apoptosis-inducing)
BTG2 BTG family, member 2
C3 complement component 3
C8A complement component 8, alpha polypeptide
CABP2 calcium binding protein 2
CALD1 caldesmon 1
CASP1 caspase 1, apoptosis-related cysteine peptidase
CDH20 cadherin 20, type 2
CDHR2 cadherin-related family member 2
CFLAR CASP8 and FADD-like apoptosis regulator
CLCN6 chloride channel, voltage-sensitive 6
DENND3 DENN/MADD domain containing 3
DRD2 dopamine receptor D2
DUOX2 dual oxidase 2
EGR1 early growth response 1
EPHB1 EPH receptor B1
EPS15L1 epidermal growth factor receptor pathway substrate 15-like 1
FBRS fibrosin
FGF21 fibroblast growth factor 21
FGFBP1 fibroblast growth factor binding protein 1
FRMD8 FERM domain containing 8
GDF2 growth differentiation factor 2
GK glycerol kinase
GSN gelsolin
HIST1H2AL histone cluster 1, H2al
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HNF1B HNF1 homeobox B
HRG histidine-rich glycoprotein
ICOSLG inducible T-cell co-stimulator ligand
IDS iduronate 2-sulfatase
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IFNA16 interferon, alpha 16
IL1RN interleukin 1 receptor antagonist
ING4 inhibitor of growth family, member 4
INSIG1 insulin induced gene 1
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
KLHL22 kelch-like family member 22
KLRD1 killer cell lectin-like receptor subfamily D, member 1
KRT24 keratin 24, type I
LDLR low density lipoprotein receptor
LOC100131510 uncharacterized LOC100131510
LRRK1 leucine-rich repeat kinase 1
MAGEA5 melanoma antigen family A5
NFX1 nuclear transcription factor, X-box binding 1
NNMT nicotinamide N-methyltransferase
NPAS1 neuronal PAS domain protein 1
NR6A1 nuclear receptor subfamily 6, group A, member 1
NUPR1 nuclear protein, transcriptional regulator, 1
OGFR opioid growth factor receptor
OR2B6 olfactory receptor, family 2, subfamily B, member 6
PBX2 pre-B-cell leukemia homeobox 2
PCSK6 proprotein convertase subtilisin/kexin type 6
PDGFB platelet-derived growth factor beta polypeptide
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PKN2 protein kinase N2
PLA2G5 phospholipase A2, group V
PLD1 phospholipase D1, phosphatidylcholine-specific
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2
PLIN2 perilipin 2
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PPP1R16B protein phosphatase 1, regulatory subunit 16B
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS11 regulator of G-protein signaling 11
RHEB Ras homolog enriched in brain
RMND5A required for meiotic nuclear division 5 homolog A (S. cerevisiae)
RPA4 replication protein A4, 30kDa
SCAND2P SCAN domain containing 2 pseudogene
SCARB1 scavenger receptor class B, member 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
SEMA3G sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC22A18AS solute carrier family 22 (organic cation transporter), member 18 antisense
SLC24A1 solute carrier family 24 (sodium/potassium/calcium exchanger), member 1
SLCO2A1 solute carrier organic anion transporter family, member 2A1
SPTB spectrin, beta, erythrocytic
SSX3 synovial sarcoma, X breakpoint 3
SSX7 synovial sarcoma, X breakpoint 7
SYNJ1 synaptojanin 1
T T, brachyury homolog (mouse)
TAF6L TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa
TAS2R10 taste receptor, type 2, member 10
TFEB transcription factor EB
TNK1 tyrosine kinase, non-receptor, 1
TRD T cell receptor delta locus
TUB tubby bipartite transcription factor
UBE2B ubiquitin-conjugating enzyme E2B
UCP1 uncoupling protein 1 (mitochondrial, proton carrier)
ULBP1 UL16 binding protein 1
VPS53 vacuolar protein sorting 53 homolog (S. cerevisiae)
ZBTB7A zinc finger and BTB domain containing 7A

decreased expression

Symbol Name
AATK apoptosis-associated tyrosine kinase
ACVR2B activin A receptor, type IIB
ADAM23 ADAM metallopeptidase domain 23
AEN apoptosis enhancing nuclease
AFF4 AF4/FMR2 family, member 4
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
ATAD5 ATPase family, AAA domain containing 5
AXIN1 axin 1
BFSP1 beaded filament structural protein 1, filensin
BRINP2 bone morphogenetic protein/retinoic acid inducible neural-specific 2
BTC betacellulin
BTF3P11 basic transcription factor 3 pseudogene 11
C7ORF43 chromosome 7 open reading frame 43
C9ORF40 chromosome 9 open reading frame 40
CAMTA2 calmodulin binding transcription activator 2
CCRN4L CCR4 carbon catabolite repression 4-like (S. cerevisiae)
CD82 CD82 molecule
CEMIP cell migration inducing protein, hyaluronan binding
CIDEC cell death-inducing DFFA-like effector c
CISH cytokine inducible SH2-containing protein
CPEB1 cytoplasmic polyadenylation element binding protein 1
CPNE7 copine VII
CPSF7 cleavage and polyadenylation specific factor 7, 59kDa
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2
DNM3 dynamin 3
DSPP dentin sialophosphoprotein
ERN2 endoplasmic reticulum to nucleus signaling 2
EXD3 exonuclease 3'-5' domain containing 3
EYA4 EYA transcriptional coactivator and phosphatase 4
FAM86C1 family with sequence similarity 86, member C1
FZD3 frizzled class receptor 3
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14
GAS8 growth arrest-specific 8
GMPR guanosine monophosphate reductase
GRAMD1C GRAM domain containing 1C
HDAC11 histone deacetylase 11
HIST1H1D histone cluster 1, H1d
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
IFNA14 interferon, alpha 14
IL36RN interleukin 36 receptor antagonist
IL4R interleukin 4 receptor
INO80D INO80 complex subunit D
ITGB7 integrin, beta 7
KIRREL kin of IRRE like (Drosophila)
KRT37 keratin 37, type I
LOC202181 SUMO-interacting motifs containing 1 pseudogene
LY6G6C lymphocyte antigen 6 complex, locus G6C
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1
LZTR1 leucine-zipper-like transcription regulator 1
MFGE8 milk fat globule-EGF factor 8 protein
MON1B MON1 secretory trafficking family member B
NPFFR1 neuropeptide FF receptor 1
NRTN neurturin
NT5M 5',3'-nucleotidase, mitochondrial
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PACS1 phosphofurin acidic cluster sorting protein 1
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta
PID1 phosphotyrosine interaction domain containing 1
PLEKHA6 pleckstrin homology domain containing, family A member 6
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PLEKHO2 pleckstrin homology domain containing, family O member 2
PODXL2 podocalyxin-like 2
PPP1R2P9 protein phosphatase 1, regulatory (inhibitor) subunit 2 pseudogene 9
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PTPRE protein tyrosine phosphatase, receptor type, E
PXMP4 peroxisomal membrane protein 4, 24kDa
REXO4 REX4, RNA exonuclease 4 homolog (S. cerevisiae)
RFWD3 ring finger and WD repeat domain 3
SCN1B sodium channel, voltage gated, type I beta subunit
SDC3 syndecan 3
SEC61A2 Sec61 alpha 2 subunit (S. cerevisiae)
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5
SMYD5 SMYD family member 5
SNORA21 small nucleolar RNA, H/ACA box 21
SPINK5 serine peptidase inhibitor, Kazal type 5
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1
TAOK1 TAO kinase 1
TESPA1 thymocyte expressed, positive selection associated 1
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TMEM212 transmembrane protein 212
TMSB15A thymosin beta 15a
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator
WDR4 WD repeat domain 4
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
ZC2HC1C zinc finger, C2HC-type containing 1C
ZNF141 zinc finger protein 141
ZNF219 zinc finger protein 219
ZNF239 zinc finger protein 239
ZNF254 zinc finger protein 254
ZNF264 zinc finger protein 264
ZNF276 zinc finger protein 276
ZNF711 zinc finger protein 711
ZNF768 zinc finger protein 768
ZXDC ZXD family zinc finger C