maprotiline-3236 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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198 genes differentially expressed following the maprotiline-3236 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACAA2 acetyl-CoA acyltransferase 2
ADAM22 ADAM metallopeptidase domain 22
ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide
AGMAT agmatine ureohydrolase (agmatinase)
AHNAK2 AHNAK nucleoprotein 2
AIF1 allograft inflammatory factor 1
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
C1QTNF9B-AS1 C1QTNF9B antisense RNA 1
CA4 carbonic anhydrase IV
CCPG1 cell cycle progression 1
CDHR2 cadherin-related family member 2
CDK13 cyclin-dependent kinase 13
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
CEL carboxyl ester lipase
CRHR2 corticotropin releasing hormone receptor 2
CTSF cathepsin F
DCBLD2 discoidin, CUB and LCCL domain containing 2
DDIT4 DNA-damage-inducible transcript 4
DENND5B DENN/MADD domain containing 5B
DNM3 dynamin 3
DST dystonin
DUSP4 dual specificity phosphatase 4
EDNRA endothelin receptor type A
EFNB3 ephrin-B3
F13A1 coagulation factor XIII, A1 polypeptide
FAM105A family with sequence similarity 105, member A
FBXW4P1 F-box and WD repeat domain containing 4 pseudogene 1
FGFR1 fibroblast growth factor receptor 1
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
GPRIN2 G protein regulated inducer of neurite outgrowth 2
GREB1L growth regulation by estrogen in breast cancer-like
GSK3A glycogen synthase kinase 3 alpha
HBS1L HBS1-like translational GTPase
HCAR3 hydroxycarboxylic acid receptor 3
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOXA4 homeobox A4
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker)
INSIG1 insulin induced gene 1
IQCG IQ motif containing G
LDLR low density lipoprotein receptor
LLPH LLP homolog, long-term synaptic facilitation (Aplysia)
LPIN1 lipin 1
LRCH4 leucine-rich repeats and calponin homology (CH) domain containing 4
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
LTBP2 latent transforming growth factor beta binding protein 2
MAN2A2 mannosidase, alpha, class 2A, member 2
MTAP methylthioadenosine phosphorylase
MTSS1 metastasis suppressor 1
NDRG2 NDRG family member 2
NEU3 sialidase 3 (membrane sialidase)
NOD1 nucleotide-binding oligomerization domain containing 1
NPR1 natriuretic peptide receptor 1
NR2E3 nuclear receptor subfamily 2, group E, member 3
NXPE3 neurexophilin and PC-esterase domain family, member 3
PBX2 pre-B-cell leukemia homeobox 2
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCBP3 poly(rC) binding protein 3
PDK2 pyruvate dehydrogenase kinase, isozyme 2
PLA2G3 phospholipase A2, group III
POU5F1B POU class 5 homeobox 1B
PSD3 pleckstrin and Sec7 domain containing 3
PTGDS prostaglandin D2 synthase 21kDa (brain)
RBFA ribosome binding factor A (putative)
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
RHBG Rh family, B glycoprotein (gene/pseudogene)
RIMS3 regulating synaptic membrane exocytosis 3
RS1 retinoschisin 1
RUNX1 runt-related transcription factor 1
SCUBE3 signal peptide, CUB domain, EGF-like 3
SHANK2 SH3 and multiple ankyrin repeat domains 2
SHOX2 short stature homeobox 2
SIPA1L3 signal-induced proliferation-associated 1 like 3
SIRT5 sirtuin 5
SLC10A1 solute carrier family 10 (sodium/bile acid cotransporter), member 1
SLCO4C1 solute carrier organic anion transporter family, member 4C1
SMIM14 small integral membrane protein 14
SOX9 SRY (sex determining region Y)-box 9
SPARCL1 SPARC-like 1 (hevin)
SQLE squalene epoxidase
SRF serum response factor (c-fos serum response element-binding transcription factor)
ST3GAL4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4
STIM1 stromal interaction molecule 1
TAGLN3 transgelin 3
TBC1D2 TBC1 domain family, member 2
TEX14 testis expressed 14
TGFB2 transforming growth factor, beta 2
TGFBR1 transforming growth factor, beta receptor 1
TGM2 transglutaminase 2
TLK1 tousled-like kinase 1
TM4SF1 transmembrane 4 L six family member 1
TM6SF2 transmembrane 6 superfamily member 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPM2 tropomyosin 2 (beta)
TRPM8 transient receptor potential cation channel, subfamily M, member 8
VWA5A von Willebrand factor A domain containing 5A
ZXDB zinc finger, X-linked, duplicated B

decreased expression

Symbol Name
AIPL1 aryl hydrocarbon receptor interacting protein-like 1
ALOX15 arachidonate 15-lipoxygenase
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle)
APLP1 amyloid beta (A4) precursor-like protein 1
ARHGAP10 Rho GTPase activating protein 10
ASPHD1 aspartate beta-hydroxylase domain containing 1
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
BMP4 bone morphogenetic protein 4
C1ORF159 chromosome 1 open reading frame 159
C22ORF46 chromosome 22 open reading frame 46
C6ORF47 chromosome 6 open reading frame 47
C8ORF60 chromosome 8 open reading frame 60
CD3D CD3d molecule, delta (CD3-TCR complex)
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD82 CD82 molecule
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1
CDK5 cyclin-dependent kinase 5
CDON cell adhesion associated, oncogene regulated
CEMIP cell migration inducing protein, hyaluronan binding
CFAP69 cilia and flagella associated protein 69
CGA glycoprotein hormones, alpha polypeptide
CORO7 coronin 7
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
CRYBB2P1 crystallin, beta B2 pseudogene 1
CRYGC crystallin, gamma C
CSF1R colony stimulating factor 1 receptor
CSTA cystatin A (stefin A)
CUEDC1 CUE domain containing 1
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
CYP4F11 cytochrome P450, family 4, subfamily F, polypeptide 11
DAGLA diacylglycerol lipase, alpha
DEAF1 DEAF1 transcription factor
DOK2 docking protein 2, 56kDa
DPYS dihydropyrimidinase
DYSF dysferlin
EXO5 exonuclease 5
FAAH fatty acid amide hydrolase
FARP2 FERM, RhoGEF and pleckstrin domain protein 2
FBXO31 F-box protein 31
FGF6 fibroblast growth factor 6
FKBP10 FK506 binding protein 10, 65 kDa
FOSL1 FOS-like antigen 1
FURIN furin (paired basic amino acid cleaving enzyme)
GIF gastric intrinsic factor (vitamin B synthesis)
GNB1L guanine nucleotide binding protein (G protein), beta polypeptide 1-like
GPATCH2L G patch domain containing 2-like
HAMP hepcidin antimicrobial peptide
HIST1H2AL histone cluster 1, H2al
HIST1H2BC histone cluster 1, H2bc
IL15RA interleukin 15 receptor, alpha
IL4R interleukin 4 receptor
IQSEC2 IQ motif and Sec7 domain 2
IRF2BP1 interferon regulatory factor 2 binding protein 1
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
KBTBD11 kelch repeat and BTB (POZ) domain containing 11
KCNA6 potassium channel, voltage gated shaker related subfamily A, member 6
KCNQ3 potassium channel, voltage gated KQT-like subfamily Q, member 3
KLHL26 kelch-like family member 26
LDHB lactate dehydrogenase B
LIN7B lin-7 homolog B (C. elegans)
LOC390998 ribosomal protein L10 pseudogene
LRP3 low density lipoprotein receptor-related protein 3
LYZ lysozyme
MSI1 musashi RNA-binding protein 1
MUL1 mitochondrial E3 ubiquitin protein ligase 1
NLGN1 neuroligin 1
NLRX1 NLR family member X1
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18
OLFML3 olfactomedin-like 3
PC pyruvate carboxylase
PCDHGB5 protocadherin gamma subfamily B, 5
PDE12 phosphodiesterase 12
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime
PODNL1 podocan-like 1
PYCRL pyrroline-5-carboxylate reductase-like
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RAD54L2 RAD54-like 2 (S. cerevisiae)
RAPSN receptor-associated protein of the synapse
RIN2 Ras and Rab interactor 2
SAMD9 sterile alpha motif domain containing 9
SAYSD1 SAYSVFN motif domain containing 1
SCG2 secretogranin II
SGK1 serum/glucocorticoid regulated kinase 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
STAB2 stabilin 2
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TCTN1 tectonic family member 1
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TMEM120B transmembrane protein 120B
TRIM25 tripartite motif containing 25
TUBA3C tubulin, alpha 3c
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific
TWF2 twinfilin actin binding protein 2
UBTD1 ubiquitin domain containing 1
ULBP2 UL16 binding protein 2
ZIC3 Zic family member 3
ZNF16 zinc finger protein 16
ZNF205 zinc finger protein 205
ZNF34 zinc finger protein 34