mantle cell lymphoma Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description A B-cell lymphocytic neoplasm due to CD5 positive antigen-naive pregerminal center B-cell within the mantle zone that surrounds normal germinal center follicles. (Human Disease Ontology, DOID_0050746)
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Genes

279 genes co-occuring with the disease mantle cell lymphoma in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
CCND1 cyclin D1 2.83348
CD5 CD5 molecule 2.52873
SOX11 SRY (sex determining region Y)-box 11 2.16602
SLC35B2 solute carrier family 35 (adenosine 3'-phospho 5'-phosphosulfate transporter), member B2 1.72456
CD19 CD19 molecule 1.59966
MTOR mechanistic target of rapamycin (serine/threonine kinase) 1.58269
BTK Bruton agammaglobulinemia tyrosine kinase 1.5216
BCL6 B-cell CLL/lymphoma 6 1.41402
ATM ATM serine/threonine kinase 1.40658
TP53 tumor protein p53 1.33763
CCND2 cyclin D2 1.32585
CD22 CD22 molecule 1.30838
IGHV5-51 immunoglobulin heavy variable 5-51 1.14687
CCND3 cyclin D3 1.13036
IGH immunoglobulin heavy locus 1.05093
CD38 CD38 molecule 1.01005
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.00879
CDKN2A cyclin-dependent kinase inhibitor 2A 0.994439
ROR1 receptor tyrosine kinase-like orphan receptor 1 0.991065
CD79B CD79b molecule, immunoglobulin-associated beta 0.97296
CD200 CD200 molecule 0.968761
RGS13 regulator of G-protein signaling 13 0.962472
BCL2L1 BCL2-like 1 0.958705
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain 0.949102
MOB3A MOB kinase activator 3A 0.939949
CD40 CD40 molecule, TNF receptor superfamily member 5 0.934556
CADM1 cell adhesion molecule 1 0.924626
MOB3B MOB kinase activator 3B 0.924213
RCC1 regulator of chromosome condensation 1 0.896641
JADE3 jade family PHD finger 3 0.874509
CDK4 cyclin-dependent kinase 4 0.869596
ZNF280A zinc finger protein 280A 0.868368
IGHV4-39 immunoglobulin heavy variable 4-39 0.865912
SETMAR SET domain and mariner transposase fusion gene 0.865093
C5ORF49 chromosome 5 open reading frame 49 0.853221
FXYD5 FXYD domain containing ion transport regulator 5 0.847488
PIK3IP1 phosphoinositide-3-kinase interacting protein 1 0.841753
IGHV3-9 immunoglobulin heavy variable 3-9 0.834788
CXCR5 chemokine (C-X-C motif) receptor 5 0.831918
SKP1 S-phase kinase-associated protein 1 0.828639
BCL2 B-cell CLL/lymphoma 2 0.819206
BAX BCL2-associated X protein 0.814283
BCL2L11 BCL2-like 11 (apoptosis facilitator) 0.813462
TUBGCP3 tubulin, gamma complex associated protein 3 0.80936
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.80936
CD34 CD34 molecule 0.801154
BCL10 B-cell CLL/lymphoma 10 0.797052
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 0.795002
SOX12 SRY (sex determining region Y)-box 12 0.791311
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) 0.790902
CIT citron rho-interacting serine/threonine kinase 0.782707
IGHV3-21 immunoglobulin heavy variable 3-21 0.777386
IGHV4-34 immunoglobulin heavy variable 4-34 0.772887
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.77207
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 0.771661
MNDA myeloid cell nuclear differentiation antigen 0.763902
TCL1A T-cell leukemia/lymphoma 1A 0.763086
HDGFRP3 hepatoma-derived growth factor, related protein 3 0.743954
MIR17 microRNA 17 0.743141
IGHV3-64 immunoglobulin heavy variable 3-64 0.737865
SURF6 surfeit 6 0.733811
IGHV1-8 immunoglobulin heavy variable 1-8 0.727738
TBC1D9 TBC1 domain family, member 9 (with GRAM domain) 0.724098
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b 0.712796
PAX5 paired box 5 0.699116
MALT1 MALT1 paracaspase 0.686291
TPX2 TPX2, microtubule-associated 0.681495
ADAMTS2 ADAM metallopeptidase with thrombospondin type 1 motif, 2 0.680697
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 0.676706
TNFRSF13C tumor necrosis factor receptor superfamily, member 13C 0.674315
BCL3 B-cell CLL/lymphoma 3 0.669936
PDE7B phosphodiesterase 7B 0.668742
BMI1 BMI1 proto-oncogene, polycomb ring finger 0.647743
CD52 CD52 molecule 0.643797
IGHV3-74 immunoglobulin heavy variable 3-74 0.643797
PTPRJ protein tyrosine phosphatase, receptor type, J 0.635135
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 0.625319
CCDC50 coiled-coil domain containing 50 0.624927
CD40LG CD40 ligand 0.622967
AICDA activation-induced cytidine deaminase 0.621792
IRF4 interferon regulatory factor 4 0.613965
ABCA6 ATP-binding cassette, sub-family A (ABC1), member 6 0.609276
DLEU2L deleted in lymphocytic leukemia 2-like 0.607714
BIRC3 baculoviral IAP repeat containing 3 0.604981
RB1 retinoblastoma 1 0.60147
CDK9 cyclin-dependent kinase 9 0.60069
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.59952
GPX7 glutathione peroxidase 7 0.59952
SERPINI2 serpin peptidase inhibitor, clade I (pancpin), member 2 0.597961
SYK spleen tyrosine kinase 0.595623
ARHGAP29 Rho GTPase activating protein 29 0.595233
IGHV3-7 immunoglobulin heavy variable 3-7 0.592506
CDK7 cyclin-dependent kinase 7 0.588222
ING1 inhibitor of growth family, member 1 0.587833
CXCL13 chemokine (C-X-C motif) ligand 13 0.583552
PHLPP2 PH domain and leucine rich repeat protein phosphatase 2 0.58005
CTRL chymotrypsin-like 0.578883
CEACAM3 carcinoembryonic antigen-related cell adhesion molecule 3 0.577327
HDAC9 histone deacetylase 9 0.573439
PIM2 Pim-2 proto-oncogene, serine/threonine kinase 0.56722
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.565666
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1 0.562558
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 0.552463
XPO1 exportin 1 0.551298
SRP9 signal recognition particle 9kDa 0.540055
SRP9P1 signal recognition particle 9 pseudogene 1 0.540055
IGLV3-19 immunoglobulin lambda variable 3-19 0.538893
VMAC vimentin-type intermediate filament associated coiled-coil protein 0.535796
SLC29A1 solute carrier family 29 (equilibrative nucleoside transporter), member 1 0.532314
OCIAD1 OCIA domain containing 1 0.51919
FCRL1 Fc receptor-like 1 0.51919
CD37 CD37 molecule 0.514186
HYLS1 hydrolethalus syndrome 1 0.513802
GPC5 glypican 5 0.513802
EIF4E eukaryotic translation initiation factor 4E 0.510344
FMOD fibromodulin 0.498085
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit 0.487407
CD7 CD7 molecule 0.471468
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 0.463527
BIRC5 baculoviral IAP repeat containing 5 0.463527
CRNN cornulin 0.463527
MUM1 melanoma associated antigen (mutated) 1 0.460506
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated) 0.452208
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.451078
CD79A CD79a molecule, immunoglobulin-associated alpha 0.450324
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.446558
SLC29A2 solute carrier family 29 (equilibrative nucleoside transporter), member 2 0.436778
RFC1 replication factor C (activator 1) 1, 145kDa 0.432646
CD27 CD27 molecule 0.430017
PAX2 paired box 2 0.429642
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast) 0.425514
RAD51AP1 RAD51 associated protein 1 0.42214
WIPF3 WAS/WASL interacting protein family, member 3 0.420266
WNT3 wingless-type MMTV integration site family, member 3 0.419142
ANXA5 annexin A5 0.418768
ATP1B2 ATPase, Na+/K+ transporting, beta 2 polypeptide 0.418394
ALK anaplastic lymphoma receptor tyrosine kinase 0.413901
KPNA3 karyopherin alpha 3 (importin alpha 4) 0.413527
LTB lymphotoxin beta (TNF superfamily, member 3) 0.410909
PARP1 poly (ADP-ribose) polymerase 1 0.407545
CDC14A cell division cycle 14A 0.404184
CNR1 cannabinoid receptor 1 (brain) 0.40008
CCNG1 cyclin G1 0.399334
CERS6 ceramide synthase 6 0.395608
ZFP64 ZFP64 zinc finger protein 0.392257
NGDN neuroguidin, EIF4E binding protein 0.392257
DLEU1 deleted in lymphocytic leukemia 1 (non-protein coding) 0.387423
PCDH9 protocadherin 9 0.387423
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase 0.386679
CLPTM1L CLPTM1-like 0.385193
MIB1 mindbomb E3 ubiquitin protein ligase 1 0.384451
HOXD8 homeobox D8 0.383337
SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 0.382223
CENPF centromere protein F, 350/400kDa 0.379997
CD33 CD33 molecule 0.377402
BIK BCL2-interacting killer (apoptosis-inducing) 0.377402
CASP9 caspase 9, apoptosis-related cysteine peptidase 0.37555
EIF4EBP2 eukaryotic translation initiation factor 4E binding protein 2 0.372217
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase 0.367779
SEMG1 semenogelin I 0.36704
CD70 CD70 molecule 0.364085
MIR96 microRNA 96 0.362978
SOX4 SRY (sex determining region Y)-box 4 0.36187
CCNH cyclin H 0.361133
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) 0.35892
SIGLEC10 sialic acid binding Ig-like lectin 10 0.355235
SAFB scaffold attachment factor B 0.35082
HACE1 HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 0.348981
CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1 0.348614
CR1 complement component (3b/4b) receptor 1 (Knops blood group) 0.347879
NEBL nebulette 0.342739
UCHL5 ubiquitin carboxyl-terminal hydrolase L5 0.342372
RANGAP1 Ran GTPase activating protein 1 0.337608
MAP3K14 mitogen-activated protein kinase kinase kinase 14 0.337242
PSMA5 proteasome (prosome, macropain) subunit, alpha type, 5 0.330295
HIST1H1D histone cluster 1, H1d 0.328469
TUBA1C tubulin, alpha 1c 0.326646
CCNK cyclin K 0.324823
LYN LYN proto-oncogene, Src family tyrosine kinase 0.319726
PRDM1 PR domain containing 1, with ZNF domain 0.315366
TUBA1B tubulin, alpha 1b 0.315003
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.314278
FBXO5 F-box protein 5 0.312102
B2M beta-2-microglobulin 0.308118
KMT2B lysine (K)-specific methyltransferase 2B 0.30342
NPW neuropeptide W 0.301976
CLLU1 chronic lymphocytic leukemia up-regulated 1 0.300173
AURKB aurora kinase B 0.298011
CRADD CASP2 and RIPK1 domain containing adaptor with death domain 0.295492
BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1 0.295132
NOTCH2 notch 2 0.286877
NOTCH2NL notch 2 N-terminal like 0.284371
SUZ12 SUZ12 polycomb repressive complex 2 subunit 0.282225
AKAP1 A kinase (PRKA) anchor protein 1 0.280082
CD160 CD160 molecule 0.279724
CHEK1 checkpoint kinase 1 0.279011
OPTC opticin 0.27687
CD80 CD80 molecule 0.273308
PRELP proline/arginine-rich end leucine-rich repeat protein 0.27153
NOTCH1 notch 1 0.270108
FCRL4 Fc receptor-like 4 0.266203
CT45A1 cancer/testis antigen family 45, member A1 0.266203
PTEN phosphatase and tensin homolog 0.265849
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein) 0.264077
CD4 CD4 molecule 0.261952
AKTIP AKT interacting protein 0.261952
IGHV1-2 immunoglobulin heavy variable 1-2 0.260891
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) 0.259124
WHSC1 Wolf-Hirschhorn syndrome candidate 1 0.257005
PRAME preferentially expressed antigen in melanoma 0.255946
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B 0.254888
IGKV1D-42 immunoglobulin kappa variable 1D-42 (non-functional) 0.252422
MYC v-myc avian myelocytomatosis viral oncogene homolog 0.248203
FAF1 Fas (TNFRSF6) associated factor 1 0.247501
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.24715
CD24 CD24 molecule 0.246098
ERAP2 endoplasmic reticulum aminopeptidase 2 0.245747
NCAM1 neural cell adhesion molecule 1 0.239799
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9 0.236312
CD44 CD44 molecule (Indian blood group) 0.231102
ATG3 autophagy related 3 0.230755
H2AFX H2A histone family, member X 0.225917
TFDP1 transcription factor Dp-1 0.223853
RXRG retinoid X receptor, gamma 0.222479
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) 0.221793
PRKACB protein kinase, cAMP-dependent, catalytic, beta 0.22145
GNPDA1 glucosamine-6-phosphate deaminase 1 0.22145
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1 0.221108
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.220766
TEAD2 TEA domain family member 2 0.220081
NCL nucleolin 0.217693
HRAS Harvey rat sarcoma viral oncogene homolog 0.217352
KLF9 Kruppel-like factor 9 0.217012
CDR2 cerebellar degeneration-related protein 2, 62kDa 0.215653
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) 0.214636
IL4 interleukin 4 0.214636
CKS1B CDC28 protein kinase regulatory subunit 1B 0.214297
HNRNPL heterogeneous nuclear ribonucleoprotein L 0.212271
TNFAIP2 tumor necrosis factor, alpha-induced protein 2 0.210253
MKI67 marker of proliferation Ki-67 0.20658
ADGRL4 adhesion G protein-coupled receptor L4 0.20658
ARHGAP32 Rho GTPase activating protein 32 0.206248
PPP2R1B protein phosphatase 2, regulatory subunit A, beta 0.205254
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 0.204923
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.203933
CDK6 cyclin-dependent kinase 6 0.203604
CSK c-src tyrosine kinase 0.199033
CENPC centromere protein C 0.197099
MAP6 microtubule-associated protein 6 0.195183
TNFRSF9 tumor necrosis factor receptor superfamily, member 9 0.194548
SERPINA9 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 9 0.189551
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.188938
NR2F1 nuclear receptor subfamily 2, group F, member 1 0.188632
TNF tumor necrosis factor 0.185313
JAM3 junctional adhesion molecule 3 0.183835
CCNB1 cyclin B1 0.182375
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.182375
MCM6 minichromosome maintenance complex component 6 0.182375
RRM2 ribonucleotide reductase M2 0.182375
AK5 adenylate kinase 5 0.182086
SLC9A3R2 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2 0.182086
TNFRSF14 tumor necrosis factor receptor superfamily, member 14 0.180367
GRB2 growth factor receptor-bound protein 2 0.180084
RFXANK regulatory factor X-associated ankyrin-containing protein 0.179802
BCR breakpoint cluster region 0.179239
ATP5B ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide 0.179239
ACTB actin, beta 0.176757
CNTN6 contactin 6 0.173314
FCER2 Fc fragment of IgE, low affinity II, receptor for (CD23) 0.172291
FLT1 fms-related tyrosine kinase 1 0.167452
UBA1 ubiquitin-like modifier activating enzyme 1 0.167452
ALDOC aldolase C, fructose-bisphosphate 0.164149
PRMT5 protein arginine methyltransferase 5 0.163523
HDAC3 histone deacetylase 3 0.163523
TUBGCP4 tubulin, gamma complex associated protein 4 0.161912
SEPT1 septin 1 0.161139
ACTG1 actin gamma 1 0.158778
LRP1B low density lipoprotein receptor-related protein 1B 0.158605
GIMAP5 GTPase, IMAP family member 5 0.158266