malignant pleural mesothelioma Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description A pleural cancer that has_material_basis_in mesothelium cells. (Human Disease Ontology, DOID_7474)
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Genes

210 genes co-occuring with the disease malignant pleural mesothelioma in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
MSLN mesothelin 2.2095
CALB2 calbindin 2 1.70178
TYMS thymidylate synthetase 1.32236
SPP1 secreted phosphoprotein 1 1.21089
KAZALD1 Kazal-type serine peptidase inhibitor domain 1 1.20569
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase 1.191
FPGS folylpolyglutamate synthase 1.0669
TMEM30B transmembrane protein 30B 1.06396
BIRC5 baculoviral IAP repeat containing 5 1.04125
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1 0.997814
CCAR1 cell division cycle and apoptosis regulator 1 0.994017
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A 0.988114
KRT5 keratin 5, type II 0.957868
ERCC1 excision repair cross-complementation group 1 0.891308
WT1 Wilms tumor 1 0.888438
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.88434
EGFR epidermal growth factor receptor 0.853221
COBLL1 cordon-bleu WH2 repeat protein-like 1 0.851173
PTGER4 prostaglandin E receptor 4 (subtype EP4) 0.850764
MYL6B myosin, light chain 6B, alkali, smooth muscle and non-muscle 0.846669
MAPK13 mitogen-activated protein kinase 13 0.840525
ANKRD11 ankyrin repeat domain 11 0.811821
DHFR dihydrofolate reductase 0.811411
SLC7A14 solute carrier family 7, member 14 0.798692
SULF1 sulfatase 1 0.798692
MIR1273D microRNA 1273d 0.778204
BCL2L1 BCL2-like 1 0.776159
TP53 tumor protein p53 0.769618
MARS methionyl-tRNA synthetase 0.753713
TUSC2 tumor suppressor candidate 2 0.748424
NF2 neurofibromin 2 (merlin) 0.747204
ILK integrin-linked kinase 0.746798
CAPS calcyphosine 0.716425
PDPN podoplanin 0.714811
MTOR mechanistic target of rapamycin (serine/threonine kinase) 0.714408
SEMA6D sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D 0.712796
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.697911
ALDH1A3 aldehyde dehydrogenase 1 family, member A3 0.684692
CDKN2A cyclin-dependent kinase inhibitor 2A 0.680697
SP1 Sp1 transcription factor 0.66914
TRIP6 thyroid hormone receptor interactor 6 0.658422
MYO18B myosin XVIIIB 0.642221
EEF1B2 eukaryotic translation elongation factor 1 beta 2 0.637889
CLNS1A chloride channel, nucleotide-sensitive, 1A 0.637495
NFRKB nuclear factor related to kappaB binding protein 0.61866
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 0.61866
THBD thrombomodulin 0.617877
OXA1L oxidase (cytochrome c) assembly 1-like 0.604591
BAX BCL2-associated X protein 0.604591
PUF60 poly-U binding splicing factor 60KDa 0.60186
PDYN prodynorphin 0.590169
TM4SF1 transmembrane 4 L six family member 1 0.58939
CD86 CD86 molecule 0.580439
VEGFA vascular endothelial growth factor A 0.579272
ASS1 argininosuccinate synthase 1 0.579272
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.566054
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.564112
AGGF1 angiogenic factor with G patch and FHA domains 1 0.563335
SLC5A7 solute carrier family 5 (sodium/choline cotransporter), member 7 0.562946
TENM2 teneurin transmembrane protein 2 0.561392
XAF1 XIAP associated factor 1 0.556344
IL2 interleukin 2 0.555956
CLDN15 claudin 15 0.547419
TOP2A topoisomerase (DNA) II alpha 170kDa 0.529608
TNIP1 TNFAIP3 interacting protein 1 0.529608
GOLIM4 golgi integral membrane protein 4 0.528835
RASSF1 Ras association (RalGDS/AF-6) domain family member 1 0.521502
DVL1 dishevelled segment polarity protein 1 0.516879
PTEN phosphatase and tensin homolog 0.514186
NDC80 NDC80 kinetochore complex component 0.513802
CD274 CD274 molecule 0.513033
KAT7 K(lysine) acetyltransferase 7 0.51188
TNS1 tensin 1 0.508808
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.506507
ITLN1 intelectin 1 (galactofuranose binding) 0.506507
EIF4A2 eukaryotic translation initiation factor 4A2 0.497703
INCENP inner centromere protein antigens 135/155kDa 0.495029
RARRES1 retinoic acid receptor responder (tazarotene induced) 1 0.490835
IL4R interleukin 4 receptor 0.490835
WAC WW domain containing adaptor with coiled-coil 0.484744
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 0.472982
RTN4R reticulon 4 receptor 0.449571
PEA15 phosphoprotein enriched in astrocytes 15 0.449194
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) 0.447687
ACTG2 actin, gamma 2, smooth muscle, enteric 0.437906
BIRC7 baculoviral IAP repeat containing 7 0.436402
NME1 NME/NM23 nucleoside diphosphate kinase 1 0.434899
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase 0.429642
MCAM melanoma cell adhesion molecule 0.419892
BAP1 BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase) 0.415398
SLC46A1 solute carrier family 46 (folate transporter), member 1 0.412405
ESR2 estrogen receptor 2 (ER beta) 0.404931
SMO smoothened, frizzled class receptor 0.404557
PLXNA1 plexin A1 0.403438
ZIC1 Zic family member 1 0.401945
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 0.400453
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 0.395608
EFNB2 ephrin-B2 0.394118
MAD2L1P1 MAD2 mitotic arrest deficient-like 1 (yeast) pseudogene 1 0.392629
BST1 bone marrow stromal cell antigen 1 0.383708
SOCS1 suppressor of cytokine signaling 1 0.379997
CD34 CD34 molecule 0.373328
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.372217
ACTR1A ARP1 actin-related protein 1 homolog A, centractin alpha (yeast) 0.363347
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.362978
DVL3 dishevelled segment polarity protein 3 0.362978
CCNB1 cyclin B1 0.359657
BIRC3 baculoviral IAP repeat containing 3 0.359289
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.356709
MCM2 minichromosome maintenance complex component 2 0.355604
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) 0.355604
EMX2 empty spiracles homeobox 2 0.353395
HAPLN1 hyaluronan and proteoglycan link protein 1 0.353395
FGFR1 fibroblast growth factor receptor 1 0.348246
IL32 interleukin 32 0.346777
TPM4 tropomyosin 4 0.344941
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) 0.344574
CAV1 caveolin 1, caveolae protein, 22kDa 0.338341
CCND1 cyclin D1 0.335046
MAPK3 mitogen-activated protein kinase 3 0.335046
NME1-NME2 NME1-NME2 readthrough 0.334681
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.333949
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.329565
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 0.319726
MIR145 microRNA 145 0.31464
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta 0.313915
CUL4A cullin 4A 0.313189
CMA1 chymase 1, mast cell 0.306672
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2 0.303059
GLI1 GLI family zinc finger 1 0.299812
LPAR2 lysophosphatidic acid receptor 2 0.288668
DPP10 dipeptidyl-peptidase 10 (non-functional) 0.287593
EPCAM epithelial cell adhesion molecule 0.287235
RASSF5 Ras association (RalGDS/AF-6) domain family member 5 0.283297
CD44 CD44 molecule (Indian blood group) 0.28151
HAT1 histone acetyltransferase 1 0.276514
KDR kinase insert domain receptor 0.276514
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) 0.266913
NME2 NME/NM23 nucleoside diphosphate kinase 2 0.265849
TICAM2 toll-like receptor adaptor molecule 2 0.261599
MCM7 minichromosome maintenance complex component 7 0.258417
NT5C2 5'-nucleotidase, cytosolic II 0.257358
FUT2 fucosyltransferase 2 (secretor status included) 0.256299
EPHA2 EPH receptor A2 0.254183
CASP9 caspase 9, apoptosis-related cysteine peptidase 0.252422
NRP2 neuropilin 2 0.251366
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha 0.249608
FNDC3A fibronectin type III domain containing 3A 0.249257
MYL3 myosin, light chain 3, alkali; ventricular, skeletal, slow 0.24715
USP9X ubiquitin specific peptidase 9, X-linked 0.244345
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.243995
NKX2-1 NK2 homeobox 1 0.242945
MMP14 matrix metallopeptidase 14 (membrane-inserted) 0.242595
NDUFS7 NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase) 0.242595
GSTA2 glutathione S-transferase alpha 2 0.240847
GSTA4 glutathione S-transferase alpha 4 0.239799
RAB1A RAB1A, member RAS oncogene family 0.237706
IGFBP4 insulin-like growth factor binding protein 4 0.23666
BIRC2 baculoviral IAP repeat containing 2 0.234573
PDPK1 3-phosphoinositide dependent protein kinase 1 0.233183
SFRP1 secreted frizzled-related protein 1 0.230409
HHIP hedgehog interacting protein 0.230063
SSTR4 somatostatin receptor 4 0.229024
RAD21 RAD21 homolog (S. pombe) 0.226262
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal) 0.223165
TPBG trophoblast glycoprotein 0.223165
ZEB1 zinc finger E-box binding homeobox 1 0.222822
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.222479
TXN thioredoxin 0.221793
FGF2 fibroblast growth factor 2 (basic) 0.218374
LGALS3 lectin, galactoside-binding, soluble, 3 0.214975
RAD23B RAD23 homolog B (S. cerevisiae) 0.213621
HGF hepatocyte growth factor (hepapoietin A; scatter factor) 0.212608
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase 0.210925
HRK harakiri, BCL2 interacting protein 0.210925
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 0.209583
HDAC9 histone deacetylase 9 0.208914
TNNT1 troponin T type 1 (skeletal, slow) 0.208914
POSTN periostin, osteoblast specific factor 0.204923
IFITM1 interferon induced transmembrane protein 1 0.200331
FOXP3 forkhead box P3 0.197742
SHANK3 SH3 and multiple ankyrin repeat domains 3 0.195501
CD1D CD1d molecule 0.192657
MIR214 microRNA 214 0.192344
KEL Kell blood group, metallo-endopeptidase 0.190786
MIR192 microRNA 192 0.190786
ALDOA aldolase A, fructose-bisphosphate 0.189859
SLC16A4 solute carrier family 16, member 4 0.188938
NKX6-2 NK6 homeobox 2 0.185016
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1 0.183248
INVS inversin 0.181222
IRF6 interferon regulatory factor 6 0.180084
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 0.175411
SDC1 syndecan 1 0.174093
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.173832
C19ORF48 chromosome 19 open reading frame 48 0.173571
SFRP5 secreted frizzled-related protein 5 0.173057
CSF1R colony stimulating factor 1 receptor 0.172799
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 0.172038
DIABLO diablo, IAP-binding mitochondrial protein 0.168617
GABARAP GABA(A) receptor-associated protein 0.167452
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) 0.166544
FXYD1 FXYD domain containing ion transport regulator 1 0.165217
CPSF3L cleavage and polyadenylation specific factor 3-like 0.164359
CD46 CD46 molecule, complement regulatory protein 0.164149
SRC SRC proto-oncogene, non-receptor tyrosine kinase 0.163523
SPHK2 sphingosine kinase 2 0.161912
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.158951
CD68 CD68 molecule 0.14575
PTPRC protein tyrosine phosphatase, receptor type, C 0.141962