malignant mesothelioma Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description A cell type cancer that has_material_basis_in mesothelial tissue. (Human Disease Ontology, DOID_1790)
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Genes

295 genes co-occuring with the disease malignant mesothelioma in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
CALB2 calbindin 2 2.36182
MSLN mesothelin 2.26376
PTGER4 prostaglandin E receptor 4 (subtype EP4) 1.74915
KRT5 keratin 5, type II 1.65385
THBD thrombomodulin 1.43113
NF2 neurofibromin 2 (merlin) 1.4149
WT1 Wilms tumor 1 1.37774
BAP1 BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase) 1.2909
CDKN2A cyclin-dependent kinase inhibitor 2A 1.17035
NKX2-1 NK2 homeobox 1 1.14263
FUT4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific) 1.13797
RNASEH2A ribonuclease H2, subunit A 1.08076
AK7 adenylate kinase 7 1.07362
CD86 CD86 molecule 1.0627
TP53 tumor protein p53 1.06102
PDPN podoplanin 1.02988
RNH1 ribonuclease/angiogenin inhibitor 1 1.0033
GTPBP4 GTP binding protein 4 0.97044
POLA2 polymerase (DNA directed), alpha 2, accessory subunit 0.93
RPL18A ribosomal protein L18a 0.918848
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.872872
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) 0.871234
EGFR epidermal growth factor receptor 0.867549
KRT7 keratin 7, type II 0.867549
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 0.866321
SDCCAG3 serologically defined colon cancer antigen 3 0.864684
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.864684
SPP1 secreted phosphoprotein 1 0.839705
NAPSA napsin A aspartic peptidase 0.800744
CD34 CD34 molecule 0.779841
SEMA3G sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G 0.777386
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.77575
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 0.767576
PDGFA platelet-derived growth factor alpha polypeptide 0.755749
MYO7B myosin VIIB 0.751678
CCSER1 coiled-coil serine-rich protein 1 0.740705
ZMAT3 zinc finger, matrin-type 3 0.71925
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa 0.718443
MYL6B myosin, light chain 6B, alkali, smooth muscle and non-muscle 0.718443
SDC1 syndecan 1 0.713198
LATS2 large tumor suppressor kinase 2 0.672324
KRT20 keratin 20, type I 0.667152
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.665166
KAZALD1 Kazal-type serine peptidase inhibitor domain 1 0.660008
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) 0.658026
LIMS2 LIM and senescent cell antigen-like domains 2 0.651694
PDGFD platelet derived growth factor D 0.640251
TGFB1 transforming growth factor, beta 1 0.622575
MMP2 matrix metallopeptidase 2 0.619051
LIMS3 LIM and senescent cell antigen-like domains 3 0.615529
RASSF1 Ras association (RalGDS/AF-6) domain family member 1 0.614747
FOLR3 folate receptor 3 (gamma) 0.609276
SDC4 syndecan 4 0.60108
DUSP7 dual specificity phosphatase 7 0.593674
VCAN versican 0.591337
IL2 interleukin 2 0.587833
TXN thioredoxin 0.585887
LOXL3 lysyl oxidase-like 3 0.583941
EFNA1 ephrin-A1 0.581996
LINGO2 leucine rich repeat and Ig domain containing 2 0.569163
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.548583
MAPK7 mitogen-activated protein kinase 7 0.542767
SDK1 sidekick cell adhesion molecule 1 0.536957
TMEM30B transmembrane protein 30B 0.529222
SEC14L2 SEC14-like 2 (S. cerevisiae) 0.529222
MMP9 matrix metallopeptidase 9 0.528063
PRDX3 peroxiredoxin 3 0.52729
PNMA2 paraneoplastic Ma antigen 2 0.519575
CLNS1A chloride channel, nucleotide-sensitive, 1A 0.51534
CDC14A cell division cycle 14A 0.510728
FOSL1 FOS-like antigen 1 0.509576
PDGFB platelet-derived growth factor beta polypeptide 0.503441
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 0.502675
CTAG1A cancer/testis antigen 1A 0.496175
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.494648
RAB12 RAB12, member RAS oncogene family 0.48893
CRTAM cytotoxic and regulatory T cell molecule 0.485505
PRPF19 pre-mRNA processing factor 19 0.482844
CTAG1B cancer/testis antigen 1B 0.482464
HAS3 hyaluronan synthase 3 0.481325
SOD2 superoxide dismutase 2, mitochondrial 0.480945
NCR1 natural cytotoxicity triggering receptor 1 0.479427
ZDHHC8 zinc finger, DHHC-type containing 8 0.478289
TENM2 teneurin transmembrane protein 2 0.475255
LOXL4 lysyl oxidase-like 4 0.471468
HMGB1 high mobility group box 1 0.46466
BRD1 bromodomain containing 1 0.463149
CD3E CD3e molecule, epsilon (CD3-TCR complex) 0.463149
SFTPB surfactant protein B 0.455224
TYMS thymidylate synthetase 0.454847
CALD1 caldesmon 1 0.452208
IFNA8 interferon, alpha 8 0.451078
TERT telomerase reverse transcriptase 0.449194
MFGE8 milk fat globule-EGF factor 8 protein 0.446935
SKP1 S-phase kinase-associated protein 1 0.440538
TEAD4 TEA domain family member 4 0.440162
PPM1B protein phosphatase, Mg2+/Mn2+ dependent, 1B 0.438658
BCL2L1 BCL2-like 1 0.436402
IGF2 insulin-like growth factor 2 0.435651
MET MET proto-oncogene, receptor tyrosine kinase 0.431894
NSL1 NSL1, MIS12 kinetochore complex component 0.430768
RBM8A RNA binding motif protein 8A 0.430393
KDR kinase insert domain receptor 0.430393
RPL29 ribosomal protein L29 0.427765
TMX1 thioredoxin-related transmembrane protein 1 0.42589
SLC6A20 solute carrier family 6 (proline IMINO transporter), member 20 0.415773
CLDN4 claudin 4 0.415024
CD9 CD9 molecule 0.412031
F8 coagulation factor VIII, procoagulant component 0.407545
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.407545
TKFC triokinase/FMN cyclase 0.406051
COPB2 coatomer protein complex, subunit beta 2 (beta prime) 0.402692
CD4 CD4 molecule 0.400453
KAT7 K(lysine) acetyltransferase 7 0.393374
BIRC5 baculoviral IAP repeat containing 5 0.391141
MTOR mechanistic target of rapamycin (serine/threonine kinase) 0.38111
CCND2 cyclin D2 0.38111
AQP1 aquaporin 1 (Colton blood group) 0.380739
CD44 CD44 molecule (Indian blood group) 0.380368
EIF4A2 eukaryotic translation initiation factor 4A2 0.379626
IFNA1 interferon, alpha 1 0.378514
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1 0.37629
RARRES1 retinoic acid receptor responder (tazarotene induced) 1 0.373328
DAPK2 death-associated protein kinase 2 0.365932
TNC tenascin C 0.362978
ORM2 orosomucoid 2 0.362239
FGF2 fibroblast growth factor 2 (basic) 0.360026
MDK midkine (neurite growth-promoting factor 2) 0.359657
EPHA2 EPH receptor A2 0.35892
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.357077
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 0.355235
HBA1 hemoglobin, alpha 1 0.353027
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker) 0.352659
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F 0.352659
FLT1 fms-related tyrosine kinase 1 0.351555
FN1 fibronectin 1 0.35082
HAS1 hyaluronan synthase 1 0.350084
TICAM2 toll-like receptor adaptor molecule 2 0.344941
SSX1 synovial sarcoma, X breakpoint 1 0.33944
ADA adenosine deaminase 0.336876
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 0.33651
SAV1 salvador family WW domain containing protein 1 0.334681
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.334681
FERMT2 fermitin family member 2 0.332852
HBA2 hemoglobin, alpha 2 0.331756
NDUFS7 NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase) 0.33066
MAPK13 mitogen-activated protein kinase 13 0.328105
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.32774
AHNAK AHNAK nucleoprotein 0.327375
GCSH glycine cleavage system protein H (aminomethyl carrier) 0.326646
HAS2 hyaluronan synthase 2 0.324094
SFRP4 secreted frizzled-related protein 4 0.322637
RRAD Ras-related associated with diabetes 0.32009
RRM1 ribonucleotide reductase M1 0.317545
BGN biglycan 0.316819
FAF1 Fas (TNFRSF6) associated factor 1 0.316456
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase 0.315366
MCAM melanoma cell adhesion molecule 0.315003
PDIA6 protein disulfide isomerase family A, member 6 0.307033
HGF hepatocyte growth factor (hepapoietin A; scatter factor) 0.304503
TGFB2 transforming growth factor, beta 2 0.300894
SDC2 syndecan 2 0.299812
FOXM1 forkhead box M1 0.298731
CDX2 caudal type homeobox 2 0.295132
SPARCL1 SPARC-like 1 (hevin) 0.292616
PLXNA1 plexin A1 0.288668
PRAMEF6 PRAME family member 6 0.286519
BTC betacellulin 0.285086
HPSE heparanase 0.284013
BAX BCL2-associated X protein 0.281153
CAT catalase 0.280082
CCND1 cyclin D1 0.274376
LZTS1 leucine zipper, putative tumor suppressor 1 0.272241
ERCC1 excision repair cross-complementation group 1 0.270108
JUN jun proto-oncogene 0.264077
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.26266
ANXA5 annexin A5 0.261245
GSTM1 glutathione S-transferase mu 1 0.260184
CXCL8 chemokine (C-X-C motif) ligand 8 0.259124
COPA coatomer protein complex, subunit alpha 0.257005
FABP9 fatty acid binding protein 9, testis 0.253831
RAB25 RAB25, member RAS oncogene family 0.250663
HRAS Harvey rat sarcoma viral oncogene homolog 0.248905
SCGB3A1 secretoglobin, family 3A, member 1 0.246448
GPC3 glypican 3 0.243995
RECQL5 RecQ protein-like 5 0.243995
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1 0.242245
GAGE1 G antigen 1 0.242245
ARHGAP32 Rho GTPase activating protein 32 0.241895
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6 0.239799
BST1 bone marrow stromal cell antigen 1 0.238054
IL6 interleukin 6 0.236312
BCL10 B-cell CLL/lymphoma 10 0.233878
DNTT DNA nucleotidylexotransferase 0.230755
LTBP1 latent transforming growth factor beta binding protein 1 0.229716
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 0.229024
PARP1 poly (ADP-ribose) polymerase 1 0.22454
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.223165
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.222136
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase 0.220424
CD3G CD3g molecule, gamma (CD3-TCR complex) 0.218715
DIRC2 disrupted in renal carcinoma 2 0.218374
CASP9 caspase 9, apoptosis-related cysteine peptidase 0.212271
GSTTP1 glutathione S-transferase theta pseudogene 1 0.210925
GSTT1 glutathione S-transferase theta 1 0.210589
IGKV3-20 immunoglobulin kappa variable 3-20 0.209918
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.208579
ALPPL2 alkaline phosphatase, placental-like 2 0.20658
ALPP alkaline phosphatase, placental 0.206248
POLD1 polymerase (DNA directed), delta 1, catalytic subunit 0.206248
MIB1 mindbomb E3 ubiquitin protein ligase 1 0.205585
ALPL alkaline phosphatase, liver/bone/kidney 0.205585
PRDX5 peroxiredoxin 5 0.205254
SPHK1 sphingosine kinase 1 0.203604
FZD2 frizzled class receptor 2 0.20229
GAGE12I G antigen 12I 0.200982
FHIT fragile histidine triad 0.199681
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.196779
RRAS related RAS viral (r-ras) oncogene homolog 0.1936
RDX radixin 0.192657
IFNB1 interferon, beta 1, fibroblast 0.190476
SLC46A1 solute carrier family 46 (folate transporter), member 1 0.190476
LEF1 lymphoid enhancer-binding factor 1 0.189551
PSG9 pregnancy specific beta-1-glycoprotein 9 0.18651
MCM7 minichromosome maintenance complex component 7 0.183248
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.182086
LTBP3 latent transforming growth factor beta binding protein 3 0.180652
IFNA21 interferon, alpha 21 0.180084
ORM1 orosomucoid 1 0.179239
FERMT1 fermitin family member 1 0.178126
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 0.178126
DCSTAMP dendrocyte expressed seven transmembrane protein 0.174354
HAT1 histone acetyltransferase 1 0.172799
CSPG4 chondroitin sulfate proteoglycan 4 0.170544
TIMP2 TIMP metallopeptidase inhibitor 2 0.169571
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1 0.167682
METTL13 methyltransferase like 13 0.166095
IFNA17 interferon, alpha 17 0.165655
PBRM1 polybromo 1 0.163938
ATF3 activating transcription factor 3 0.162707
ERBB2 erb-b2 receptor tyrosine kinase 2 0.162109
HOPX HOP homeobox 0.160203
PIAS3 protein inhibitor of activated STAT, 3 0.159302
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.159302
WNT3 wingless-type MMTV integration site family, member 3 0.159302
PROS2P protein S (beta) pseudogene 0.159302
ILK integrin-linked kinase 0.159302
SEMA3F sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F 0.159124
LTBP2 latent transforming growth factor beta binding protein 2 0.158266
NRP2 neuropilin 2 0.157765
PIP prolactin-induced protein 0.144501
CLDN15 claudin 15 0.143693
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) 0.142261
KRT18 keratin 18, type I 0.142102
PHYH phytanoyl-CoA 2-hydroxylase 0.142069
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2 0.141836
CD274 CD274 molecule 0.141685
MUC4 mucin 4, cell surface associated 0.141343
BCAM basal cell adhesion molecule (Lutheran blood group) 0.141185
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.139324
FXYD1 FXYD domain containing ion transport regulator 1 0.139217
NME1 NME/NM23 nucleoside diphosphate kinase 1 0.138561
UMOD uromodulin 0.137333
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 0.137305
S100A9 S100 calcium binding protein A9 0.136885
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.136368
RICTOR RPTOR independent companion of MTOR, complex 2 0.135383
CCNE1 cyclin E1 0.134277
CFB complement factor B 0.13421
FABP4 fatty acid binding protein 4, adipocyte 0.13417
EPCAM epithelial cell adhesion molecule 0.133716
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog 0.132577
MUC1 mucin 1, cell surface associated 0.13166
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) 0.131105
CD68 CD68 molecule 0.131013
TYRO3 TYRO3 protein tyrosine kinase 0.130304
CD276 CD276 molecule 0.130184
HLA-G major histocompatibility complex, class I, G 0.129182
DIABLO diablo, IAP-binding mitochondrial protein 0.128394
CTSS cathepsin S 0.128277
ANGPT1 angiopoietin 1 0.127479
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 0.126007
AFP alpha-fetoprotein 0.125614
CTGF connective tissue growth factor 0.125357
CD24 CD24 molecule 0.122552
SYP synaptophysin 0.122552
THY1 Thy-1 cell surface antigen 0.121887
CD5 CD5 molecule 0.121815
CDK1 cyclin-dependent kinase 1 0.121273
CALM3 calmodulin 3 (phosphorylase kinase, delta) 0.121236
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.121162
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.120601
CTSB cathepsin B 0.119985
NOTCH3 notch 3 0.118857
SAA1 serum amyloid A1 0.118652