malate-aspartate shuttle Gene Set

Dataset HumanCyc Pathways
Category structural or functional annotations
Type pathway
Description The process of transferring reducing equivalents from the cytosol into the mitochondria; NADH is used to synthesise malate in the cytosol; this compound is then transported into the mitochondria where it is converted to oxaloacetate using NADH, the oxaloacetate reacts with gluamate to form aspartate, and the aspartate then returns to the cytosol to complete the cycle. (Gene Ontology, GO_0043490)
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4 proteins participating in the malate-aspartate shuttle pathway from the HumanCyc Pathways dataset.

Symbol Name
GOT1 glutamic-oxaloacetic transaminase 1, soluble
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial
MDH1 malate dehydrogenase 1, NAD (soluble)
MDH2 malate dehydrogenase 2, NAD (mitochondrial)