major depressive disorder Gene Set

Dataset GAD Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description An endogenous depression that is characterized by an all-encompassing low mood accompanied by low self-esteem, and by loss of interest or pleasure in normally enjoyable activities. (Human Disease Ontology, DOID_1470)
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Genes

61 genes associated with the disease major depressive disorder in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

Symbol Name
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary)
ADRA1A adrenoceptor alpha 1A
AKT1 v-akt murine thymoma viral oncogene homolog 1
AMPD2 adenosine monophosphate deaminase 2
APOE apolipoprotein E
ATXN7L2 ataxin 7-like 2
BDNF brain-derived neurotrophic factor
BMP7 bone morphogenetic protein 7
C2ORF71 chromosome 2 open reading frame 71
CCND2 cyclin D2
CHRNA7 cholinergic receptor, nicotinic, alpha 7 (neuronal)
CLOCK clock circadian regulator
COMT catechol-O-methyltransferase
CREB1 cAMP responsive element binding protein 1
CYB561D1 cytochrome b561 family, member D1
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
DRD3 dopamine receptor D3
DSEL dermatan sulfate epimerase-like
FAM179A family with sequence similarity 179, member A
FGFR2 fibroblast growth factor receptor 2
FHIT fragile histidine triad
FKBP5 FK506 binding protein 5
GDNF glial cell derived neurotrophic factor
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3
GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3
GRIK1 glutamate receptor, ionotropic, kainate 1
GSK3B glycogen synthase kinase 3 beta
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
HTR2B 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic
HTR3B 5-hydroxytryptamine (serotonin) receptor 3B, ionotropic
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled
IL10 interleukin 10
IL19 interleukin 19
IL20 interleukin 20
IL24 interleukin 24
KCNK2 potassium channel, two pore domain subfamily K, member 2
MAOA monoamine oxidase A
MC2R melanocortin 2 receptor (adrenocorticotropic hormone)
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
ORM1 orosomucoid 1
PCLO piccolo presynaptic cytomatrix protein
PCNT pericentrin
PDE4B phosphodiesterase 4B, cAMP-specific
PTPRG protein tyrosine phosphatase, receptor type, G
RGS4 regulator of G-protein signaling 4
RORA RAR-related orphan receptor A
S100A10 S100 calcium binding protein A10
S100B S100 calcium binding protein B
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SP4 Sp4 transcription factor
SYPL2 synaptophysin-like 2
TPH1 tryptophan hydroxylase 1
UBE3C ubiquitin protein ligase E3C
VEGFA vascular endothelial growth factor A