macrophage foam cell Gene Set

Dataset TISSUES Text-mining Tissue Protein Expression Evidence Scores
Category structural or functional annotations
Type tissue
Description Cells in an atheroma derived from macrophages which have engulfed low-density lipoproteins by endocytosis. (BRENDA Tissue and Enzyme Source Ontology, BTO_0005054)
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Genes

129 proteins co-occuring with the tissue macrophage foam cell in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset.

Symbol Name Standardized Value
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 2.52166
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1 2.32572
SCARB1 scavenger receptor class B, member 1 2.15755
SCARB2 scavenger receptor class B, member 2 2.03856
APOE apolipoprotein E 2.00545
CD36 CD36 molecule (thrombospondin receptor) 2.00013
LPA lipoprotein, Lp(a) 1.82708
SOAT1 sterol O-acyltransferase 1 1.68703
APOA1 apolipoprotein A-I 1.68204
NCEH1 neutral cholesterol ester hydrolase 1 1.56086
TOR2A torsin family 2, member A 1.46682
APOBR apolipoprotein B receptor 1.42414
PON2 paraoxonase 2 1.34315
LDLR low density lipoprotein receptor 1.32777
LIPE lipase, hormone-sensitive 1.1554
CMA1 chymase 1, mast cell 1.14653
PON1 paraoxonase 1 1.14387
APOA2 apolipoprotein A-II 1.09518
PON3 paraoxonase 3 1.06382
PPARG peroxisome proliferator-activated receptor gamma 1.05017
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1 1.03741
CES3 carboxylesterase 3 1.01725
PLIN2 perilipin 2 1.01069
NR1H3 nuclear receptor subfamily 1, group H, member 3 0.967225
APOO apolipoprotein O 0.966793
APOB apolipoprotein B 0.964631
PLTP phospholipid transfer protein 0.941355
ACAT1 acetyl-CoA acetyltransferase 1 0.940925
SOAT2 sterol O-acyltransferase 2 0.843286
ABCG4 ATP-binding cassette, sub-family G (WHITE), member 4 0.826523
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 0.813562
LPL lipoprotein lipase 0.77774
LCAT lecithin-cholesterol acyltransferase 0.776494
ZNF23 zinc finger protein 23 0.758673
LIPA lipase A, lysosomal acid, cholesterol esterase 0.758259
PLA2G10 phospholipase A2, group X 0.72322
GPR78 G protein-coupled receptor 78 0.719524
ABCB4 ATP-binding cassette, sub-family B (MDR/TAP), member 4 0.698625
CETP cholesteryl ester transfer protein, plasma 0.689226
ZNF202 zinc finger protein 202 0.688409
UTS2 urotensin 2 0.688409
MSR1 macrophage scavenger receptor 1 0.685143
CCL2 chemokine (C-C motif) ligand 2 0.663555
STARD3 StAR-related lipid transfer (START) domain containing 3 0.659085
OSBPL8 oxysterol binding protein-like 8 0.657866
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) 0.625869
MSRA methionine sulfoxide reductase A 0.621428
PRSS30P protease, serine, 30, pseudogene 0.597263
PPARA peroxisome proliferator-activated receptor alpha 0.596862
CES1 carboxylesterase 1 0.586026
CEL carboxyl ester lipase 0.581618
CH25H cholesterol 25-hydroxylase 0.578816
SREBF1 sterol regulatory element binding transcription factor 1 0.573217
TLR4 toll-like receptor 4 0.540981
CYP2S1 cytochrome P450, family 2, subfamily S, polypeptide 1 0.529903
KIF20A kinesin family member 20A 0.523588
CD68 CD68 molecule 0.521617
GIP gastric inhibitory polypeptide 0.518859
EXOSC4 exosome component 4 0.510206
AP1G1 adaptor-related protein complex 1, gamma 1 subunit 0.503926
PLIN4 perilipin 4 0.503141
LPAR4 lysophosphatidic acid receptor 4 0.497266
CRP C-reactive protein, pentraxin-related 0.486326
LTB4R leukotriene B4 receptor 0.476979
MIR185 microRNA 185 0.465723
PLA2G2D phospholipase A2, group IID 0.447961
FABP4 fatty acid binding protein 4, adipocyte 0.441426
ABCG5 ATP-binding cassette, sub-family G (WHITE), member 5 0.438739
PLIN5 perilipin 5 0.438739
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7 0.430695
CLPS colipase, pancreatic 0.428401
GJA4 gap junction protein, alpha 4, 37kDa 0.421148
CTSK cathepsin K 0.417718
NR1H2 nuclear receptor subfamily 1, group H, member 2 0.401386
NRG1 neuregulin 1 0.401386
MMP9 matrix metallopeptidase 9 0.398735
SNN stannin 0.394953
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 0.382884
SDC4 syndecan 4 0.374618
ITGAD integrin, alpha D 0.373493
NPC1 Niemann-Pick disease, type C1 0.371994
PLA2G1B phospholipase A2, group IB (pancreas) 0.368998
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1 0.366381
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 0.359292
APOM apolipoprotein M 0.357802
PLA2G2F phospholipase A2, group IIF 0.35557
MIR96 microRNA 96 0.354084
PLIN1 perilipin 1 0.354084
KDM6B lysine (K)-specific demethylase 6B 0.35334
APOL1 apolipoprotein L, 1 0.34926
ATF6 activating transcription factor 6 0.346668
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.34334
GNMT glycine N-methyltransferase 0.338177
ZFP36 ZFP36 ring finger protein 0.324239
SCARF1 scavenger receptor class F, member 1 0.32205
PLA2G2E phospholipase A2, group IIE 0.320956
MMP2 matrix metallopeptidase 2 0.303919
ADIPOR1 adiponectin receptor 1 0.303919
MMP3 matrix metallopeptidase 3 0.301039
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal 0.294581
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1 0.287803
CSK c-src tyrosine kinase 0.283191
SIRT1 sirtuin 1 0.283191
APOPT1 apoptogenic 1, mitochondrial 0.282483
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D 0.279307
ALOX15 arachidonate 15-lipoxygenase 0.278251
VCAM1 vascular cell adhesion molecule 1 0.267102
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial 0.261284
ADM2 adrenomedullin 2 0.253908
VAV1 vav 1 guanine nucleotide exchange factor 0.253908
SDC3 syndecan 3 0.252919
TNFRSF25 tumor necrosis factor receptor superfamily, member 25 0.251279
CTSS cathepsin S 0.250953
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.245807
MPO myeloperoxidase 0.245491
ELANE elastase, neutrophil expressed 0.241438
MYD88 myeloid differentiation primary response 88 0.237513
IL6 interleukin 6 0.23604
MMP1 matrix metallopeptidase 1 0.234878
SREBF2 sterol regulatory element binding transcription factor 2 0.232039
UTS2R urotensin 2 receptor 0.229032
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.227186
NDRG2 NDRG family member 2 0.2259
ULK1 unc-51 like autophagy activating kinase 1 0.225144
PTGES prostaglandin E synthase 0.223177
JUN jun proto-oncogene 0.220831
SAA1 serum amyloid A1 0.219264
CXCL8 chemokine (C-X-C motif) ligand 8 0.217554
TGOLN2 trans-golgi network protein 2 0.217554