mTOR signaling pathway Gene Set

Dataset PID Pathways
Category structural or functional annotations
Type pathway
Description mTOR signaling pathway regulates cellular processes such as translation, ribosome biogenesis, cell growth and autophagy and is regulated or responds to growth factors, energy metabolites and/or levels of nutrients. (Pathway Ontology, PW_0000180)
External Link http://public.ndexbio.org/#/network/559dd850-6194-11e5-8ac5-06603eb7f303
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Genes

67 proteins participating in the mTOR signaling pathway pathway from the PID Pathways dataset.

Symbol Name
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT1S1 AKT1 substrate 1 (proline-rich)
ATG13 autophagy related 13
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BRAF B-Raf proto-oncogene, serine/threonine kinase
CCNE1 cyclin E1
CDK2 cyclin-dependent kinase 2
CLIP1 CAP-GLY domain containing linker protein 1
CYCS cytochrome c, somatic
DDIT4 DNA-damage-inducible transcript 4
DEPTOR DEP domain containing MTOR-interacting protein
EEF2 eukaryotic translation elongation factor 2
EIF4A1 eukaryotic translation initiation factor 4A1
EIF4B eukaryotic translation initiation factor 4B
EIF4E eukaryotic translation initiation factor 4E
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
FBXW11 F-box and WD repeat domain containing 11
HRAS Harvey rat sarcoma viral oncogene homolog
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IRS1 insulin receptor substrate 1
MAP2K1 mitogen-activated protein kinase kinase 1
MAP2K2 mitogen-activated protein kinase kinase 2
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MAPKAP1 mitogen-activated protein kinase associated protein 1
MLST8 MTOR associated protein, LST8 homolog (S. cerevisiae)
MTOR mechanistic target of rapamycin (serine/threonine kinase)
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDPK1 3-phosphoinositide dependent protein kinase 1
PLD1 phospholipase D1, phosphatidylcholine-specific
PLD2 phospholipase D2
PML promyelocytic leukemia
POLDIP3 polymerase (DNA-directed), delta interacting protein 3
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PRKCA protein kinase C, alpha
PRR5 proline rich 5 (renal)
PXN paxillin
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RB1CC1 RB1-inducible coiled-coil 1
RHEB Ras homolog enriched in brain
RHOA ras homolog family member A
RICTOR RPTOR independent companion of MTOR, complex 2
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
RPTOR regulatory associated protein of MTOR, complex 1
RRAGA Ras-related GTP binding A
RRAGB Ras-related GTP binding B
RRAGC Ras-related GTP binding C
RRAGD Ras-related GTP binding D
RRN3 RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae)
SFN stratifin
SGK1 serum/glucocorticoid regulated kinase 1
SREBF1 sterol regulatory element binding transcription factor 1
SSPO SCO-spondin
TSC1 tuberous sclerosis 1
TSC2 tuberous sclerosis 2
ULK1 unc-51 like autophagy activating kinase 1
ULK2 unc-51 like autophagy activating kinase 2
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
YY1 YY1 transcription factor