lytic vacuole Gene Set

Dataset LOCATE Curated Protein Localization Annotations
Category proteomics
Type cellular component
Description A vacuole that is maintained at an acidic pH and which contains degradative enzymes, including a wide variety of acid hydrolases. (Gene Ontology, GO_0000323)
External Link http://locate.imb.uq.edu.au/searchpages/HumanGO:0000323.shtml
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Genes

212 proteins localized to the lytic vacuole cellular component in low- or high-throughput protein localization assays from the LOCATE Curated Protein Localization Annotations dataset.

Symbol Name
ABCA2 ATP-binding cassette, sub-family A (ABC1), member 2
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5
ABCB9 ATP-binding cassette, sub-family B (MDR/TAP), member 9
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ACP2 acid phosphatase 2, lysosomal
ACP5 acid phosphatase 5, tartrate resistant
ACRV1 acrosomal vesicle protein 1
AGA aspartylglucosaminidase
ALOX15B arachidonate 15-lipoxygenase, type B
ANKFY1 ankyrin repeat and FYVE domain containing 1
AOAH acyloxyacyl hydrolase (neutrophil)
APOA5 apolipoprotein A-V
APP amyloid beta (A4) precursor protein
AQP4 aquaporin 4
ARSA arylsulfatase A
ARSB arylsulfatase B
ARSD arylsulfatase D
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
ASGR1 asialoglycoprotein receptor 1
ASGR2 asialoglycoprotein receptor 2
ATP5B ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide
ATP6V0C ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c
ATP6V1A ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
ATP6V1B2 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2
ATP6V1E1 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1
ATP6V1G1 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1
ATRAID all-trans retinoic acid-induced differentiation factor
BACE1 beta-site APP-cleaving enzyme 1
BHMT2 betaine--homocysteine S-methyltransferase 2
BID BH3 interacting domain death agonist
BRI3 brain protein I3
C1GALT1 core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1
CAMLG calcium modulating ligand
CANX calnexin
CD14 CD14 molecule
CD1E CD1e molecule
CD209 CD209 molecule
CD3G CD3g molecule, gamma (CD3-TCR complex)
CD63 CD63 molecule
CD68 CD68 molecule
CHMP4A charged multivesicular body protein 4A
CLCN7 chloride channel, voltage-sensitive 7
CLN3 ceroid-lipofuscinosis, neuronal 3
CST7 cystatin F (leukocystatin)
CTBS chitobiase, di-N-acetyl-
CTNS cystinosin, lysosomal cystine transporter
CTSA cathepsin A
CTSB cathepsin B
CTSC cathepsin C
CTSD cathepsin D
CTSF cathepsin F
CTSG cathepsin G
CTSH cathepsin H
CTSK cathepsin K
CTSL cathepsin L
CTSO cathepsin O
CTSS cathepsin S
CTSV cathepsin V
CTSZ cathepsin Z
CYB5A cytochrome b5 type A (microsomal)
CYBA cytochrome b-245, alpha polypeptide
CYTH1 cytohesin 1
CYTH2 cytohesin 2
DAPK2 death-associated protein kinase 2
DCTN2 dynactin 2 (p50)
DIABLO diablo, IAP-binding mitochondrial protein
DNASE2 deoxyribonuclease II, lysosomal
DPP7 dipeptidyl-peptidase 7
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1
EDNRB endothelin receptor type B
ENTPD4 ectonucleoside triphosphate diphosphohydrolase 4
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
FAM193A family with sequence similarity 193, member A
FKBP2 FK506 binding protein 2, 13kDa
FLOT1 flotillin 1
FLOT2 flotillin 2
FN1 fibronectin 1
FUCA2 fucosidase, alpha-L- 2, plasma
GAA glucosidase, alpha; acid
GALC galactosylceramidase
GBA glucosidase, beta, acid
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GLA galactosidase, alpha
GLB1 galactosidase, beta 1
GM2A GM2 ganglioside activator
GNS glucosamine (N-acetyl)-6-sulfatase
GPR143 G protein-coupled receptor 143
GSG2 germ cell associated 2 (haspin)
GUSB glucuronidase, beta
HAX1 HCLS1 associated protein X-1
HCK HCK proto-oncogene, Src family tyrosine kinase
HEXA hexosaminidase A (alpha polypeptide)
HEXB hexosaminidase B (beta polypeptide)
HLA-DMA major histocompatibility complex, class II, DM alpha
HLA-DOA major histocompatibility complex, class II, DO alpha
HLA-DOB major histocompatibility complex, class II, DO beta
HPSE heparanase
HS2ST1 heparan sulfate 2-O-sulfotransferase 1
HYAL2 hyaluronoglucosaminidase 2
IAPP islet amyloid polypeptide
IDS iduronate 2-sulfatase
IDUA iduronidase, alpha-L-
IFI27 interferon, alpha-inducible protein 27
IFI30 interferon, gamma-inducible protein 30
IFITM3 interferon induced transmembrane protein 3
IPO4 importin 4
ITM2C integral membrane protein 2C
KIF1B kinesin family member 1B
KTN1 kinectin 1 (kinesin receptor)
LAMP1 lysosomal-associated membrane protein 1
LAMP2 lysosomal-associated membrane protein 2
LAMTOR2 late endosomal/lysosomal adaptor, MAPK and MTOR activator 2
LAPTM4A lysosomal protein transmembrane 4 alpha
LAPTM4B lysosomal protein transmembrane 4 beta
LAT linker for activation of T cells
LDLR low density lipoprotein receptor
LGMN legumain
LIPA lipase A, lysosomal acid, cholesterol esterase
LMAN2 lectin, mannose-binding 2
LYST lysosomal trafficking regulator
LYZL2 lysozyme-like 2
MAN2B1 mannosidase, alpha, class 2B, member 1
MANBA mannosidase, beta A, lysosomal
MARC2 mitochondrial amidoxime reducing component 2
MAST3 microtubule associated serine/threonine kinase 3
MBTPS1 membrane-bound transcription factor peptidase, site 1
MCOLN1 mucolipin 1
MFSD8 major facilitator superfamily domain containing 8
MGST1 microsomal glutathione S-transferase 1
MMD monocyte to macrophage differentiation-associated
MON1B MON1 secretory trafficking family member B
NAAA N-acylethanolamine acid amidase
NAGA N-acetylgalactosaminidase, alpha-
NAGLU N-acetylglucosaminidase, alpha
NAPA N-ethylmaleimide-sensitive factor attachment protein, alpha
NDST1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
NEU1 sialidase 1 (lysosomal sialidase)
NEU4 sialidase 4
NIPSNAP1 nipsnap homolog 1 (C. elegans)
NPC1 Niemann-Pick disease, type C1
NPC2 Niemann-Pick disease, type C2
OCRL oculocerebrorenal syndrome of Lowe
PAQR8 progestin and adipoQ receptor family member VIII
PARM1 prostate androgen-regulated mucin-like protein 1
PARP14 poly (ADP-ribose) polymerase family, member 14
PEBP4 phosphatidylethanolamine-binding protein 4
PGRMC1 progesterone receptor membrane component 1
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PLA2G15 phospholipase A2, group XV
PLEKHF2 pleckstrin homology domain containing, family F (with FYVE domain) member 2
PPT1 palmitoyl-protein thioesterase 1
PRCP prolylcarboxypeptidase (angiotensinase C)
PRDX5 peroxiredoxin 5
PRDX6 peroxiredoxin 6
PRTN3 proteinase 3
PSAP prosaposin
PSAPL1 prosaposin-like 1 (gene/pseudogene)
RAB2A RAB2A, member RAS oncogene family
RAB7B RAB7B, member RAS oncogene family
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAMP2 receptor (G protein-coupled) activity modifying protein 2
RAMP3 receptor (G protein-coupled) activity modifying protein 3
RAP1A RAP1A, member of RAS oncogene family
REN renin
RILP Rab interacting lysosomal protein
RNF115 ring finger protein 115
SCARB2 scavenger receptor class B, member 2
SCP2 sterol carrier protein 2
SEBOX SEBOX homeobox
SELE selectin E
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SIDT2 SID1 transmembrane family, member 2
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5
SLC2A11 solute carrier family 2 (facilitated glucose transporter), member 11
SLC31A2 solute carrier family 31 (copper transporter), member 2
SLC36A1 solute carrier family 36 (proton/amino acid symporter), member 1
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal
SNX16 sorting nexin 16
SPACA1 sperm acrosome associated 1
SPESP1 sperm equatorial segment protein 1
SPNS1 spinster homolog 1 (Drosophila)
SPPL2B signal peptide peptidase like 2B
SPRY2 sprouty homolog 2 (Drosophila)
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
STX7 syntaxin 7
SYT2 synaptotagmin II
SYT7 synaptotagmin VII
TIAL1 TIA1 cytotoxic granule-associated RNA binding protein-like 1
TM9SF1 transmembrane 9 superfamily member 1
TM9SF2 transmembrane 9 superfamily member 2
TMEM192 transmembrane protein 192
TMEM9 transmembrane protein 9
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOLLIP toll interacting protein
TPP1 tripeptidyl peptidase I
TRIM14 tripartite motif containing 14
TRIM23 tripartite motif containing 23
VAMP7 vesicle-associated membrane protein 7
VAMP8 vesicle-associated membrane protein 8
VMA21 VMA21 vacuolar H+-ATPase homolog (S. cerevisiae)
VPS11 vacuolar protein sorting 11 homolog (S. cerevisiae)
VPS16 vacuolar protein sorting 16 homolog (S. cerevisiae)
VPS18 vacuolar protein sorting 18 homolog (S. cerevisiae)
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae)
VPS35 vacuolar protein sorting 35 homolog (S. cerevisiae)
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae)
VTI1B vesicle transport through interaction with t-SNAREs 1B
WDR48 WD repeat domain 48
ZNRF2 zinc and ring finger 2, E3 ubiquitin protein ligase