lynestrenol-2037 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the lynestrenol-2037 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A4GNT alpha-1,4-N-acetylglucosaminyltransferase
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ACOT9 acyl-CoA thioesterase 9
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
APOBEC3C apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C
ARL4C ADP-ribosylation factor-like 4C
ARR3 arrestin 3, retinal (X-arrestin)
BCAM basal cell adhesion molecule (Lutheran blood group)
C14ORF1 chromosome 14 open reading frame 1
C1ORF159 chromosome 1 open reading frame 159
C2CD2L C2CD2-like
C9ORF156 chromosome 9 open reading frame 156
CAST calpastatin
CBY1 chibby homolog 1 (Drosophila)
CDHR2 cadherin-related family member 2
CIDEC cell death-inducing DFFA-like effector c
CKB creatine kinase, brain
CRY2 cryptochrome circadian clock 2
CTBP2 C-terminal binding protein 2
DIEXF digestive organ expansion factor homolog (zebrafish)
DIO2 deiodinase, iodothyronine, type II
DNAJB5 DnaJ (Hsp40) homolog, subfamily B, member 5
ELMO2 engulfment and cell motility 2
ENG endoglin
ERCC8 excision repair cross-complementation group 8
ETV7 ets variant 7
FAM102A family with sequence similarity 102, member A
FASN fatty acid synthase
FPR2 formyl peptide receptor 2
FSCN1 fascin actin-bundling protein 1
FSCN3 fascin actin-bundling protein 3, testicular
GOSR1 golgi SNAP receptor complex member 1
GPR12 G protein-coupled receptor 12
GPX2 glutathione peroxidase 2
H6PD hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
HIP1 huntingtin interacting protein 1
HIST1H1D histone cluster 1, H1d
HIST1H4J histone cluster 1, H4j
HLA-DOA major histocompatibility complex, class II, DO alpha
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled
ICAM2 intercellular adhesion molecule 2
IDS iduronate 2-sulfatase
IFNA17 interferon, alpha 17
IL1R2 interleukin 1 receptor, type II
IL1RAPL2 interleukin 1 receptor accessory protein-like 2
INO80D INO80 complex subunit D
ITGA10 integrin, alpha 10
KBTBD4 kelch repeat and BTB (POZ) domain containing 4
KCNC3 potassium channel, voltage gated Shaw related subfamily C, member 3
KRT32 keratin 32, type I
KRT6B keratin 6B, type II
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2
LRRK1 leucine-rich repeat kinase 1
METTL5 methyltransferase like 5
MT3 metallothionein 3
MTM1 myotubularin 1
MYLIP myosin regulatory light chain interacting protein
MYOC myocilin, trabecular meshwork inducible glucocorticoid response
NEBL nebulette
NEUROD2 neuronal differentiation 2
NF1 neurofibromin 1
NPFFR1 neuropeptide FF receptor 1
NUDT2 nudix (nucleoside diphosphate linked moiety X)-type motif 2
PADI1 peptidyl arginine deiminase, type I
PAX3 paired box 3
PCGF2 polycomb group ring finger 2
PCSK6 proprotein convertase subtilisin/kexin type 6
PDK2 pyruvate dehydrogenase kinase, isozyme 2
PGC progastricsin (pepsinogen C)
PLEK2 pleckstrin 2
PLS1 plastin 1
PPP2R2B protein phosphatase 2, regulatory subunit B, beta
PQLC2 PQ loop repeat containing 2
RARS arginyl-tRNA synthetase
RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated)
RASL11B RAS-like, family 11, member B
RGS16 regulator of G-protein signaling 16
ROBO4 roundabout, axon guidance receptor, homolog 4 (Drosophila)
RPL23AP32 ribosomal protein L23a pseudogene 32
SAG S-antigen; retina and pineal gland (arrestin)
SAP30 Sin3A-associated protein, 30kDa
SEZ6L seizure related 6 homolog (mouse)-like
SLC22A18AS solute carrier family 22 (organic cation transporter), member 18 antisense
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SMAD6 SMAD family member 6
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SOCS2 suppressor of cytokine signaling 2
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1
TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3
TBC1D29 TBC1 domain family, member 29
TBL1X transducin (beta)-like 1X-linked
TMEM74B transmembrane protein 74B
TSC22D3 TSC22 domain family, member 3
TSSK2 testis-specific serine kinase 2
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial
ZNF268 zinc finger protein 268
ZNF79 zinc finger protein 79

decreased expression

Symbol Name
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12
AEN apoptosis enhancing nuclease
AKIP1 A kinase (PRKA) interacting protein 1
AP3M2 adaptor-related protein complex 3, mu 2 subunit
BAHD1 bromo adjacent homology domain containing 1
BATF basic leucine zipper transcription factor, ATF-like
BBC3 BCL2 binding component 3
C1ORF109 chromosome 1 open reading frame 109
C9ORF40 chromosome 9 open reading frame 40
CD33 CD33 molecule
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11
CISD1 CDGSH iron sulfur domain 1
COG4 component of oligomeric golgi complex 4
DDB1 damage-specific DNA binding protein 1, 127kDa
DEAF1 DEAF1 transcription factor
DECR2 2,4-dienoyl CoA reductase 2, peroxisomal
DENND4B DENN/MADD domain containing 4B
DERL2 derlin 2
DOK2 docking protein 2, 56kDa
DUSP22 dual specificity phosphatase 22
DYSF dysferlin
EDC3 enhancer of mRNA decapping 3
EGLN2 egl-9 family hypoxia-inducible factor 2
FAM46A family with sequence similarity 46, member A
FANCF Fanconi anemia, complementation group F
FBXL15 F-box and leucine-rich repeat protein 15
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
FKBP2 FK506 binding protein 2, 13kDa
FLT3 fms-related tyrosine kinase 3
GAB2 GRB2-associated binding protein 2
GALR3 galanin receptor 3
GATAD2A GATA zinc finger domain containing 2A
GOLPH3L golgi phosphoprotein 3-like
GPNMB glycoprotein (transmembrane) nmb
HMBOX1 homeobox containing 1
IGFLR1 IGF-like family receptor 1
IL2RG interleukin 2 receptor, gamma
IL4R interleukin 4 receptor
IRF2BP1 interferon regulatory factor 2 binding protein 1
KCNMB1 potassium channel subfamily M regulatory beta subunit 1
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2
KIAA0907 KIAA0907
KIFAP3 kinesin-associated protein 3
KIFC1 kinesin family member C1
LHFPL2 lipoma HMGIC fusion partner-like 2
LIN7A lin-7 homolog A (C. elegans)
LXN latexin
MAPKBP1 mitogen-activated protein kinase binding protein 1
MECR mitochondrial trans-2-enoyl-CoA reductase
MGRN1 mahogunin ring finger 1, E3 ubiquitin protein ligase
MLC1 megalencephalic leukoencephalopathy with subcortical cysts 1
MPP6 membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)
MTRF1 mitochondrial translational release factor 1
MX2 MX dynamin-like GTPase 2
NAGPA N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
OSGEPL1 O-sialoglycoprotein endopeptidase-like 1
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PEF1 penta-EF-hand domain containing 1
PEX26 peroxisomal biogenesis factor 26
PIGR polymeric immunoglobulin receptor
PLCD1 phospholipase C, delta 1
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2
PLEKHO2 pleckstrin homology domain containing, family O member 2
PMEL premelanosome protein
POR P450 (cytochrome) oxidoreductase
PRR14L proline rich 14-like
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1
PTTG3P pituitary tumor-transforming 3, pseudogene
RAB36 RAB36, member RAS oncogene family
RBM47 RNA binding motif protein 47
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RECQL4 RecQ protein-like 4
RHOC ras homolog family member C
RHOH ras homolog family member H
RNF122 ring finger protein 122
RWDD2B RWD domain containing 2B
SELP selectin P (granule membrane protein 140kDa, antigen CD62)
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SEPW1 selenoprotein W, 1
SH3YL1 SH3 and SYLF domain containing 1
SLC25A22 solute carrier family 25 (mitochondrial carrier: glutamate), member 22
SLC27A5 solute carrier family 27 (fatty acid transporter), member 5
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae)
TAF12 TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa
TMUB2 transmembrane and ubiquitin-like domain containing 2
TSPAN32 tetraspanin 32
TTC23 tetratricopeptide repeat domain 23
TTC31 tetratricopeptide repeat domain 31
USP8 ubiquitin specific peptidase 8
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae)
WDR82 WD repeat domain 82
XAF1 XIAP associated factor 1
ZC3H12A zinc finger CCCH-type containing 12A
ZNF32 zinc finger protein 32