lymphocyte activation Gene Set

Dataset GO Biological Process Annotations
Category structural or functional annotations
Type biological process
Description A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor. (Gene Ontology, GO_0046649)
External Link http://amigo.geneontology.org/amigo/term/GO:0046649
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Genes

305 genes participating in the lymphocyte activation biological process from the curated GO Biological Process Annotations dataset.

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase
ADA adenosine deaminase
ADAM17 ADAM metallopeptidase domain 17
AICDA activation-induced cytidine deaminase
AKAP17A A kinase (PRKA) anchor protein 17A
AMICA1 adhesion molecule, interacts with CXADR antigen 1
ANXA1 annexin A1
APC adenomatous polyposis coli
ATP11C ATPase, class VI, type 11C
ATP7A ATPase, Cu++ transporting, alpha polypeptide
AXL AXL receptor tyrosine kinase
AZI2 5-azacytidine induced 2
B2M beta-2-microglobulin
BANK1 B-cell scaffold protein with ankyrin repeats 1
BATF basic leucine zipper transcription factor, ATF-like
BAX BCL2-associated X protein
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BCL2 B-cell CLL/lymphoma 2
BCL3 B-cell CLL/lymphoma 3
BCL6 B-cell CLL/lymphoma 6
BLK BLK proto-oncogene, Src family tyrosine kinase
BLM Bloom syndrome, RecQ helicase-like
BLNK B-cell linker
BRAF B-Raf proto-oncogene, serine/threonine kinase
BST2 bone marrow stromal cell antigen 2
BTK Bruton agammaglobulinemia tyrosine kinase
BTN3A1 butyrophilin, subfamily 3, member A1
CADM1 cell adhesion molecule 1
CASP8 caspase 8, apoptosis-related cysteine peptidase
CBFB core-binding factor, beta subunit
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCND3 cyclin D3
CD151 CD151 molecule (Raph blood group)
CD180 CD180 molecule
CD1C CD1c molecule
CD2 CD2 molecule
CD276 CD276 molecule
CD28 CD28 molecule
CD3D CD3d molecule, delta (CD3-TCR complex)
CD3E CD3e molecule, epsilon (CD3-TCR complex)
CD3G CD3g molecule, gamma (CD3-TCR complex)
CD4 CD4 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CD40LG CD40 ligand
CD7 CD7 molecule
CD79A CD79a molecule, immunoglobulin-associated alpha
CD80 CD80 molecule
CD86 CD86 molecule
CD8A CD8a molecule
CD8B CD8b molecule
CDK6 cyclin-dependent kinase 6
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHD7 chromodomain helicase DNA binding protein 7
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal)
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)
CLCF1 cardiotrophin-like cytokine factor 1
CLEC4F C-type lectin domain family 4, member F
CLEC7A C-type lectin domain family 7, member A
CMTM7 CKLF-like MARVEL transmembrane domain containing 7
CR2 complement component (3d/Epstein Barr virus) receptor 2
CRIP3 cysteine-rich protein 3
CRTAM cytotoxic and regulatory T cell molecule
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTPS1 CTP synthase 1
CXADR coxsackie virus and adenovirus receptor
CXCL12 chemokine (C-X-C motif) ligand 12
CXCR4 chemokine (C-X-C motif) receptor 4
CXCR5 chemokine (C-X-C motif) receptor 5
DCLRE1C DNA cross-link repair 1C
DDOST dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic)
DLG1 discs, large homolog 1 (Drosophila)
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
DOCK2 dedicator of cytokinesis 2
DOCK8 dedicator of cytokinesis 8
DPP4 dipeptidyl-peptidase 4
EGR1 early growth response 1
ELF4 E74-like factor 4 (ets domain transcription factor)
EOMES eomesodermin
ERCC1 excision repair cross-complementation group 1
EXO1 exonuclease 1
EXOSC3 exosome component 3
EXOSC6 exosome component 6
F2RL1 coagulation factor II (thrombin) receptor-like 1
FADD Fas (TNFRSF6)-associated via death domain
FKBP1A FK506 binding protein 1A, 12kDa
FKBP1B FK506 binding protein 1B, 12.6 kDa
FLT3 fms-related tyrosine kinase 3
FLT3LG fms-related tyrosine kinase 3 ligand
FNIP1 folliculin interacting protein 1
FOXP1 forkhead box P1
FOXP3 forkhead box P3
FUT7 fucosyltransferase 7 (alpha (1,3) fucosyltransferase)
FYN FYN proto-oncogene, Src family tyrosine kinase
FZD5 frizzled class receptor 5
FZD7 frizzled class receptor 7
FZD8 frizzled class receptor 8
FZD9 frizzled class receptor 9
GAPT GRB2-binding adaptor protein, transmembrane
GATA3 GATA binding protein 3
GIMAP1 GTPase, IMAP family member 1
GLI3 GLI family zinc finger 3
GPR183 G protein-coupled receptor 183
HDAC4 histone deacetylase 4
HDAC5 histone deacetylase 5
HDAC9 histone deacetylase 9
HELLS helicase, lymphoid-specific
HHEX hematopoietically expressed homeobox
HLA-E major histocompatibility complex, class I, E
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSH2D hematopoietic SH2 domain containing
HSPD1 heat shock 60kDa protein 1 (chaperonin)
ICAM1 intercellular adhesion molecule 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IFNA10 interferon, alpha 10
IFNA14 interferon, alpha 14
IFNA16 interferon, alpha 16
IFNA17 interferon, alpha 17
IFNA21 interferon, alpha 21
IFNA4 interferon, alpha 4
IFNA5 interferon, alpha 5
IFNA6 interferon, alpha 6
IFNA7 interferon, alpha 7
IFNA8 interferon, alpha 8
IFNAR1 interferon (alpha, beta and omega) receptor 1
IFNB1 interferon, beta 1, fibroblast
IFNE interferon, epsilon
IFNG interferon, gamma
IFNK interferon, kappa
IFNW1 interferon, omega 1
IGBP1 immunoglobulin (CD79A) binding protein 1
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IKZF3 IKAROS family zinc finger 3 (Aiolos)
IL10 interleukin 10
IL11 interleukin 11
IL12B interleukin 12B
IL15 interleukin 15
IL18 interleukin 18
IL18R1 interleukin 18 receptor 1
IL2 interleukin 2
IL21R interleukin 21 receptor
IL23A interleukin 23, alpha subunit p19
IL4 interleukin 4
IL7R interleukin 7 receptor
IMPDH1 IMP (inosine 5'-monophosphate) dehydrogenase 1
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
INS insulin
IRF1 interferon regulatory factor 1
IRF4 interferon regulatory factor 4
ITFG2 integrin alpha FG-GAP repeat containing 2
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
ITGAD integrin, alpha D
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
ITK IL2-inducible T-cell kinase
JAG2 jagged 2
JAK3 Janus kinase 3
JMJD6 jumonji domain containing 6
KIF13B kinesin family member 13B
KIR3DS1 killer cell immunoglobulin-like receptor, three domains, short cytoplasmic tail, 1
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KLF6 Kruppel-like factor 6
KLRF2 killer cell lectin-like receptor subfamily F, member 2
LAT linker for activation of T cells
LAT2 linker for activation of T cells family, member 2
LAX1 lymphocyte transmembrane adaptor 1
LCK LCK proto-oncogene, Src family tyrosine kinase
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
LEF1 lymphoid enhancer-binding factor 1
LGALS1 lectin, galactoside-binding, soluble, 1
LGALS8 lectin, galactoside-binding, soluble, 8
LIG4 ligase IV, DNA, ATP-dependent
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1
LRRC8A leucine rich repeat containing 8 family, member A
LY6D lymphocyte antigen 6 complex, locus D
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MALT1 MALT1 paracaspase
MEF2C myocyte enhancer factor 2C
MERTK MER proto-oncogene, tyrosine kinase
MICA MHC class I polypeptide-related sequence A
MICB MHC class I polypeptide-related sequence B
MLH1 mutL homolog 1
MPZL2 myelin protein zero-like 2
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MSH2 mutS homolog 2
MSH6 mutS homolog 6
MYB v-myb avian myeloblastosis viral oncogene homolog
NBN nibrin
NCK1 NCK adaptor protein 1
NCK2 NCK adaptor protein 2
NCOR1 nuclear receptor corepressor 1
NCR1 natural cytotoxicity triggering receptor 1
NCSTN nicastrin
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
NFAM1 NFAT activating protein with ITAM motif 1
NHEJ1 nonhomologous end-joining factor 1
NKAP NFKB activating protein
NKX2-3 NK2 homeobox 3
NLRC3 NLR family, CARD domain containing 3
NTRK1 neurotrophic tyrosine kinase, receptor, type 1
ONECUT1 one cut homeobox 1
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PAX1 paired box 1
PFDN1 prefoldin subunit 1
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PKNOX1 PBX/knotted 1 homeobox 1
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PLCL2 phospholipase C-like 2
POLM polymerase (DNA directed), mu
POU1F1 POU class 1 homeobox 1
POU2F2 POU class 2 homeobox 2
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PPP3CB protein phosphatase 3, catalytic subunit, beta isozyme
PREX1 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
PRKCB protein kinase C, beta
PRKCD protein kinase C, delta
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PRLR prolactin receptor
PSEN1 presenilin 1
PSEN2 presenilin 2
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTK2B protein tyrosine kinase 2 beta
PTPN2 protein tyrosine phosphatase, non-receptor type 2
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
PTPRC protein tyrosine phosphatase, receptor type, C
RAB27A RAB27A, member RAS oncogene family
RAG1 recombination activating gene 1
RAG2 recombination activating gene 2
RBPJ recombination signal binding protein for immunoglobulin kappa J region
RC3H1 ring finger and CCCH-type domains 1
RC3H2 ring finger and CCCH-type domains 2
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RHOH ras homolog family member H
RIPK2 receptor-interacting serine-threonine kinase 2
RIPK3 receptor-interacting serine-threonine kinase 3
RNF168 ring finger protein 168, E3 ubiquitin protein ligase
RNF8 ring finger protein 8, E3 ubiquitin protein ligase
RORA RAR-related orphan receptor A
RORC RAR-related orphan receptor C
RPL22 ribosomal protein L22
RPS6 ribosomal protein S6
RSAD2 radical S-adenosyl methionine domain containing 2
RUNX2 runt-related transcription factor 2
SATB1 SATB homeobox 1
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
SHH sonic hedgehog
SKAP2 src kinase associated phosphoprotein 2
SLA2 Src-like-adaptor 2
SLAMF1 signaling lymphocytic activation molecule family member 1
SLAMF7 SLAM family member 7
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
SMAD3 SMAD family member 3
SOX4 SRY (sex determining region Y)-box 4
SP3 Sp3 transcription factor
SPI1 Spi-1 proto-oncogene
STAT5A signal transducer and activator of transcription 5A
STAT5B signal transducer and activator of transcription 5B
STOML2 stomatin (EPB72)-like 2
STX11 syntaxin 11
SWAP70 SWAP switching B-cell complex 70kDa subunit
TBK1 TANK-binding kinase 1
TBX21 T-box 21
TCF3 transcription factor 3
TCF7 transcription factor 7 (T-cell specific, HMG-box)
TGFB1 transforming growth factor, beta 1
TLR4 toll-like receptor 4
TNFRSF4 tumor necrosis factor receptor superfamily, member 4
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14
TNFSF18 tumor necrosis factor (ligand) superfamily, member 18
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TNFSF8 tumor necrosis factor (ligand) superfamily, member 8
TP53 tumor protein p53
TPD52 tumor protein D52
TREML2 triggering receptor expressed on myeloid cells-like 2
TUSC2 tumor suppressor candidate 2
TXK TXK tyrosine kinase
TXLNA taxilin alpha
TYRO3 TYRO3 protein tyrosine kinase
ULBP1 UL16 binding protein 1
ULBP2 UL16 binding protein 2
ULBP3 UL16 binding protein 3
UNC13D unc-13 homolog D (C. elegans)
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2)
VAMP7 vesicle-associated membrane protein 7
VAV1 vav 1 guanine nucleotide exchange factor
VCAM1 vascular cell adhesion molecule 1
VPRBP Vpr (HIV-1) binding protein
WAS Wiskott-Aldrich syndrome
WNT1 wingless-type MMTV integration site family, member 1
WNT4 wingless-type MMTV integration site family, member 4
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa
ZBTB1 zinc finger and BTB domain containing 1
ZBTB32 zinc finger and BTB domain containing 32
ZFP36L1 ZFP36 ring finger protein-like 1
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF683 zinc finger protein 683