lymecycline-2953 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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199 genes differentially expressed following the lymecycline-2953 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCA2 ATP-binding cassette, sub-family A (ABC1), member 2
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
AKAP6 A kinase (PRKA) anchor protein 6
AP5S1 adaptor-related protein complex 5, sigma 1 subunit
APOM apolipoprotein M
ARHGAP1 Rho GTPase activating protein 1
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
ATN1 atrophin 1
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
B4GALT2 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
BPI bactericidal/permeability-increasing protein
BTN3A1 butyrophilin, subfamily 3, member A1
CD180 CD180 molecule
CD22 CD22 molecule
CDC25C cell division cycle 25C
CDKL1 cyclin-dependent kinase-like 1 (CDC2-related kinase)
CDKN2A cyclin-dependent kinase inhibitor 2A
CDRT1 CMT1A duplicated region transcript 1
CELSR3 cadherin, EGF LAG seven-pass G-type receptor 3
CLTA clathrin, light chain A
COL11A2 collagen, type XI, alpha 2
CUX1 cut-like homeobox 1
DDX31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31
DES desmin
DHODH dihydroorotate dehydrogenase (quinone)
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5
EPAS1 endothelial PAS domain protein 1
EPHB6 EPH receptor B6
ETV1 ets variant 1
EXOC7 exocyst complex component 7
GALK1 galactokinase 1
GNG3 guanine nucleotide binding protein (G protein), gamma 3
GPR153 G protein-coupled receptor 153
GPR21 G protein-coupled receptor 21
HDAC11 histone deacetylase 11
HDAC7 histone deacetylase 7
HFE hemochromatosis
HIST1H2AI histone cluster 1, H2ai
HIST1H4E histone cluster 1, H4e
IGFBP5 insulin-like growth factor binding protein 5
IL12RB1 interleukin 12 receptor, beta 1
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1
KHK ketohexokinase (fructokinase)
LRRC23 leucine rich repeat containing 23
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MEFV Mediterranean fever
MET MET proto-oncogene, receptor tyrosine kinase
MID1 midline 1
MIOS missing oocyte, meiosis regulator, homolog (Drosophila)
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
MR1 major histocompatibility complex, class I-related
MVK mevalonate kinase
MYOZ3 myozenin 3
NOP16 NOP16 nucleolar protein
NOVA1 neuro-oncological ventral antigen 1
NRF1 nuclear respiratory factor 1
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18
OXTR oxytocin receptor
PADI2 peptidyl arginine deiminase, type II
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PDGFB platelet-derived growth factor beta polypeptide
PDLIM7 PDZ and LIM domain 7 (enigma)
PI4KB phosphatidylinositol 4-kinase, catalytic, beta
PLAA phospholipase A2-activating protein
PLCD1 phospholipase C, delta 1
PLCG1 phospholipase C, gamma 1
PPT2 palmitoyl-protein thioesterase 2
PRICKLE3 prickle homolog 3 (Drosophila)
PTK2B protein tyrosine kinase 2 beta
PTPRS protein tyrosine phosphatase, receptor type, S
QTRT1 queuine tRNA-ribosyltransferase 1
RAB6A RAB6A, member RAS oncogene family
RAD51B RAD51 paralog B
RAP1GAP RAP1 GTPase activating protein
RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated)
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2
SIGLEC7 sialic acid binding Ig-like lectin 7
SLC16A5 solute carrier family 16 (monocarboxylate transporter), member 5
SLC23A2 solute carrier family 23 (ascorbic acid transporter), member 2
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6
SMG5 SMG5 nonsense mediated mRNA decay factor
SMURF1 SMAD specific E3 ubiquitin protein ligase 1
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6
ST5 suppression of tumorigenicity 5
STAB1 stabilin 1
SULT4A1 sulfotransferase family 4A, member 1
THBS3 thrombospondin 3
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TNK2 tyrosine kinase, non-receptor, 2
TSC22D4 TSC22 domain family, member 4
UBA6 ubiquitin-like modifier activating enzyme 6
WDR78 WD repeat domain 78
WWC1 WW and C2 domain containing 1
ZER1 zyg-11 related, cell cycle regulator
ZNF428 zinc finger protein 428
ZNF512B zinc finger protein 512B
ZNF549 zinc finger protein 549
ZNF695 zinc finger protein 695
ZNF783 zinc finger family member 783

decreased expression

Symbol Name
ACSL4 acyl-CoA synthetase long-chain family member 4
ACTR8 ARP8 actin-related protein 8 homolog (yeast)
ADRB2 adrenoceptor beta 2, surface
AGO1 argonaute RISC catalytic component 1
AGO3 argonaute RISC catalytic component 3
AHR aryl hydrocarbon receptor
AMIGO2 adhesion molecule with Ig-like domain 2
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1
BAP1 BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
C11ORF30 chromosome 11 open reading frame 30
CA5BP1 carbonic anhydrase VB pseudogene 1
CCNJ cyclin J
CD3D CD3d molecule, delta (CD3-TCR complex)
CD69 CD69 molecule
CD9 CD9 molecule
CENPJ centromere protein J
CIDEB cell death-inducing DFFA-like effector b
CLEC7A C-type lectin domain family 7, member A
CLK1 CDC-like kinase 1
COQ3 coenzyme Q3 methyltransferase
CRYBB2P1 crystallin, beta B2 pseudogene 1
CX3CR1 chemokine (C-X3-C motif) receptor 1
DENND2D DENN/MADD domain containing 2D
DHRS9 dehydrogenase/reductase (SDR family) member 9
DNMBP dynamin binding protein
ECM1 extracellular matrix protein 1
FADD Fas (TNFRSF6)-associated via death domain
FAM184A family with sequence similarity 184, member A
FAM192A family with sequence similarity 192, member A
FHIT fragile histidine triad
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
FYCO1 FYVE and coiled-coil domain containing 1
GEM GTP binding protein overexpressed in skeletal muscle
GID4 GID complex subunit 4
GK3P glycerol kinase 3 pseudogene
GPR85 G protein-coupled receptor 85
GRAMD1B GRAM domain containing 1B
HCAR3 hydroxycarboxylic acid receptor 3
HECTD3 HECT domain containing E3 ubiquitin protein ligase 3
HIRA histone cell cycle regulator
HLA-DMA major histocompatibility complex, class II, DM alpha
ICAM4 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
INHBE inhibin, beta E
INPP5E inositol polyphosphate-5-phosphatase, 72 kDa
IREB2 iron-responsive element binding protein 2
KIF13B kinesin family member 13B
KIF18A kinesin family member 18A
LINS lines homolog (Drosophila)
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAP1S microtubule-associated protein 1S
MCRS1 microspherule protein 1
MRPL44 mitochondrial ribosomal protein L44
MTCP1 mature T-cell proliferation 1
MX1 MX dynamin-like GTPase 1
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NABP2 nucleic acid binding protein 2
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1
OSGEPL1 O-sialoglycoprotein endopeptidase-like 1
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PBLD phenazine biosynthesis-like protein domain containing
PDZD7 PDZ domain containing 7
PHACTR1 phosphatase and actin regulator 1
POMGNT1 protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-)
PPDPF pancreatic progenitor cell differentiation and proliferation factor
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha
PTH2R parathyroid hormone 2 receptor
PTX3 pentraxin 3, long
RARS arginyl-tRNA synthetase
RGS13 regulator of G-protein signaling 13
RNF11 ring finger protein 11
RNF121 ring finger protein 121
RPL23AP32 ribosomal protein L23a pseudogene 32
RPL23AP7 ribosomal protein L23a pseudogene 7
RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2
RUSC2 RUN and SH3 domain containing 2
SALL2 spalt-like transcription factor 2
SARS2 seryl-tRNA synthetase 2, mitochondrial
SCML1 sex comb on midleg-like 1 (Drosophila)
SCRN3 secernin 3
SFXN1 sideroflexin 1
SLC4A1AP solute carrier family 4 (anion exchanger), member 1, adaptor protein
SLC4A2 solute carrier family 4 (anion exchanger), member 2
SPIDR scaffolding protein involved in DNA repair
TMA16 translation machinery associated 16 homolog (S. cerevisiae)
TMED1 transmembrane emp24 protein transport domain containing 1
TMEM115 transmembrane protein 115
TOPORS topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
UBQLN4 ubiquilin 4
USP32 ubiquitin specific peptidase 32
VNN2 vanin 2
WDR13 WD repeat domain 13
XPC xeroderma pigmentosum, complementation group C
ZBTB10 zinc finger and BTB domain containing 10
ZBTB48 zinc finger and BTB domain containing 48
ZNF10 zinc finger protein 10
ZNF443 zinc finger protein 443
ZNF83 zinc finger protein 83
ZNF862 zinc finger protein 862