lupus erythematosus, systemic Gene Set

Dataset GAD Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description A lupus erythematosus that is an inflammation of connective tissue marked by skin rashes, joint pain and swelling, inflammation of the kidneys and inflammation of the tissue surrounding the heart. (Human Disease Ontology, DOID_9074)
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Genes

293 genes associated with the disease lupus erythematosus, systemic in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

Symbol Name
ABCF1 ATP-binding cassette, sub-family F (GCN20), member 1
ABHD16A abhydrolase domain containing 16A
ACE angiotensin I converting enzyme
ACP1 acid phosphatase 1, soluble
AFF1 AF4/FMR2 family, member 1
AGER advanced glycosylation end product-specific receptor
AGPAT1 1-acylglycerol-3-phosphate O-acyltransferase 1
AIF1 allograft inflammatory factor 1
ATAT1 alpha tubulin acetyltransferase 1
ATF6B activating transcription factor 6 beta
ATP6V1G2 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2
AUH AU RNA binding protein/enoyl-CoA hydratase
B3GALT4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
BAG6 BCL2-associated athanogene 6
BANK1 B-cell scaffold protein with ankyrin repeats 1
BLK BLK proto-oncogene, Src family tyrosine kinase
BRD2 bromodomain containing 2
BTN2A1 butyrophilin, subfamily 2, member A1
BTN3A2 butyrophilin, subfamily 3, member A2
BTNL2 butyrophilin-like 2
C1QA complement component 1, q subcomponent, A chain
C1QB complement component 1, q subcomponent, B chain
C1QC complement component 1, q subcomponent, C chain
C2 complement component 2
C3 complement component 3
C4A complement component 4A (Rodgers blood group)
C6ORF10 chromosome 6 open reading frame 10
C6ORF15 chromosome 6 open reading frame 15
C6ORF25 chromosome 6 open reading frame 25
C6ORF47 chromosome 6 open reading frame 47
C6ORF48 chromosome 6 open reading frame 48
CAT catalase
CCHCR1 coiled-coil alpha-helical rod protein 1
CD247 CD247 molecule
CDSN corneodesmosin
CFB complement factor B
CLDN10 claudin 10
CLEC16A C-type lectin domain family 16, member A
CLIC1 chloride intracellular channel 1
COL11A2 collagen, type XI, alpha 2
CR2 complement component (3d/Epstein Barr virus) receptor 2
CRP C-reactive protein, pentraxin-related
CSNK2B casein kinase 2, beta polypeptide
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CTNNA3 catenin (cadherin-associated protein), alpha 3
CUTA cutA divalent cation tolerance homolog (E. coli)
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DAXX death-domain associated protein
DDAH2 dimethylarginine dimethylaminohydrolase 2
DDR1 discoidin domain receptor tyrosine kinase 1
DHX16 DEAH (Asp-Glu-Ala-His) box polypeptide 16
DLG2 discs, large homolog 2 (Drosophila)
DPCR1 diffuse panbronchiolitis critical region 1
DXO decapping exoribonuclease
EGFL8 EGF-like-domain, multiple 8
EHMT2 euchromatic histone-lysine N-methyltransferase 2
ELF1 E74-like factor 1 (ets domain transcription factor)
ERCC2 excision repair cross-complementation group 2
ESR1 estrogen receptor 1
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FAM167A family with sequence similarity 167, member A
FASLG Fas ligand (TNF superfamily, member 6)
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
FEN1 flap structure-specific endonuclease 1
FKBPL FK506 binding protein like
FLOT1 flotillin 1
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
GNL1 guanine nucleotide binding protein-like 1
GPANK1 G patch domain and ankyrin repeats 1
GPSM3 G-protein signaling modulator 3
GSTM1 glutathione S-transferase mu 1
GTF2H4 general transcription factor IIH, polypeptide 4, 52kDa
HCG22 HLA complex group 22
HCG27 HLA complex group 27 (non-protein coding)
HCG9 HLA complex group 9 (non-protein coding)
HCP5 HLA complex P5 (non-protein coding)
HECW1 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
HIP1 huntingtin interacting protein 1
HIST1H1B histone cluster 1, H1b
HLA-A major histocompatibility complex, class I, A
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-DMA major histocompatibility complex, class II, DM alpha
HLA-DMB major histocompatibility complex, class II, DM beta
HLA-DOA major histocompatibility complex, class II, DO alpha
HLA-DOB major histocompatibility complex, class II, DO beta
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQA2 major histocompatibility complex, class II, DQ alpha 2
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DQB2 major histocompatibility complex, class II, DQ beta 2
HLA-DRA major histocompatibility complex, class II, DR alpha
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HLA-DRB3 major histocompatibility complex, class II, DR beta 3
HLA-DRB4 major histocompatibility complex, class II, DR beta 4
HLA-DRB5 major histocompatibility complex, class II, DR beta 5
HLA-E major histocompatibility complex, class I, E
HLA-F major histocompatibility complex, class I, F
HLA-G major histocompatibility complex, class I, G
HLA-K major histocompatibility complex, class I, K (pseudogene)
HLA-L major histocompatibility complex, class I, L (pseudogene)
HRES1 HTLV-1 related endogenous sequence
HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8
HSPA1A heat shock 70kDa protein 1A
HSPA1B heat shock 70kDa protein 1B
HSPA1L heat shock 70kDa protein 1-like
IER3 immediate early response 3
IFIH1 interferon induced with helicase C domain 1
IFNA1 interferon, alpha 1
IFNA17 interferon, alpha 17
IFNA2 interferon, alpha 2
IFNA5 interferon, alpha 5
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL10 interleukin 10
IL12B interleukin 12B
IL16 interleukin 16
IL18 interleukin 18
IL1B interleukin 1, beta
IL1RN interleukin 1 receptor antagonist
IL2 interleukin 2
IL21 interleukin 21
IL21R interleukin 21 receptor
IL23R interleukin 23 receptor
IP6K3 inositol hexakisphosphate kinase 3
IRAK1 interleukin-1 receptor-associated kinase 1
IRF3 interferon regulatory factor 3
IRF5 interferon regulatory factor 5
IRF7 interferon regulatory factor 7
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit)
ITPA inosine triphosphatase (nucleoside triphosphate pyrophosphatase)
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
JAZF1 JAZF zinc finger 1
KIFC1 kinesin family member C1
KLRK1 killer cell lectin-like receptor subfamily K, member 1
LAMC2 laminin, gamma 2
LEF1 lymphoid enhancer-binding factor 1
LEMD2 LEM domain containing 2
LINC01556 long intergenic non-protein coding RNA 1556
LRRC18 leucine rich repeat containing 18
LSM2 LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LST1 leukocyte specific transcript 1
LTA lymphotoxin alpha
LTB lymphotoxin beta (TNF superfamily, member 3)
LY6G5B lymphocyte antigen 6 complex, locus G5B
LY6G5C lymphocyte antigen 6 complex, locus G5C
LY6G6C lymphocyte antigen 6 complex, locus G6C
LY6G6E lymphocyte antigen 6 complex, locus G6E (pseudogene)
LY6G6F lymphocyte antigen 6 complex, locus G6F
LY9 lymphocyte antigen 9
LYN LYN proto-oncogene, Src family tyrosine kinase
LYPLA2P1 lysophospholipase II pseudogene 1
MAS1L MAS1 proto-oncogene like, G protein-coupled receptor
MAS1LP1 MAS1L pseudogene 1
MBL2 mannose-binding lectin (protein C) 2, soluble
MCCD1 mitochondrial coiled-coil domain 1
MDC1 mediator of DNA-damage checkpoint 1
MECP2 methyl CpG binding protein 2
MFGE8 milk fat globule-EGF factor 8 protein
MICA MHC class I polypeptide-related sequence A
MICB MHC class I polypeptide-related sequence B
MLN motilin
MMP9 matrix metallopeptidase 9
MOG myelin oligodendrocyte glycoprotein
MRPS18B mitochondrial ribosomal protein S18B
MSH5 mutS homolog 5
MUC21 mucin 21, cell surface associated
MYD88 myeloid differentiation primary response 88
MYL8P myosin, light chain 8, pseudogene
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase)
NCR3 natural cytotoxicity triggering receptor 3
NEGR1 neuronal growth regulator 1
NELFE negative elongation factor complex member E
NEU1 sialidase 1 (lysosomal sialidase)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NOTCH4 notch 4
NRM nurim (nuclear envelope membrane protein)
NTNG2 netrin G2
OR11A1 olfactory receptor, family 11, subfamily A, member 1
OR12D2 olfactory receptor, family 12, subfamily D, member 2 (gene/pseudogene)
OR12D3 olfactory receptor, family 12, subfamily D, member 3
OR14J1 olfactory receptor, family 14, subfamily J, member 1
OR2B3 olfactory receptor, family 2, subfamily B, member 3
OR2H1 olfactory receptor, family 2, subfamily H, member 1
OR2H2 olfactory receptor, family 2, subfamily H, member 2
OR2J2 olfactory receptor, family 2, subfamily J, member 2
OR2J3 olfactory receptor, family 2, subfamily J, member 3
OR2W1 olfactory receptor, family 2, subfamily W, member 1
OR4A15 olfactory receptor, family 4, subfamily A, member 15
OR5V1 olfactory receptor, family 5, subfamily V, member 1
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7
PBX2 pre-B-cell leukemia homeobox 2
PDCD1 programmed cell death 1
PFDN6 prefoldin subunit 6
PGBD1 piggyBac transposable element derived 1
PHF1 PHD finger protein 1
PHRF1 PHD and ring finger domains 1
PLXNA4 plexin A4
POU5F1 POU class 5 homeobox 1
PPP1R10 protein phosphatase 1, regulatory subunit 10
PPP1R11 protein phosphatase 1, regulatory (inhibitor) subunit 11
PPP1R18 protein phosphatase 1, regulatory subunit 18
PPT2 palmitoyl-protein thioesterase 2
PRDM1 PR domain containing 1, with ZNF domain
PRR3 proline rich 3
PRRC2A proline-rich coiled-coil 2A
PRRT1 proline-rich transmembrane protein 1
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PSORS1C1 psoriasis susceptibility 1 candidate 1
PSORS1C2 psoriasis susceptibility 1 candidate 2
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
PUM1 pumilio RNA-binding family member 1
PXK PX domain containing serine/threonine kinase
RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated)
RGL2 ral guanine nucleotide dissociation stimulator-like 2
RING1 ring finger protein 1
RNF39 ring finger protein 39
RNF5 ring finger protein 5, E3 ubiquitin protein ligase
RPP21 ribonuclease P/MRP 21kDa subunit
RPS18 ribosomal protein S18
RXRB retinoid X receptor, beta
SAPCD1 suppressor APC domain containing 1
SELP selectin P (granule membrane protein 140kDa, antigen CD62)
SFTA2 surfactant associated 2
SH2B3 SH2B adaptor protein 3
SKIV2L superkiller viralicidic activity 2-like (S. cerevisiae)
SLAMF7 SLAM family member 7
SLC15A4 solute carrier family 15 (oligopeptide transporter), member 4
SLC39A7 solute carrier family 39 (zinc transporter), member 7
SLC44A4 solute carrier family 44, member 4
SLC5A11 solute carrier family 5 (sodium/inositol cotransporter), member 11
SPP1 secreted phosphoprotein 1
SRCIN1 SRC kinase signaling inhibitor 1
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT4 signal transducer and activator of transcription 4
STK19 serine/threonine kinase 19
SYNGAP1 synaptic Ras GTPase activating protein 1
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
TAPBP TAP binding protein (tapasin)
TCF19 transcription factor 19
TGFB1 transforming growth factor, beta 1
TLR5 toll-like receptor 5
TLR7 toll-like receptor 7
TLR9 toll-like receptor 9
TMC2 transmembrane channel-like 2
TNF tumor necrosis factor
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TNIP1 TNFAIP3 interacting protein 1
TNPO3 transportin 3
TNXB tenascin XB
TREX1 three prime repair exonuclease 1
TREX2 three prime repair exonuclease 2
TRIM10 tripartite motif containing 10
TRIM15 tripartite motif containing 15
TRIM26 tripartite motif containing 26
TRIM27 tripartite motif containing 27
TRIM31 tripartite motif containing 31
TRIM39 tripartite motif containing 39
TRIM40 tripartite motif containing 40
TRIM72 tripartite motif containing 72, E3 ubiquitin protein ligase
TSPAN11 tetraspanin 11
TUBB tubulin, beta class I
UBD ubiquitin D
UBE2L3 ubiquitin-conjugating enzyme E2L 3
UHRF1BP1 UHRF1 binding protein 1
UQCC2 ubiquinol-cytochrome c reductase complex assembly factor 2
VARS valyl-tRNA synthetase
VARS2 valyl-tRNA synthetase 2, mitochondrial
VPS52 vacuolar protein sorting 52 homolog (S. cerevisiae)
VWA7 von Willebrand factor A domain containing 7
WDFY4 WDFY family member 4
WDR46 WD repeat domain 46
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
ZBTB12 zinc finger and BTB domain containing 12
ZBTB22 zinc finger and BTB domain containing 22
ZBTB9 zinc finger and BTB domain containing 9
ZFP57 ZFP57 zinc finger protein
ZNF112 zinc finger protein 112
ZNF311 zinc finger protein 311
ZNRD1 zinc ribbon domain containing 1
ZNRD1-AS1 ZNRD1 antisense RNA 1
ZSCAN26 zinc finger and SCAN domain containing 26
ZSCAN31 zinc finger and SCAN domain containing 31