lung disease Gene Set

Dataset DISEASES Experimental Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description A lower respiratory tract disease in which the function of the lungs is adversely affected by narrowing or blockage of the airways resulting in poor air flow, a loss of elasticity in the lungs that produces a decrease in the total volume of air that the lungs are able to hold, and clotting, scarring, or inflammation of the blood vessels that affect the ability of the lungs to take up oxygen and to release carbon dioxide. (Human Disease Ontology, DOID_850)
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Genes

233 genes associated with the disease lung disease in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
MUC2 mucin 2, oligomeric mucus/gel-forming 1.85886
GSTCD glutathione S-transferase, C-terminal domain containing 1.51016
ZPBP2 zona pellucida binding protein 2 1.50071
NOTCH4 notch 4 1.49392
IKZF3 IKAROS family zinc finger 3 (Aiolos) 1.47477
DSP desmoplakin 1.33613
TERT telomerase reverse transcriptase 1.32252
INTS12 integrator complex subunit 12 1.20753
MFAP2 microfibrillar-associated protein 2 1.10381
PBX2 pre-B-cell leukemia homeobox 2 1.07383
TSLP thymic stromal lymphopoietin 1.02486
MAPT microtubule-associated protein tau 0.968307
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39) 0.965481
CRB1 crumbs family member 1, photoreceptor morphogenesis associated 0.945428
STAC2 SH3 and cysteine rich domain 2 0.945428
IKZF4 IKAROS family zinc finger 4 (Eos) 0.945428
SLC30A8 solute carrier family 30 (zinc transporter), member 8 0.916033
LRRC34 leucine rich repeat containing 34 0.901326
TNS1 tensin 1 0.894262
DPP9 dipeptidyl-peptidase 9 0.872896
TWIST2 twist family bHLH transcription factor 2 0.872896
USP38 ubiquitin specific peptidase 38 0.872896
IL33 interleukin 33 0.872896
HLA-DQA2 major histocompatibility complex, class II, DQ alpha 2 0.842276
TOP2A topoisomerase (DNA) II alpha 170kDa 0.835734
IVD isovaleryl-CoA dehydrogenase 0.817078
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled 0.817078
CFDP1 craniofacial development protein 1 0.790827
FAM13A family with sequence similarity 13, member A 0.790827
CCDC38 coiled-coil domain containing 38 0.790827
CDK2 cyclin-dependent kinase 2 0.724323
ADAM19 ADAM metallopeptidase domain 19 0.724323
NCR3 natural cytotoxicity triggering receptor 3 0.69843
ZSCAN31 zinc finger and SCAN domain containing 31 0.69843
ZKSCAN3 zinc finger with KRAB and SCAN domains 3 0.69843
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 0.69843
HNMT histamine N-methyltransferase 0.647573
ADGRG6 adhesion G protein-coupled receptor G6 0.63207
IL18R1 interleukin 18 receptor 1 0.63207
IL1RL1 interleukin 1 receptor-like 1 0.63207
NRG1 neuregulin 1 0.602429
MAGEE1 melanoma antigen family E1 0.602429
RAB4B RAB4B, member RAS oncogene family 0.58494
HLA-DOA major histocompatibility complex, class II, DO alpha 0.572184
PYHIN1 pyrin and HIN domain family, member 1 0.572184
SMAD3 SMAD family member 3 0.572184
GSDMA gasdermin A 0.561725
ATP11A ATPase, class VI, type 11A 0.544585
ARMC2 armadillo repeat containing 2 0.537125
AZGP1P1 alpha-2-glycoprotein 1, zinc-binding pseudogene 1 0.52461
C1ORF143 chromosome 1 open reading frame 143 0.52461
ANTXR1 anthrax toxin receptor 1 0.52461
C1ORF53 chromosome 1 open reading frame 53 0.52461
IL2RB interleukin 2 receptor, beta 0.52461
ORMDL3 ORMDL sphingolipid biosynthesis regulator 3 0.52461
OBFC1 oligonucleotide/oligosaccharide-binding fold containing 1 0.486425
SUMF1 sulfatase modifying factor 1 0.486425
C11ORF30 chromosome 11 open reading frame 30 0.486425
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 0.486425
SPATA9 spermatogenesis associated 9 0.486425
IL6R interleukin 6 receptor 0.486425
MRPS6 mitochondrial ribosomal protein S6 0.464771
MECOM MDS1 and EVI1 complex locus 0.464771
PDE4D phosphodiesterase 4D, cAMP-specific 0.464771
FTO fat mass and obesity associated 0.449873
PTCH1 patched 1 0.438544
TUSC3 tumor suppressor candidate 3 0.438544
PID1 phosphotyrosine interaction domain containing 1 0.429338
DENND1B DENN/MADD domain containing 1B 0.429338
ASB1 ankyrin repeat and SOCS box containing 1 0.4215
GAB1 GRB2-associated binding protein 1 0.4215
DMRTB1 DMRT-like family B with proline-rich C-terminal, 1 0.4215
LDB2 LIM domain binding 2 0.414708
DAAM2 dishevelled associated activator of morphogenesis 2 0.414708
RORA RAR-related orphan receptor A 0.403461
THSD4 thrombospondin, type I, domain containing 4 0.403461
HHIP hedgehog interacting protein 0.403461
GSDMB gasdermin B 0.403461
HYKK hydroxylysine kinase 0.403461
CD96 CD96 molecule 0.403461
OR5V1 olfactory receptor, family 5, subfamily V, member 1 0.403461
IL13 interleukin 13 0.403461
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38 0.368757
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal) 0.368757
DEPTOR DEP domain containing MTOR-interacting protein 0.368757
MSH6 mutS homolog 6 0.368757
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5 0.368757
WWOX WW domain containing oxidoreductase 0.368757
TSPYL1 TSPY-like 1 0.345945
CDYL chromodomain protein, Y-like 0.345945
CDC123 cell division cycle 123 0.345945
RAD50 RAD50 homolog (S. cerevisiae) 0.345945
TSPYL4 TSPY-like 4 0.345945
ST8SIA2 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 0.327313
PLCE1 phospholipase C, epsilon 1 0.327313
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit 0.327313
ANXA5 annexin A5 0.311576
PRKG1 protein kinase, cGMP-dependent, type I 0.311576
RBM19 RNA binding motif protein 19 0.297866
CCDC91 coiled-coil domain containing 91 0.297866
BICD1 bicaudal D homolog 1 (Drosophila) 0.297866
SYNE2 spectrin repeat containing, nuclear envelope 2 0.297866
TET2 tet methylcytosine dioxygenase 2 0.297866
ERO1LB ERO1-like beta (S. cerevisiae) 0.285417
CHCHD2P9 coiled-coil-helix-coiled-coil-helix domain containing 2 pseudogene 9 0.285417
SVEP1 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 0.285417
ADCY2 adenylate cyclase 2 (brain) 0.274608
SPATA13 spermatogenesis associated 13 0.274608
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.274608
LY6G6F lymphocyte antigen 6 complex, locus G6F 0.274608
NT5DC1 5'-nucleotidase domain containing 1 0.274608
DCDC2 doublecortin domain containing 2 0.274608
PCDH8 protocadherin 8 0.274608
CCBL2 cysteine conjugate-beta lyase 2 0.264872
MICB MHC class I polypeptide-related sequence B 0.256228
PTPRD protein tyrosine phosphatase, receptor type, D 0.256228
ZNF462 zinc finger protein 462 0.256228
TMEM163 transmembrane protein 163 0.256228
DLG2 discs, large homolog 2 (Drosophila) 0.256228
RARB retinoic acid receptor, beta 0.256228
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.256228
PCDH15 protocadherin-related 15 0.256228
TAF7 TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa 0.256228
IREB2 iron-responsive element binding protein 2 0.256228
SPATS2L spermatogenesis associated, serine-rich 2-like 0.256228
CTNNA3 catenin (cadherin-associated protein), alpha 3 0.256228
SNURF SNRPN upstream reading frame 0.256228
FAM65B family with sequence similarity 65, member B 0.197766
AKAP13 A kinase (PRKA) anchor protein 13 0.197766
ITGA1 integrin, alpha 1 0.197766
PLXNA4 plexin A4 0.197766
VPS53 vacuolar protein sorting 53 homolog (S. cerevisiae) 0.197766
FBXO38 F-box protein 38 0.197766
CALN1 calneuron 1 0.197766
SCG3 secretogranin III 0.197766
PPP1R14C protein phosphatase 1, regulatory (inhibitor) subunit 14C 0.197766
C5ORF56 chromosome 5 open reading frame 56 0.197766
COL1A2 collagen, type I, alpha 2 0.197766
VAT1L vesicle amine transport 1-like 0.197766
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal) 0.15771
MARCH5 membrane-associated ring finger (C3HC4) 5 0.15771
C10ORF11 chromosome 10 open reading frame 11 0.15771
FMO4 flavin containing monooxygenase 4 0.15771
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 0.15771
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 0.15771
PDZRN3 PDZ domain containing ring finger 3 0.15771
ACKR3 atypical chemokine receptor 3 0.15771
DCLK1 doublecortin-like kinase 1 0.15771
PGBD1 piggyBac transposable element derived 1 0.15771
ADARB1 adenosine deaminase, RNA-specific, B1 0.15771
ZNF665 zinc finger protein 665 0.126165
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 0.126165
CNIH3 cornichon family AMPA receptor auxiliary protein 3 0.126165
ACO1 aconitase 1, soluble 0.126165
ZNF28 zinc finger protein 28 0.126165
CCDC67 coiled-coil domain containing 67 0.126165
SNRPF small nuclear ribonucleoprotein polypeptide F 0.126165
APP amyloid beta (A4) precursor protein 0.126165
PCDH9 protocadherin 9 0.126165
MMP15 matrix metallopeptidase 15 (membrane-inserted) 0.126165
C20ORF85 chromosome 20 open reading frame 85 0.126165
TRIM71 tripartite motif containing 71, E3 ubiquitin protein ligase 0.126165
NWD2 NACHT and WD repeat domain containing 2 0.126165
C15ORF32 chromosome 15 open reading frame 32 0.126165
DKK2 dickkopf WNT signaling pathway inhibitor 2 0.126165
NDFIP1 Nedd4 family interacting protein 1 0.126165
SNTG1 syntrophin, gamma 1 0.100789
ZNF644 zinc finger protein 644 0.100789
PDIA4 protein disulfide isomerase family A, member 4 0.100789
ANXA2 annexin A2 0.100789
RAB5B RAB5B, member RAS oncogene family 0.100789
SLC16A10 solute carrier family 16 (aromatic amino acid transporter), member 10 0.100789
ANK1 ankyrin 1, erythrocytic 0.100789
RHBDD1 rhomboid domain containing 1 0.100789
SEZ6L seizure related 6 homolog (mouse)-like 0.100789
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3 0.100789
DLEU1 deleted in lymphocytic leukemia 1 (non-protein coding) 0.100789
ZBED9 zinc finger, BED-type containing 9 0.100789
TRIM27 tripartite motif containing 27 0.100789
SRP72 signal recognition particle 72kDa 0.100789
CDH23 cadherin-related 23 0.080593
NID2 nidogen 2 (osteonidogen) 0.080593
LRRC9 leucine rich repeat containing 9 0.080593
PDE9A phosphodiesterase 9A 0.080593
C10ORF54 chromosome 10 open reading frame 54 0.080593
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) 0.080593
LCE3C late cornified envelope 3C 0.080593
NTN4 netrin 4 0.080593
TBCK TBC1 domain containing kinase 0.080593
TMEM72 transmembrane protein 72 0.080593
CTNND2 catenin (cadherin-associated protein), delta 2 0.080593
T T, brachyury homolog (mouse) 0.080593
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 0.064973
CBLN2 cerebellin 2 precursor 0.064973
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 0.064973
MPP7 membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7) 0.064973
KANSL1 KAT8 regulatory NSL complex subunit 1 0.064973
RPL10AP3 ribosomal protein L10a pseudogene 3 0.064973
USP15 ubiquitin specific peptidase 15 0.064973
PRKCE protein kinase C, epsilon 0.064973
WDR11 WD repeat domain 11 0.064973
WNT3 wingless-type MMTV integration site family, member 3 0.064973
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 0.064973
PTPRH protein tyrosine phosphatase, receptor type, H 0.064973
SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D 0.064973
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) 0.052255
GTF2H4 general transcription factor IIH, polypeptide 4, 52kDa 0.052255
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.052255
SOX30 SRY (sex determining region Y)-box 30 0.052255
HNF1B HNF1 homeobox B 0.052255
SECTM1 secreted and transmembrane 1 0.052255
CDRT4 CMT1A duplicated region transcript 4 0.052255
MAVS mitochondrial antiviral signaling protein 0.052255
MAP3K13 mitogen-activated protein kinase kinase kinase 13 0.043246
KANK1 KN motif and ankyrin repeat domains 1 0.043246
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.043246
S100B S100 calcium binding protein B 0.043246
CSMD1 CUB and Sushi multiple domains 1 0.043246
CPO carboxypeptidase O 0.043246
DUSP23 dual specificity phosphatase 23 0.043246
DENND1A DENN/MADD domain containing 1A 0.043246
ABT1 activator of basal transcription 1 0.043246
TRPM8 transient receptor potential cation channel, subfamily M, member 8 0.043246
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5 0.043246
COL22A1 collagen, type XXII, alpha 1 0.043246
CNTLN centlein, centrosomal protein 0.043246
SEPT9 septin 9 0.043246
ZNF311 zinc finger protein 311 0.043246
SYT10 synaptotagmin X 0.035343
GSTO2 glutathione S-transferase omega 2 0.035343
TRPC6 transient receptor potential cation channel, subfamily C, member 6 0.035343
KCNH5 potassium channel, voltage gated eag related subfamily H, member 5 0.035343
FHIT fragile histidine triad 0.035343