lung carcinoma Gene Set

Dataset GWASdb SNP-Disease Associations
Category disease or phenotype associations
Type disease
Description A lung cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells and is located_in the lungs and has_symptom cough and has_symptom chest discomfort or pain and has_symptom weight loss and has_symptom hemoptysis. (Human Disease Ontology, DOID_3905)
External Link http://jjwanglab.org/gwasdb/gwasdb2/gwasdb2/go_trait/DOID:3905
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Genes

335 genes associated with the disease lung carcinoma in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset.

Symbol Name Standardized Value
XKR6 XK, Kell blood group complex subunit-related family, member 6 2.63396
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal) 1.91515
HYKK hydroxylysine kinase 1.84421
TERT telomerase reverse transcriptase 1.74905
CHRNB4 cholinergic receptor, nicotinic, beta 4 (neuronal) 1.18315
IREB2 iron-responsive element binding protein 2 1.12744
TP63 tumor protein p63 1.07246
BTNL2 butyrophilin-like 2 0.878827
CSMD1 CUB and Sushi multiple domains 1 0.826791
SGCZ sarcoglycan, zeta 0.752368
JAZF1 JAZF zinc finger 1 0.717298
APOM apolipoprotein M 0.625316
FAM13A family with sequence similarity 13, member A 0.571534
CLPTM1L CLPTM1-like 0.563782
BPTF bromodomain PHD finger transcription factor 0.56243
CACHD1 cache domain containing 1 0.545775
MSH5 mutS homolog 5 0.54369
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.540838
C6ORF10 chromosome 6 open reading frame 10 0.536554
APBA2 amyloid beta (A4) precursor protein-binding, family A, member 2 0.530417
C2 complement component 2 0.530079
NELL1 NEL-like 1 (chicken) 0.527275
TRPM1 transient receptor potential cation channel, subfamily M, member 1 0.518492
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) 0.515335
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1 0.509675
ZNRD1 zinc ribbon domain containing 1 0.507209
HCG18 HLA complex group 18 (non-protein coding) 0.506127
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 0.503546
CFB complement factor B 0.503092
STK19 serine/threonine kinase 19 0.502704
PPP1R18 protein phosphatase 1, regulatory subunit 18 0.500723
KDM1A lysine (K)-specific demethylase 1A 0.499937
ATP2A3 ATPase, Ca++ transporting, ubiquitous 0.497813
CYP39A1 cytochrome P450, family 39, subfamily A, polypeptide 1 0.495931
PPEF1 protein phosphatase, EF-hand calcium binding domain 1 0.495566
CREB3L2 cAMP responsive element binding protein 3-like 2 0.490167
DMD dystrophin 0.489786
RNF39 ring finger protein 39 0.486602
ABCF1 ATP-binding cassette, sub-family F (GCN20), member 1 0.483577
HCG9 HLA complex group 9 (non-protein coding) 0.483577
HELQ helicase, POLQ-like 0.482351
TCF19 transcription factor 19 0.480321
NPFFR2 neuropeptide FF receptor 2 0.478786
PPME1 protein phosphatase methylesterase 1 0.478722
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 0.478231
UTP18 UTP18 small subunit (SSU) processome component homolog (yeast) 0.478012
XXYLT1 xyloside xylosyltransferase 1 0.472904
TNXB tenascin XB 0.472583
DPCR1 diffuse panbronchiolitis critical region 1 0.468362
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal) 0.465282
NOTCH4 notch 4 0.464422
EIF4E2 eukaryotic translation initiation factor 4E family member 2 0.463687
LOC100507065 uncharacterized LOC100507065 0.460831
FCGBP Fc fragment of IgG binding protein 0.456466
SAXO1 stabilizer of axonemal microtubules 1 0.456271
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 0.456271
DAB1 Dab, reelin signal transducer, homolog 1 (Drosophila) 0.450691
ZNRD1-AS1 ZNRD1 antisense RNA 1 0.449183
CMKLR1 chemerin chemokine-like receptor 1 0.446685
LDB2 LIM domain binding 2 0.4461
TRIM31 tripartite motif containing 31 0.445358
LOC100129636 uncharacterized LOC100129636 0.440871
CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2 0.439536
PIEZO2 piezo-type mechanosensitive ion channel component 2 0.438494
ZNRF3 zinc and ring finger 3 0.436921
ADAMTS7 ADAM metallopeptidase with thrombospondin type 1 motif, 7 0.436817
STXBP5 syntaxin binding protein 5 (tomosyn) 0.435724
PRRC2A proline-rich coiled-coil 2A 0.434813
TMEM163 transmembrane protein 163 0.434385
C6ORF15 chromosome 6 open reading frame 15 0.433897
GPANK1 G patch domain and ankyrin repeats 1 0.432338
SEC63 SEC63 homolog (S. cerevisiae) 0.431862
SORCS2 sortilin-related VPS10 domain containing receptor 2 0.431535
OR12D3 olfactory receptor, family 12, subfamily D, member 3 0.429581
FLOT1 flotillin 1 0.429206
VLDLR very low density lipoprotein receptor 0.428895
M6PR mannose-6-phosphate receptor (cation dependent) 0.428844
PHC1 polyhomeotic homolog 1 (Drosophila) 0.428642
VARS2 valyl-tRNA synthetase 2, mitochondrial 0.427501
MAP2K4 mitogen-activated protein kinase kinase 4 0.427367
EML1 echinoderm microtubule associated protein like 1 0.427146
KCNJ3 potassium channel, inwardly rectifying subfamily J, member 3 0.426131
TLE2 transducin-like enhancer of split 2 0.425181
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 0.424945
SKIV2L superkiller viralicidic activity 2-like (S. cerevisiae) 0.424154
PDCD6 programmed cell death 6 0.42369
RGS7 regulator of G-protein signaling 7 0.42362
UBR1 ubiquitin protein ligase E3 component n-recognin 1 0.423515
KCNN3 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 3 0.423344
DSCAM Down syndrome cell adhesion molecule 0.422054
LOC100507424 uncharacterized LOC100507424 0.421634
FKBP11 FK506 binding protein 11, 19 kDa 0.420891
MEOX2 mesenchyme homeobox 2 0.419335
ARMC4 armadillo repeat containing 4 0.418025
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 0.417896
LRRC16A leucine rich repeat containing 16A 0.417085
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A 0.417062
USP10 ubiquitin specific peptidase 10 0.417062
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.417062
PGBD1 piggyBac transposable element derived 1 0.416723
CYP4F8 cytochrome P450, family 4, subfamily F, polypeptide 8 0.416112
DPF3 D4, zinc and double PHD fingers, family 3 0.41609
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein 0.41609
RYR2 ryanodine receptor 2 (cardiac) 0.415106
THSD7B thrombospondin, type I, domain containing 7B 0.414949
DLST dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) 0.414949
KAT2B K(lysine) acetyltransferase 2B 0.414949
NCOA2 nuclear receptor coactivator 2 0.414949
LAMA1 laminin, alpha 1 0.414949
ZFP57 ZFP57 zinc finger protein 0.414338
LINC00189 long intergenic non-protein coding RNA 189 0.413127
CDH8 cadherin 8, type 2 0.413127
BCR breakpoint cluster region 0.411939
C10ORF11 chromosome 10 open reading frame 11 0.411893
CDC123 cell division cycle 123 0.411769
PRR16 proline rich 16 0.411754
DCC DCC netrin 1 receptor 0.411526
NALCN sodium leak channel, non selective 0.411526
C8ORF34 chromosome 8 open reading frame 34 0.411526
SLC35D2 solute carrier family 35 (UDP-GlcNAc/UDP-glucose transporter), member D2 0.411526
KLRG1 killer cell lectin-like receptor subfamily G, member 1 0.410665
DEC1 deleted in esophageal cancer 1 0.410595
PUS10 pseudouridylate synthase 10 0.410455
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 0.410372
EGFL8 EGF-like-domain, multiple 8 0.408935
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit 0.408812
C5 complement component 5 0.408331
FAM178B family with sequence similarity 178, member B 0.407856
PSORS1C1 psoriasis susceptibility 1 candidate 1 0.407465
SH3PXD2B SH3 and PX domains 2B 0.407209
OGFRL1 opioid growth factor receptor-like 1 0.406958
FRMD8 FERM domain containing 8 0.406711
KIAA1147 KIAA1147 0.405647
PCSK6 proprotein convertase subtilisin/kexin type 6 0.403924
TGM5 transglutaminase 5 0.403229
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.402751
PTPRD protein tyrosine phosphatase, receptor type, D 0.402751
MPP7 membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7) 0.402472
USP34 ubiquitin specific peptidase 34 0.402289
IQSEC3 IQ motif and Sec7 domain 3 0.402198
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.401929
CNTN5 contactin 5 0.401929
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B 0.400651
CPNE5 copine V 0.400328
FRRS1L ferric-chelate reductase 1-like 0.400248
MAN1B1 mannosidase, alpha, class 1B, member 1 0.399779
LOC146513 uncharacterized LOC146513 0.3994
SHROOM3 shroom family member 3 0.3994
ZMYND15 zinc finger, MYND-type containing 15 0.398526
CHODL chondrolectin 0.398246
HPSE2 heparanase 2 (inactive) 0.397176
KCNE1 potassium channel, voltage gated subfamily E regulatory beta subunit 1 0.397048
TTYH1 tweety family member 1 0.396982
LOC100507195 uncharacterized LOC100507195 0.396686
LOC441601 septin 7 pseudogene 0.396323
CAMKMT calmodulin-lysine N-methyltransferase 0.39618
ARHGAP24 Rho GTPase activating protein 24 0.396038
SLC13A5 solute carrier family 13 (sodium-dependent citrate transporter), member 5 0.395481
OBFC1 oligonucleotide/oligosaccharide-binding fold containing 1 0.395413
PLEKHG4B pleckstrin homology domain containing, family G (with RhoGef domain) member 4B 0.394942
MYH9 myosin, heavy chain 9, non-muscle 0.39481
SLC2A7 solute carrier family 2 (facilitated glucose transporter), member 7 0.394614
SLC17A1 solute carrier family 17 (organic anion transporter), member 1 0.394356
SRD5A2 steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) 0.393851
CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin 0.39318
ALKBH6 alkB, alkylation repair homolog 6 (E. coli) 0.393061
SRD5A3 steroid 5 alpha-reductase 3 0.393001
DOCK1 dedicator of cytokinesis 1 0.392192
TMCO6 transmembrane and coiled-coil domains 6 0.39208
PRC1 protein regulator of cytokinesis 1 0.391637
AMICA1 adhesion molecule, interacts with CXADR antigen 1 0.391474
ZC3H3 zinc finger CCCH-type containing 3 0.391474
EHMT2 euchromatic histone-lysine N-methyltransferase 2 0.391474
TRPC7 transient receptor potential cation channel, subfamily C, member 7 0.391313
CA10 carbonic anhydrase X 0.391259
CLIP3 CAP-GLY domain containing linker protein 3 0.391206
SUN5 Sad1 and UNC84 domain containing 5 0.39089
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.390734
SGMS1 sphingomyelin synthase 1 0.390375
CAPN12 calpain 12 0.390224
TCEA3 transcription elongation factor A (SII), 3 0.390174
ZBTB16 zinc finger and BTB domain containing 16 0.390124
EFCAB8 EF-hand calcium binding domain 8 0.390074
MEMO1 mediator of cell motility 1 0.389876
MORF4L1 mortality factor 4 like 1 0.389827
LINGO2 leucine rich repeat and Ig domain containing 2 0.389729
PCDH17 protocadherin 17 0.389248
COL19A1 collagen, type XIX, alpha 1 0.389013
SCARB1 scavenger receptor class B, member 1 0.388551
LOC100506985 uncharacterized LOC100506985 0.388415
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 0.38837
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein) 0.38797
PTPRO protein tyrosine phosphatase, receptor type, O 0.387239
PAQR5 progestin and adipoQ receptor family member V 0.387155
GPA33 glycoprotein A33 (transmembrane) 0.387114
TP53BP1 tumor protein p53 binding protein 1 0.386824
GLDN gliomedin 0.38662
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) 0.386539
JADE2 jade family PHD finger 2 0.386378
PRKG1 protein kinase, cGMP-dependent, type I 0.38618
AIFM2 apoptosis-inducing factor, mitochondrion-associated, 2 0.386101
NIM1K NIM1 serine/threonine protein kinase 0.386101
SP100 SP100 nuclear antigen 0.385867
EBF3 early B-cell factor 3 0.385828
SEMA6D sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D 0.385712
AHSA2 AHA1, activator of heat shock 90kDa protein ATPase homolog 2 (yeast) 0.385559
WNK1 WNK lysine deficient protein kinase 1 0.385559
NUCB2 nucleobindin 2 0.385446
AGBL4 ATP/GTP binding protein-like 4 0.385446
C6ORF7 chromosome 6 open reading frame 7 0.385072
ULK2 unc-51 like autophagy activating kinase 2 0.384815
GTSF1 gametocyte specific factor 1 0.384706
PPARA peroxisome proliferator-activated receptor alpha 0.384706
PSD3 pleckstrin and Sec7 domain containing 3 0.38467
TENM2 teneurin transmembrane protein 2 0.384562
RNF168 ring finger protein 168, E3 ubiquitin protein ligase 0.38445
ATP6V0A4 ATPase, H+ transporting, lysosomal V0 subunit a4 0.384371
SETBP1 SET binding protein 1 0.384332
TAF9 TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa 0.384292
LOC644662 0.383941
DPH6 diphthamine biosynthesis 6 0.383788
MRPL54 mitochondrial ribosomal protein L54 0.383749
LOC285692 uncharacterized LOC285692 0.383409
TMEM255B transmembrane protein 255B 0.383037
ACTN4 actinin, alpha 4 0.382818
MRPL23 mitochondrial ribosomal protein L23 0.382637
FOXP1 forkhead box P1 0.382637
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 0.382211
NELFE negative elongation factor complex member E 0.382106
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 0.381794
EIF3K eukaryotic translation initiation factor 3, subunit K 0.381623
RYR1 ryanodine receptor 1 (skeletal) 0.381487
ZNF229 zinc finger protein 229 0.38142
HS6ST3 heparan sulfate 6-O-sulfotransferase 3 0.381186
LBH limb bud and heart development 0.380889
AMPD3 adenosine monophosphate deaminase 3 0.380152
IP6K2 inositol hexakisphosphate kinase 2 0.38012
DNAH11 dynein, axonemal, heavy chain 11 0.379809
PPA2 pyrophosphatase (inorganic) 2 0.379809
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3 0.379717
SFTPB surfactant protein B 0.378673
KLF12 Kruppel-like factor 12 0.378644
MS4A2 membrane-spanning 4-domains, subfamily A, member 2 0.378558
GPR158 G protein-coupled receptor 158 0.378244
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.378131
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 0.377991
PSMA4 proteasome (prosome, macropain) subunit, alpha type, 4 0.377879
LOC440600 uncharacterized LOC440600 0.377714
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.377549
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.377441
HCG27 HLA complex group 27 (non-protein coding) 0.377306
DLG2 discs, large homolog 2 (Drosophila) 0.377279
CTNNA2 catenin (cadherin-associated protein), alpha 2 0.377119
PARK2 parkin RBR E3 ubiquitin protein ligase 0.377039
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 0.376986
LRRC4C leucine rich repeat containing 4C 0.37696
NUDT3 nudix (nucleoside diphosphate linked moiety X)-type motif 3 0.376854
PITPNM3 PITPNM family member 3 0.376776
CNTN4 contactin 4 0.376439
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.376439
DOCK5 dedicator of cytokinesis 5 0.376414
KMT2E lysine (K)-specific methyltransferase 2E 0.376185
CDH23 cadherin-related 23 0.376084
BAZ1A bromodomain adjacent to zinc finger domain, 1A 0.375934
SORBS3 sorbin and SH3 domain containing 3 0.375735
MCHR2 melanin-concentrating hormone receptor 2 0.375686
BSN bassoon presynaptic cytomatrix protein 0.375588
DGKI diacylglycerol kinase, iota 0.375515
REM1 RAS (RAD and GEM)-like GTP-binding 1 0.375515
TMEM222 transmembrane protein 222 0.375418
EFR3A EFR3 homolog A (S. cerevisiae) 0.375321
CEP128 centrosomal protein 128kDa 0.375034
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) 0.374751
PKHD1 polycystic kidney and hepatic disease 1 (autosomal recessive) 0.374109
RNF165 ring finger protein 165 0.373974
FMN1 formin 1 0.373952
GABRB1 gamma-aminobutyric acid (GABA) A receptor, beta 1 0.373863
MIR3135B microRNA 3135b 0.373774
AADACL3 arylacetamide deacetylase-like 3 0.373686
ATP8A2 ATPase, aminophospholipid transporter, class I, type 8A, member 2 0.373686
ROR1 receptor tyrosine kinase-like orphan receptor 1 0.373165
PCDHA9 protocadherin alpha 9 0.372973
RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated) 0.372867
ARID1A AT rich interactive domain 1A (SWI-like) 0.372867
LINC00473 long intergenic non-protein coding RNA 473 0.372783
UBOX5 U-box domain containing 5 0.372721
INSC inscuteable homolog (Drosophila) 0.372617
SCAF11 SR-related CTD-associated factor 11 0.372431
TGFB2 transforming growth factor, beta 2 0.372328
LOXHD1 lipoxygenase homology domains 1 0.372267
MARCH1 membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase 0.372227
SECISBP2L SECIS binding protein 2-like 0.372025
MTHFR methylenetetrahydrofolate reductase (NAD(P)H) 0.371964
HS3ST4 heparan sulfate (glucosamine) 3-O-sulfotransferase 4 0.371865
SLIT3 slit homolog 3 (Drosophila) 0.371825
MROH2A maestro heat-like repeat family member 2A 0.371746
RAI1 retinoic acid induced 1 0.371667
ZNF287 zinc finger protein 287 0.371627
MTUS1 microtubule associated tumor suppressor 1 0.371354
ADGRB3 adhesion G protein-coupled receptor B3 0.371335
SH2D4B SH2 domain containing 4B 0.371162
PDGFB platelet-derived growth factor beta polypeptide 0.371104
SASH1 SAM and SH3 domain containing 1 0.370931
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.370911
ONECUT2 one cut homeobox 2 0.370772
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.36998
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 0.36942
PTCHD3 patched domain containing 3 0.368005
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 0.368005
LAMA4 laminin, alpha 4 0.3675
XPO1 exportin 1 0.365759
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1 0.364446
CDH10 cadherin 10, type 2 (T2-cadherin) 0.363755
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1 0.363089
TACC2 transforming, acidic coiled-coil containing protein 2 0.360299
TBC1D22A TBC1 domain family, member 22A 0.359527
PBX1 pre-B-cell leukemia homeobox 1 0.35889
NEBL nebulette 0.358275
GSG1L GSG1-like 0.357293
KLHL31 kelch-like family member 31 0.356263
TSPAN9 tetraspanin 9 0.354052
LHFP lipoma HMGIC fusion partner 0.352816
SPACA1 sperm acrosome associated 1 0.352561
MAPK4 mitogen-activated protein kinase 4 0.35206
C3 complement component 3 0.351015
F2RL2 coagulation factor II (thrombin) receptor-like 2 0.349005
CARD8 caspase recruitment domain family, member 8 0.348446
LGMN legumain 0.345804
C2ORF74 chromosome 2 open reading frame 74 0.345386
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 0.343852
WWOX WW domain containing oxidoreductase 0.335564
SPRED1 sprouty-related, EVH1 domain containing 1 0.335564
KSR2 kinase suppressor of ras 2 0.335476
TSPAN33 tetraspanin 33 0.326244
FRMD5 FERM domain containing 5 0.325063