lumicolchicine-3254 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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193 genes differentially expressed following the lumicolchicine-3254 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AAGAB alpha- and gamma-adaptin binding protein
ACVR1B activin A receptor, type IB
AGO4 argonaute RISC catalytic component 4
AKR1C1 aldo-keto reductase family 1, member C1
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
AP2B1 adaptor-related protein complex 2, beta 1 subunit
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28
ARNT aryl hydrocarbon receptor nuclear translocator
ART1 ADP-ribosyltransferase 1
ASB1 ankyrin repeat and SOCS box containing 1
ASPH aspartate beta-hydroxylase
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4
C17ORF59 chromosome 17 open reading frame 59
C3 complement component 3
CALB1 calbindin 1, 28kDa
CAMTA2 calmodulin binding transcription activator 2
CASP1 caspase 1, apoptosis-related cysteine peptidase
CCDC85C coiled-coil domain containing 85C
CDC25A cell division cycle 25A
CDIP1 cell death-inducing p53 target 1
CENPO centromere protein O
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)
CST4 cystatin S
CYTH1 cytohesin 1
DICER1 dicer 1, ribonuclease type III
DLK2 delta-like 2 homolog (Drosophila)
DNAAF1 dynein, axonemal, assembly factor 1
ECE1 endothelin converting enzyme 1
EDRF1 erythroid differentiation regulatory factor 1
ERP44 endoplasmic reticulum protein 44
ETV5 ets variant 5
EWSR1 EWS RNA-binding protein 1
FAM120C family with sequence similarity 120C
FBXL7 F-box and leucine-rich repeat protein 7
FCMR Fc fragment of IgM receptor
FHIT fragile histidine triad
FRMD4B FERM domain containing 4B
FSCN1 fascin actin-bundling protein 1
GK glycerol kinase
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HIPK2 homeodomain interacting protein kinase 2
HN1L hematological and neurological expressed 1-like
HPS1 Hermansky-Pudlak syndrome 1
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
KCTD17 potassium channel tetramerization domain containing 17
LONRF3 LON peptidase N-terminal domain and ring finger 3
LTBP4 latent transforming growth factor beta binding protein 4
MAGEA5 melanoma antigen family A5
MAPK14 mitogen-activated protein kinase 14
MATK megakaryocyte-associated tyrosine kinase
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MDM4 MDM4, p53 regulator
MED28 mediator complex subunit 28
MOCS1 molybdenum cofactor synthesis 1
MST1L macrophage stimulating 1-like
MYB v-myb avian myeloblastosis viral oncogene homolog
MYL4 myosin, light chain 4, alkali; atrial, embryonic
NGDN neuroguidin, EIF4E binding protein
NR4A1 nuclear receptor subfamily 4, group A, member 1
OR7A5 olfactory receptor, family 7, subfamily A, member 5
PAIP2B poly(A) binding protein interacting protein 2B
PDE3B phosphodiesterase 3B, cGMP-inhibited
PDPR pyruvate dehydrogenase phosphatase regulatory subunit
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PLCD1 phospholipase C, delta 1
PLTP phospholipid transfer protein
PNRC1 proline-rich nuclear receptor coactivator 1
POM121L2 POM121 transmembrane nucleoporin-like 2
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
RAB6A RAB6A, member RAS oncogene family
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RBM19 RNA binding motif protein 19
RHEB Ras homolog enriched in brain
RHOH ras homolog family member H
RPL10L ribosomal protein L10-like
RRBP1 ribosome binding protein 1
S100A13 S100 calcium binding protein A13
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)
SH3BP2 SH3-domain binding protein 2
SIM2 single-minded family bHLH transcription factor 2
SLC35E2 solute carrier family 35, member E2
SSBP3 single stranded DNA binding protein 3
STC1 stanniocalcin 1
STRA6 stimulated by retinoic acid 6
STRN3 striatin, calmodulin binding protein 3
SUGP1 SURP and G patch domain containing 1
SYNRG synergin, gamma
TMEM120B transmembrane protein 120B
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMLHE trimethyllysine hydroxylase, epsilon
TNFRSF4 tumor necrosis factor receptor superfamily, member 4
TTC39A tetratricopeptide repeat domain 39A
UBTD1 ubiquitin domain containing 1
UTRN utrophin
ZNF444 zinc finger protein 444

decreased expression

Symbol Name
AES amino-terminal enhancer of split
ALOX12P2 arachidonate 12-lipoxygenase pseudogene 2
ARHGDIG Rho GDP dissociation inhibitor (GDI) gamma
ARRB1 arrestin, beta 1
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1
BCAS1 breast carcinoma amplified sequence 1
BPGM 2,3-bisphosphoglycerate mutase
BTF3P12 basic transcription factor 3 pseudogene 12
C19ORF40 chromosome 19 open reading frame 40
C4ORF29 chromosome 4 open reading frame 29
CALCOCO1 calcium binding and coiled-coil domain 1
CCNO cyclin O
CCZ1B CCZ1 vacuolar protein trafficking and biogenesis associated homolog B (S. cerevisiae)
COL4A5 collagen, type IV, alpha 5
COQ4 coenzyme Q4
CORO2A coronin, actin binding protein, 2A
CSTA cystatin A (stefin A)
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila)
EFNA3 ephrin-A3
EHHADH enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase
ERCC4 excision repair cross-complementation group 4
FAAH fatty acid amide hydrolase
FADS2 fatty acid desaturase 2
FBXO22 F-box protein 22
FBXW12 F-box and WD repeat domain containing 12
FKBPL FK506 binding protein like
FLRT3 fibronectin leucine rich transmembrane protein 3
GINS4 GINS complex subunit 4 (Sld5 homolog)
GLI3 GLI family zinc finger 3
GPX2 glutathione peroxidase 2
GTF2I general transcription factor IIi
GUSBP3 glucuronidase, beta pseudogene 3
HDAC11 histone deacetylase 11
HOXC10 homeobox C10
HPS6 Hermansky-Pudlak syndrome 6
HSPA1L heat shock 70kDa protein 1-like
INF2 inverted formin, FH2 and WH2 domain containing
KBTBD11 kelch repeat and BTB (POZ) domain containing 11
KCNMB4 potassium channel subfamily M regulatory beta subunit 4
KDM5C lysine (K)-specific demethylase 5C
KIAA0513 KIAA0513
LAMA5 laminin, alpha 5
LRRC37A2 leucine rich repeat containing 37, member A2
LY6D lymphocyte antigen 6 complex, locus D
LYPD1 LY6/PLAUR domain containing 1
MBOAT2 membrane bound O-acyltransferase domain containing 2
MBTD1 mbt domain containing 1
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
METTL2B methyltransferase like 2B
MFAP2 microfibrillar-associated protein 2
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
PARP16 poly (ADP-ribose) polymerase family, member 16
PCDHA9 protocadherin alpha 9
PLA2G10 phospholipase A2, group X
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2
PP14571 uncharacterized LOC100130449
PRICKLE3 prickle homolog 3 (Drosophila)
PTDSS2 phosphatidylserine synthase 2
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RGP1 RGP1 retrograde golgi transport homolog (S. cerevisiae)
RWDD3 RWD domain containing 3
SECTM1 secreted and transmembrane 1
SLC12A9 solute carrier family 12, member 9
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SLC4A8 solute carrier family 4, sodium bicarbonate cotransporter, member 8
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
SPRYD7 SPRY domain containing 7
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma)
STAG3 stromal antigen 3
STAG3L1 stromal antigen 3-like 1 (pseudogene)
STAG3L4 stromal antigen 3-like 4 (pseudogene)
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
TAOK1 TAO kinase 1
TDRD1 tudor domain containing 1
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor)
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TMEM209 transmembrane protein 209
TMEM53 transmembrane protein 53
TRMT2B tRNA methyltransferase 2 homolog B (S. cerevisiae)
USB1 U6 snRNA biogenesis 1
USP20 ubiquitin specific peptidase 20
USP36 ubiquitin specific peptidase 36
WDR76 WD repeat domain 76
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
ZFHX3 zinc finger homeobox 3
ZNF141 zinc finger protein 141
ZNF160 zinc finger protein 160
ZNF282 zinc finger protein 282
ZNF329 zinc finger protein 329
ZNF652 zinc finger protein 652
ZNF778 zinc finger protein 778