lovastatin-4978 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the lovastatin-4978 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
ARRB1 arrestin, beta 1
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
ATF3 activating transcription factor 3
BAX BCL2-associated X protein
BMP4 bone morphogenetic protein 4
C8ORF60 chromosome 8 open reading frame 60
CABIN1 calcineurin binding protein 1
CARF calcium responsive transcription factor
CASP10 caspase 10, apoptosis-related cysteine peptidase
CCNG2 cyclin G2
CD6 CD6 molecule
CDHR2 cadherin-related family member 2
CDK13 cyclin-dependent kinase 13
CFHR4 complement factor H-related 4
CLCN7 chloride channel, voltage-sensitive 7
CLIC5 chloride intracellular channel 5
CLTA clathrin, light chain A
CPN2 carboxypeptidase N, polypeptide 2
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DDIT3 DNA-damage-inducible transcript 3
DUSP4 dual specificity phosphatase 4
EGR1 early growth response 1
EPS15L1 epidermal growth factor receptor pathway substrate 15-like 1
ERC2-IT1 ERC2 intronic transcript 1
FAM46C family with sequence similarity 46, member C
FOS FBJ murine osteosarcoma viral oncogene homolog
FSCN3 fascin actin-bundling protein 3, testicular
FUZ fuzzy planar cell polarity protein
GAMT guanidinoacetate N-methyltransferase
GPER1 G protein-coupled estrogen receptor 1
GSPT1 G1 to S phase transition 1
HIRA histone cell cycle regulator
HIST1H3B histone cluster 1, H3b
HIST1H4F histone cluster 1, H4f
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HOMER3 homer scaffolding protein 3
HSPB6 heat shock protein, alpha-crystallin-related, B6
IL5RA interleukin 5 receptor, alpha
INO80D INO80 complex subunit D
IQSEC2 IQ motif and Sec7 domain 2
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3
KLF2 Kruppel-like factor 2
KLF6 Kruppel-like factor 6
LAT2 linker for activation of T cells family, member 2
LMF2 lipase maturation factor 2
LMNB1 lamin B1
LRRC37A3 leucine rich repeat containing 37, member A3
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP4 microtubule-associated protein 4
MCOLN3 mucolipin 3
MED16 mediator complex subunit 16
MON2 MON2 homolog (S. cerevisiae)
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
NAT6 N-acetyltransferase 6 (GCN5-related)
NDRG2 NDRG family member 2
NDUFA2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa
NOVA2 neuro-oncological ventral antigen 2
NPM3 nucleophosmin/nucleoplasmin 3
NR2F6 nuclear receptor subfamily 2, group F, member 6
NUCB1 nucleobindin 1
PCDH11X protocadherin 11 X-linked
PCDHGA10 protocadherin gamma subfamily A, 10
PCNX pecanex homolog (Drosophila)
PIGC phosphatidylinositol glycan anchor biosynthesis, class C
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PLCE1 phospholipase C, epsilon 1
PLCG1 phospholipase C, gamma 1
PLG plasminogen
PLK3 polo-like kinase 3
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha
RAD23B RAD23 homolog B (S. cerevisiae)
RBM3 RNA binding motif (RNP1, RRM) protein 3
RBM5 RNA binding motif protein 5
RPS4Y1 ribosomal protein S4, Y-linked 1
RTEL1 regulator of telomere elongation helicase 1
SAYSD1 SAYSVFN motif domain containing 1
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPINK1 serine peptidase inhibitor, Kazal type 1
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
TAS2R1 taste receptor, type 2, member 1
TAT tyrosine aminotransferase
TBC1D19 TBC1 domain family, member 19
TEP1 telomerase-associated protein 1
TFF2 trefoil factor 2
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TRHDE thyrotropin-releasing hormone degrading enzyme
TTC9 tetratricopeptide repeat domain 9
TUBGCP3 tubulin, gamma complex associated protein 3
UBE2J1 ubiquitin-conjugating enzyme E2, J1
VTCN1 V-set domain containing T cell activation inhibitor 1

decreased expression

Symbol Name
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6
ACSF2 acyl-CoA synthetase family member 2
ADCY7 adenylate cyclase 7
ALKBH4 alkB, alkylation repair homolog 4 (E. coli)
ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like
B3GALT4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
BAP1 BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
C19ORF73 chromosome 19 open reading frame 73
C5ORF45 chromosome 5 open reading frame 45
CA5BP1 carbonic anhydrase VB pseudogene 1
CABYR calcium binding tyrosine-(Y)-phosphorylation regulated
CDC25A cell division cycle 25A
CHKB choline kinase beta
CST6 cystatin E/M
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
CTNNBL1 catenin, beta like 1
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
ELMO3 engulfment and cell motility 3
FAM50B family with sequence similarity 50, member B
FBXL6 F-box and leucine-rich repeat protein 6
FBXO22 F-box protein 22
FGD1 FYVE, RhoGEF and PH domain containing 1
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HIST1H2AL histone cluster 1, H2al
HOXC13 homeobox C13
HSPA1L heat shock 70kDa protein 1-like
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled
IER3IP1 immediate early response 3 interacting protein 1
IFI27 interferon, alpha-inducible protein 27
IFI35 interferon-induced protein 35
IFI6 interferon, alpha-inducible protein 6
IFNAR1 interferon (alpha, beta and omega) receptor 1
IRAK4 interleukin-1 receptor-associated kinase 4
ITGA10 integrin, alpha 10
ITPKB inositol-trisphosphate 3-kinase B
KCTD7 potassium channel tetramerization domain containing 7
KIAA0754 KIAA0754
LRFN3 leucine rich repeat and fibronectin type III domain containing 3
LRRC20 leucine rich repeat containing 20
MCTP1 multiple C2 domains, transmembrane 1
MMP15 matrix metallopeptidase 15 (membrane-inserted)
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
NDUFAF5 NADH dehydrogenase (ubiquinone) complex I, assembly factor 5
NPTX1 neuronal pentraxin I
NT5E 5'-nucleotidase, ecto (CD73)
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
ONECUT2 one cut homeobox 2
PCSK7 proprotein convertase subtilisin/kexin type 7
PEX26 peroxisomal biogenesis factor 26
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
POLL polymerase (DNA directed), lambda
PROCR protein C receptor, endothelial
PRODH proline dehydrogenase (oxidase) 1
RAB30 RAB30, member RAS oncogene family
RABL6 RAB, member RAS oncogene family-like 6
RNF39 ring finger protein 39
ROBO3 roundabout, axon guidance receptor, homolog 3 (Drosophila)
RPL13P5 ribosomal protein L13 pseudogene 5
RRP9 ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast)
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
SIX1 SIX homeobox 1
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
SOWAHC sosondowah ankyrin repeat domain family member C
SPINK5 serine peptidase inhibitor, Kazal type 5
SPRY2 sprouty homolog 2 (Drosophila)
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast)
TMEM242 transmembrane protein 242
TMEM51 transmembrane protein 51
TRIM21 tripartite motif containing 21
TUBA3C tubulin, alpha 3c
UPK3B uroplakin 3B
USP27X ubiquitin specific peptidase 27, X-linked
WDR62 WD repeat domain 62
WFDC2 WAP four-disulfide core domain 2
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
XYLT2 xylosyltransferase II
ZBTB48 zinc finger and BTB domain containing 48
ZC3H3 zinc finger CCCH-type containing 3
ZNF136 zinc finger protein 136
ZNF14 zinc finger protein 14
ZNF16 zinc finger protein 16
ZNF219 zinc finger protein 219
ZNF282 zinc finger protein 282
ZNF304 zinc finger protein 304
ZNF329 zinc finger protein 329
ZNF34 zinc finger protein 34
ZNF747 zinc finger protein 747
ZNF804A zinc finger protein 804A