lossoffunction Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
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Genes

318 genes co-occuring with the biological term lossoffunction in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
AAGAB alpha- and gamma-adaptin binding protein
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCA4 ATP-binding cassette, sub-family A (ABC1), member 4
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ACADM acyl-CoA dehydrogenase, C-4 to C-12 straight chain
ACVRL1 activin A receptor type II-like 1
ADAM17 ADAM metallopeptidase domain 17
ADIPOQ adiponectin, C1Q and collagen domain containing
ADRA2A adrenoceptor alpha 2A
ADRB2 adrenoceptor beta 2, surface
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ALAS2 5'-aminolevulinate synthase 2
ALOX12B arachidonate 12-lipoxygenase, 12R type
ALOXE3 arachidonate lipoxygenase 3
ANGPTL3 angiopoietin-like 3
ANK2 ankyrin 2, neuronal
APOB apolipoprotein B
APOC3 apolipoprotein C-III
APP amyloid beta (A4) precursor protein
APTX aprataxin
ARF6 ADP-ribosylation factor 6
ARG1 arginase 1
ARX aristaless related homeobox
ASPA aspartoacylase
ASXL1 additional sex combs like transcriptional regulator 1
ATAD5 ATPase family, AAA domain containing 5
ATP13A2 ATPase type 13A2
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide
ATP6V0A2 ATPase, H+ transporting, lysosomal V0 subunit a2
ATXN1 ataxin 1
AVPR2 arginine vasopressin receptor 2
BACE1 beta-site APP-cleaving enzyme 1
BAP1 BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
BLK BLK proto-oncogene, Src family tyrosine kinase
BMP4 bone morphogenetic protein 4
BRCA2 breast cancer 2, early onset
BRCC3 BRCA1/BRCA2-containing complex, subunit 3
BRF1 BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit
BTK Bruton agammaglobulinemia tyrosine kinase
C1GALT1C1 C1GALT1-specific chaperone 1
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1
CACNB2 calcium channel, voltage-dependent, beta 2 subunit
CAMTA1 calmodulin binding transcription activator 1
CASR calcium-sensing receptor
CCM2 cerebral cavernous malformation 2
CECR1 cat eye syndrome chromosome region, candidate 1
CES1P1 carboxylesterase 1 pseudogene 1
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CHD2 chromodomain helicase DNA binding protein 2
CHEK1 checkpoint kinase 1
CHL1 cell adhesion molecule L1-like
CHM choroideremia (Rab escort protein 1)
CKAP2L cytoskeleton associated protein 2-like
CLDN1 claudin 1
CLMP CXADR-like membrane protein
CNP 2',3'-cyclic nucleotide 3' phosphodiesterase
COL2A1 collagen, type II, alpha 1
COPS2 COP9 signalosome subunit 2
CP ceruloplasmin (ferroxidase)
CPSF6 cleavage and polyadenylation specific factor 6, 68kDa
CSF3R colony stimulating factor 3 receptor (granulocyte)
CSTA cystatin A (stefin A)
CTRC chymotrypsin C (caldecrin)
CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
CYP4A11 cytochrome P450, family 4, subfamily A, polypeptide 11
DAPK3 death-associated protein kinase 3
DDAH1 dimethylarginine dimethylaminohydrolase 1
DDR2 discoidin domain receptor tyrosine kinase 2
DEPDC5 DEP domain containing 5
DGAT1 diacylglycerol O-acyltransferase 1
DMD dystrophin
DMRT1 doublesex and mab-3 related transcription factor 1
DNAAF3 dynein, axonemal, assembly factor 3
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3
DNASE1L1 deoxyribonuclease I-like 1
DRC1 dynein regulatory complex subunit 1
DSP desmoplakin
EFTUD2 elongation factor Tu GTP binding domain containing 2
EGFR epidermal growth factor receptor
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EPAS1 endothelial PAS domain protein 1
ERBB4 erb-b2 receptor tyrosine kinase 4
ERG v-ets avian erythroblastosis virus E26 oncogene homolog
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FAM134B family with sequence similarity 134, member B
FAM161A family with sequence similarity 161, member A
FAM20A family with sequence similarity 20, member A
FANCB Fanconi anemia, complementation group B
FBLIM1 filamin binding LIM protein 1
FECH ferrochelatase
FERMT1 fermitin family member 1
FERMT2 fermitin family member 2
FGF8 fibroblast growth factor 8 (androgen-induced)
FGFR1 fibroblast growth factor receptor 1
FGFR3 fibroblast growth factor receptor 3
FHL1 four and a half LIM domains 1
FLG filaggrin
FLT3 fms-related tyrosine kinase 3
FOXM1 forkhead box M1
FUS FUS RNA binding protein
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2
GATA4 GATA binding protein 4
GATA5 GATA binding protein 5
GATA6 GATA binding protein 6
GDF1 growth differentiation factor 1
GJA8 gap junction protein, alpha 8, 50kDa
GJB2 gap junction protein, beta 2, 26kDa
GNAS GNAS complex locus
GNB2L1 guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
GOLPH3 golgi phosphoprotein 3 (coat-protein)
GORAB golgin, RAB6-interacting
GPC3 glypican 3
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GPR143 G protein-coupled receptor 143
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1
GRK5 G protein-coupled receptor kinase 5
GRN granulin
GSK3B glycogen synthase kinase 3 beta
HAMP hepcidin antimicrobial peptide
HCCS holocytochrome c synthase
HCN2 hyperpolarization activated cyclic nucleotide gated potassium channel 2
HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4
HDAC8 histone deacetylase 8
HNF1A HNF1 homeobox A
HNF4A hepatocyte nuclear factor 4, alpha
HNRNPLL heterogeneous nuclear ribonucleoprotein L-like
HOXA9 homeobox A9
HOXC13 homeobox C13
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IDH3B isocitrate dehydrogenase 3 (NAD+) beta
IGF1R insulin-like growth factor 1 receptor
IGSF1 immunoglobulin superfamily, member 1
IL10RA interleukin 10 receptor, alpha
IL18R1 interleukin 18 receptor 1
IL18RAP interleukin 18 receptor accessory protein
IL1R1 interleukin 1 receptor, type I
IL23R interleukin 23 receptor
IL6 interleukin 6
ILDR1 immunoglobulin-like domain containing receptor 1
ISPD isoprenoid synthase domain containing
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITGB6 integrin, beta 6
JPH2 junctophilin 2
KANSL1 KAT8 regulatory NSL complex subunit 1
KARS lysyl-tRNA synthetase
KCNC1 potassium channel, voltage gated Shaw related subfamily C, member 1
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1
KIF14 kinesin family member 14
KIF1B kinesin family member 1B
KISS1R KISS1 receptor
KL klotho
KLK1 kallikrein 1
KRIT1 KRIT1, ankyrin repeat containing
KRT5 keratin 5, type II
L1CAM L1 cell adhesion molecule
LAMB2 laminin, beta 2 (laminin S)
LGI1 leucine-rich, glioma inactivated 1
LIPG lipase, endothelial
LITAF lipopolysaccharide-induced TNF factor
LPL lipoprotein lipase
LRP6 low density lipoprotein receptor-related protein 6
LRRC6 leucine rich repeat containing 6
LZTR1 leucine-zipper-like transcription regulator 1
MBD1 methyl-CpG binding domain protein 1
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
MC2R melanocortin 2 receptor (adrenocorticotropic hormone)
MC4R melanocortin 4 receptor
MCHR1 melanin-concentrating hormone receptor 1
MECP2 methyl CpG binding protein 2
MGME1 mitochondrial genome maintenance exonuclease 1
MICU1 mitochondrial calcium uptake 1
MIR142 microRNA 142
MSH3 mutS homolog 3
MSTN myostatin
MTM1 myotubularin 1
MURC muscle-related coiled-coil protein
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYD88 myeloid differentiation primary response 88
MYLK myosin light chain kinase
MYO5B myosin VB
NCSTN nicastrin
NEUROD1 neuronal differentiation 1
NF1 neurofibromin 1
NIPBL Nipped-B homolog (Drosophila)
NKX2-5 NK2 homeobox 5
NKX3-1 NK3 homeobox 1
NLGN2 neuroligin 2
NOD2 nucleotide-binding oligomerization domain containing 2
NRL neural retina leucine zipper
NSD1 nuclear receptor binding SET domain protein 1
NUMB numb homolog (Drosophila)
OCLN occludin
OPTN optineurin
OTX2 orthodenticle homeobox 2
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7
PALB2 partner and localizer of BRCA2
PARK2 parkin RBR E3 ubiquitin protein ligase
PARK7 parkinson protein 7
PAX6 paired box 6
PAX9 paired box 9
PBRM1 polybromo 1
PCNT pericentrin
PCSK9 proprotein convertase subtilisin/kexin type 9
PCYT1A phosphate cytidylyltransferase 1, choline, alpha
PDCD10 programmed cell death 10
PHOX2B paired-like homeobox 2b
PINK1 PTEN induced putative kinase 1
PITX2 paired-like homeodomain 2
PKLR pyruvate kinase, liver and RBC
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae)
POMGNT1 protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-)
PON1 paraoxonase 1
POT1 protection of telomeres 1
POU1F1 POU class 1 homeobox 1
POU2F1 POU class 2 homeobox 1
PPARG peroxisome proliferator-activated receptor gamma
PRLR prolactin receptor
PROK2 prokineticin 2
PROKR2 prokineticin receptor 2
PSEN1 presenilin 1
PSENEN presenilin enhancer gamma secretase subunit
PTCH1 patched 1
PTH1R parathyroid hormone 1 receptor
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
PTPRT protein tyrosine phosphatase, receptor type, T
RAB18 RAB18, member RAS oncogene family
RAB5A RAB5A, member RAS oncogene family
RAD51D RAD51 paralog D
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1
RBM28 RNA binding motif protein 28
RDH12 retinol dehydrogenase 12 (all-trans/9-cis/11-cis)
RET ret proto-oncogene
RIN1 Ras and Rab interactor 1
RNASET2 ribonuclease T2
SBF2 SET binding factor 2
SCN1A sodium channel, voltage gated, type I alpha subunit
SCN5A sodium channel, voltage gated, type V alpha subunit
SCN9A sodium channel, voltage gated, type IX alpha subunit
SDHA succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
SDHAF2 succinate dehydrogenase complex assembly factor 2
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
SETD1A SET domain containing 1A
SETD2 SET domain containing 2
SETX senataxin
SIL1 SIL1 nucleotide exchange factor
SIX3 SIX homeobox 3
SLC12A4 solute carrier family 12 (potassium/chloride transporter), member 4
SLC22A1 solute carrier family 22 (organic cation transporter), member 1
SLC22A12 solute carrier family 22 (organic anion/urate transporter), member 12
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5
SLC29A3 solute carrier family 29 (equilibrative nucleoside transporter), member 3
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9
SLC40A1 solute carrier family 40 (iron-regulated transporter), member 1
SLC46A1 solute carrier family 46 (folate transporter), member 1
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3
SLC9A9 solute carrier family 9, subfamily A (NHE9, cation proton antiporter 9), member 9
SMAP1 small ArfGAP 1
SOCS6 suppressor of cytokine signaling 6
SOX10 SRY (sex determining region Y)-box 10
SP4 Sp4 transcription factor
SPATA7 spermatogenesis associated 7
SPG11 spastic paraplegia 11 (autosomal recessive)
SPG7 spastic paraplegia 7 (pure and complicated autosomal recessive)
SPINK1 serine peptidase inhibitor, Kazal type 1
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SREBF1 sterol regulatory element binding transcription factor 1
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
SYN1 synapsin I
TAC3 tachykinin 3
TACR3 tachykinin receptor 3
TARDBP TAR DNA binding protein
TAZ tafazzin
TBC1D20 TBC1 domain family, member 20
TBX1 T-box 1
TDGF1 teratocarcinoma-derived growth factor 1
TDP1 tyrosyl-DNA phosphodiesterase 1
TDRD7 tudor domain containing 7
TERT telomerase reverse transcriptase
TET2 tet methylcytosine dioxygenase 2
TLN1 talin 1
TLR2 toll-like receptor 2
TLR3 toll-like receptor 3
TMPRSS2 transmembrane protease, serine 2
TP53 tumor protein p53
TPH2 tryptophan hydroxylase 2
TRAP1 TNF receptor-associated protein 1
TRAPPC9 trafficking protein particle complex 9
TRPM6 transient receptor potential cation channel, subfamily M, member 6
TRPV4 transient receptor potential cation channel, subfamily V, member 4
TSHR thyroid stimulating hormone receptor
TYMP thymidine phosphorylase
TYROBP TYRO protein tyrosine kinase binding protein
UBE2L6 ubiquitin-conjugating enzyme E2L 6
UNC13D unc-13 homolog D (C. elegans)
UTRN utrophin
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
VWF von Willebrand factor
WASL Wiskott-Aldrich syndrome-like
WEE1 WEE1 G2 checkpoint kinase
WFS1 Wolfram syndrome 1 (wolframin)
WRN Werner syndrome, RecQ helicase-like
YAP1 Yes-associated protein 1
ZIC2 Zic family member 2
ZMPSTE24 zinc metallopeptidase STE24
ZNF469 zinc finger protein 469