loracarbef-2970 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the loracarbef-2970 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADGRG2 adhesion G protein-coupled receptor G2
ADORA1 adenosine A1 receptor
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ANGPTL2 angiopoietin-like 2
AP1B1 adaptor-related protein complex 1, beta 1 subunit
APOC1 apolipoprotein C-I
APOE apolipoprotein E
ARID1A AT rich interactive domain 1A (SWI-like)
BCR breakpoint cluster region
BMP6 bone morphogenetic protein 6
CAPN15 calpain 15
CCDC106 coiled-coil domain containing 106
CCDC57 coiled-coil domain containing 57
CCDC85B coiled-coil domain containing 85B
CD47 CD47 molecule
CDK20 cyclin-dependent kinase 20
CDKL1 cyclin-dependent kinase-like 1 (CDC2-related kinase)
CEP164 centrosomal protein 164kDa
CIZ1 CDKN1A interacting zinc finger protein 1
CLCN4 chloride channel, voltage-sensitive 4
CLUH clustered mitochondria (cluA/CLU1) homolog
COL4A2 collagen, type IV, alpha 2
CORT cortistatin
CSF3R colony stimulating factor 3 receptor (granulocyte)
CTTN cortactin
CYLD cylindromatosis (turban tumor syndrome)
DCAF15 DDB1 and CUL4 associated factor 15
DHDDS dehydrodolichyl diphosphate synthase
DHODH dihydroorotate dehydrogenase (quinone)
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
F12 coagulation factor XII (Hageman factor)
FBRS fibrosin
FBXL6 F-box and leucine-rich repeat protein 6
FBXO41 F-box protein 41
FCAR Fc fragment of IgA receptor
FDX1 ferredoxin 1
FOXA1 forkhead box A1
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)
HPS4 Hermansky-Pudlak syndrome 4
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
IL5RA interleukin 5 receptor, alpha
INPP5D inositol polyphosphate-5-phosphatase, 145kDa
LCMT2 leucine carboxyl methyltransferase 2
LHX2 LIM homeobox 2
LOC399491
LPCAT3 lysophosphatidylcholine acyltransferase 3
LRP6 low density lipoprotein receptor-related protein 6
LRRK1 leucine-rich repeat kinase 1
MAP2K7 mitogen-activated protein kinase kinase 7
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MLH3 mutL homolog 3
MR1 major histocompatibility complex, class I-related
MTA1 metastasis associated 1
MYOZ3 myozenin 3
NAGPA N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
NLE1 notchless homolog 1 (Drosophila)
NR0B1 nuclear receptor subfamily 0, group B, member 1
NTSR1 neurotensin receptor 1 (high affinity)
OMG oligodendrocyte myelin glycoprotein
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PDLIM2 PDZ and LIM domain 2 (mystique)
PDLIM7 PDZ and LIM domain 7 (enigma)
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
PLCD1 phospholipase C, delta 1
PLCG1 phospholipase C, gamma 1
PRR7 proline rich 7 (synaptic)
RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated)
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
RHBDF2 rhomboid 5 homolog 2 (Drosophila)
RHOD ras homolog family member D
RNF40 ring finger protein 40, E3 ubiquitin protein ligase
RPL18 ribosomal protein L18
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4
SAYSD1 SAYSVFN motif domain containing 1
SFI1 Sfi1 homolog, spindle assembly associated (yeast)
SLC15A3 solute carrier family 15 (oligopeptide transporter), member 3
SLCO3A1 solute carrier organic anion transporter family, member 3A1
SMAD3 SMAD family member 3
ST3GAL4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4
STX1A syntaxin 1A (brain)
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae)
TBRG4 transforming growth factor beta regulator 4
TCF7 transcription factor 7 (T-cell specific, HMG-box)
THBS3 thrombospondin 3
TJAP1 tight junction associated protein 1 (peripheral)
TNK2 tyrosine kinase, non-receptor, 2
TPMT thiopurine S-methyltransferase
TRIM29 tripartite motif containing 29
UCN urocortin
UNC13B unc-13 homolog B (C. elegans)
USE1 unconventional SNARE in the ER 1 homolog (S. cerevisiae)
USP20 ubiquitin specific peptidase 20
ZNF428 zinc finger protein 428
ZNF609 zinc finger protein 609
ZNF695 zinc finger protein 695
ZNF710 zinc finger protein 710

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
ABCB4 ATP-binding cassette, sub-family B (MDR/TAP), member 4
ACPP acid phosphatase, prostate
ALS2CL ALS2 C-terminal like
APH1B APH1B gamma secretase subunit
APOL6 apolipoprotein L, 6
APPL2 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2
ARHGAP10 Rho GTPase activating protein 10
ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like
ASCC1 activating signal cointegrator 1 complex subunit 1
BAK1 BCL2-antagonist/killer 1
BHLHE41 basic helix-loop-helix family, member e41
C19ORF40 chromosome 19 open reading frame 40
C5AR1 complement component 5a receptor 1
CCNT1 cyclin T1
CDCP1 CUB domain containing protein 1
CES3 carboxylesterase 3
CFP complement factor properdin
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle)
CIC capicua transcriptional repressor
CLGN calmegin
COL9A2 collagen, type IX, alpha 2
CRELD1 cysteine-rich with EGF-like domains 1
CRYBB2P1 crystallin, beta B2 pseudogene 1
CXORF56 chromosome X open reading frame 56
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
DCAF17 DDB1 and CUL4 associated factor 17
DGKG diacylglycerol kinase, gamma 90kDa
DHRS3 dehydrogenase/reductase (SDR family) member 3
FBXL7 F-box and leucine-rich repeat protein 7
FBXO31 F-box protein 31
FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64)
GDAP1 ganglioside induced differentiation associated protein 1
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3
GEM GTP binding protein overexpressed in skeletal muscle
GK3P glycerol kinase 3 pseudogene
GLTP glycolipid transfer protein
GPR22 G protein-coupled receptor 22
GPR27 G protein-coupled receptor 27
HHLA3 HERV-H LTR-associating 3
HIST1H2AE histone cluster 1, H2ae
HIST1H2AJ histone cluster 1, H2aj
HIST1H2BI histone cluster 1, H2bi
IDI2-AS1 IDI2 antisense RNA 1
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit)
KLHL21 kelch-like family member 21
KLRG1 killer cell lectin-like receptor subfamily G, member 1
LNPEP leucyl/cystinyl aminopeptidase
LZTS3 leucine zipper, putative tumor suppressor family member 3
MAPK3 mitogen-activated protein kinase 3
MBTPS2 membrane-bound transcription factor peptidase, site 2
METTL16 methyltransferase like 16
MILR1 mast cell immunoglobulin-like receptor 1
MRPL44 mitochondrial ribosomal protein L44
MTCP1 mature T-cell proliferation 1
NCS1 neuronal calcium sensor 1
NINJ2 ninjurin 2
NPFFR1 neuropeptide FF receptor 1
OCEL1 occludin/ELL domain containing 1
PLS1 plastin 1
PMFBP1 polyamine modulated factor 1 binding protein 1
POM121 POM121 transmembrane nucleoporin
PRR14L proline rich 14-like
QPCT glutaminyl-peptide cyclotransferase
RAB8B RAB8B, member RAS oncogene family
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RETN resistin
RGP1 RGP1 retrograde golgi transport homolog (S. cerevisiae)
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
RUSC2 RUN and SH3 domain containing 2
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SERTAD3 SERTA domain containing 3
SIGLEC15 sialic acid binding Ig-like lectin 15
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
TCTN2 tectonic family member 2
TGFBR1 transforming growth factor, beta receptor 1
TGFBRAP1 transforming growth factor, beta receptor associated protein 1
TLR6 toll-like receptor 6
TLR8 toll-like receptor 8
TMEM140 transmembrane protein 140
TMEM53 transmembrane protein 53
TRAF1 TNF receptor-associated factor 1
TRANK1 tetratricopeptide repeat and ankyrin repeat containing 1
TRIP10 thyroid hormone receptor interactor 10
TTLL1 tubulin tyrosine ligase-like family member 1
TWSG1 twisted gastrulation BMP signaling modulator 1
ULBP2 UL16 binding protein 2
USP18 ubiquitin specific peptidase 18
ZC3H3 zinc finger CCCH-type containing 3
ZKSCAN8 zinc finger with KRAB and SCAN domains 8
ZNF253 zinc finger protein 253
ZNF329 zinc finger protein 329
ZNF480 zinc finger protein 480
ZNF552 zinc finger protein 552
ZNF93 zinc finger protein 93