loperamide-1949 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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197 genes differentially expressed following the loperamide-1949 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACRV1 acrosomal vesicle protein 1
ACVR2B activin A receptor, type IIB
ADARB1 adenosine deaminase, RNA-specific, B1
AGRP agouti related neuropeptide
ARFIP1 ADP-ribosylation factor interacting protein 1
ARSJ arylsulfatase family, member J
ATAT1 alpha tubulin acetyltransferase 1
ATP5G2 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9)
ATXN2 ataxin 2
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BCL2L14 BCL2-like 14 (apoptosis facilitator)
CA12 carbonic anhydrase XII
CCHCR1 coiled-coil alpha-helical rod protein 1
CCPG1 cell cycle progression 1
CD53 CD53 molecule
CDK19 cyclin-dependent kinase 19
CDS1 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CIZ1 CDKN1A interacting zinc finger protein 1
CLTA clathrin, light chain A
CNOT4 CCR4-NOT transcription complex, subunit 4
COPS7B COP9 signalosome subunit 7B
CPD carboxypeptidase D
CRCP CGRP receptor component
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CTH cystathionine gamma-lyase
CYHR1 cysteine/histidine-rich 1
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
DENND3 DENN/MADD domain containing 3
DGKA diacylglycerol kinase, alpha 80kDa
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DTNA dystrobrevin, alpha
DXO decapping exoribonuclease
EID1 EP300 interacting inhibitor of differentiation 1
ERN2 endoplasmic reticulum to nucleus signaling 2
FGFR1 fibroblast growth factor receptor 1
GAS7 growth arrest-specific 7
GPN3 GPN-loop GTPase 3
GSK3A glycogen synthase kinase 3 alpha
GYG2 glycogenin 2
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HMOX2 heme oxygenase 2
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
INSIG1 insulin induced gene 1
KDM6B lysine (K)-specific demethylase 6B
LDLR low density lipoprotein receptor
LINC00312 long intergenic non-protein coding RNA 312
MAP7D3 MAP7 domain containing 3
MECP2 methyl CpG binding protein 2
MED14 mediator complex subunit 14
MLH3 mutL homolog 3
MSH3 mutS homolog 3
MYL3 myosin, light chain 3, alkali; ventricular, skeletal, slow
MYL4 myosin, light chain 4, alkali; atrial, embryonic
NCKAP1 NCK-associated protein 1
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NFYA nuclear transcription factor Y, alpha
NKX3-1 NK3 homeobox 1
NSD1 nuclear receptor binding SET domain protein 1
PASK PAS domain containing serine/threonine kinase
PBX2 pre-B-cell leukemia homeobox 2
PCIF1 PDX1 C-terminal inhibiting factor 1
PEX13 peroxisomal biogenesis factor 13
PHEX phosphate regulating endopeptidase homolog, X-linked
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PLIN2 perilipin 2
PPP2R1B protein phosphatase 2, regulatory subunit A, beta
PRSS8 protease, serine, 8
PSG9 pregnancy specific beta-1-glycoprotein 9
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
RHAG Rh-associated glycoprotein
RPL7 ribosomal protein L7
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
SFTPB surfactant protein B
SIRT3 sirtuin 3
SKAP2 src kinase associated phosphoprotein 2
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
STX16 syntaxin 16
STX5 syntaxin 5
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
TCP11L1 t-complex 11, testis-specific-like 1
TMEM8B transmembrane protein 8B
TMEM97 transmembrane protein 97
TNFAIP1 tumor necrosis factor, alpha-induced protein 1 (endothelial)
TOMM22 translocase of outer mitochondrial membrane 22 homolog (yeast)
TRD T cell receptor delta locus
UBA5 ubiquitin-like modifier activating enzyme 5
UPK1B uroplakin 1B
VIPR1 vasoactive intestinal peptide receptor 1
WIPI1 WD repeat domain, phosphoinositide interacting 1
WWOX WW domain containing oxidoreductase
WWP2 WW domain containing E3 ubiquitin protein ligase 2
ZKSCAN4 zinc finger with KRAB and SCAN domains 4
ZNF165 zinc finger protein 165
ZNF609 zinc finger protein 609
ZNF611 zinc finger protein 611

decreased expression

Symbol Name
AATK apoptosis-associated tyrosine kinase
ANXA2P3 annexin A2 pseudogene 3
ASB13 ankyrin repeat and SOCS box containing 13
C8ORF60 chromosome 8 open reading frame 60
CTDNEP1 CTD nuclear envelope phosphatase 1
CTDSP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1
DCLRE1B DNA cross-link repair 1B
DDX31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31
DEAF1 DEAF1 transcription factor
DTX4 deltex 4, E3 ubiquitin ligase
EFNB2 ephrin-B2
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
ENO2 enolase 2 (gamma, neuronal)
ERCC2 excision repair cross-complementation group 2
EVA1B eva-1 homolog B (C. elegans)
EVPL envoplakin
EXOSC9 exosome component 9
EXTL2 exostosin-like glycosyltransferase 2
FAM222B family with sequence similarity 222, member B
FAM50B family with sequence similarity 50, member B
FDXR ferredoxin reductase
GBF1 golgi brefeldin A resistant guanine nucleotide exchange factor 1
GPATCH1 G patch domain containing 1
GPKOW G patch domain and KOW motifs
GSTT1 glutathione S-transferase theta 1
H2AFY2 H2A histone family, member Y2
HDHD1 haloacid dehalogenase-like hydrolase domain containing 1
HELLS helicase, lymphoid-specific
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
HMG20A high mobility group 20A
ICAM3 intercellular adhesion molecule 3
JUNB jun B proto-oncogene
KIAA1549L KIAA1549-like
KIFC1 kinesin family member C1
KLHL21 kelch-like family member 21
KRBOX4 KRAB box domain containing 4
LINC00339 long intergenic non-protein coding RNA 339
LIPT1 lipoyltransferase 1
LRRC20 leucine rich repeat containing 20
LYPD1 LY6/PLAUR domain containing 1
MAP3K6 mitogen-activated protein kinase kinase kinase 6
MGA MGA, MAX dimerization protein
MNX1 motor neuron and pancreas homeobox 1
MPG N-methylpurine-DNA glycosylase
MPST mercaptopyruvate sulfurtransferase
MRPL12 mitochondrial ribosomal protein L12
MSRB1 methionine sulfoxide reductase B1
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing
NAP1L3 nucleosome assembly protein 1-like 3
NOL6 nucleolar protein 6 (RNA-associated)
NR1H2 nuclear receptor subfamily 1, group H, member 2
NUDT11 nudix (nucleoside diphosphate linked moiety X)-type motif 11
P3H4 prolyl 3-hydroxylase family member 4 (non-enzymatic)
PCF11 PCF11 cleavage and polyadenylation factor subunit
PCTP phosphatidylcholine transfer protein
PELP1 proline, glutamate and leucine rich protein 1
PEMT phosphatidylethanolamine N-methyltransferase
PFAS phosphoribosylformylglycinamidine synthase
PLEKHO2 pleckstrin homology domain containing, family O member 2
PMM2 phosphomannomutase 2
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit
PPDPF pancreatic progenitor cell differentiation and proliferation factor
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1
PTCD1 pentatricopeptide repeat domain 1
PYGB phosphorylase, glycogen; brain
RNMTL1 RNA methyltransferase like 1
RPL34 ribosomal protein L34
RUVBL2 RuvB-like AAA ATPase 2
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
SEZ6L2 seizure related 6 homolog (mouse)-like 2
SF3B2 splicing factor 3b, subunit 2, 145kDa
SLC10A1 solute carrier family 10 (sodium/bile acid cotransporter), member 1
SLC25A15 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15
SLC25A22 solute carrier family 25 (mitochondrial carrier: glutamate), member 22
SLC31A1 solute carrier family 31 (copper transporter), member 1
SLC4A2 solute carrier family 4 (anion exchanger), member 2
SLC50A1 solute carrier family 50 (sugar efflux transporter), member 1
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5
SOD3 superoxide dismutase 3, extracellular
STK25 serine/threonine kinase 25
TGS1 trimethylguanosine synthase 1
TINF2 TERF1 (TRF1)-interacting nuclear factor 2
TMEM187 transmembrane protein 187
TOE1 target of EGR1, member 1 (nuclear)
TSPYL1 TSPY-like 1
TTI1 TELO2 interacting protein 1
UBAC1 UBA domain containing 1
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2
URGCP upregulator of cell proliferation
VPS4A vacuolar protein sorting 4 homolog A (S. cerevisiae)
WDR13 WD repeat domain 13
ZBED1 zinc finger, BED-type containing 1
ZC3H3 zinc finger CCCH-type containing 3
ZDHHC18 zinc finger, DHHC-type containing 18
ZMYM3 zinc finger, MYM-type 3
ZNF532 zinc finger protein 532
ZNF552 zinc finger protein 552