longevity Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description The length of time of an organism's life. (Experimental Factor Ontology, EFO_0004300)
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Genes

108 genes co-occuring with the biological term longevity in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ACE angiotensin I converting enzyme
ADA adenosine deaminase
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional)
ADIPOQ adiponectin, C1Q and collagen domain containing
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
APOA4 apolipoprotein A-IV
APOB apolipoprotein B
APOC3 apolipoprotein C-III
APOE apolipoprotein E
APP amyloid beta (A4) precursor protein
ASF1A anti-silencing function 1A histone chaperone
ATG12 autophagy related 12
ATG5 autophagy related 5
ATM ATM serine/threonine kinase
BCL2L1 BCL2-like 1
CAMK4 calcium/calmodulin-dependent protein kinase IV
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CETP cholesteryl ester transfer protein, plasma
CFLAR CASP8 and FADD-like apoptosis regulator
CHIT1 chitinase 1 (chitotriosidase)
CLEC4M C-type lectin domain family 4, member M
CNDP1 carnosine dipeptidase 1 (metallopeptidase M20 family)
CRP C-reactive protein, pentraxin-related
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
CYP2C18 cytochrome P450, family 2, subfamily C, polypeptide 18
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
DRD4 dopamine receptor D4
EGFR epidermal growth factor receptor
ELN elastin
ESR1 estrogen receptor 1
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FOXO1 forkhead box O1
FOXO3 forkhead box O3
FOXO4 forkhead box O4
FOXO6 forkhead box O6
GHRHR growth hormone releasing hormone receptor
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3
GPX1 glutathione peroxidase 1
GSTZ1 glutathione S-transferase zeta 1
HFE hemochromatosis
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HNRNPLL heterogeneous nuclear ribonucleoprotein L-like
HSPA1A heat shock 70kDa protein 1A
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
IL10 interleukin 10
IL22 interleukin 22
IL6 interleukin 6
IRS2 insulin receptor substrate 2
IRS4 insulin receptor substrate 4
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
KL klotho
LEP leptin
LPA lipoprotein, Lp(a)
LYN LYN proto-oncogene, Src family tyrosine kinase
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAP3K7 mitogen-activated protein kinase kinase kinase 7
MEFV Mediterranean fever
MLH1 mutL homolog 1
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
MSTN myostatin
MT-CYB cytochrome b
MT1A metallothionein 1A
MT2A metallothionein 2A
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase
MTTP microsomal triglyceride transfer protein
NAMPT nicotinamide phosphoribosyltransferase
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NOS1 nitric oxide synthase 1 (neuronal)
NOS2 nitric oxide synthase 2, inducible
NOS3 nitric oxide synthase 3 (endothelial cell)
PAX4 paired box 4
PCSK1 proprotein convertase subtilisin/kexin type 1
PON1 paraoxonase 1
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PTPN6 protein tyrosine phosphatase, non-receptor type 6
REST RE1-silencing transcription factor
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SIGLEC9 sialic acid binding Ig-like lectin 9
SIRT1 sirtuin 1
SIRT2 sirtuin 2
SIRT3 sirtuin 3
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SOD1 superoxide dismutase 1, soluble
SOD2 superoxide dismutase 2, mitochondrial
SOD3 superoxide dismutase 3, extracellular
TERC telomerase RNA component
TERT telomerase reverse transcriptase
TGFB1 transforming growth factor, beta 1
TLR4 toll-like receptor 4
TNF tumor necrosis factor
TP53 tumor protein p53
TRPA1 transient receptor potential cation channel, subfamily A, member 1
UCP1 uncoupling protein 1 (mitochondrial, proton carrier)
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
XPC xeroderma pigmentosum, complementation group C
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
YTHDF2 YTH N(6)-methyladenosine RNA binding protein 2