longevity Gene Set

Dataset GAD Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description The length of time of an organism's life. (Experimental Factor Ontology, EFO_0004300)
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Genes

102 genes associated with the disease longevity in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ACE angiotensin I converting enzyme
ADARB1 adenosine deaminase, RNA-specific, B1
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional)
ADGRD1 adhesion G protein-coupled receptor D1
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AKR1B15 aldo-keto reductase family 1, member B15
APOA1 apolipoprotein A-I
APOA4 apolipoprotein A-IV
APOC1 apolipoprotein C-I
APOC3 apolipoprotein C-III
APOE apolipoprotein E
ATCAY ataxia, cerebellar, Cayman type
ATRIP ATR interacting protein
BIN2 bridging integrator 2
C3 complement component 3
C4B complement component 4B (Chido blood group)
C7ORF50 chromosome 7 open reading frame 50
CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
CAMK4 calcium/calmodulin-dependent protein kinase IV
CARS cysteinyl-tRNA synthetase
CAT catalase
CBS cystathionine-beta-synthase
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CDH4 cadherin 4, type 1, R-cadherin (retinal)
CHIT1 chitinase 1 (chitotriosidase)
COL5A1 collagen, type V, alpha 1
COL6A3 collagen, type VI, alpha 3
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DRD4 dopamine receptor D4
DUSP6 dual specificity phosphatase 6
ERCC2 excision repair cross-complementation group 2
F2 coagulation factor II (thrombin)
F5 coagulation factor V (proaccelerin, labile factor)
F7 coagulation factor VII (serum prothrombin conversion accelerator)
FGB fibrinogen beta chain
FOXO1 forkhead box O1
FOXO3 forkhead box O3
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B
GSTM1 glutathione S-transferase mu 1
GSTP1 glutathione S-transferase pi 1
GSTT1 glutathione S-transferase theta 1
HFE hemochromatosis
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA1B heat shock 70kDa protein 1B
HSPA1L heat shock 70kDa protein 1-like
IFNG interferon, gamma
IGF2 insulin-like growth factor 2
IL10 interleukin 10
IL12A interleukin 12A
IL2 interleukin 2
IL6 interleukin 6
INS insulin
INSR insulin receptor
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
KL klotho
LPL lipoprotein lipase
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast)
MT-ATP6 ATP synthase F0 subunit 6
MT-ND2 MTND2
MT-ND3 NADH dehydrogenase, subunit 3 (complex I)
MT-TP tRNA
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
NCAM2 neural cell adhesion molecule 2
NLRP1 NLR family, pyrin domain containing 1
NRDE2 NRDE-2, necessary for RNA interference, domain containing
NRXN1 neurexin 1
NTHL1 nth endonuclease III-like 1 (E. coli)
PERP PERP, TP53 apoptosis effector
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PON1 paraoxonase 1
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
RASSF7 Ras association (RalGDS/AF-6) domain family (N-terminal) member 7
SDAD1 SDA1 domain containing 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SIRT3 sirtuin 3
SLC38A10 solute carrier family 38, member 10
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SOD2 superoxide dismutase 2, mitochondrial
ST3GAL3 ST3 beta-galactoside alpha-2,3-sialyltransferase 3
STK24 serine/threonine kinase 24
SVEP1 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
TBC1D22A TBC1 domain family, member 22A
TGFA transforming growth factor, alpha
TH tyrosine hydroxylase
TNF tumor necrosis factor
TP53 tumor protein p53
TSC2 tuberous sclerosis 2
UVSSA UV-stimulated scaffold protein A
VWA5A von Willebrand factor A domain containing 5A
WDR72 WD repeat domain 72
ZNF516 zinc finger protein 516