long qt syndrome Gene Set

Dataset GWASdb SNP-Disease Associations
Category disease or phenotype associations
Type disease
Description An autosomal genetic disease that is characterized by delayed repolarization of the heart following a heartbeat increases the risk of episodes of torsade de pointes (TDP, a form of irregular heartbeat that originates from the ventricles). (Human Disease Ontology, DOID_2843)
External Link http://jjwanglab.org/gwasdb/gwasdb2/gwasdb2/go_trait/DOID:2843
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Genes

62 genes associated with the disease long qt syndrome in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset.

Symbol Name Standardized Value
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein 2.50028
CNOT1 CCR4-NOT transcription complex, subunit 1 2.152
CEP85L centrosomal protein 85kDa-like 2.06757
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1 1.90321
RNF207 ring finger protein 207 1.8787
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 1.83309
SCN5A sodium channel, voltage gated, type V alpha subunit 1.78856
LIG3 ligase III, DNA, ATP-dependent 1.65151
FADS1 fatty acid desaturase 1 1.35434
C18ORF21 chromosome 18 open reading frame 21 1.25477
TCL6 T-cell leukemia/lymphoma 6 (non-protein coding) 1.24194
DPT dermatopontin 1.23976
TMEM44 transmembrane protein 44 1.21996
ARHGAP10 Rho GTPase activating protein 10 1.21996
PTPRG protein tyrosine phosphatase, receptor type, G 1.21019
RPRD1A regulation of nuclear pre-mRNA domain containing 1A 1.1984
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4 1.19386
PDE3A phosphodiesterase 3A, cGMP-inhibited 1.19386
TTN titin 1.14463
IL5RA interleukin 5 receptor, alpha 1.14463
ELMO1 engulfment and cell motility 1 1.14463
TRPM7 transient receptor potential cation channel, subfamily M, member 7 1.14463
CLDN15 claudin 15 1.14463
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2 1.10764
OSBPL6 oxysterol binding protein-like 6 1.10764
CNTNAP2 contactin associated protein-like 2 1.07599
CCND2 cyclin D2 1.07599
PDZRN3 PDZ domain containing ring finger 3 1.07599
CLDN14 claudin 14 1.04846
CAMK1D calcium/calmodulin-dependent protein kinase ID 1.02476
FOXP1 forkhead box P1 1.02476
LDB2 LIM domain binding 2 1.00407
PRKCE protein kinase C, epsilon 0.986376
ADAMTSL1 ADAMTS-like 1 0.986376
ROS1 ROS proto-oncogene 1 , receptor tyrosine kinase 0.986376
FGF14 fibroblast growth factor 14 0.986376
GNAL guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type 0.986376
MBP myelin basic protein 0.971169
CREBBP CREB binding protein 0.971169
NME7 NME/NM23 family member 7 0.960292
NUAK1 NUAK family, SNF1-like kinase, 1 0.960171
UNC13C unc-13 homolog C (C. elegans) 0.959328
FRMD6 FERM domain containing 6 0.958374
NCOA2 nuclear receptor coactivator 2 0.93456
NKX2-5 NK2 homeobox 5 0.865448
DAB1 Dab, reelin signal transducer, homolog 1 (Drosophila) 0.826445
AJAP1 adherens junctions associated protein 1 0.801631
PACSIN1 protein kinase C and casein kinase substrate in neurons 1 0.785362
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.74447
SOX5 SRY (sex determining region Y)-box 5 0.724637
TUSC3 tumor suppressor candidate 3 0.722241
CORIN corin, serine peptidase 0.667834
C11ORF21 chromosome 11 open reading frame 21 0.640498
USP31 ubiquitin specific peptidase 31 0.637975
TCEA3 transcription elongation factor A (SII), 3 0.628075
LPP LIM domain containing preferred translocation partner in lipoma 0.62455
SLC6A5 solute carrier family 6 (neurotransmitter transporter), member 5 0.567598
SLC9A9 solute carrier family 9, subfamily A (NHE9, cation proton antiporter 9), member 9 0.542589
ASTN1 astrotactin 1 0.539566
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.531096
AKAP6 A kinase (PRKA) anchor protein 6 0.524864
LYRM4 LYR motif containing 4 0.524033