long qt syndrome Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description An autosomal genetic disease that is characterized by delayed repolarization of the heart following a heartbeat increases the risk of episodes of torsade de pointes (TDP, a form of irregular heartbeat that originates from the ventricles). (Human Disease Ontology, DOID_2843)
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Genes

161 genes co-occuring with the disease long qt syndrome in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1 4.15841
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2 3.57008
SCN5A sodium channel, voltage gated, type V alpha subunit 3.49146
KCNE1 potassium channel, voltage gated subfamily E regulatory beta subunit 1 3.35661
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2 2.89787
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2 2.60464
ANK2 ankyrin 2, neuronal 2.05135
AKAP9 A kinase (PRKA) anchor protein 9 1.71864
COLQ collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase 1.67412
SNTA1 syntrophin, alpha 1 1.6543
KCNE3 potassium channel, voltage gated subfamily E regulatory beta subunit 3 1.6525
RYR2 ryanodine receptor 2 (cardiac) 1.63993
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5 1.61262
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit 1.49877
ALG10B ALG10B, alpha-1,2-glucosyltransferase 1.47418
SCN4B sodium channel, voltage gated, type IV beta subunit 1.45133
KCNQ3 potassium channel, voltage gated KQT-like subfamily Q, member 3 1.35115
KCNQ2 potassium channel, voltage gated KQT-like subfamily Q, member 2 1.34199
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3 1.32541
CAV3 caveolin 3 1.32105
SCN8A sodium channel, voltage gated, type VIII alpha subunit 1.27563
KCNE5 potassium channel, voltage gated subfamily E regulatory beta subunit 5 1.26516
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 1.21132
KCNA4 potassium channel, voltage gated shaker related subfamily A, member 4 1.18841
SCN3A sodium channel, voltage gated, type III alpha subunit 1.17121
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4 1.13585
SETD6 SET domain containing 6 1.10973
KCND2 potassium channel, voltage gated Shal related subfamily D, member 2 1.10048
KCNC1 potassium channel, voltage gated Shaw related subfamily C, member 1 1.07362
KCNA10 potassium channel, voltage gated shaker related subfamily A, member 10 1.06732
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5 1.06732
HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4 1.0627
KCNJ12 potassium channel, inwardly rectifying subfamily J, member 12 1.0484
HCN2 hyperpolarization activated cyclic nucleotide gated potassium channel 2 1.04209
ALG10 ALG10, alpha-1,2-glucosyltransferase 1.02692
KCNQ4 potassium channel, voltage gated KQT-like subfamily Q, member 4 1.01976
AKAP1 A kinase (PRKA) anchor protein 1 1.0033
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.985585
RAB11B RAB11B, member RAS oncogene family 0.962053
SGK3 serum/glucocorticoid regulated kinase family, member 3 0.960797
KCNH1 potassium channel, voltage gated eag related subfamily H, member 1 0.939534
SCN4A sodium channel, voltage gated, type IV alpha subunit 0.933313
RNF207 ring finger protein 207 0.930414
AP1G2 adaptor-related protein complex 1, gamma 2 subunit 0.929173
RAB43 RAB43, member RAS oncogene family 0.927519
KCNH6 potassium channel, voltage gated eag related subfamily H, member 6 0.924213
NAV1 neuron navigator 1 0.919673
BLVRA biliverdin reductase A 0.912668
CA5B carbonic anhydrase VB, mitochondrial 0.90732
SCN1B sodium channel, voltage gated, type I beta subunit 0.906086
KCNH7 potassium channel, voltage gated eag related subfamily H, member 7 0.892948
KCNA2 potassium channel, voltage gated shaker related subfamily A, member 2 0.880653
KCNB2 potassium channel, voltage gated Shab related subfamily B, member 2 0.869596
GINS3 GINS complex subunit 3 (Psf3 homolog) 0.869596
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.863865
PTPRB protein tyrosine phosphatase, receptor type, B 0.852811
KCTD1 potassium channel tetramerization domain containing 1 0.829049
TPTE transmembrane phosphatase with tensin homology 0.826589
CALM3 calmodulin 3 (phosphorylase kinase, delta) 0.801154
SCN3B sodium channel, voltage gated, type III beta subunit 0.795821
NFASC neurofascin 0.787213
KCNJ4 potassium channel, inwardly rectifying subfamily J, member 4 0.785574
SGK1 serum/glucocorticoid regulated kinase 1 0.774932
KCNA1 potassium channel, voltage gated shaker related subfamily A, member 1 0.763902
GPD1L glycerol-3-phosphate dehydrogenase 1-like 0.759008
MINK1 misshapen-like kinase 1 0.756564
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.756564
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.75005
KCNA6 potassium channel, voltage gated shaker related subfamily A, member 6 0.75005
ERG v-ets avian erythroblastosis virus E26 oncogene homolog 0.734217
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 0.731786
STX12 syntaxin 12 0.716828
KCNG2 potassium channel, voltage gated modifier subfamily G, member 2 0.71078
ENPEP glutamyl aminopeptidase (aminopeptidase A) 0.694301
UPF1 UPF1 regulator of nonsense transcripts homolog (yeast) 0.691495
CANX calnexin 0.688692
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1 0.680297
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15 0.668742
ZNF385B zinc finger protein 385B 0.66755
CACNB3 calcium channel, voltage-dependent, beta 3 subunit 0.654463
DNAJA2 DnaJ (Hsp40) homolog, subfamily A, member 2 0.637102
CASQ2 calsequestrin 2 (cardiac muscle) 0.633169
HIST1H1A histone cluster 1, H1a 0.613574
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1 0.610838
DPP6 dipeptidyl-peptidase 6 0.606543
ADRB1 adrenoceptor beta 1 0.59991
KCNG1 potassium channel, voltage gated modifier subfamily G, member 1 0.59874
FHL2 four and a half LIM domains 2 0.580828
CSMD2 CUB and Sushi multiple domains 2 0.576939
TMEM43 transmembrane protein 43 0.56722
HSPBP1 HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1 0.563335
KCNIP2 Kv channel interacting protein 2 0.560616
TRPM4 transient receptor potential cation channel, subfamily M, member 4 0.539667
IRX5 iroquois homeobox 5 0.536183
CACNA1S calcium channel, voltage-dependent, L type, alpha 1S subunit 0.490454
NOTCH1 notch 1 0.486266
SLC18A1 solute carrier family 18 (vesicular monoamine transporter), member 1 0.482084
KCNB1 potassium channel, voltage gated Shab related subfamily B, member 1 0.469954
GPD1 glycerol-3-phosphate dehydrogenase 1 (soluble) 0.46466
ARHGAP6 Rho GTPase activating protein 6 0.453339
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.448817
NEBL nebulette 0.442418
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.43753
HRH1 histamine receptor H1 0.431144
CAV1 caveolin 1, caveolae protein, 22kDa 0.430393
DNAH8 dynein, axonemal, heavy chain 8 0.421016
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1 0.416147
MYH6 myosin, heavy chain 6, cardiac muscle, alpha 0.413153
FKBP8 FK506 binding protein 8, 38kDa 0.412405
SCN2B sodium channel, voltage gated, type II beta subunit 0.408666
BLOC1S6 biogenesis of lysosomal organelles complex-1, subunit 6, pallidin 0.403438
WNK3 WNK lysine deficient protein kinase 3 0.394118
KCNJ6 potassium channel, inwardly rectifying subfamily J, member 6 0.393746
MYH7 myosin, heavy chain 7, cardiac muscle, beta 0.390769
KCNJ8 potassium channel, inwardly rectifying subfamily J, member 8 0.382966
IRX6 iroquois homeobox 6 0.376661
RFC2 replication factor C (activator 1) 2, 40kDa 0.37629
IRX1 iroquois homeobox 1 0.374068
ATF6 activating transcription factor 6 0.372587
BAG2 BCL2-associated athanogene 2 0.369628
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.369628
SLN sarcolipin 0.351187
NEXN nexilin (F actin binding protein) 0.337242
ACYP2 acylphosphatase 2, muscle type 0.336144
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.32774
LINC00207 long intergenic non-protein coding RNA 207 0.327375
GYG1 glycogenin 1 0.307757
IRX3 iroquois homeobox 3 0.304503
CLCN1 chloride channel, voltage-sensitive 1 0.301976
TPM1 tropomyosin 1 (alpha) 0.301615
NDRG4 NDRG family member 4 0.296931
MGAM maltase-glucoamylase 0.290462
HIST1H1C histone cluster 1, H1c 0.290103
KCNJ11 potassium channel, inwardly rectifying subfamily J, member 11 0.289386
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 0.289386
CNOT1 CCR4-NOT transcription complex, subunit 1 0.287952
BEST2 bestrophin 2 0.27687
ACTN2 actinin, alpha 2 0.272597
CACNB2 calcium channel, voltage-dependent, beta 2 subunit 0.259124
RAB5A RAB5A, member RAS oncogene family 0.250663
ABCC9 ATP-binding cassette, sub-family C (CFTR/MRP), member 9 0.248905
HSPA4 heat shock 70kDa protein 4 0.245046
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.242595
GLE1 GLE1 RNA export mediator 0.23666
SLC1A7 solute carrier family 1 (glutamate transporter), member 7 0.232836
TPM4 tropomyosin 4 0.227642
RREB1 ras responsive element binding protein 1 0.226607
CALR calreticulin 0.213621
ADRA2C adrenoceptor alpha 2C 0.210925
MYBPC3 myosin binding protein C, cardiac 0.208914
KCNK6 potassium channel, two pore domain subfamily K, member 6 0.20229
TLK2 tousled-like kinase 2 0.18472
DNM2 dynamin 2 0.183248
CELSR3 cadherin, EGF LAG seven-pass G-type receptor 3 0.179239
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic 0.176757
SLCO2B1 solute carrier organic anion transporter family, member 2B1 0.170789
PTRF polymerase I and transcript release factor 0.168381
ADCY9 adenylate cyclase 9 0.157929
RIPK4 receptor-interacting serine-threonine kinase 4 0.145975
KCNJ10 potassium channel, inwardly rectifying subfamily J, member 10 0.144588
TYRO3 TYRO3 protein tyrosine kinase 0.142251