long bone Gene Set

Dataset TISSUES Text-mining Tissue Protein Expression Evidence Scores
Category structural or functional annotations
Type tissue
Description In limbs of vertebrate animals. A long cylindrical bone that contains marrow. (BRENDA Tissue and Enzyme Source Ontology, BTO_0004256)
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Genes

316 proteins co-occuring with the tissue long bone in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset.

Symbol Name Standardized Value
EXT2 exostosin glycosyltransferase 2 2.42235
PTH parathyroid hormone 2.18135
EXT1 exostosin glycosyltransferase 1 2.14959
IHH indian hedgehog 2.09685
ALPL alkaline phosphatase, liver/bone/kidney 1.9258
FGFR3 fibroblast growth factor receptor 3 1.91434
ALPPL2 alkaline phosphatase, placental-like 2 1.90862
ALPP alkaline phosphatase, placental 1.90654
BGLAP bone gamma-carboxyglutamate (gla) protein 1.83939
PTHLH parathyroid hormone-like hormone 1.79803
BMP2 bone morphogenetic protein 2 1.74925
COL10A1 collagen, type X, alpha 1 1.67755
AMER1 APC membrane recruitment protein 1 1.59869
COL2A1 collagen, type II, alpha 1 1.5888
ACPP acid phosphatase, prostate 1.58831
RUNX2 runt-related transcription factor 2 1.57945
SOST sclerostin 1.50764
CTSK cathepsin K 1.50433
IFT80 intraflagellar transport 80 1.49538
BMP7 bone morphogenetic protein 7 1.46635
COL1A1 collagen, type I, alpha 1 1.46076
SOX9 SRY (sex determining region Y)-box 9 1.43246
CALCA calcitonin-related polypeptide alpha 1.37499
PHOSPHO1 phosphatase, orphan 1 1.36131
SPP1 secreted phosphoprotein 1 1.35222
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b 1.34089
BCS1L BC1 (ubiquinol-cytochrome c reductase) synthesis-like 1.31874
IGF1 insulin-like growth factor 1 (somatomedin C) 1.31829
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1 1.2461
ACAN aggrecan 1.20689
ANKH ANKH inorganic pyrophosphate transport regulator 1.20156
GDF5 growth differentiation factor 5 1.19845
COL1A2 collagen, type I, alpha 2 1.19489
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3 1.19356
EVC2 Ellis van Creveld syndrome 2 1.17402
SP7 Sp7 transcription factor 1.17003
TGFB1 transforming growth factor, beta 1 1.15096
PHEX phosphate regulating endopeptidase homolog, X-linked 1.13678
MEPE matrix extracellular phosphoglycoprotein 1.13147
MMP13 matrix metallopeptidase 13 1.12571
SHOX short stature homeobox 1.12394
ASB12 ankyrin repeat and SOCS box containing 12 1.11154
NPPC natriuretic peptide C 1.07088
FGF23 fibroblast growth factor 23 1.06956
COMP cartilage oligomeric matrix protein 1.05369
EXTL2 exostosin-like glycosyltransferase 2 1.04928
NPR2 natriuretic peptide receptor 2 1.0339
ARHGAP28 Rho GTPase activating protein 28 1.0339
EXTL1 exostosin-like glycosyltransferase 1 1.00414
BMP6 bone morphogenetic protein 6 0.999344
COL11A2 collagen, type XI, alpha 2 0.985425
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 0.970253
FAM20C family with sequence similarity 20, member C 0.958585
PKDCC protein kinase domain containing, cytoplasmic 0.957722
WDR60 WD repeat domain 60 0.955134
ACP5 acid phosphatase 5, tartrate resistant 0.954703
LRP5 low density lipoprotein receptor-related protein 5 0.951685
PEX7 peroxisomal biogenesis factor 7 0.950393
COL11A2P1 collagen, type XI, alpha 2 pseudogene 1 0.939636
NF1 neurofibromin 1 0.934482
FGFR2 fibroblast growth factor receptor 2 0.933624
NOG noggin 0.930621
EXOC6B exocyst complex component 6B 0.915642
MATN3 matrilin 3 0.879935
CD68 CD68 molecule 0.878666
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11 0.876129
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.871905
SDC3 syndecan 3 0.861363
KIAA1468 KIAA1468 0.849165
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.844545
IBSP integrin-binding sialoprotein 0.841188
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator 0.83448
OBSL1 obscurin-like 1 0.816904
FBN1 fibrillin 1 0.790212
MMP9 matrix metallopeptidase 9 0.784804
WDR34 WD repeat domain 34 0.782725
FLNB filamin B, beta 0.780648
GHR growth hormone receptor 0.775249
EWSR1 EWS RNA-binding protein 1 0.767783
DIS3L2 DIS3 like 3'-5' exoribonuclease 2 0.758259
COL9A1 collagen, type IX, alpha 1 0.755364
IL1A interleukin 1, alpha 0.747515
MATN4 matrilin 4 0.746277
IFITM5 interferon induced transmembrane protein 5 0.745864
TMEM5 transmembrane protein 5 0.740503
LECT1 leukocyte cell derived chemotaxin 1 0.727741
CALCR calcitonin receptor 0.725274
VEGFA vascular endothelial growth factor A 0.719934
GLI2 GLI family zinc finger 2 0.719113
ZSCAN10 zinc finger and SCAN domain containing 10 0.713779
SLC26A2 solute carrier family 26 (anion exchanger), member 2 0.70886
CRTAP cartilage associated protein 0.70845
BMP3 bone morphogenetic protein 3 0.70845
LEMD3 LEM domain containing 3 0.704764
THBS2 thrombospondin 2 0.703127
FGF2 fibroblast growth factor 2 (basic) 0.702717
IQUB IQ motif and ubiquitin domain containing 0.699853
HSPG2 heparan sulfate proteoglycan 2 0.695763
CLCN7 chloride channel, voltage-sensitive 7 0.694946
POSTN periostin, osteoblast specific factor 0.680656
DMP1 dentin matrix acidic phosphoprotein 1 0.67984
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.670064
EBP emopamil binding protein (sterol isomerase) 0.66925
BMP1 bone morphogenetic protein 1 0.665588
TTC21B tetratricopeptide repeat domain 21B 0.664775
CUL7 cullin 7 0.663962
TXLNG taxilin gamma 0.66071
KL klotho 0.654618
MRPL49 mitochondrial ribosomal protein L49 0.648938
RIMS4 regulating synaptic membrane exocytosis 4 0.6461
FGFR1 fibroblast growth factor receptor 1 0.639619
MGP matrix Gla protein 0.639214
FRZB frizzled-related protein 0.638404
WDR19 WD repeat domain 19 0.635572
NPTXR neuronal pentraxin receptor 0.634358
HOXD13 homeobox D13 0.627081
COL11A1 collagen, type XI, alpha 1 0.624658
LIFR leukemia inhibitory factor receptor alpha 0.622235
CCDC8 coiled-coil domain containing 8 0.619007
AHSG alpha-2-HS-glycoprotein 0.614571
COPS3 COP9 signalosome subunit 3 0.613361
PTH1R parathyroid hormone 1 receptor 0.612152
EXTL3 exostosin-like glycosyltransferase 3 0.605306
ESR1 estrogen receptor 1 0.603295
IL1B interleukin 1, beta 0.598469
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 0.597666
P3H1 prolyl 3-hydroxylase 1 0.59124
BMP4 bone morphogenetic protein 4 0.588431
SPP2 secreted phosphoprotein 2, 24kDa 0.58322
IL6 interleukin 6 0.572818
FKBP11 FK506 binding protein 11, 19 kDa 0.570021
UCMA upper zone of growth plate and cartilage matrix associated 0.561644
DISP1 dispatched homolog 1 (Drosophila) 0.561245
GLI3 GLI family zinc finger 3 0.554876
GDF10 growth differentiation factor 10 0.553286
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1 0.553286
TRIP11 thyroid hormone receptor interactor 11 0.549709
TNF tumor necrosis factor 0.548914
THBS3 thrombospondin 3 0.546929
GDF6 growth differentiation factor 6 0.546136
CSF1 colony stimulating factor 1 (macrophage) 0.546136
NKX3-2 NK3 homeobox 2 0.541773
BMP5 bone morphogenetic protein 5 0.537416
HOXD12 homeobox D12 0.536625
OGN osteoglycin 0.533065
PKMYT1 protein kinase, membrane associated tyrosine/threonine 1 0.530298
TNC tenascin C 0.524377
ARSE arylsulfatase E (chondrodysplasia punctata 1) 0.520041
MATN1 matrilin 1, cartilage matrix protein 0.519253
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1 0.518465
FBN2 fibrillin 2 0.518072
SNX10 sorting nexin 10 0.518072
TGFB2 transforming growth factor, beta 2 0.518072
PCNA proliferating cell nuclear antigen 0.51453
NOTCH1 notch 1 0.512171
FAM120A family with sequence similarity 120A 0.509027
EVC Ellis van Creveld protein 0.50471
ARSB arylsulfatase B 0.498048
FGF1 fibroblast growth factor 1 (acidic) 0.494918
CSF1R colony stimulating factor 1 receptor 0.494136
MRC2 mannose receptor, C type 2 0.493354
SFRP4 secreted frizzled-related protein 4 0.490619
CTGF connective tissue growth factor 0.488276
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.487886
NPR3 natriuretic peptide receptor 3 0.483986
PTCH1 patched 1 0.482817
GBA glucosidase, beta, acid 0.476589
TYRP1 tyrosinase-related protein 1 0.475812
GPR68 G protein-coupled receptor 68 0.463013
GNAS GNAS complex locus 0.460305
FOXM1 forkhead box M1 0.4576
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 0.452584
WNT5A wingless-type MMTV integration site family, member 5A 0.452198
NELL1 NEL-like 1 (chicken) 0.450271
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3 0.447961
XYLT1 xylosyltransferase I 0.447961
SPTA1 spectrin, alpha, erythrocytic 1 0.447576
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor 0.446807
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.446807
PLXND1 plexin D1 0.442962
IFT172 intraflagellar transport 172 0.442962
DCN decorin 0.442578
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.439507
MMP12 matrix metallopeptidase 12 0.430312
PSG5 pregnancy specific beta-1-glycoprotein 5 0.42993
GLI1 GLI family zinc finger 1 0.425726
FLNA filamin A, alpha 0.423436
PTGER4 prostaglandin E receptor 4 (subtype EP4) 0.422292
CTSB cathepsin B 0.420766
LTBP3 latent transforming growth factor beta binding protein 3 0.419242
ADAMTS3 ADAM metallopeptidase with thrombospondin type 1 motif, 3 0.41848
HBA1 hemoglobin, alpha 1 0.409351
LTBP2 latent transforming growth factor beta binding protein 2 0.406694
TRPS1 trichorhinophalangeal syndrome I 0.405176
SCUBE3 signal peptide, CUB domain, EGF-like 3 0.404797
MMP2 matrix metallopeptidase 2 0.402901
HOXD11 homeobox D11 0.400628
FN1 fibronectin 1 0.398357
OSTN osteocrin 0.396844
HBA2 hemoglobin, alpha 2 0.396844
WNT5B wingless-type MMTV integration site family, member 5B 0.396844
CD34 CD34 molecule 0.391931
IL1RN interleukin 1 receptor antagonist 0.389289
PRKCA protein kinase C, alpha 0.389289
CRP C-reactive protein, pentraxin-related 0.387027
DKK1 dickkopf WNT signaling pathway inhibitor 1 0.38665
ARHGAP6 Rho GTPase activating protein 6 0.38665
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.385143
TRAPPC10 trafficking protein particle complex 10 0.376494
HYLS1 hydrolethalus syndrome 1 0.371619
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5 0.371619
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1 0.371245
HIF3A hypoxia inducible factor 3, alpha subunit 0.37087
SMARCAL1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1 0.369747
PEF1 penta-EF-hand domain containing 1 0.367129
ALB albumin 0.366381
SEC23A Sec23 homolog A (S. cerevisiae) 0.36302
ARL13B ADP-ribosylation factor-like 13B 0.360782
VANGL2 VANGL planar cell polarity protein 2 0.35743
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3 0.357058
PCOLCE procollagen C-endopeptidase enhancer 0.35557
PAX1 paired box 1 0.354455
ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif, 4 0.353712
ROR2 receptor tyrosine kinase-like orphan receptor 2 0.352969
GC group-specific component (vitamin D binding protein) 0.352969
SQLE squalene epoxidase 0.352598
STAB2 stabilin 2 0.352227
HOXA13 homeobox A13 0.351856
HOXA11 homeobox A11 0.346668
GPNMB glycoprotein (transmembrane) nmb 0.344449
SEBOX SEBOX homeobox 0.340019
CD44 CD44 molecule (Indian blood group) 0.338545
TAOK1 TAO kinase 1 0.337072
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.335233
NOV nephroblastoma overexpressed 0.330094
CLEC4D C-type lectin domain family 4, member D 0.329361
TNS3 tensin 3 0.328628
FBXO44 F-box protein 44 0.32753
HTRA1 HtrA serine peptidase 1 0.326432
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.32132
GALNS galactosamine (N-acetyl)-6-sulfatase 0.320956
GPC6 glypican 6 0.31877
DAXX death-domain associated protein 0.315861
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.315135
PITX1 paired-like homeodomain 1 0.314409
SHH sonic hedgehog 0.31332
CHSY3 chondroitin sulfate synthase 3 0.309335
CA10 carbonic anhydrase X 0.308612
TGFBR1 transforming growth factor, beta receptor 1 0.305361
INS insulin 0.30464
BMP2K BMP2 inducible kinase 0.301758
FGF10 fibroblast growth factor 10 0.30032
SNAI2 snail family zinc finger 2 0.29996
ITM2A integral membrane protein 2A 0.298165
PPIB peptidylprolyl isomerase B (cyclophilin B) 0.297089
S100B S100 calcium binding protein B 0.296372
CCND1 cyclin D1 0.294939
CLEC2D C-type lectin domain family 2, member D 0.293866
SMOC2 SPARC related modular calcium binding 2 0.291008
USP6 ubiquitin specific peptidase 6 0.290652
CYP4F22 cytochrome P450, family 4, subfamily F, polypeptide 22 0.290652
SATB2 SATB homeobox 2 0.290295
LEP leptin 0.289939
CTSS cathepsin S 0.288514
CA2 carbonic anhydrase II 0.283191
DEFB105B defensin, beta 105B 0.281776
POU6F2 POU class 6 homeobox 2 0.281423
OMD osteomodulin 0.279307
PRKACA protein kinase, cAMP-dependent, catalytic, alpha 0.274045
SRC SRC proto-oncogene, non-receptor tyrosine kinase 0.273346
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 0.271952
PAPPA pregnancy-associated plasma protein A, pappalysin 1 0.271604
NPPA natriuretic peptide A 0.270909
RGS12 regulator of G-protein signaling 12 0.270561
PIN4 peptidylprolyl cis/trans isomerase, NIMA-interacting 4 0.270214
CP ceruloplasmin (ferroxidase) 0.268482
LOX lysyl oxidase 0.263327
MKS1 Meckel syndrome, type 1 0.262986
MMP14 matrix metallopeptidase 14 (membrane-inserted) 0.261624
GPHA2 glycoprotein hormone alpha 2 0.260945
BCO1 beta-carotene oxygenase 1 0.260945
SMC1A structural maintenance of chromosomes 1A 0.259929
ZNF384 zinc finger protein 384 0.257237
LTBP4 latent transforming growth factor beta binding protein 4 0.2559
LAX1 lymphocyte transmembrane adaptor 1 0.255234
TNNI2 troponin I type 2 (skeletal, fast) 0.25457
VPS35 vacuolar protein sorting 35 homolog (S. cerevisiae) 0.253578
ACP2 acid phosphatase 2, lysosomal 0.249329
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 0.241746
EMC3 ER membrane protein complex subunit 3 0.240216
ANO5 anoctamin 5 0.238108
SPATA5 spermatogenesis associated 5 0.237513
ELANE elastase, neutrophil expressed 0.236921
EMCN endomucin 0.23459
ARHGEF9 Cdc42 guanine nucleotide exchange factor (GEF) 9 0.232881
ANXA8 annexin A8 0.23176
FGF18 fibroblast growth factor 18 0.231206
MEOX1 mesenchyme homeobox 1 0.231206
TBCA tubulin folding cofactor A 0.230656
MATN2 matrilin 2 0.229839
GUSB glucuronidase, beta 0.229032
CTSL cathepsin L 0.228764
TCOF1 Treacher Collins-Franceschetti syndrome 1 0.226155
OAF OAF homolog (Drosophila) 0.226155
NCOA1 nuclear receptor coactivator 1 0.221755
COL9A2 collagen, type IX, alpha 2 0.221061
MSX1 msh homeobox 1 0.220604
ANGPTL1 angiopoietin-like 1 0.220604
COL13A1 collagen, type XIII, alpha 1 0.220378
SMO smoothened, frizzled class receptor 0.220378
XYLT2 xylosyltransferase II 0.219485
TP53 tumor protein p53 0.219485
ADAM12 ADAM metallopeptidase domain 12 0.219047
TUBGCP4 tubulin, gamma complex associated protein 4 0.218613
GLB1 galactosidase, beta 1 0.214954
DSPP dentin sialophosphoprotein 0.214202