lomustine-7094 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

200 genes differentially expressed following the lomustine-7094 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABHD3 abhydrolase domain containing 3
ADM adrenomedullin
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
APOL2 apolipoprotein L, 2
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASPH aspartate beta-hydroxylase
ATF3 activating transcription factor 3
ATP6V1C1 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1
AZI2 5-azacytidine induced 2
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1
BAG3 BCL2-associated athanogene 3
BRAP BRCA1 associated protein
C5ORF28 chromosome 5 open reading frame 28
C5ORF30 chromosome 5 open reading frame 30
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal)
CLN8 ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation)
COQ7 coenzyme Q7 homolog, ubiquinone (yeast)
CREM cAMP responsive element modulator
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2
CSRP2 cysteine and glycine-rich protein 2
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DST dystonin
DUSP1 dual specificity phosphatase 1
EAF2 ELL associated factor 2
ELF1 E74-like factor 1 (ets domain transcription factor)
ETV5 ets variant 5
GABARAPL1 GABA(A) receptor-associated protein like 1
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
GLA galactosidase, alpha
GLS glutaminase
HBEGF heparin-binding EGF-like growth factor
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HN1L hematological and neurological expressed 1-like
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB8 heat shock 22kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IDI1 isopentenyl-diphosphate delta isomerase 1
IL1RL1 interleukin 1 receptor-like 1
IL6R interleukin 6 receptor
INSIG1 insulin induced gene 1
KIAA0232 KIAA0232
KLC2 kinesin light chain 2
KLF6 Kruppel-like factor 6
KLHL21 kelch-like family member 21
KLHL24 kelch-like family member 24
LDLR low density lipoprotein receptor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G
MBOAT7 membrane bound O-acyltransferase domain containing 7
MDC1 mediator of DNA-damage checkpoint 1
MICB MHC class I polypeptide-related sequence B
MTMR6 myotubularin related protein 6
NCF2 neutrophil cytosolic factor 2
NCOA3 nuclear receptor coactivator 3
NFE2L2 nuclear factor, erythroid 2-like 2
NMT1 N-myristoyltransferase 1
NUPR1 nuclear protein, transcriptional regulator, 1
NXF1 nuclear RNA export factor 1
OSGIN1 oxidative stress induced growth inhibitor 1
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PELI1 pellino E3 ubiquitin protein ligase 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRR13 proline rich 13
RANGAP1 Ran GTPase activating protein 1
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RND3 Rho family GTPase 3
RNF19B ring finger protein 19B
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
SETX senataxin
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
STIP1 stress-induced phosphoprotein 1
TMBIM1 transmembrane BAX inhibitor motif containing 1
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TRAFD1 TRAF-type zinc finger domain containing 1
TRIM16 tripartite motif containing 16
TULP3 tubby like protein 3
UHRF1BP1L UHRF1 binding protein 1-like
ZFP36 ZFP36 ring finger protein
ZSCAN31 zinc finger and SCAN domain containing 31

decreased expression

Symbol Name
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ABI3BP ABI family, member 3 (NESH) binding protein
ADRB2 adrenoceptor beta 2, surface
ALKBH1 alkB, alkylation repair homolog 1 (E. coli)
ASB13 ankyrin repeat and SOCS box containing 13
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
BNC2 basonuclin 2
C4ORF19 chromosome 4 open reading frame 19
CCDC25 coiled-coil domain containing 25
CD83 CD83 molecule
CFL1 cofilin 1 (non-muscle)
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
DHRS3 dehydrogenase/reductase (SDR family) member 3
DHX57 DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57
E2F8 E2F transcription factor 8
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
FAM105A family with sequence similarity 105, member A
FAM111A family with sequence similarity 111, member A
FJX1 four jointed box 1 (Drosophila)
FZD4 frizzled class receptor 4
G0S2 G0/G1 switch 2
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GAMT guanidinoacetate N-methyltransferase
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GLI3 GLI family zinc finger 3
GRHL2 grainyhead-like 2 (Drosophila)
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
H1F0 H1 histone family, member 0
HAS2 hyaluronan synthase 2
HOXA5 homeobox A5
HOXC6 homeobox C6
HPS6 Hermansky-Pudlak syndrome 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFIT5 interferon-induced protein with tetratricopeptide repeats 5
IL1B interleukin 1, beta
INF2 inverted formin, FH2 and WH2 domain containing
INPP1 inositol polyphosphate-1-phosphatase
IRF9 interferon regulatory factor 9
KDM5C lysine (K)-specific demethylase 5C
KIAA1549L KIAA1549-like
KLHL26 kelch-like family member 26
LIF leukemia inhibitory factor
LONRF3 LON peptidase N-terminal domain and ring finger 3
LPAR6 lysophosphatidic acid receptor 6
LRRC37A3 leucine rich repeat containing 37, member A3
MAGEF1 melanoma antigen family F1
MB myoglobin
MEIS3P1 Meis homeobox 3 pseudogene 1
MGC12488
NHLRC2 NHL repeat containing 2
NPY1R neuropeptide Y receptor Y1
NSUN3 NOP2/Sun domain family, member 3
NTSR1 neurotensin receptor 1 (high affinity)
NUAK1 NUAK family, SNF1-like kinase, 1
P2RY2 purinergic receptor P2Y, G-protein coupled, 2
PAK6 p21 protein (Cdc42/Rac)-activated kinase 6
PAX6 paired box 6
PELP1 proline, glutamate and leucine rich protein 1
PLCXD1 phosphatidylinositol-specific phospholipase C, X domain containing 1
PLD3 phospholipase D family, member 3
PPAP2B phosphatidic acid phosphatase type 2B
PSRC1 proline/serine-rich coiled-coil 1
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
PTX3 pentraxin 3, long
PYCARD PYD and CARD domain containing
RAB20 RAB20, member RAS oncogene family
RANBP6 RAN binding protein 6
RIN2 Ras and Rab interactor 2
RIPK4 receptor-interacting serine-threonine kinase 4
RNF220 ring finger protein 220
RPL13P5 ribosomal protein L13 pseudogene 5
RPS17P5 ribosomal protein S17 pseudogene 5
RPUSD2 RNA pseudouridylate synthase domain containing 2
SDC3 syndecan 3
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SPAG16 sperm associated antigen 16
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
ST5 suppression of tumorigenicity 5
STARD13 StAR-related lipid transfer (START) domain containing 13
TAOK1 TAO kinase 1
TARS2 threonyl-tRNA synthetase 2, mitochondrial (putative)
TENM4 teneurin transmembrane protein 4
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TMC5 transmembrane channel-like 5
TNS3 tensin 3
TOE1 target of EGR1, member 1 (nuclear)
TRAF5 TNF receptor-associated factor 5
TRIB2 tribbles pseudokinase 2
TSKU tsukushi, small leucine rich proteoglycan
TSPYL5 TSPY-like 5
TXNIP thioredoxin interacting protein
VEGFB vascular endothelial growth factor B
ZBED8 zinc finger, BED-type containing 8
ZBTB25 zinc finger and BTB domain containing 25
ZDHHC14 zinc finger, DHHC-type containing 14
ZHX2 zinc fingers and homeoboxes 2
ZNF365 zinc finger protein 365
ZNF512B zinc finger protein 512B