lomustine-7089 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the lomustine-7089 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABHD3 abhydrolase domain containing 3
AGFG2 ArfGAP with FG repeats 2
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ANXA1 annexin A1
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
BAIAP2 BAI1-associated protein 2
BANP BTG3 associated nuclear protein
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BFSP1 beaded filament structural protein 1, filensin
CA12 carbonic anhydrase XII
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKL3 cyclin-dependent kinase-like 3
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHRM3 cholinergic receptor, muscarinic 3
CREM cAMP responsive element modulator
CTNS cystinosin, lysosomal cystine transporter
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DDIT3 DNA-damage-inducible transcript 3
DENND4A DENN/MADD domain containing 4A
DEPTOR DEP domain containing MTOR-interacting protein
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNM1 dynamin 1
DUSP4 dual specificity phosphatase 4
E2F3 E2F transcription factor 3
FOSL1 FOS-like antigen 1
FZD7 frizzled class receptor 7
GADD45A growth arrest and DNA-damage-inducible, alpha
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
GOSR2 golgi SNAP receptor complex member 2
HGSNAT heparan-alpha-glucosaminide N-acetyltransferase
HMOX1 heme oxygenase 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
ISG20 interferon stimulated exonuclease gene 20kDa
KDM4A lysine (K)-specific demethylase 4A
KIAA0513 KIAA0513
KIF1C kinesin family member 1C
LAMP1 lysosomal-associated membrane protein 1
LNPEP leucyl/cystinyl aminopeptidase
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
LYRM9 LYR motif containing 9
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MIR22HG MIR22 host gene
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NKIRAS2 NFKB inhibitor interacting Ras-like 2
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
OLFML2A olfactomedin-like 2A
OSGIN1 oxidative stress induced growth inhibitor 1
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PCYOX1L prenylcysteine oxidase 1 like
PGAP1 post-GPI attachment to proteins 1
PLK3 polo-like kinase 3
PLXNA1 plexin A1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POFUT1 protein O-fucosyltransferase 1
PPFIA3 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
PRMT2 protein arginine methyltransferase 2
RECQL4 RecQ protein-like 4
REPS1 RALBP1 associated Eps domain containing 1
SAYSD1 SAYSVFN motif domain containing 1
SF3A2 splicing factor 3a, subunit 2, 66kDa
SH3BGR SH3 domain binding glutamate-rich protein
SIK1 salt-inducible kinase 1
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC23A2 solute carrier family 23 (ascorbic acid transporter), member 2
SLC29A1 solute carrier family 29 (equilibrative nucleoside transporter), member 1
SLC36A1 solute carrier family 36 (proton/amino acid symporter), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNAI2 snail family zinc finger 2
SOCS6 suppressor of cytokine signaling 6
SOWAHC sosondowah ankyrin repeat domain family member C
SQSTM1 sequestosome 1
STOML1 stomatin (EPB72)-like 1
TDRD3 tudor domain containing 3
TES testin LIM domain protein
TMEM161A transmembrane protein 161A
TMEM97 transmembrane protein 97
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TNK1 tyrosine kinase, non-receptor, 1
TPST2 tyrosylprotein sulfotransferase 2
TRIM16 tripartite motif containing 16
TUBA3C tubulin, alpha 3c
TXNRD1 thioredoxin reductase 1
USP22 ubiquitin specific peptidase 22
VEGFA vascular endothelial growth factor A
VLDLR very low density lipoprotein receptor
WHSC1L1 Wolf-Hirschhorn syndrome candidate 1-like 1
ZBTB22 zinc finger and BTB domain containing 22
ZHX3 zinc fingers and homeoboxes 3
ZNF571 zinc finger protein 571

decreased expression

Symbol Name
ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ARL15 ADP-ribosylation factor-like 15
ARMCX1 armadillo repeat containing, X-linked 1
ASB7 ankyrin repeat and SOCS box containing 7
ASH2L ash2 (absent, small, or homeotic)-like (Drosophila)
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BCORL1 BCL6 corepressor-like 1
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3
C1ORF106 chromosome 1 open reading frame 106
C3ORF52 chromosome 3 open reading frame 52
CAMK1 calcium/calmodulin-dependent protein kinase I
CAPG capping protein (actin filament), gelsolin-like
CCDC170 coiled-coil domain containing 170
CCDC57 coiled-coil domain containing 57
CERK ceramide kinase
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11
CLSPN claspin
CORO1A coronin, actin binding protein, 1A
CRYBB2P1 crystallin, beta B2 pseudogene 1
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP20A1 cytochrome P450, family 20, subfamily A, polypeptide 1
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
DNAJC22 DnaJ (Hsp40) homolog, subfamily C, member 22
EFNA1 ephrin-A1
EGLN3 egl-9 family hypoxia-inducible factor 3
FOLR1 folate receptor 1 (adult)
GBAS glioblastoma amplified sequence
GLI3 GLI family zinc finger 3
GPR19 G protein-coupled receptor 19
H2AFJ H2A histone family, member J
HIST1H2AI histone cluster 1, H2ai
HIST1H2AJ histone cluster 1, H2aj
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HOXC11 homeobox C11
HOXC6 homeobox C6
IREB2 iron-responsive element binding protein 2
IRX5 iroquois homeobox 5
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1
KCNMB3 potassium channel subfamily M regulatory beta subunit 3
KRT13 keratin 13, type I
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
LMCD1 LIM and cysteine-rich domains 1
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1
MAN2C1 mannosidase, alpha, class 2C, member 1
MPPED2 metallophosphoesterase domain containing 2
MXD3 MAX dimerization protein 3
NLRX1 NLR family member X1
NPIPB15 nuclear pore complex interacting protein family, member B15
NT5DC3 5'-nucleotidase domain containing 3
OSR2 odd-skipped related transciption factor 2
P2RY2 purinergic receptor P2Y, G-protein coupled, 2
PARP16 poly (ADP-ribose) polymerase family, member 16
PGGT1B protein geranylgeranyltransferase type I, beta subunit
PGP phosphoglycolate phosphatase
PIGL phosphatidylinositol glycan anchor biosynthesis, class L
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLXNA3 plexin A3
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PPT2 palmitoyl-protein thioesterase 2
PRODH proline dehydrogenase (oxidase) 1
PRR15L proline rich 15-like
PRR3 proline rich 3
PRRG2 proline rich Gla (G-carboxyglutamic acid) 2
RGS16 regulator of G-protein signaling 16
SMPDL3B sphingomyelin phosphodiesterase, acid-like 3B
SPATA7 spermatogenesis associated 7
SRPX sushi-repeat containing protein, X-linked
STARD13 StAR-related lipid transfer (START) domain containing 13
STK25 serine/threonine kinase 25
SUSD4 sushi domain containing 4
SYCP2 synaptonemal complex protein 2
SYT17 synaptotagmin XVII
SYTL2 synaptotagmin-like 2
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TBC1D17 TBC1 domain family, member 17
TCEAL1 transcription elongation factor A (SII)-like 1
TCTA T-cell leukemia translocation altered
TESK2 testis-specific kinase 2
TET3 tet methylcytosine dioxygenase 3
TH tyrosine hydroxylase
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TRAF5 TNF receptor-associated factor 5
TSC22D4 TSC22 domain family, member 4
TTC26 tetratricopeptide repeat domain 26
TXNIP thioredoxin interacting protein
UBQLN4 ubiquilin 4
UNC119 unc-119 homolog (C. elegans)
WDR62 WD repeat domain 62
ZBED1 zinc finger, BED-type containing 1
ZHX2 zinc fingers and homeoboxes 2
ZNF141 zinc finger protein 141
ZNF22 zinc finger protein 22
ZNF276 zinc finger protein 276