lomustine-7045 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the lomustine-7045 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ADM adrenomedullin
AEN apoptosis enhancing nuclease
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ANXA1 annexin A1
AP5Z1 adaptor-related protein complex 5, zeta 1 subunit
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATRN attractin
BCAM basal cell adhesion molecule (Lutheran blood group)
BCL2L11 BCL2-like 11 (apoptosis facilitator)
C12ORF4 chromosome 12 open reading frame 4
C15ORF39 chromosome 15 open reading frame 39
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CBR3 carbonyl reductase 3
CCNE1 cyclin E1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDADC1 cytidine and dCMP deaminase domain containing 1
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1
CDYL chromodomain protein, Y-like
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLUHP3 clustered mitochondria (cluA/CLU1) homolog pseudogene 3
CREM cAMP responsive element modulator
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
DDIT3 DNA-damage-inducible transcript 3
DGAT1 diacylglycerol O-acyltransferase 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DUSP4 dual specificity phosphatase 4
EGR1 early growth response 1
ELF4 E74-like factor 4 (ets domain transcription factor)
ELK4 ELK4, ETS-domain protein (SRF accessory protein 1)
ELMO2 engulfment and cell motility 2
EPHA2 EPH receptor A2
ESRRA estrogen-related receptor alpha
ETV5 ets variant 5
FAM188A family with sequence similarity 188, member A
FOSL1 FOS-like antigen 1
GCLM glutamate-cysteine ligase, modifier subunit
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GRB10 growth factor receptor-bound protein 10
HBEGF heparin-binding EGF-like growth factor
HMOX1 heme oxygenase 1
HOMER3 homer scaffolding protein 3
HSPA1L heat shock 70kDa protein 1-like
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ICOSLG inducible T-cell co-stimulator ligand
ING1 inhibitor of growth family, member 1
ISG20 interferon stimulated exonuclease gene 20kDa
ITGB5 integrin, beta 5
KIAA0319L KIAA0319-like
KIF5C kinesin family member 5C
LDB1 LIM domain binding 1
LOC644450 uncharacterized LOC644450
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MIR22HG MIR22 host gene
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
MYCL v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog
NR1D2 nuclear receptor subfamily 1, group D, member 2
NUPR1 nuclear protein, transcriptional regulator, 1
OMG oligodendrocyte myelin glycoprotein
OSGIN1 oxidative stress induced growth inhibitor 1
PCGF3 polycomb group ring finger 3
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PCLO piccolo presynaptic cytomatrix protein
PHLDA1 pleckstrin homology-like domain, family A, member 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POLL polymerase (DNA directed), lambda
PRNP prion protein
PSEN1 presenilin 1
RNGTT RNA guanylyltransferase and 5'-phosphatase
SAPCD1 suppressor APC domain containing 1
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMURF1 SMAD specific E3 ubiquitin protein ligase 1
STIP1 stress-induced phosphoprotein 1
STOML1 stomatin (EPB72)-like 1
STYK1 serine/threonine/tyrosine kinase 1
TBC1D30 TBC1 domain family, member 30
TES testin LIM domain protein
TICAM1 toll-like receptor adaptor molecule 1
TIMM10B translocase of inner mitochondrial membrane 10 homolog B (yeast)
TINF2 TERF1 (TRF1)-interacting nuclear factor 2
TMEM158 transmembrane protein 158 (gene/pseudogene)
TRIM16 tripartite motif containing 16
TXNRD1 thioredoxin reductase 1
UNKL unkempt family zinc finger-like
VEGFA vascular endothelial growth factor A
ZNF609 zinc finger protein 609
ZYX zyxin

decreased expression

Symbol Name
ACTN3 actinin, alpha 3 (gene/pseudogene)
ARID5A AT rich interactive domain 5A (MRF1-like)
ARMCX1 armadillo repeat containing, X-linked 1
ARMCX2 armadillo repeat containing, X-linked 2
ASB7 ankyrin repeat and SOCS box containing 7
ASPHD1 aspartate beta-hydroxylase domain containing 1
ATAT1 alpha tubulin acetyltransferase 1
BAHCC1 BAH domain and coiled-coil containing 1
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3
CSTA cystatin A (stefin A)
CTSF cathepsin F
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
DBNDD1 dysbindin (dystrobrevin binding protein 1) domain containing 1
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DNA2 DNA replication helicase/nuclease 2
DNAJC22 DnaJ (Hsp40) homolog, subfamily C, member 22
DZANK1 double zinc ribbon and ankyrin repeat domains 1
EMID1 EMI domain containing 1
EPB41L5 erythrocyte membrane protein band 4.1 like 5
F2R coagulation factor II (thrombin) receptor
FAM46C family with sequence similarity 46, member C
FAM63A family with sequence similarity 63, member A
FLJ11710 uncharacterized protein FLJ11710
FUZ fuzzy planar cell polarity protein
GATA4 GATA binding protein 4
GJA1 gap junction protein, alpha 1, 43kDa
GLB1L galactosidase, beta 1-like
GLCE glucuronic acid epimerase
GUCY1B2 guanylate cyclase 1, soluble, beta 2 (pseudogene)
H2AFJ H2A histone family, member J
HIST1H2BI histone cluster 1, H2bi
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HOXB2 homeobox B2
HOXC6 homeobox C6
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
JAK2 Janus kinase 2
KLK5 kallikrein-related peptidase 5
LHX6 LIM homeobox 6
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MPPED2 metallophosphoesterase domain containing 2
MXD3 MAX dimerization protein 3
MYLIP myosin regulatory light chain interacting protein
N4BP3 NEDD4 binding protein 3
NIPAL2 NIPA-like domain containing 2
NOD1 nucleotide-binding oligomerization domain containing 1
NRSN2 neurensin 2
NUDT13 nudix (nucleoside diphosphate linked moiety X)-type motif 13
NYNRIN NYN domain and retroviral integrase containing
OSMR oncostatin M receptor
PARP12 poly (ADP-ribose) polymerase family, member 12
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha
PLSCR4 phospholipid scramblase 4
PMCHL1 pro-melanin-concentrating hormone-like 1, pseudogene
PMP22 peripheral myelin protein 22
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PPT2 palmitoyl-protein thioesterase 2
PRR15L proline rich 15-like
PRR3 proline rich 3
RAB27B RAB27B, member RAS oncogene family
RGS17 regulator of G-protein signaling 17
RGS2 regulator of G-protein signaling 2
RIBC2 RIB43A domain with coiled-coils 2
RNF2 ring finger protein 2
RPL23AP32 ribosomal protein L23a pseudogene 32
RPRM reprimo, TP53 dependent G2 arrest mediator candidate
SALL2 spalt-like transcription factor 2
SAYSD1 SAYSVFN motif domain containing 1
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)
SLC12A9 solute carrier family 12, member 9
SLC16A10 solute carrier family 16 (aromatic amino acid transporter), member 10
SLC25A40 solute carrier family 25, member 40
SLC52A1 solute carrier family 52 (riboflavin transporter), member 1
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2
SLC9A3R2 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
SMAD7 SMAD family member 7
SOBP sine oculis binding protein homolog (Drosophila)
SPINK5 serine peptidase inhibitor, Kazal type 5
STARD13 StAR-related lipid transfer (START) domain containing 13
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
TCEAL1 transcription elongation factor A (SII)-like 1
TESK2 testis-specific kinase 2
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TMC5 transmembrane channel-like 5
TMEM104 transmembrane protein 104
TRAF5 TNF receptor-associated factor 5
TXNIP thioredoxin interacting protein
UBQLN4 ubiquilin 4
VASH2 vasohibin 2
VIPR1 vasoactive intestinal peptide receptor 1
ZHX2 zinc fingers and homeoboxes 2
ZNF350 zinc finger protein 350