lomefloxacin-4281 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

194 genes differentially expressed following the lomefloxacin-4281 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC9 ATP-binding cassette, sub-family C (CFTR/MRP), member 9
ACSBG1 acyl-CoA synthetase bubblegum family member 1
ADGRB2 adhesion G protein-coupled receptor B2
ADGRL2 adhesion G protein-coupled receptor L2
AIRE autoimmune regulator
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17
BCL2L11 BCL2-like 11 (apoptosis facilitator)
C3AR1 complement component 3a receptor 1
CADM4 cell adhesion molecule 4
CAMTA1 calmodulin binding transcription activator 1
CASZ1 castor zinc finger 1
CD40 CD40 molecule, TNF receptor superfamily member 5
CD48 CD48 molecule
CD6 CD6 molecule
CLTB clathrin, light chain B
CPNE7 copine VII
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
CUBN cubilin (intrinsic factor-cobalamin receptor)
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6
DKFZP434C153 DKFZP434C153 protein
DNAI2 dynein, axonemal, intermediate chain 2
DNAJB12 DnaJ (Hsp40) homolog, subfamily B, member 12
DST dystonin
DUSP7 dual specificity phosphatase 7
ELOVL2 ELOVL fatty acid elongase 2
ENO3 enolase 3 (beta, muscle)
EPN1 epsin 1
ERN2 endoplasmic reticulum to nucleus signaling 2
FABP3 fatty acid binding protein 3, muscle and heart
FBXL18 F-box and leucine-rich repeat protein 18
FMO2 flavin containing monooxygenase 2 (non-functional)
FUBP1 far upstream element (FUSE) binding protein 1
GIPR gastric inhibitory polypeptide receptor
GK glycerol kinase
GNAQ guanine nucleotide binding protein (G protein), q polypeptide
GPC3 glypican 3
GPX7 glutathione peroxidase 7
GREB1L growth regulation by estrogen in breast cancer-like
HHIPL2 HHIP-like 2
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IQGAP2 IQ motif containing GTPase activating protein 2
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2
KCTD17 potassium channel tetramerization domain containing 17
KIF25-AS1 KIF25 antisense RNA 1
KSR1 kinase suppressor of ras 1
LAMP1 lysosomal-associated membrane protein 1
LOC57399 uncharacterized gastric protein ZA52P
LOXL3 lysyl oxidase-like 3
LSP1 lymphocyte-specific protein 1
LTC4S leukotriene C4 synthase
MARK1 MAP/microtubule affinity-regulating kinase 1
MOBP myelin-associated oligodendrocyte basic protein
MSX2 msh homeobox 2
MUC8 mucin 8
MYLPF myosin light chain, phosphorylatable, fast skeletal muscle
N4BP2L1 NEDD4 binding protein 2-like 1
NEURL1 neuralized E3 ubiquitin protein ligase 1
NPTX1 neuronal pentraxin I
NRP2 neuropilin 2
NYNRIN NYN domain and retroviral integrase containing
ONECUT2 one cut homeobox 2
OTUD7B OTU deubiquitinase 7B
PBX1 pre-B-cell leukemia homeobox 1
PHOX2A paired-like homeobox 2a
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PKP3 plakophilin 3
PLXND1 plexin D1
PON3 paraoxonase 3
PROL1 proline rich, lacrimal 1
RARG retinoic acid receptor, gamma
REC8 REC8 meiotic recombination protein
RETN resistin
RIBC2 RIB43A domain with coiled-coils 2
RPS6KA6 ribosomal protein S6 kinase, 90kDa, polypeptide 6
SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SOD2 superoxide dismutase 2, mitochondrial
SORT1 sortilin 1
SOX30 SRY (sex determining region Y)-box 30
SPN sialophorin
SSTR5 somatostatin receptor 5
SUGP1 SURP and G patch domain containing 1
TAC3 tachykinin 3
TBRG4 transforming growth factor beta regulator 4
TCL6 T-cell leukemia/lymphoma 6 (non-protein coding)
TIMP4 TIMP metallopeptidase inhibitor 4
TNXB tenascin XB
TPP1 tripeptidyl peptidase I
TRPM3 transient receptor potential cation channel, subfamily M, member 3
TTC38 tetratricopeptide repeat domain 38
WIZ widely interspaced zinc finger motifs
WT1 Wilms tumor 1
WTAP Wilms tumor 1 associated protein
XIST X inactive specific transcript (non-protein coding)
ZMIZ2 zinc finger, MIZ-type containing 2
ZNF609 zinc finger protein 609
ZSWIM1 zinc finger, SWIM-type containing 1

decreased expression

Symbol Name
ANKH ANKH inorganic pyrophosphate transport regulator
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BTC betacellulin
C11ORF63 chromosome 11 open reading frame 63
CCDC94 coiled-coil domain containing 94
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2)
CEP295 centrosomal protein 295kDa
CHRNA9 cholinergic receptor, nicotinic, alpha 9 (neuronal)
CIR1 corepressor interacting with RBPJ, 1
CORO1A coronin, actin binding protein, 1A
DCBLD2 discoidin, CUB and LCCL domain containing 2
EHF ets homologous factor
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
ELP6 elongator acetyltransferase complex subunit 6
EPPK1 epiplakin 1
ERCC2 excision repair cross-complementation group 2
FAM186A family with sequence similarity 186, member A
FAM86C1 family with sequence similarity 86, member C1
FLJ10038 uncharacterized protein FLJ10038
GATC glutamyl-tRNA(Gln) amidotransferase, subunit C
GINS4 GINS complex subunit 4 (Sld5 homolog)
GLS2 glutaminase 2 (liver, mitochondrial)
GPX2 glutathione peroxidase 2
HAUS6 HAUS augmin-like complex, subunit 6
HIST1H1D histone cluster 1, H1d
HIST1H1E histone cluster 1, H1e
HIST1H1T histone cluster 1, H1t
HIST1H2AI histone cluster 1, H2ai
HIST1H3F histone cluster 1, H3f
HIST1H4C histone cluster 1, H4c
HOXC5 homeobox C5
HOXC8 homeobox C8
HSF2BP heat shock transcription factor 2 binding protein
IDI2-AS1 IDI2 antisense RNA 1
IFI6 interferon, alpha-inducible protein 6
KLC2 kinesin light chain 2
KLHL28 kelch-like family member 28
LINC00216 long intergenic non-protein coding RNA 216
LPPR4 lipid phosphate phosphatase-related protein type 4
LRP2 low density lipoprotein receptor-related protein 2
LRRC37A3 leucine rich repeat containing 37, member A3
MAGEA6 melanoma antigen family A6
MED18 mediator complex subunit 18
METTL16 methyltransferase like 16
MMP3 matrix metallopeptidase 3
MTA2 metastasis associated 1 family, member 2
MYL5 myosin, light chain 5, regulatory
NABP1 nucleic acid binding protein 1
NFIX nuclear factor I/X (CCAAT-binding transcription factor)
NME3 NME/NM23 nucleoside diphosphate kinase 3
PCDHA9 protocadherin alpha 9
PDGFA platelet-derived growth factor alpha polypeptide
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
POLL polymerase (DNA directed), lambda
PRB3 proline-rich protein BstNI subfamily 3
RAB11B RAB11B, member RAS oncogene family
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
RBM42 RNA binding motif protein 42
RBMS3 RNA binding motif, single stranded interacting protein 3
RFX7 regulatory factor X, 7
RNF125 ring finger protein 125, E3 ubiquitin protein ligase
RPL10L ribosomal protein L10-like
RPRM reprimo, TP53 dependent G2 arrest mediator candidate
S100A3 S100 calcium binding protein A3
SCARA3 scavenger receptor class A, member 3
SCG5 secretogranin V
SCN1B sodium channel, voltage gated, type I beta subunit
SCRN3 secernin 3
SLC44A1 solute carrier family 44 (choline transporter), member 1
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SP4 Sp4 transcription factor
SRD5A3 steroid 5 alpha-reductase 3
TCEAL2 transcription elongation factor A (SII)-like 2
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor)
TEP1 telomerase-associated protein 1
TIPRL TOR signaling pathway regulator
TMEM209 transmembrane protein 209
TSPAN2 tetraspanin 2
USP36 ubiquitin specific peptidase 36
VGF VGF nerve growth factor inducible
WHSC1L1 Wolf-Hirschhorn syndrome candidate 1-like 1
YY2 YY2 transcription factor
ZFHX2 zinc finger homeobox 2
ZFP30 ZFP30 zinc finger protein
ZNF10 zinc finger protein 10
ZNF264 zinc finger protein 264
ZNF286A zinc finger protein 286A
ZNF426 zinc finger protein 426
ZNF573 zinc finger protein 573
ZNF652 zinc finger protein 652
ZNF667 zinc finger protein 667
ZNF701 zinc finger protein 701
ZNF74 zinc finger protein 74