lobeline-2763 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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198 genes differentially expressed following the lobeline-2763 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACTG2 actin, gamma 2, smooth muscle, enteric
AIM2 absent in melanoma 2
ALDH1L1 aldehyde dehydrogenase 1 family, member L1
ALPL alkaline phosphatase, liver/bone/kidney
ANGPTL2 angiopoietin-like 2
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17
ARSD arylsulfatase D
ATAT1 alpha tubulin acetyltransferase 1
ATF6B activating transcription factor 6 beta
ATXN2L ataxin 2-like
BGN biglycan
C1QTNF1 C1q and tumor necrosis factor related protein 1
C22ORF46 chromosome 22 open reading frame 46
C3AR1 complement component 3a receptor 1
CD1A CD1a molecule
CD36 CD36 molecule (thrombospondin receptor)
CD83 CD83 molecule
CEP112 centrosomal protein 112kDa
CNTN1 contactin 1
COL1A1 collagen, type I, alpha 1
COX10 COX10 heme A:farnesyltransferase cytochrome c oxidase assembly factor
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa
CTSF cathepsin F
DLGAP4 discs, large (Drosophila) homolog-associated protein 4
DNASE1L2 deoxyribonuclease I-like 2
DRD1 dopamine receptor D1
DRD5 dopamine receptor D5
EDIL3 EGF-like repeats and discoidin I-like domains 3
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2
ELOVL2 ELOVL fatty acid elongase 2
ELOVL5 ELOVL fatty acid elongase 5
ETV5 ets variant 5
FAM214B family with sequence similarity 214, member B
FST follistatin
FUT2 fucosyltransferase 2 (secretor status included)
GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1
GUCY1B2 guanylate cyclase 1, soluble, beta 2 (pseudogene)
GUCY1B3 guanylate cyclase 1, soluble, beta 3
HFE hemochromatosis
HOXB6 homeobox B6
HSD3B1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
IDS iduronate 2-sulfatase
IGF1 insulin-like growth factor 1 (somatomedin C)
IL6ST interleukin 6 signal transducer
IRF8 interferon regulatory factor 8
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
KIAA0319L KIAA0319-like
KRT19P2 keratin 19 pseudogene 2
LENEP lens epithelial protein
LIMCH1 LIM and calponin homology domains 1
LINC01587 long intergenic non-protein coding RNA 1587
LRRC6 leucine rich repeat containing 6
MAGEB2 melanoma antigen family B2
MAPK14 mitogen-activated protein kinase 14
MARK4 MAP/microtubule affinity-regulating kinase 4
MFGE8 milk fat globule-EGF factor 8 protein
MFNG MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
MINK1 misshapen-like kinase 1
MYOZ1 myozenin 1
N4BP2L1 NEDD4 binding protein 2-like 1
NAA11 N(alpha)-acetyltransferase 11, NatA catalytic subunit
NBR2 neighbor of BRCA1 gene 2 (non-protein coding)
NEURL1 neuralized E3 ubiquitin protein ligase 1
NR6A1 nuclear receptor subfamily 6, group A, member 1
NUMA1 nuclear mitotic apparatus protein 1
NUP88 nucleoporin 88kDa
OSBPL10 oxysterol binding protein-like 10
OTOR otoraplin
PHOX2B paired-like homeobox 2b
PKP1 plakophilin 1
PLP1 proteolipid protein 1
POU2F2 POU class 2 homeobox 2
RIN3 Ras and Rab interactor 3
RPS4Y1 ribosomal protein S4, Y-linked 1
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
RTN2 reticulon 2
S100A9 S100 calcium binding protein A9
SAMD4B sterile alpha motif domain containing 4B
SEMA4G sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
SIGLEC7 sialic acid binding Ig-like lectin 7
SLC34A1 solute carrier family 34 (type II sodium/phosphate cotransporter), member 1
SLC9A5 solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
SPPL2B signal peptide peptidase like 2B
STMN1 stathmin 1
STX7 syntaxin 7
SYNDIG1 synapse differentiation inducing 1
TAGLN3 transgelin 3
THRB thyroid hormone receptor, beta
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11
TRIM31 tripartite motif containing 31
UPK3B uroplakin 3B
VIPR2 vasoactive intestinal peptide receptor 2
WNT2 wingless-type MMTV integration site family member 2
WSCD1 WSC domain containing 1
ZBTB7A zinc finger and BTB domain containing 7A

decreased expression

Symbol Name
ACTR8 ARP8 actin-related protein 8 homolog (yeast)
ADM adrenomedullin
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3
ARHGAP10 Rho GTPase activating protein 10
ASPHD1 aspartate beta-hydroxylase domain containing 1
BAP1 BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
BCL7C B-cell CLL/lymphoma 7C
C1ORF159 chromosome 1 open reading frame 159
C9ORF40 chromosome 9 open reading frame 40
CAPN1 calpain 1, (mu/I) large subunit
CD2AP CD2-associated protein
CD302 CD302 molecule
CHKB choline kinase beta
CHST10 carbohydrate sulfotransferase 10
CLASP1 cytoplasmic linker associated protein 1
CLCN5 chloride channel, voltage-sensitive 5
CSTA cystatin A (stefin A)
CTC1 CTS telomere maintenance complex component 1
CTSV cathepsin V
CYB5R1 cytochrome b5 reductase 1
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
DGKD diacylglycerol kinase, delta 130kDa
DNA2 DNA replication helicase/nuclease 2
EGLN2 egl-9 family hypoxia-inducible factor 2
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
EPHA2 EPH receptor A2
ERCC5 excision repair cross-complementation group 5
FAM189B family with sequence similarity 189, member B
FAM50B family with sequence similarity 50, member B
FBXL4 F-box and leucine-rich repeat protein 4
FCHSD2 FCH and double SH3 domains 2
FHOD1 formin homology 2 domain containing 1
FUZ fuzzy planar cell polarity protein
FZD4 frizzled class receptor 4
GAA glucosidase, alpha; acid
GLS2 glutaminase 2 (liver, mitochondrial)
GLTSCR1 glioma tumor suppressor candidate region gene 1
GTF2F2 general transcription factor IIF, polypeptide 2, 30kDa
HIRA histone cell cycle regulator
HIST1H2AE histone cluster 1, H2ae
HIST3H2A histone cluster 3, H2a
HOXC13 homeobox C13
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1
HYAL2 hyaluronoglucosaminidase 2
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
ITPKC inositol-trisphosphate 3-kinase C
KCNMB4 potassium channel subfamily M regulatory beta subunit 4
KIAA1551 KIAA1551
KIF16B kinesin family member 16B
KRBOX4 KRAB box domain containing 4
LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase
LINC00115 long intergenic non-protein coding RNA 115
MKNK2 MAP kinase interacting serine/threonine kinase 2
MTMR11 myotubularin related protein 11
MTMR6 myotubularin related protein 6
MXD3 MAX dimerization protein 3
NDUFA7 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDa
NFE2L3 nuclear factor, erythroid 2-like 3
NME3 NME/NM23 nucleoside diphosphate kinase 3
NME7 NME/NM23 family member 7
PARP12 poly (ADP-ribose) polymerase family, member 12
PFAS phosphoribosylformylglycinamidine synthase
PHC1 polyhomeotic homolog 1 (Drosophila)
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PILRB paired immunoglobin-like type 2 receptor beta
PKN1 protein kinase N1
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2
PNRC1 proline-rich nuclear receptor coactivator 1
POLDIP2 polymerase (DNA-directed), delta interacting protein 2
PPIP5K2 diphosphoinositol pentakisphosphate kinase 2
PRAF2 PRA1 domain family, member 2
PRRG1 proline rich Gla (G-carboxyglutamic acid) 1
PYCRL pyrroline-5-carboxylate reductase-like
QTRT1 queuine tRNA-ribosyltransferase 1
RAB33B RAB33B, member RAS oncogene family
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4
RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2
SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
SIX1 SIX homeobox 1
SLC39A4 solute carrier family 39 (zinc transporter), member 4
SNIP1 Smad nuclear interacting protein 1
STXBP2 syntaxin binding protein 2
THYN1 thymocyte nuclear protein 1
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast)
TMEM104 transmembrane protein 104
TMEM110 transmembrane protein 110
TMEM180 transmembrane protein 180
TMEM254 transmembrane protein 254
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TSPO translocator protein (18kDa)
UBXN8 UBX domain protein 8
UNC119 unc-119 homolog (C. elegans)
USP18 ubiquitin specific peptidase 18
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae)
WASF1 WAS protein family, member 1
ZBED1 zinc finger, BED-type containing 1
ZNF468 zinc finger protein 468