lobelanidine-5080 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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198 genes differentially expressed following the lobelanidine-5080 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAM3A ADAM metallopeptidase domain 3A (pseudogene)
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AIPL1 aryl hydrocarbon receptor interacting protein-like 1
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
APOBEC3F apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F
AQP4 aquaporin 4
AVPR1A arginine vasopressin receptor 1A
BARX1 BARX homeobox 1
CABP1 calcium binding protein 1
CACNG1 calcium channel, voltage-dependent, gamma subunit 1
CADM3 cell adhesion molecule 3
CCND2 cyclin D2
CD244 CD244 molecule, natural killer cell receptor 2B4
CD6 CD6 molecule
CDHR5 cadherin-related family member 5
CELA2A chymotrypsin-like elastase family, member 2A
CHN2 chimerin 2
CLEC10A C-type lectin domain family 10, member A
CLEC4A C-type lectin domain family 4, member A
CLEC7A C-type lectin domain family 7, member A
CPN2 carboxypeptidase N, polypeptide 2
CRYGC crystallin, gamma C
DAZL deleted in azoospermia-like
DCSTAMP dendrocyte expressed seven transmembrane protein
DFNB31 deafness, autosomal recessive 31
DHX34 DEAH (Asp-Glu-Ala-His) box polypeptide 34
DIAPH2-AS1 DIAPH2 antisense RNA 1
DRD1 dopamine receptor D1
ENPEP glutamyl aminopeptidase (aminopeptidase A)
EPHA1 EPH receptor A1
EPO erythropoietin
EPS8L3 EPS8-like 3
FBXO21 F-box protein 21
FGB fibrinogen beta chain
GAS2L1 growth arrest-specific 2 like 1
GCGR glucagon receptor
GFER growth factor, augmenter of liver regeneration
GP2 glycoprotein 2 (zymogen granule membrane)
GPR68 G protein-coupled receptor 68
GYPB glycophorin B (MNS blood group)
GZMK granzyme K (granzyme 3; tryptase II)
GZMM granzyme M (lymphocyte met-ase 1)
HAND1 heart and neural crest derivatives expressed 1
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HPS1 Hermansky-Pudlak syndrome 1
HPSE2 heparanase 2 (inactive)
IL1RL1 interleukin 1 receptor-like 1
IMPG1 interphotoreceptor matrix proteoglycan 1
IRAK3 interleukin-1 receptor-associated kinase 3
KCNJ1 potassium channel, inwardly rectifying subfamily J, member 1
KIR2DS1 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1
LEFTY2 left-right determination factor 2
LGALS4 lectin, galactoside-binding, soluble, 4
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LINC00652 long intergenic non-protein coding RNA 652
LRMP lymphoid-restricted membrane protein
LRRN3 leucine rich repeat neuronal 3
MDFI MyoD family inhibitor
MRAS muscle RAS oncogene homolog
MTSS1L metastasis suppressor 1-like
NDUFB7 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa
NEUROD1 neuronal differentiation 1
NOP16 NOP16 nucleolar protein
NPPB natriuretic peptide B
NPR1 natriuretic peptide receptor 1
NR4A1 nuclear receptor subfamily 4, group A, member 1
OMD osteomodulin
PALM paralemmin
PAX2 paired box 2
PCDHB17P protocadherin beta 17 pseudogene
PODNL1 podocan-like 1
PSG9 pregnancy specific beta-1-glycoprotein 9
RBMY2FP RNA binding motif protein, Y-linked, family 2, member F pseudogene
RGR retinal G protein coupled receptor
RGS11 regulator of G-protein signaling 11
RGS12 regulator of G-protein signaling 12
RNF122 ring finger protein 122
RPL7 ribosomal protein L7
RYR2 ryanodine receptor 2 (cardiac)
SLC44A1 solute carrier family 44 (choline transporter), member 1
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3
SOGA1 suppressor of glucose, autophagy associated 1
SORBS2 sorbin and SH3 domain containing 2
SRD5A2 steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)
SRSF7 serine/arginine-rich splicing factor 7
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
SUSD5 sushi domain containing 5
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
THRA thyroid hormone receptor, alpha
TPTE transmembrane phosphatase with tensin homology
TRAPPC9 trafficking protein particle complex 9
TRIM29 tripartite motif containing 29
TSPAN7 tetraspanin 7
TUBA4B tubulin, alpha 4b
UBE3A ubiquitin protein ligase E3A
UBXN1 UBX domain protein 1
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17
UST uronyl-2-sulfotransferase
VAV2 vav 2 guanine nucleotide exchange factor
ZC3H7B zinc finger CCCH-type containing 7B

decreased expression

Symbol Name
ADAMTS3 ADAM metallopeptidase with thrombospondin type 1 motif, 3
ADGRG2 adhesion G protein-coupled receptor G2
AK5 adenylate kinase 5
ALDH4A1 aldehyde dehydrogenase 4 family, member A1
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2
C9ORF91 chromosome 9 open reading frame 91
CEP85 centrosomal protein 85kDa
CFAP69 cilia and flagella associated protein 69
CINP cyclin-dependent kinase 2 interacting protein
CLDN15 claudin 15
CLK1 CDC-like kinase 1
CLN8 ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation)
CPNE7 copine VII
CSRNP3 cysteine-serine-rich nuclear protein 3
CXORF56 chromosome X open reading frame 56
DNAL4 dynein, axonemal, light chain 4
EDIL3 EGF-like repeats and discoidin I-like domains 3
EFNA3 ephrin-A3
EHD3 EH-domain containing 3
EHHADH enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase
EPHB3 EPH receptor B3
ERCC5 excision repair cross-complementation group 5
FAM114A2 family with sequence similarity 114, member A2
FAT4 FAT atypical cadherin 4
FLCN folliculin
FPGS folylpolyglutamate synthase
FRS3 fibroblast growth factor receptor substrate 3
GID4 GID complex subunit 4
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
GUSBP3 glucuronidase, beta pseudogene 3
H2AFJ H2A histone family, member J
HDAC7 histone deacetylase 7
HMHA1 histocompatibility (minor) HA-1
HNRNPA3P1 heterogeneous nuclear ribonucleoprotein A3 pseudogene 1
HOOK1 hook microtubule-tethering protein 1
IL17RA interleukin 17 receptor A
INPP5B inositol polyphosphate-5-phosphatase, 75kDa
IPPK inositol 1,3,4,5,6-pentakisphosphate 2-kinase
KIAA0753 KIAA0753
LINC00341 long intergenic non-protein coding RNA 341
LMO7 LIM domain 7
LOC100286895 cell division cycle 27 homolog pseudogene
LRRC37A4P leucine rich repeat containing 37, member A4, pseudogene
LRRC61 leucine rich repeat containing 61
LZTS3 leucine zipper, putative tumor suppressor family member 3
METTL4 methyltransferase like 4
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3
MITF microphthalmia-associated transcription factor
MORC3 MORC family CW-type zinc finger 3
MTA2 metastasis associated 1 family, member 2
MX1 MX dynamin-like GTPase 1
MYH9 myosin, heavy chain 9, non-muscle
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NME5 NME/NM23 family member 5
NOD1 nucleotide-binding oligomerization domain containing 1
NOTCH1 notch 1
NUDT13 nudix (nucleoside diphosphate linked moiety X)-type motif 13
PARD6A par-6 family cell polarity regulator alpha
PCYT2 phosphate cytidylyltransferase 2, ethanolamine
PDZD2 PDZ domain containing 2
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PLD3 phospholipase D family, member 3
PRR4 proline rich 4 (lacrimal)
PTK6 protein tyrosine kinase 6
PWAR5 Prader Willi/Angelman region RNA 5
QSER1 glutamine and serine rich 1
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RPL23AP32 ribosomal protein L23a pseudogene 32
S100A3 S100 calcium binding protein A3
SCG5 secretogranin V
SCN8A sodium channel, voltage gated, type VIII alpha subunit
SETBP1 SET binding protein 1
SH2D2A SH2 domain containing 2A
SLC12A9 solute carrier family 12, member 9
SLC39A7 solute carrier family 39 (zinc transporter), member 7
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
SNIP1 Smad nuclear interacting protein 1
SPEG SPEG complex locus
SUV39H2 suppressor of variegation 3-9 homolog 2 (Drosophila)
TEX40 testis expressed 40
TM6SF1 transmembrane 6 superfamily member 1
TMEM127 transmembrane protein 127
TRIM45 tripartite motif containing 45
TRPM4 transient receptor potential cation channel, subfamily M, member 4
TSC22D4 TSC22 domain family, member 4
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific
VSIG10 V-set and immunoglobulin domain containing 10
ZBTB48 zinc finger and BTB domain containing 48
ZMAT5 zinc finger, matrin-type 5
ZNF350 zinc finger protein 350
ZNF37BP zinc finger protein 37B, pseudogene
ZNF668 zinc finger protein 668
ZNF767P zinc finger family member 767, pseudogene
ZXDC ZXD family zinc finger C