liver disease Gene Set

Dataset GWASdb SNP-Disease Associations
Category disease or phenotype associations
Type disease
External Link http://jjwanglab.org/gwasdb/gwasdb2/gwasdb2/go_trait/DOID:409
Similar Terms
Downloads & Tools

Genes

224 genes associated with the disease liver disease in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset.

Symbol Name Standardized Value
HECTD4 HECT domain containing E3 ubiquitin protein ligase 4 3.20189
GGT1 gamma-glutamyltransferase 1 3.11567
PNPLA3 patatin-like phospholipase domain containing 3 2.50375
HNF1A HNF1 homeobox A 2.49646
EXOC3L4 exocyst complex component 3-like 4 2.245
ZNF827 zinc finger protein 827 2.20043
GPLD1 glycosylphosphatidylinositol specific phospholipase D1 2.16801
C6ORF10 chromosome 6 open reading frame 10 2.14125
JMJD1C jumonji domain containing 1C 2.08981
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase) 2.05009
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13 2.03389
RORA RAR-related orphan receptor A 1.99623
GCKR glucokinase (hexokinase 4) regulator 1.97083
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B 1.94711
HPN hepsin 1.93435
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 1.8787
FUT2 fucosyltransferase 2 (secretor status included) 1.83309
MIR22HG MIR22 host gene 1.78856
C12ORF43 chromosome 12 open reading frame 43 1.75331
OASL 2'-5'-oligoadenylate synthetase-like 1.68731
MYO1B myosin IB 1.63837
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2 1.59102
ITGA1 integrin, alpha 1 1.54533
DLG5 discs, large homolog 5 (Drosophila) 1.52524
ABHD12 abhydrolase domain containing 12 1.52067
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1 1.51254
CD276 CD276 molecule 1.50906
EFHD1 EF-hand domain family, member D1 1.50906
ST3GAL4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4 1.48714
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 1.48714
MLXIPL MLX interacting protein-like 1.47287
FADS2 fatty acid desaturase 2 1.47287
MLIP muscular LMNA-interacting protein 1.47287
RPS11 ribosomal protein S11 1.4479
CEPT1 choline/ethanolamine phosphotransferase 1 1.44134
HCP5 HLA complex P5 (non-protein coding) 1.4259
ELL2 elongation factor, RNA polymerase II, 2 1.42467
STK26 serine/threonine protein kinase 26 1.40726
FRMD5 FERM domain containing 5 1.39396
HLA-DPB1 major histocompatibility complex, class II, DP beta 1 1.35625
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3 1.32598
FRMD7 FERM domain containing 7 1.29372
ST6GALNAC3 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 1.28906
CELF2 CUGBP, Elav-like family member 2 1.25477
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal) 1.23034
LMX1A LIM homeobox transcription factor 1, alpha 1.23034
GOT1 glutamic-oxaloacetic transaminase 1, soluble 1.20161
LINC00540 long intergenic non-protein coding RNA 540 1.18637
HNF4A hepatocyte nuclear factor 4, alpha 1.16174
CERS3 ceramide synthase 3 1.16132
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1 1.15436
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 1.14463
ACOT9 acyl-CoA thioesterase 9 1.13248
KIF3A kinesin family member 3A 1.12663
CORO2A coronin, actin binding protein, 2A 1.11123
CCDC102B coiled-coil domain containing 102B 1.10764
GMDS GDP-mannose 4,6-dehydratase 1.10153
LOC643542 uncharacterized LOC643542 1.08274
RGS5 regulator of G-protein signaling 5 1.07599
THSD7B thrombospondin, type I, domain containing 7B 1.07599
GALNT13 polypeptide N-acetylgalactosaminyltransferase 13 1.07599
EFHC2 EF-hand domain (C-terminal) containing 2 1.07422
TRPM1 transient receptor potential cation channel, subfamily M, member 1 1.06224
EXOC1 exocyst complex component 1 1.05742
LOC100505718 1.05657
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 1.02476
SLC39A11 solute carrier family 39, member 11 1.02476
MUC5B mucin 5B, oligomeric mucus/gel-forming 1.00711
ETNK2 ethanolamine kinase 2 1.00407
HSF2 heat shock transcription factor 2 0.991774
DMD dystrophin 0.987533
KLF5 Kruppel-like factor 5 (intestinal) 0.983144
ABHD17C abhydrolase domain containing 17C 0.976976
CDH13 cadherin 13 0.972161
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.966942
ARHGAP15 Rho GTPase activating protein 15 0.960535
ASTN2 astrotactin 2 0.959568
CLUAP1 clusterin associated protein 1 0.958374
MGRN1 mahogunin ring finger 1, E3 ubiquitin protein ligase 0.950418
ART3 ADP-ribosyltransferase 3 0.923572
SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8 0.897579
ALDH1A3 aldehyde dehydrogenase 1 family, member A3 0.896938
MAN2A1 mannosidase, alpha, class 2A, member 1 0.889594
IL23R interleukin 23 receptor 0.885884
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) 0.882152
KCNJ3 potassium channel, inwardly rectifying subfamily J, member 3 0.875106
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) 0.873717
RNF34 ring finger protein 34, E3 ubiquitin protein ligase 0.869084
MCTP1 multiple C2 domains, transmembrane 1 0.86494
SPAG16 sperm associated antigen 16 0.855811
LAMA4 laminin, alpha 4 0.851812
UBASH3A ubiquitin associated and SH3 domain containing A 0.850837
PCBD2 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2 0.841599
RAP1GAP2 RAP1 GTPase activating protein 2 0.826866
IL12RB2 interleukin 12 receptor, beta 2 0.826018
THBS2 thrombospondin 2 0.820721
HID1 HID1 domain containing 0.815307
HDAC4 histone deacetylase 4 0.804284
TNRC18 trinucleotide repeat containing 18 0.803614
LOC100506944 uncharacterized LOC100506944 0.798811
MFSD4 major facilitator superfamily domain containing 4 0.798811
VIT vitrin 0.790866
CD9 CD9 molecule 0.789217
SYN3 synapsin III 0.78195
FHIT fragile histidine triad 0.778061
GNAS GNAS complex locus 0.775739
ENPEP glutamyl aminopeptidase (aminopeptidase A) 0.775167
WDR7 WD repeat domain 7 0.7718
CSMD1 CUB and Sushi multiple domains 1 0.767585
NELL1 NEL-like 1 (chicken) 0.767289
PTGFRN prostaglandin F2 receptor inhibitor 0.751374
GFRA2 GDNF family receptor alpha 2 0.745911
PVT1 Pvt1 oncogene (non-protein coding) 0.744948
SERINC5 serine incorporator 5 0.74447
CREB3L3 cAMP responsive element binding protein 3-like 3 0.742344
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit 0.73454
DNTTIP1 deoxynucleotidyltransferase, terminal, interacting protein 1 0.727538
TPD52L1 tumor protein D52-like 1 0.727312
SLC26A9 solute carrier family 26 (anion exchanger), member 9 0.726189
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) 0.722457
GRIA4 glutamate receptor, ionotropic, AMPA 4 0.72032
NEB nebulin 0.719058
UTRN utrophin 0.718849
NR2C2 nuclear receptor subfamily 2, group C, member 2 0.711585
FBXO39 F-box protein 39 0.707377
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.70084
CASC15 cancer susceptibility candidate 15 (non-protein coding) 0.700315
STAB1 stabilin 1 0.699101
LOC339622 uncharacterized LOC339622 0.697901
XPO7 exportin 7 0.694877
SLIT2 slit homolog 2 (Drosophila) 0.694877
WFDC3 WAP four-disulfide core domain 3 0.692585
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.689554
DAAM2 dishevelled associated activator of morphogenesis 2 0.688459
SYNE3 spectrin repeat containing, nuclear envelope family member 3 0.685395
METTL22 methyltransferase like 22 0.683452
DMRT1 doublesex and mab-3 related transcription factor 1 0.680104
FGD5 FYVE, RhoGEF and PH domain containing 5 0.678682
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8 0.67576
CALD1 caldesmon 1 0.674941
CYP7B1 cytochrome P450, family 7, subfamily B, polypeptide 1 0.674399
TNPO3 transportin 3 0.671729
LCT lactase 0.671205
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.670156
GRID2 glutamate receptor, ionotropic, delta 2 0.669341
TRRAP transformation/transcription domain-associated protein 0.668836
EMC2 ER membrane protein complex subunit 2 0.615118
TNFAIP1 tumor necrosis factor, alpha-induced protein 1 (endothelial) 0.615118
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.615118
SLC22A12 solute carrier family 22 (organic anion/urate transporter), member 12 0.615118
OSBPL3 oxysterol binding protein-like 3 0.615118
ZNF221 zinc finger protein 221 0.586345
CDH4 cadherin 4, type 1, R-cadherin (retinal) 0.586345
FAM107B family with sequence similarity 107, member B 0.564734
MCC mutated in colorectal cancers 0.564734
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.564734
ANXA2 annexin A2 0.564734
ZDHHC6 zinc finger, DHHC-type containing 6 0.564734
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15 0.561648
MSH6 mutS homolog 6 0.547225
HNF1B HNF1 homeobox B 0.547225
MED15 mediator complex subunit 15 0.547225
PARD3B par-3 family cell polarity regulator beta 0.547225
LHX6 LIM homeobox 6 0.547225
ZNF214 zinc finger protein 214 0.532547
SPIB Spi-B transcription factor (Spi-1/PU.1 related) 0.523946
BTNL2 butyrophilin-like 2 0.522709
SLC25A19 solute carrier family 25 (mitochondrial thiamine pyrophosphate carrier), member 19 0.520364
TRAF3IP1 TNF receptor-associated factor 3 interacting protein 1 0.520364
TRAF4 TNF receptor-associated factor 4 0.520364
LARS2 leucyl-tRNA synthetase 2, mitochondrial 0.520364
CHST9 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9 0.510061
SDHAF3 succinate dehydrogenase complex assembly factor 3 0.502485
NOD2 nucleotide-binding oligomerization domain containing 2 0.502485
ADAMTS2 ADAM metallopeptidase with thrombospondin type 1 motif, 2 0.502485
FCHO1 FCH domain only 1 0.502485
RPL3 ribosomal protein L3 0.494878
CLEC16A C-type lectin domain family 16, member A 0.486121
BAG6 BCL2-associated athanogene 6 0.484952
RAD51B RAD51 paralog B 0.477616
TNFSF8 tumor necrosis factor (ligand) superfamily, member 8 0.475934
TIMMDC1 translocase of inner mitochondrial membrane domain containing 1 0.475708
HLA-DRA major histocompatibility complex, class II, DR alpha 0.47404
EHMT2 euchromatic histone-lysine N-methyltransferase 2 0.472313
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4 0.466435
ARHGAP31 Rho GTPase activating protein 31 0.466236
TMEM39A transmembrane protein 39A 0.465576
IL7R interleukin 7 receptor 0.464125
PBX2 pre-B-cell leukemia homeobox 2 0.462641
PRRC2A proline-rich coiled-coil 2A 0.456983
GPANK1 G patch domain and ankyrin repeats 1 0.454426
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 0.452405
IKZF3 IKAROS family zinc finger 3 (Aiolos) 0.452405
DENND1B DENN/MADD domain containing 1B 0.452158
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 0.438494
PRDM16 PR domain containing 16 0.437473
PPARG peroxisome proliferator-activated receptor gamma 0.432325
PLCL2 phospholipase C-like 2 0.432325
MED1 mediator complex subunit 1 0.431106
PRICKLE1 prickle homolog 1 (Drosophila) 0.426981
COL17A1 collagen, type XVII, alpha 1 0.426374
ELMO1 engulfment and cell motility 1 0.426309
TP63 tumor protein p63 0.425346
CDK12 cyclin-dependent kinase 12 0.41697
SDK1 sidekick cell adhesion molecule 1 0.416785
LY6G5B lymphocyte antigen 6 complex, locus G5B 0.414493
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.409887
FBXL20 F-box and leucine-rich repeat protein 20 0.409006
SLC17A8 solute carrier family 17 (vesicular glutamate transporter), member 8 0.408005
PAX3 paired box 3 0.404413
GRIK1 glutamate receptor, ionotropic, kainate 1 0.403487
CNTN5 contactin 5 0.403311
GLI3 GLI family zinc finger 3 0.401837
MANBA mannosidase, beta A, lysosomal 0.400858
STAT4 signal transducer and activator of transcription 4 0.392011
CCDC88B coiled-coil domain containing 88B 0.390632
LBH limb bud and heart development 0.384116
AIF1 allograft inflammatory factor 1 0.378024
HNRNPK heterogeneous nuclear ribonucleoprotein K 0.375799
ALG10B ALG10B, alpha-1,2-glucosyltransferase 0.374828
MCTP2 multiple C2 domains, transmembrane 2 0.372858
C5ORF30 chromosome 5 open reading frame 30 0.367293
MAPT microtubule-associated protein tau 0.36707
COLEC12 collectin sub-family member 12 0.364634