lithocholic acid-4373 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the lithocholic acid-4373 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCG4 ATP-binding cassette, sub-family G (WHITE), member 4
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
ATN1 atrophin 1
BRF1 BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit
C19ORF73 chromosome 19 open reading frame 73
C21ORF2 chromosome 21 open reading frame 2
CAMK2B calcium/calmodulin-dependent protein kinase II beta
CD1E CD1e molecule
CD300C CD300c molecule
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CDK13 cyclin-dependent kinase 13
CDK18 cyclin-dependent kinase 18
CLCA1 chloride channel accessory 1
CPA4 carboxypeptidase A4
CST4 cystatin S
CSTF2T cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant
DNAH7 dynein, axonemal, heavy chain 7
DTX3 deltex 3, E3 ubiquitin ligase
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
ERBB2 erb-b2 receptor tyrosine kinase 2
ETV7 ets variant 7
EYA4 EYA transcriptional coactivator and phosphatase 4
FBLN1 fibulin 1
FMO5 flavin containing monooxygenase 5
FRMD8 FERM domain containing 8
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
GK glycerol kinase
GP2 glycoprotein 2 (zymogen granule membrane)
GP6 glycoprotein VI (platelet)
GRM1 glutamate receptor, metabotropic 1
GUCA1A guanylate cyclase activator 1A (retina)
GVINP1 GTPase, very large interferon inducible pseudogene 1
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3
HIRA histone cell cycle regulator
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HRH4 histamine receptor H4
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IZUMO4 IZUMO family member 4
KCNIP1 Kv channel interacting protein 1
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
LAT2 linker for activation of T cells family, member 2
LDHB lactate dehydrogenase B
LIMK1 LIM domain kinase 1
LMF2 lipase maturation factor 2
LMNB1 lamin B1
LOC100127972 uncharacterized LOC100127972
LRCH4 leucine-rich repeats and calponin homology (CH) domain containing 4
LSP1 lymphocyte-specific protein 1
LTC4S leukotriene C4 synthase
LY9 lymphocyte antigen 9
MAN1C1 mannosidase, alpha, class 1C, member 1
MCAM melanoma cell adhesion molecule
MED1 mediator complex subunit 1
MGAT3 mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
MUC3B mucin 3B, cell surface associated
NPAS2 neuronal PAS domain protein 2
NUDCD3 NudC domain containing 3
NUP188 nucleoporin 188kDa
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OR52A1 olfactory receptor, family 52, subfamily A, member 1
PCBP3 poly(rC) binding protein 3
PCDHGA8 protocadherin gamma subfamily A, 8
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PKP1 plakophilin 1
PLXNA2 plexin A2
PPP2R1B protein phosphatase 2, regulatory subunit A, beta
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha
PXDC1 PX domain containing 1
RABEP2 rabaptin, RAB GTPase binding effector protein 2
RAD52 RAD52 homolog (S. cerevisiae)
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RTEL1 regulator of telomere elongation helicase 1
RYR1 ryanodine receptor 1 (skeletal)
SERHL2 serine hydrolase-like 2
SGK2 serum/glucocorticoid regulated kinase 2
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC9A3R2 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
SPOCK3 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
SYNE1 spectrin repeat containing, nuclear envelope 1
TAGLN3 transgelin 3
TBX3 T-box 3
TBXA2R thromboxane A2 receptor
TFCP2 transcription factor CP2
TM4SF1 transmembrane 4 L six family member 1
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TNFRSF9 tumor necrosis factor receptor superfamily, member 9
TRAF3IP1 TNF receptor-associated factor 3 interacting protein 1
TREM1 triggering receptor expressed on myeloid cells 1
TRIM10 tripartite motif containing 10
TRPM1 transient receptor potential cation channel, subfamily M, member 1
UGT8 UDP glycosyltransferase 8
XAF1 XIAP associated factor 1
XYLB xylulokinase homolog (H. influenzae)
ZER1 zyg-11 related, cell cycle regulator
ZFP64 ZFP64 zinc finger protein
ZNF175 zinc finger protein 175

decreased expression

Symbol Name
AATK apoptosis-associated tyrosine kinase
ACTL8 actin-like 8
ADGRE5 adhesion G protein-coupled receptor E5
ANKFY1 ankyrin repeat and FYVE domain containing 1
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle)
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ASPHD1 aspartate beta-hydroxylase domain containing 1
ATG16L1 autophagy related 16-like 1 (S. cerevisiae)
ATHL1 ATH1, acid trehalase-like 1 (yeast)
BCO1 beta-carotene oxygenase 1
BIRC7 baculoviral IAP repeat containing 7
BLNK B-cell linker
C11ORF63 chromosome 11 open reading frame 63
C11ORF80 chromosome 11 open reading frame 80
C14ORF79 chromosome 14 open reading frame 79
CALML5 calmodulin-like 5
CAMK1D calcium/calmodulin-dependent protein kinase ID
CAPN5 calpain 5
CFHR4 complement factor H-related 4
CLDN1 claudin 1
CNTFR ciliary neurotrophic factor receptor
COL5A2 collagen, type V, alpha 2
CSTA cystatin A (stefin A)
DAAM2 dishevelled associated activator of morphogenesis 2
DAGLA diacylglycerol lipase, alpha
DBF4B DBF4 zinc finger B
DDX51 DEAD (Asp-Glu-Ala-Asp) box polypeptide 51
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DNAJC28 DnaJ (Hsp40) homolog, subfamily C, member 28
DNASE1L2 deoxyribonuclease I-like 2
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DRD1 dopamine receptor D1
EFNA3 ephrin-A3
ELSPBP1 epididymal sperm binding protein 1
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5
EPHX2 epoxide hydrolase 2, cytoplasmic
ETV6 ets variant 6
EXOC6B exocyst complex component 6B
FAM184A family with sequence similarity 184, member A
FAM46C family with sequence similarity 46, member C
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GPR39 G protein-coupled receptor 39
GPRC5D G protein-coupled receptor, class C, group 5, member D
HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4
HIST1H2AK histone cluster 1, H2ak
HIST1H4A histone cluster 1, H4a
HOXC10 homeobox C10
HTR1F 5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled
ICAM4 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
IL12RB1 interleukin 12 receptor, beta 1
ISL1 ISL LIM homeobox 1
ITM2C integral membrane protein 2C
KANSL1L KAT8 regulatory NSL complex subunit 1-like
LGALS9 lectin, galactoside-binding, soluble, 9
LOC729164 hCG1732469
MAP2 microtubule-associated protein 2
MED31 mediator complex subunit 31
MFAP2 microfibrillar-associated protein 2
MICALL2 MICAL-like 2
MMP3 matrix metallopeptidase 3
NDE1 nudE neurodevelopment protein 1
NOL12 nucleolar protein 12
NPTX1 neuronal pentraxin I
NT5E 5'-nucleotidase, ecto (CD73)
OLFML2A olfactomedin-like 2A
OSGIN1 oxidative stress induced growth inhibitor 1
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2
PCDHA6 protocadherin alpha 6
PDE8B phosphodiesterase 8B
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PHF14 PHD finger protein 14
PODNL1 podocan-like 1
POU3F2 POU class 3 homeobox 2
RAB40C RAB40C, member RAS oncogene family
RFPL1S RFPL1 antisense RNA 1
RND1 Rho family GTPase 1
SAYSD1 SAYSVFN motif domain containing 1
SCARA3 scavenger receptor class A, member 3
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SKI SKI proto-oncogene
SLC22A18AS solute carrier family 22 (organic cation transporter), member 18 antisense
STEAP1 six transmembrane epithelial antigen of the prostate 1
TFF2 trefoil factor 2
THAP9 THAP domain containing 9
THBS3 thrombospondin 3
TLR2 toll-like receptor 2
TM4SF4 transmembrane 4 L six family member 4
TM4SF5 transmembrane 4 L six family member 5
TPSG1 tryptase gamma 1
TSNAXIP1 translin-associated factor X interacting protein 1
TTLL1 tubulin tyrosine ligase-like family member 1
TUBA4B tubulin, alpha 4b
UPK2 uroplakin 2
USP27X ubiquitin specific peptidase 27, X-linked
WFDC2 WAP four-disulfide core domain 2
ZC2HC1C zinc finger, C2HC-type containing 1C