lithocholic acid-3816 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the lithocholic acid-3816 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABI2 abl-interactor 2
ACOX3 acyl-CoA oxidase 3, pristanoyl
AKR1C1 aldo-keto reductase family 1, member C1
BZRAP1 benzodiazepine receptor (peripheral) associated protein 1
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
CASP2 caspase 2, apoptosis-related cysteine peptidase
CASP5 caspase 5, apoptosis-related cysteine peptidase
CCDC170 coiled-coil domain containing 170
CCDC57 coiled-coil domain containing 57
CCL22 chemokine (C-C motif) ligand 22
CD4 CD4 molecule
CLEC4A C-type lectin domain family 4, member A
CLTA clathrin, light chain A
COL10A1 collagen, type X, alpha 1
COL15A1 collagen, type XV, alpha 1
CSF1R colony stimulating factor 1 receptor
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
DGCR8 DGCR8 microprocessor complex subunit
DGCR9 DiGeorge syndrome critical region gene 9 (non-protein coding)
DIAPH2-AS1 DIAPH2 antisense RNA 1
DIO2 deiodinase, iodothyronine, type II
DLG4 discs, large homolog 4 (Drosophila)
DNAH6 dynein, axonemal, heavy chain 6
DOCK9 dedicator of cytokinesis 9
DPY19L1P1 DPY19L1 pseudogene 1
EMID1 EMI domain containing 1
EPAS1 endothelial PAS domain protein 1
FAM110D family with sequence similarity 110, member D
FAM212B family with sequence similarity 212, member B
FAM65B family with sequence similarity 65, member B
GDAP1 ganglioside induced differentiation associated protein 1
HIC2 hypermethylated in cancer 2
HIPK3 homeodomain interacting protein kinase 3
IL36G interleukin 36, gamma
INPP5D inositol polyphosphate-5-phosphatase, 145kDa
IQCC IQ motif containing C
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
KIR2DL3 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3
KITLG KIT ligand
KLHL22 kelch-like family member 22
KLK10 kallikrein-related peptidase 10
LAMA2 laminin, alpha 2
LINC00115 long intergenic non-protein coding RNA 115
LIPF lipase, gastric
LOC100131532 uncharacterized LOC100131532
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1
LRRC48 leucine rich repeat containing 48
LRTM1 leucine-rich repeats and transmembrane domains 1
LUZP4 leucine zipper protein 4
MAP3K13 mitogen-activated protein kinase kinase kinase 13
MAPK11 mitogen-activated protein kinase 11
MAPK8 mitogen-activated protein kinase 8
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3
MBNL2 muscleblind-like splicing regulator 2
MFI2 antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5
MT4 metallothionein 4
MYH2 myosin, heavy chain 2, skeletal muscle, adult
NPAS3 neuronal PAS domain protein 3
NPTX1 neuronal pentraxin I
NPTX2 neuronal pentraxin II
NR0B2 nuclear receptor subfamily 0, group B, member 2
NRL neural retina leucine zipper
OR10H1 olfactory receptor, family 10, subfamily H, member 1
OSBP2 oxysterol binding protein 2
PBX2 pre-B-cell leukemia homeobox 2
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PML promyelocytic leukemia
PNMAL1 paraneoplastic Ma antigen family-like 1
PNPLA3 patatin-like phospholipase domain containing 3
POU2F2 POU class 2 homeobox 2
PRPH2 peripherin 2 (retinal degeneration, slow)
PRX periaxin
PVR poliovirus receptor
RAB6A RAB6A, member RAS oncogene family
RUNX1 runt-related transcription factor 1
SCGB1D1 secretoglobin, family 1D, member 1
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
SIRPA signal-regulatory protein alpha
SLC17A2 solute carrier family 17, member 2
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2
SLC19A1 solute carrier family 19 (folate transporter), member 1
SLC24A1 solute carrier family 24 (sodium/potassium/calcium exchanger), member 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SOCS7 suppressor of cytokine signaling 7
SPATA6 spermatogenesis associated 6
SRSF5 serine/arginine-rich splicing factor 5
TEC tec protein tyrosine kinase
TESC tescalcin
TGFB2 transforming growth factor, beta 2
TM4SF5 transmembrane 4 L six family member 5
TPSG1 tryptase gamma 1
TTC12 tetratricopeptide repeat domain 12
UBR2 ubiquitin protein ligase E3 component n-recognin 2
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
USP2 ubiquitin specific peptidase 2

decreased expression

Symbol Name
ACBD4 acyl-CoA binding domain containing 4
ADAP2 ArfGAP with dual PH domains 2
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ALOX12P2 arachidonate 12-lipoxygenase pseudogene 2
ALPK3 alpha-kinase 3
ARHGAP24 Rho GTPase activating protein 24
ARID3A AT rich interactive domain 3A (BRIGHT-like)
ART1 ADP-ribosyltransferase 1
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BICC1 BicC family RNA binding protein 1
C17ORF70 chromosome 17 open reading frame 70
C3 complement component 3
CBX8 chromobox homolog 8
CDK3 cyclin-dependent kinase 3
CLDN8 claudin 8
CPZ carboxypeptidase Z
CRMP1 collapsin response mediator protein 1
DNAJC28 DnaJ (Hsp40) homolog, subfamily C, member 28
DSPP dentin sialophosphoprotein
DUSP2 dual specificity phosphatase 2
ELSPBP1 epididymal sperm binding protein 1
ETV6 ets variant 6
FBXO31 F-box protein 31
FKRP fukutin related protein
FOS FBJ murine osteosarcoma viral oncogene homolog
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3
GLB1L galactosidase, beta 1-like
GLDC glycine dehydrogenase (decarboxylating)
GLS2 glutaminase 2 (liver, mitochondrial)
GNA14 guanine nucleotide binding protein (G protein), alpha 14
GNG3 guanine nucleotide binding protein (G protein), gamma 3
GPR21 G protein-coupled receptor 21
GPRIN2 G protein regulated inducer of neurite outgrowth 2
GRAMD4 GRAM domain containing 4
GRB7 growth factor receptor-bound protein 7
GREB1L growth regulation by estrogen in breast cancer-like
GUSBP3 glucuronidase, beta pseudogene 3
HIRA histone cell cycle regulator
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HSPA1L heat shock 70kDa protein 1-like
IL33 interleukin 33
INO80D INO80 complex subunit D
IRF2BP1 interferon regulatory factor 2 binding protein 1
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2
KLHL25 kelch-like family member 25
KRT4 keratin 4, type II
LOC390998 ribosomal protein L10 pseudogene
LYPD3 LY6/PLAUR domain containing 3
MAGEA5 melanoma antigen family A5
MMP13 matrix metallopeptidase 13
NME5 NME/NM23 family member 5
NPIPB15 nuclear pore complex interacting protein family, member B15
NPY1R neuropeptide Y receptor Y1
NSUN6 NOP2/Sun domain family, member 6
NTNG1 netrin G1
NTSR1 neurotensin receptor 1 (high affinity)
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PODNL1 podocan-like 1
PPP2R3B protein phosphatase 2, regulatory subunit B'', beta
PTPRU protein tyrosine phosphatase, receptor type, U
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RNF2 ring finger protein 2
RPGRIP1L RPGRIP1-like
RPH3A rabphilin 3A
SCAMP5 secretory carrier membrane protein 5
SIRT6 sirtuin 6
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9
SLC46A3 solute carrier family 46, member 3
SLC4A8 solute carrier family 4, sodium bicarbonate cotransporter, member 8
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
SLMO1 slowmo homolog 1 (Drosophila)
SPANXC SPANX family, member C
SPEG SPEG complex locus
SSBP3 single stranded DNA binding protein 3
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
TAGLN3 transgelin 3
TDRKH tudor and KH domain containing
TGFB3 transforming growth factor, beta 3
TMEM19 transmembrane protein 19
TMEM8B transmembrane protein 8B
TNRC6B trinucleotide repeat containing 6B
TRMT44 tRNA methyltransferase 44 homolog (S. cerevisiae)
TSKU tsukushi, small leucine rich proteoglycan
TUBA4B tubulin, alpha 4b
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific
UNC93B1 unc-93 homolog B1 (C. elegans)
XDH xanthine dehydrogenase
ZBTB3 zinc finger and BTB domain containing 3
ZNF214 zinc finger protein 214
ZNF358 zinc finger protein 358
ZNF446 zinc finger protein 446
ZNF74 zinc finger protein 74
ZNF747 zinc finger protein 747
ZNF862 zinc finger protein 862