lithocholic acid-3433 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the lithocholic acid-3433 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ACTG2 actin, gamma 2, smooth muscle, enteric
ALDH1L1 aldehyde dehydrogenase 1 family, member L1
ALDOB aldolase B, fructose-bisphosphate
ALPPL2 alkaline phosphatase, placental-like 2
AMPD3 adenosine monophosphate deaminase 3
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle)
AP1S2 adaptor-related protein complex 1, sigma 2 subunit
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
APOD apolipoprotein D
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
CAMK2G calcium/calmodulin-dependent protein kinase II gamma
CCKAR cholecystokinin A receptor
CCRL2 chemokine (C-C motif) receptor-like 2
CD82 CD82 molecule
CDKN2A cyclin-dependent kinase inhibitor 2A
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
CRYBB2P1 crystallin, beta B2 pseudogene 1
CRYGC crystallin, gamma C
CTNNBIP1 catenin, beta interacting protein 1
CYLD cylindromatosis (turban tumor syndrome)
DCN decorin
DOC2A double C2-like domains, alpha
EML2 echinoderm microtubule associated protein like 2
EXOC7 exocyst complex component 7
FBLN1 fibulin 1
FGF22 fibroblast growth factor 22
FNDC3A fibronectin type III domain containing 3A
FOXN2 forkhead box N2
FUT7 fucosyltransferase 7 (alpha (1,3) fucosyltransferase)
GAMT guanidinoacetate N-methyltransferase
GAS6 growth arrest-specific 6
GCNT4 glucosaminyl (N-acetyl) transferase 4, core 2
GIPR gastric inhibitory polypeptide receptor
GPER1 G protein-coupled estrogen receptor 1
GRB7 growth factor receptor-bound protein 7
HIPK2 homeodomain interacting protein kinase 2
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2
HOXC5 homeobox C5
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL22 interleukin 22
ING2 inhibitor of growth family, member 2
IPO5 importin 5
IRF2BP1 interferon regulatory factor 2 binding protein 1
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
KHSRP KH-type splicing regulatory protein
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LOC390998 ribosomal protein L10 pseudogene
LOC647070 uncharacterized LOC647070
LPCAT4 lysophosphatidylcholine acyltransferase 4
MAGOH2P mago-nashi homolog 2, pseudogene
MAPK14 mitogen-activated protein kinase 14
MAST3 microtubule associated serine/threonine kinase 3
MINK1 misshapen-like kinase 1
MMP16 matrix metallopeptidase 16 (membrane-inserted)
MMP3 matrix metallopeptidase 3
MR1 major histocompatibility complex, class I-related
MRPS14 mitochondrial ribosomal protein S14
MTSS1L metastasis suppressor 1-like
NME5 NME/NM23 family member 5
PARVA parvin, alpha
PAWR PRKC, apoptosis, WT1, regulator
PCDHB13 protocadherin beta 13
PCNXL2 pecanex-like 2 (Drosophila)
PDE8B phosphodiesterase 8B
PEX5 peroxisomal biogenesis factor 5
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
POMT2 protein-O-mannosyltransferase 2
PPAP2B phosphatidic acid phosphatase type 2B
QPCTL glutaminyl-peptide cyclotransferase-like
RPL10L ribosomal protein L10-like
RYR2 ryanodine receptor 2 (cardiac)
SCAPER S-phase cyclin A-associated protein in the ER
SCRN3 secernin 3
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLCO2A1 solute carrier organic anion transporter family, member 2A1
SND1-IT1 SND1 intronic transcript 1
SOCS1 suppressor of cytokine signaling 1
SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)
SPTBN2 spectrin, beta, non-erythrocytic 2
SUGP1 SURP and G patch domain containing 1
TAT tyrosine aminotransferase
TDRD1 tudor domain containing 1
TEX40 testis expressed 40
TGM2 transglutaminase 2
TIAM2 T-cell lymphoma invasion and metastasis 2
TK2 thymidine kinase 2, mitochondrial
TMEM259 transmembrane protein 259
TRIM21 tripartite motif containing 21
TSGA10 testis specific, 10
VGF VGF nerve growth factor inducible
WNK1 WNK lysine deficient protein kinase 1
XYLT1 xylosyltransferase I
ZC2HC1C zinc finger, C2HC-type containing 1C
ZNF253 zinc finger protein 253

decreased expression

Symbol Name
ACTN4 actinin, alpha 4
ANKZF1 ankyrin repeat and zinc finger domain containing 1
ARHGAP5 Rho GTPase activating protein 5
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ATAD5 ATPase family, AAA domain containing 5
ATF7IP2 activating transcription factor 7 interacting protein 2
BBS7 Bardet-Biedl syndrome 7
BRAF B-Raf proto-oncogene, serine/threonine kinase
CAMTA2 calmodulin binding transcription activator 2
CCNE1 cyclin E1
CDC7 cell division cycle 7
CNP 2',3'-cyclic nucleotide 3' phosphodiesterase
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6
DENND4A DENN/MADD domain containing 4A
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DVL1 dishevelled segment polarity protein 1
EFNA3 ephrin-A3
ENO2 enolase 2 (gamma, neuronal)
FAM102A family with sequence similarity 102, member A
FAM114A2 family with sequence similarity 114, member A2
FAM53B family with sequence similarity 53, member B
FBRS fibrosin
FBXW12 F-box and WD repeat domain containing 12
FEM1C fem-1 homolog c (C. elegans)
FGGY FGGY carbohydrate kinase domain containing
GCA grancalcin, EF-hand calcium binding protein
GINS4 GINS complex subunit 4 (Sld5 homolog)
GNL3LP1 guanine nucleotide binding protein-like 3 (nucleolar)-like pseudogene 1
GTF2H3 general transcription factor IIH, polypeptide 3, 34kDa
GTF2IRD1 GTF2I repeat domain containing 1
HGSNAT heparan-alpha-glucosaminide N-acetyltransferase
HIRA histone cell cycle regulator
HIST1H2AG histone cluster 1, H2ag
HOOK1 hook microtubule-tethering protein 1
IREB2 iron-responsive element binding protein 2
IRF6 interferon regulatory factor 6
KLHL26 kelch-like family member 26
KLHL36 kelch-like family member 36
LIG4 ligase IV, DNA, ATP-dependent
LINC00339 long intergenic non-protein coding RNA 339
LMBR1L limb development membrane protein 1-like
LNPEP leucyl/cystinyl aminopeptidase
MAN2B1 mannosidase, alpha, class 2B, member 1
MED24 mediator complex subunit 24
MRPL2 mitochondrial ribosomal protein L2
MTCL1 microtubule crosslinking factor 1
NBEAL2 neurobeachin-like 2
NSD1 nuclear receptor binding SET domain protein 1
PANK4 pantothenate kinase 4
PARP16 poly (ADP-ribose) polymerase family, member 16
PC pyruvate carboxylase
PCDHB3 protocadherin beta 3
PCSK7 proprotein convertase subtilisin/kexin type 7
PHF21A PHD finger protein 21A
PPIP5K1 diphosphoinositol pentakisphosphate kinase 1
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
RAB33B RAB33B, member RAS oncogene family
RAD54L RAD54-like (S. cerevisiae)
RCOR3 REST corepressor 3
RFWD3 ring finger and WD repeat domain 3
RGP1 RGP1 retrograde golgi transport homolog (S. cerevisiae)
RIN2 Ras and Rab interactor 2
SEZ6L2 seizure related 6 homolog (mouse)-like 2
SGK1 serum/glucocorticoid regulated kinase 1
SLC37A1 solute carrier family 37 (glucose-6-phosphate transporter), member 1
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SMAD7 SMAD family member 7
SMARCAL1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma)
STAG3 stromal antigen 3
STAG3L4 stromal antigen 3-like 4 (pseudogene)
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TMEM104 transmembrane protein 104
TMEM57 transmembrane protein 57
TRAIP TRAF interacting protein
TRAPPC6A trafficking protein particle complex 6A
TRMT2B tRNA methyltransferase 2 homolog B (S. cerevisiae)
UBXN6 UBX domain protein 6
VWA1 von Willebrand factor A domain containing 1
WBP2 WW domain binding protein 2
WDR4 WD repeat domain 4
WDR76 WD repeat domain 76
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
ZBED1 zinc finger, BED-type containing 1
ZKSCAN3 zinc finger with KRAB and SCAN domains 3
ZNF280D zinc finger protein 280D
ZNF282 zinc finger protein 282
ZNF350 zinc finger protein 350
ZNF516 zinc finger protein 516
ZNF652 zinc finger protein 652
ZNF721 zinc finger protein 721
ZNF91 zinc finger protein 91
ZNRD1-AS1 ZNRD1 antisense RNA 1
ZSCAN9 zinc finger and SCAN domain containing 9