lithocholic acid-2571 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the lithocholic acid-2571 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACPP acid phosphatase, prostate
ACSL1 acyl-CoA synthetase long-chain family member 1
ADORA3 adenosine A3 receptor
AMH anti-Mullerian hormone
AREG amphiregulin
ARG1 arginase 1
ARHGEF9 Cdc42 guanine nucleotide exchange factor (GEF) 9
BIN1 bridging integrator 1
C16ORF59 chromosome 16 open reading frame 59
C17ORF59 chromosome 17 open reading frame 59
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1
CCL20 chemokine (C-C motif) ligand 20
CD163 CD163 molecule
CD24 CD24 molecule
CD69 CD69 molecule
CDC25C cell division cycle 25C
CDC42 cell division cycle 42
CLCN4 chloride channel, voltage-sensitive 4
COPE coatomer protein complex, subunit epsilon
CPQ carboxypeptidase Q
CRTC1 CREB regulated transcription coactivator 1
CRY2 cryptochrome circadian clock 2
CSF2RA colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)
DNAJB12 DnaJ (Hsp40) homolog, subfamily B, member 12
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
EDNRA endothelin receptor type A
EDRF1 erythroid differentiation regulatory factor 1
EFNA3 ephrin-A3
EGR3 early growth response 3
EMP1 epithelial membrane protein 1
FAM13A family with sequence similarity 13, member A
FAM65B family with sequence similarity 65, member B
FKBP5 FK506 binding protein 5
FLT3 fms-related tyrosine kinase 3
FSD1 fibronectin type III and SPRY domain containing 1
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GALR3 galanin receptor 3
GATA6 GATA binding protein 6
GPR153 G protein-coupled receptor 153
GRAMD3 GRAM domain containing 3
HCAR3 hydroxycarboxylic acid receptor 3
ICOSLG inducible T-cell co-stimulator ligand
IL1R2 interleukin 1 receptor, type II
IL27RA interleukin 27 receptor, alpha
INSR insulin receptor
ITGB5 integrin, beta 5
IZUMO4 IZUMO family member 4
KIF1C kinesin family member 1C
KLF12 Kruppel-like factor 12
KLF9 Kruppel-like factor 9
KRT86 keratin 86, type II
LAMB2 laminin, beta 2 (laminin S)
LARP7 La ribonucleoprotein domain family, member 7
LOC100286895 cell division cycle 27 homolog pseudogene
LRP6 low density lipoprotein receptor-related protein 6
LTBP2 latent transforming growth factor beta binding protein 2
METTL7A methyltransferase like 7A
MMP19 matrix metallopeptidase 19
MYRF myelin regulatory factor
NPHS1 nephrosis 1, congenital, Finnish type (nephrin)
OLAH oleoyl-ACP hydrolase
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PDCD2 programmed cell death 2
PER1 period circadian clock 1
POFUT1 protein O-fucosyltransferase 1
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2
PTK2B protein tyrosine kinase 2 beta
RBM19 RNA binding motif protein 19
REC8 REC8 meiotic recombination protein
RERE arginine-glutamic acid dipeptide (RE) repeats
RGS10 regulator of G-protein signaling 10
RHOB ras homolog family member B
RHOH ras homolog family member H
RND1 Rho family GTPase 1
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SDC2 syndecan 2
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
SPTB spectrin, beta, erythrocytic
ST14 suppression of tumorigenicity 14 (colon carcinoma)
TBCD tubulin folding cofactor D
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2)
THBS1 thrombospondin 1
THBS3 thrombospondin 3
TIMP2 TIMP metallopeptidase inhibitor 2
TJAP1 tight junction associated protein 1 (peripheral)
TMOD1 tropomodulin 1
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TSC22D3 TSC22 domain family, member 3
UBOX5 U-box domain containing 5
UPP1 uridine phosphorylase 1
USP2 ubiquitin specific peptidase 2
VCX2 variable charge, X-linked 2
VNN1 vanin 1
YLPM1 YLP motif containing 1
ZBTB16 zinc finger and BTB domain containing 16
ZBTB6 zinc finger and BTB domain containing 6
ZFYVE9 zinc finger, FYVE domain containing 9
ZNF215 zinc finger protein 215

decreased expression

Symbol Name
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
AIRE autoimmune regulator
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle)
ARRB1 arrestin, beta 1
ATAT1 alpha tubulin acetyltransferase 1
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
BHLHE41 basic helix-loop-helix family, member e41
BTBD18 BTB (POZ) domain containing 18
C17ORF80 chromosome 17 open reading frame 80
C22ORF29 chromosome 22 open reading frame 29
C5ORF45 chromosome 5 open reading frame 45
C9ORF9 chromosome 9 open reading frame 9
CAPN5 calpain 5
CCDC176 coiled-coil domain containing 176
CCL2 chemokine (C-C motif) ligand 2
CD3D CD3d molecule, delta (CD3-TCR complex)
CDHR2 cadherin-related family member 2
CDK20 cyclin-dependent kinase 20
CFAP69 cilia and flagella associated protein 69
CNKSR2 connector enhancer of kinase suppressor of Ras 2
COL4A2 collagen, type IV, alpha 2
CORT cortistatin
CPNE7 copine VII
CROT carnitine O-octanoyltransferase
CXCR3 chemokine (C-X-C motif) receptor 3
DDN dendrin
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3
DOC2A double C2-like domains, alpha
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
ENO3 enolase 3 (beta, muscle)
FAM50B family with sequence similarity 50, member B
FAM86C1 family with sequence similarity 86, member C1
FBXO31 F-box protein 31
FBXO40 F-box protein 40
GID4 GID complex subunit 4
GRAMD1B GRAM domain containing 1B
GRPR gastrin-releasing peptide receptor
HIST1H1T histone cluster 1, H1t
HOXC8 homeobox C8
HSPA2 heat shock 70kDa protein 2
IL1RAPL2 interleukin 1 receptor accessory protein-like 2
ITGA10 integrin, alpha 10
KCNA3 potassium channel, voltage gated shaker related subfamily A, member 3
LOC100287590 uncharacterized LOC100287590
LOXL3 lysyl oxidase-like 3
LRRC23 leucine rich repeat containing 23
LY6D lymphocyte antigen 6 complex, locus D
MBTPS2 membrane-bound transcription factor peptidase, site 2
MDM4 MDM4, p53 regulator
MGP matrix Gla protein
MRPL44 mitochondrial ribosomal protein L44
MYOZ3 myozenin 3
N6AMT1 N-6 adenine-specific DNA methyltransferase 1 (putative)
NAG18 NAG18 mRNA
NEB nebulin
NOD2 nucleotide-binding oligomerization domain containing 2
NRGN neurogranin (protein kinase C substrate, RC3)
NSD1 nuclear receptor binding SET domain protein 1
OCLN occludin
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
PADI1 peptidyl arginine deiminase, type I
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)
PBOV1 prostate and breast cancer overexpressed 1
PDE8B phosphodiesterase 8B
PER3 period circadian clock 3
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma
PLEKHG6 pleckstrin homology domain containing, family G (with RhoGef domain) member 6
PLSCR4 phospholipid scramblase 4
PMEL premelanosome protein
POM121L2 POM121 transmembrane nucleoporin-like 2
PRDM12 PR domain containing 12
PTGIR prostaglandin I2 (prostacyclin) receptor (IP)
RETN resistin
RNF126P1 ring finger protein 126 pseudogene 1
SCN10A sodium channel, voltage gated, type X alpha subunit
SIGLEC9 sialic acid binding Ig-like lectin 9
SLC16A2 solute carrier family 16, member 2 (thyroid hormone transporter)
SLC26A4 solute carrier family 26 (anion exchanger), member 4
SLC44A1 solute carrier family 44 (choline transporter), member 1
SLCO1B1 solute carrier organic anion transporter family, member 1B1
STMN4 stathmin-like 4
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1
SYTL2 synaptotagmin-like 2
TAS2R10 taste receptor, type 2, member 10
TCEB3B transcription elongation factor B polypeptide 3B (elongin A2)
TGFBR1 transforming growth factor, beta receptor 1
TLR4 toll-like receptor 4
TMC5 transmembrane channel-like 5
TNFRSF17 tumor necrosis factor receptor superfamily, member 17
TPM3 tropomyosin 3
TWSG1 twisted gastrulation BMP signaling modulator 1
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
ZBTB25 zinc finger and BTB domain containing 25
ZNF280A zinc finger protein 280A
ZNF747 zinc finger protein 747
ZNF76 zinc finger protein 76